Great to see publication of this amazing paper in Nature Health from colleagues in the Futures, Copilot Health and Data teams, led by Beatriz Costa Gomes and Pavel Tolmachev.

This is the first time anyone is sharing and analysing detailed information on how AI is being used for health reasons. It's a hugely important and revealing picture. If there was any doubt that the frontier for healthcare delivery is AI, it has now been dispelled. Certainly in the UK, most of are painfully aware of the problems within our health system. I genuinely believe that AI is probably the best shot we have at upgrading the entire experience in the manner we did once before across the middle decades of the twentieth century.

It is though a huge responsibility for those building these systems to get it right. There is no area with higher stakes or greater demands.

New study out in BMJ Open -> We audited five major AI chatbots using adversarial-style prompts to assess how they respond to health and medical questions in misinformation-prone contexts. Nearly half (49.6%) of responses were rated problematic (e.g., suggesting possible alternative cancer clinics for treatment), with little evidence of meaningful guardrails (e.g., question refusals) and frequent use of poor or fabricated citations.

Link to study: https://lnkd.in/gXk9YDuy. Completed with a great team: Nicholas Tiller, Alessandro R Marcon, Zubin Master, Kristine Kidd, Asker Jeukendrup, & Timothy Caulfield.

New paper published in BMC Medicine:
https://lnkd.in/g8h_zDsP

Among many viruses, SARS-CoV-2 has provided a rare opportunity to understand how immune protection develops following vaccination in the absence of prior infection.

In this study, we analyzed data from the MARVELS (MARkers of Vaccine Efficacy and Longevity in SARS-CoV-2) cohort—a longitudinal study of healthy children aged 5–12 years vaccinated with BNT162b2 in Singapore. Participants were followed for over a year (now extended to three years, with the final year ongoing), with repeated measurements of key immunological markers, including binding and neutralizing antibody titers (nAbs), spike-specific memory B cells (MBCs), and spike-reactive T cell responses.

Using a mathematical modeling framework, we reconstructed the dynamics of these immune responses over time and evaluated their association with infection risk. A few key findings:

1. Antibodies drive early protection, but their role declines over time
2. From ~3 months onward, T cell responses become the dominant correlate of protection
3. This effect is strongest under hybrid immunity
4. Memory B cells and T cells show more sustained dynamics than antibodies
5. Model projections suggest ~500 days of protection under hybrid immunity (requires external validation)

These findings highlight the time-dependent nature of correlates of protection and the importance of moving beyond single time-point measurements when interpreting immune responses.

This work was a collaboration with the MARVELS team. The study was designed by Prof Lynette Shek, Prof Elizabeth Tham, and Prof Youjia Zhong. I am grateful to all clinicians and scientists involved in data collection, and to the children and families who participated. I would also like to congratulate my team, particularly Hoong Kai Chua and YIYU LIAO, for their excellent work on the data analyses.

We celebrated this milestone over lunch (photo) and are already discussing the next phase of analyses using the full three-year dataset. Stay tuned!

Boon Kiat Law, Yuqian Wang, Franciszek Polak, Allyson Choi, Carina Tay, Hui’En Li

NTU LKCMedicine PHD Programme, NUS Yong Loo Lin School of Medicine, Duke-NUS Medical School

Are campaign-style approaches the most efficient way to vaccinate missed children?

This study from Ethiopia examines the cost of using Periodic Intensification of Routine Immunization (PIRI) to reach zero-dose children in hard-to-reach areas—and highlights important trade-offs for programme design.

📊 Key findings:
• 1,449 zero-dose children were reached (64% of Penta1 doses delivered) across assessed PIRI sessions
• Economic cost per zero-dose child reached: $6.65
• Strong regional variation ($13.06 in Afar vs $4.82 in Somali)
• Higher delivery volumes in Somali were associated with lower unit costs
• Per diem and travel allowances accounted for over half of costs

💡 While PIRI can reach many zero-dose children cost-efficiently, infrequent campaigns may increase dropout if children are not effectively linked to routine services. Caregivers may wait for the next PIRI for follow-up doses, increasing the time children are left off-schedule. More frequent PIRIs could reduce this risk—but would likely reduce cost-efficiency.

Ensuring strong routine immunization systems is key to sustaining the gains achieved through campaign-style strategies.

Read more here 👉 https://lnkd.in/es5_h3zJ

Authors: Abdi Gari, Firew Bobo, Flavia Moi, Melkamu Ayalew, Yohannes Lakew Tefera, Mirkuzie Woldie, Girmaye D Dinsa, Laura Boonstoppel

Haramaya University Fenot Associates Federal Ministry of Health Ethiopia
Health Systems Insight Jimma University Harvard T.H. Chan School of Public Health

Confused why a lawyer would be talking about vaccines? It's because mandates infringe on civil and individual rights. Pushing mandates by claiming vaccines are "safe and effective" made this claim a legal and political issue. To reverse course, end mandates, immunity to liability, and gov't involvement. But that is unlikely to happen willingly because these products can't survive on their own merit. | 17 comments on LinkedIn

HPV vaccines could be even more of a game-changer for head and neck cancers than for cervical cancer, Otis Brawley told me maybe 15 years so ago.

A new study suggests he was right. Find out why in my latest story for CIDRAP News.

P.S. Getting the chance to interview Otis was the highlight of my work week.

https://lnkd.in/eMqcEva3

Business as usual isn't working for vaccines – and the Australian College of Nursing is calling for change.

Vaccination coverage is sliding, and now at five-year lows for children. Influenza rates have been at record highs, and other vaccine-preventable diseases like measles are circulating.

ACN is urging the Federal Government to fund nurses to deliver vaccines where people are: Urgent Care Clinics, and community settings from libraries to men's sheds.

Nurses already deliver more vaccines than any other profession, even though they’re not funded to.

Let’s increase access to trusted health care, and prevent avoidable hospitalisations and hospital spending.

Read the full media release: https://ow.ly/bOyA50YIwM7

Featured: ACN Chief Nursing Officer Frances Rice MACN appearing on SBS World News.

Hier, une patiente me dit :
“𝗔𝗵 𝗯𝗼𝗻 ? 𝗢𝗻 𝗽𝗲𝘂𝘁 𝘀𝗲 𝗳𝗮𝗶𝗿𝗲 𝘃𝗮𝗰𝗰𝗶𝗻𝗲𝗿 𝗶𝗰𝗶 ?”

𝘚𝘪𝘭𝘦𝘯𝘤𝘦.

Parce que derrière cette question, il y a une réalité un peu dérangeante :

👉 𝘖𝘯 𝘷𝘢𝘤𝘤𝘪𝘯𝘦... 𝘮𝘢𝘪𝘴 𝘱𝘦𝘳𝘴𝘰𝘯𝘯𝘦 𝘯𝘦 𝘭𝘦 𝘴𝘢𝘪𝘵.

On a :
✔️ les compétences
✔️ les formations
✔️ les protocoles
✔️ la confiance des patients

On participe aux campagnes de santé publique.
On désengorge les cabinets médicaux.
On capte des patients qui, sinon, ne se feraient pas vacciner.

𝗕𝗿𝗲𝗳, 𝗼𝗻 𝗳𝗮𝗶𝘁 𝗹𝗲 𝗷𝗼𝗯.

Mais dans la tête des patients ?

👉 La pharmacie = médicaments
👉 Le médecin = vaccination

𝗘𝘁 𝗹𝗮, 𝗶𝗹 𝘆 𝗮 𝘂𝗻 𝘃𝗿𝗮𝗶 𝗱𝗲𝗰𝗮𝗹𝗮𝗴𝗲.

Pas un problème de compétence.
Un problème de perception.

𝘗𝘢𝘳𝘤𝘦 𝘲𝘶’𝘢𝘶𝘫𝘰𝘶𝘳𝘥’𝘩𝘶𝘪, 𝘤𝘦 𝘲𝘶𝘪 𝘯’𝘦𝘴𝘵 𝘱𝘢𝘴 𝘷𝘪𝘴𝘪𝘣𝘭𝘦... 𝘯’𝘦𝘹𝘪𝘴𝘵𝘦 𝘱𝘢𝘴.

(Et en santé, c’est encore plus vrai.)

𝗖’𝗲𝘀𝘁 𝗲𝘅𝗮𝗰𝘁𝗲𝗺𝗲𝗻𝘁 𝗰𝗲 𝗾𝘂’𝗼𝗻 𝗼𝗯𝘀𝗲𝗿𝘃𝗲 𝗮𝘃𝗲𝗰 𝗦𝘁𝘂𝗱𝗶𝗼 𝗕𝗹𝗼𝗼𝘇 :
Des officines qui proposent des services clés (TROD cystite, vaccination, dépistage…) 👉 mais qui ne les rendent pas visibles.

Résultats :
❌ des patients qui passent à côté
❌ des équipes qui sous-exploitent leur potentiel
❌ un rôle de pharmacien qui évolue… sans être perçu comme tel
🚨Communiquer, ce n’est pas “faire du marketing”. 🚨

Communiquer c’est :
✅ rendre visible une mission de santé
✅ informer correctement
✅ permettre au patient de faire le bon choix

𝘈𝘶𝘫𝘰𝘶𝘳𝘥’𝘩𝘶𝘪, 𝘭𝘦 𝘱𝘩𝘢𝘳𝘮𝘢𝘤𝘪𝘦𝘯 𝘷𝘢𝘤𝘤𝘪𝘯𝘦.
𝗠𝗮𝗶𝘀 𝗱𝗲𝗺𝗮𝗶𝗻,𝗰𝗲𝘂𝘅 𝗾𝘂𝗶 𝗳𝗲𝗿𝗼𝗻𝘁 𝗹𝗮 𝗱𝗶𝗳𝗳𝗲𝗿𝗲𝗻𝗰𝗲, 𝗰𝗲 𝘀𝗲𝗿𝗼𝗻𝘁 𝗰𝗲𝘂𝘅 𝗾𝘂𝗶 𝗹𝗲 𝗺𝗼𝗻𝘁𝗿𝗲𝗻𝘁.

Et vous, combien de vos patients savent que vous vaccinez ? 🤔


#communication #communitymanager #officine #vaccin #studioblooz Sarah Talhaoui

Before a vaccine is ever introduced, clinical trials follow established processes to support rigorous, well-governed research.

Data and Safety Monitoring Boards (DSMBs) are part of that process. These independent groups review accumulating trial data and provide recommendations to support appropriate study conduct.

A recent article from The Task Force for Global Health, Inc. highlights the importance of this role and the need to strengthen global capacity.

Through its DSMB training program, SPEAC is helping prepare experts to serve on these boards. The program focuses on technical competency alongside core governance principles such as independence, transparency, and consistency in data review.

As a program of Brighton Collaboration, this work contributes to strengthening standardized approaches to clinical trial oversight across settings.

📖 Read the full article:
https://lnkd.in/eCTaNXjx

SPEAC is fully funded by CEPI, the Coalition for Epidemic Preparedness Innovations.

#VaccineSafety #ClinicalTrials #DSMB #GlobalHealth #Pharmacovigilance

Very excited about this webinar with National Academy of Medicine, the American Public Health Association, and a few of our favorite experts, Katelyn Jetelina, Amanda Kwong, MPH, Nita Mohanty, MD, MS, Todd Wolynn MD, MMM, FAAP, Anne Zink all coming to a computer screen near you to talk tactical communications strategies and tools on a topic that's unfortunately keeping many of us up at night right now: measles.

Join us for this important, timely, and rockstar-filled conversation!

Common Health Coalition Dave A. Chokshi, MD Rebecca Giglio, MPH Michael Lanza Janine Knudsen Christopher Chen, MD, MBA Paul R. Rodríguez

#VAXVOICE #POSTS @vaxvoice.org
HPV PHARMACCINES LANDSCAPE
"This review provide s an overview of current therapeutic human papillomavirus (HPV) vaccination approaches. We review important criteria for their development, and present vaccines currently being actively followed in clinical trials, for precursor lesions or established cancers. Subsequently, we list approaches that reached clinical trial stage but were abandoned. Lastly, we discuss promising preclinical studies. We conclude with a brief overview of novel in silico tools developed to enhance vaccine design." https://lnkd.in/dXaKbe2M

Substantial amount of medical information provided by popular chatbots inaccurate and incomplete

Half of answers to evidence based questions “somewhat” or “highly” problematic; public education and oversight needed to avoid amplifying misinformation, urge researchers

A substantial amount of medical information provided by 5 popular chatbots is inaccurate and incomplete, with half of the answers to clear evidence based questions “somewhat” or “highly” problematic, show the results of a study published in the open access journal BMJ Open.

Continued deployment of these chatbots without public education and oversight risks amplifying misinformation, warn the researchers.

While the quality of responses didn’t differ significantly among the 5 chatbots, Grok generated significantly more highly problematic responses than would be expected (29/50; 58%). Gemini generated the fewest highly problematic responses and the most non-problematic ones.

The chatbots performed best in the area of vaccines and cancer, and worst in the area of stem cells, athletic performance, and nutrition.

Source in comments.

poor antivax ! their universe is collapsing 🤣😂

CIDRAP's Vaccine Integrity Project posted protocols for their upcoming systematic reviews of three immunizations against respiratory pathogens. Full details of the systematic reviews are available publicly. ⬇️


💉 Effectiveness and Safety of COVID-19 Immunizations in Adults and Children: Evidence Review to Inform the 2026-27 Respiratory Virus Season
https://ow.ly/bhPS50YIYqw

💉 Effectiveness and Safety of Influenza Immunizations in Adults and Children: Evidence Review to Inform the 2026-27 Respiratory Virus Season https://ow.ly/e0si50YIYqy

💉 Effectiveness and Safety of Respiratory Syncytial Virus (RSV) Immunizations in Adults and Children: Evidence Review to Inform the 2026-27 Respiratory Virus Season https://ow.ly/lWuv50YIYqx


Research protocols are important because they show methodological rigor and transparency, and once they're in place, they can't be changed based on what researchers find. They also allow others to follow and duplicate the work.

More information on the Project: https://ow.ly/15un50YIYqv

This cross-sectional study examined perceptions of health and ageing, and their influence on vaccine acceptance among individuals aged 65 and older living

Western Australian children can now access a game changing needle-free influenza vaccination, with Australia’s most comprehensive FluMist program launched yesterday by Hon Meredith Hammat MLA, Minister for Health; Mental Health, and Hon Sabine Winton MLA, Minister for Education; Early Childhood; Preventative Health; Wheatbelt.

Eligible children aged 2 to 11 years can access the intranasal spray vaccine, offering a simple and painless alternative to the traditional injection.

The vaccine will be available through Child and Adolescent Community Health Immunisation clinics and at the Perth Children’s Hospital Stan Perron Immunisation Centre, as well as GPs, Aboriginal Medical Services and pharmacies across the state.

FluMist provides a safe and painless alternative for many children who may be anxious about needles.

The vaccine is highly effective, providing equivalent protection against influenza A and B as traditional injectable influenza vaccines.

FluMist is expected to increase influenza vaccine rates among young children and help reduce the spread of influenza across the community during winter. 

Learn more at https://lnkd.in/gcuWN3CV

"Shortly after Kennedy was nominated, questions swirled over how he might overhaul America’s immunization system. Two Stanford University researchers wondered how many people would suffer if vaccination rates dropped or shots became entirely unavailable for four of the most infamous diseases: polio, measles, rubella and diphtheria.

Outbreaks often start when an American catches one of these illnesses abroad and returns home. So epidemiologists Mathew Kiang and Nathan Lo, who is also an infectious diseases doctor, built a model to simulate how the four contagions could spread from sick travelers based on each state’s vaccination rates.

Since a sizable chunk of the population is currently vaccinated, some of the infections wouldn’t get a foothold right away. But over time, as more babies are born and not vaccinated, a larger share of the population would become susceptible.

The professors ran thousands of simulations for each disease, producing a range of possible outcomes. From there, they figured out the average number of deaths and disabilities over a 25-year period.

Their model shows that at current vaccination rates, the nation is already teetering on the brink of an explosion in measles cases — one that would be virtually wiped out with just a 5% increase in vaccination. But if current rates drop by half, all four diseases could return."
https://lnkd.in/gCXPq6M6

Would you believe that a anti-vaccine/ pro-ivermectin/ McCullough Foundation minion has reported this as misinformation ? And that LinkedIn has yet to understand that there is no reason for such. The reality is simplement and remains: the #mccullough paper is a terrible paper that should never have been published, and that must retracted. It is simply a trash paper that does hold to any standards of an oncology study. As said, poor on methods, science, reporting, assessment of patient demographics, staging of their cancer and responses. A paper that simply is the perfect definition of a placebo is in the mind of patients brain washed to believe it might help them which is not the case as ivermectin adds nothing to the standard of care and optimized cancer therapies they are on…

Can free HPV vaccination actually save money for health systems?

This new peer-reviwed study explores that question by modelling the costs and health benefits of introducing free HPV vaccination for adolescent girls in Rajasthan, India, compared to the current scenario without vaccination.

What stands out:
💰 Free HPV vaccination is not only cost-effective—but cost-saving
📊 Strong economic value is maintained across multiple scenarios
📈 The intervention meets standard cost-effectiveness thresholds
💉 A single-dose schedule could further enhance affordability and feasibility
🌐 The model offers a scalable approach for similar settings

🔗 Read more here: https://lnkd.in/eqhAWAZE

Authors: Saloni Munot, Narayana Prasad MD,MPH,MS,ALM,FASE, Rashmi Paudel, Sarthak Gaurav, Sujata Saunik, Robert Paulino-Ramirez, MD, MPH, MSc, DTMH, MA, AAHIVS, Edima Ottoho, Mayra Volquez, M.S., Rezaul Karim Ripon, Priyanka Manghani, Nachiket Thakkar, BDS, MSHI, Shishir Gokhale

See my full thread on X and BlueSky

#Measles outbreaks aren't just preventable and often tragic -- they're also expensive.

A new study in PNAS by Chad Wells, Burton Singer and Alison Galvani finds that a sustained drop in childhood vaccinations could cost the US about $7.8 billion in outbreaks by 2030.

Free 🎁 🔗 ⬇️
https://lnkd.in/gJpW2GVJ

#SEV2026 🔊La FRAPS vous présente son classeur d'activités CAPSule Santé #Vaccination 👉 Il contient 10 fiches activités pour promouvoir la vaccination auprès des enfants de 7 à 12 ans.

💡 Une éducation à la vaccination dès l’âge scolaire, sous forme participative, d’expérimentations et d’apports de connaissances permet aux enfants de mieux comprendre l’intérêt et l’importance de la vaccination. C'est également un moyen de lutter contre la #désinformation parfois véhiculée sur les réseaux sociaux autour de la vaccination, en encourageant le déveleoppement de l’#espritcritique.

📞 N'hésitez-pas à contacter vos antennes FRAPS Promotion Santé en Région Centre-val de Loire pour découvrir l'outil ➡️ https://lnkd.in/ePJ6-Vit

Anti vaccine mindset is a cult. A deadly one

What Implementation Strategies Can Help To Improve Vaccine Uptake?

Improving vaccine uptake remains one of the most impactful and increasingly complex challenges in modern healthcare.

This article highlights strategies that can be implemented to increase vaccine acceptance and uptake including case studies from the Maternal Vaccination Service, South Warwickshire University NHS Foundation Trust and UHCW Maternity Vaccination Service.