Analyzing nasal swabs taken during the pandemic, researchers at Yale School of Medicine suggest that the frequent presence of other viruses and bacteria may have helped to protect children from the worst effects of COVID-19 by boosting their immune systems.
FOR IMMEDIATE RELEASECredit: Public Domain Image FOR IMMEDIATE RELEASE People who have received solid organ transplants and take immunosuppressant medications to prevent rejection are among those most susceptible to the damaging effects of COVID-19, including breakthrough infections, severe illness,...
Biomolecular condensates are membraneless hubs of condensed proteins and nucleic acids within cells, which researchers are realizing are tied to an increasing number of cellular processes and diseases.
"Who are we and where do we come from?" This quintessential question has intrigued humanity for millennia. Currently, the "Out-of-Africa (OOA) theory" is prevailingly accepted regarding the origin of modern humans, as a line of evidence indicates that Homo sapiens originated in Africa.
A research team from Constructor University, led by geochemist and geoscientist Prof. Dr. Michael Bau, and including his former students Lea Krohn, Franziska Klimpel and Pauline Béziat, has presented a new study on the effects of COVID-19 and climate change on wastewater-derived substances in...
Researchers have described the optimal timing for COVID-19 patients to take the antiviral, Paxlovid, to get the most benefit from the treatment, according to a study published April 16 in eLife.
The availability of new technologies for deep sequencing, including next-generation sequencing (NGS), allows for the detection of viral genome variations. The epidemiological determination of SARS-CoV-2 viral genome changes during the pandemic waves displayed the genome evolution and subsequent...
The COVID-19 pandemic has underscored the critical need for the advancement of diagnostic and therapeutic platforms. These platforms rely on the rapid development of molecular binders that should facilitate surveillance and swift intervention against viral infections.
Intranasal administration of neomycin sulfate in murine models shows promise as a prophylactic and therapeutic agent against respiratory viruses like influenza A and SARS-CoV-2 by inducing interferon-stimulated gene (ISG) expression, independent of microbiota and interferon activation.
Vaccines remain the gold standard of protection against dangerous pathogens, but take considerable time and vast resources to develop. Rapidly mutating viruses such as SARS-CoV-2 can blunt their effectiveness and even render them obsolete.
Background: SARS-CoV-2 can damage human placentas, leading to pregnancy complications, such as preeclampsia and premature birth. This study investigates the histopathological changes found in COVID-19-affected placentas.
Chang MH, Park JH, Lee HK, Choi JY, Koh YH. SARS-CoV-2 Spike Protein 1 Causes Aggregation of α-Synuclein via Microglia-Induced Inflammation and Production of Mitochondrial ROS: Potential Therapeutic Applications of Metformin. Biomedicines. 2024 May 31;12(6) PubMed.
New research provides the clearest evidence yet that the Cambrian explosion—a rapid burst of evolution 540 million years ago, could have been triggered by only a small increase in oxygen levels in Earth's atmosphere and shallow ocean waters.
Researchers at Arizona State University have made a significant advance in understanding how genes are controlled in living organisms. The new study, published in the journal Nucleic Acids Research, focuses on critical snippets of RNA in the tiny, transparent roundworm Caenorhabditis elegans (C.
Whole genome sequencing was crucial in combatting the COVID-19 pandemic—from real-time monitoring of SARS-CoV-2 spread and evolution, to guiding public health responses, treatments, and vaccine development.
Building on this, Struelens et al. advocate for integration of pathogen genomic data and epidemiological data into globally interconnected One Health surveillance systems. Their lead article outlines necessary enablers for deploying real-time genomic surveillance of pathogens and antimicrobial resistance worldwide—including data-sharing platforms, new sequencing technologies, and cross-sector collaborations.
Citation: Struelens MJ, Ludden C, Werner G, Sintchenko V, Jokelainen P and Ip M. Real-time genomic surveillance for enhanced control of infectious diseases and antimicrobial resistance. Front Sci (2024) 2:1298248. doi: 10.3389/fsci.2024.1298248
Adjuvants enhance immune responses stimulated by vaccines. To date, many seasonal influenza vaccines are not formulated with an adjuvant. In the present study, the adjuvant Advax-SM™ was combined with next generation, broadly reactive influenza hemagglutinin (HA) vaccines that were designed using...
Initially reported as pneumonia of unknown origin, COVID-19 is increasingly being recognized for its impact on the nervous system, despite nervous system invasions being extremely rare. As a result, numerous studies have been conducted to elucidate the mechanisms of nervous system damage and...
SARS-CoV-2, the causative agent of the ongoing COVID-19 pandemic, has revealed a broader impact beyond the respiratory system, predominantly affecting the vascular system with various adverse manifestations.
WHAT IS ALREADY KNOWN ON THIS TOPICCancer can be controlled by T cells that recognize tumor antigens. Checkpoint immunotherapy increases the effectiveness of T cells in controlling cancer by restoring function to exhausted T cells. In a significant fraction of patients, immunotherapy is not successful, most likely because there are not a sufficient number of T cells that target tumor antigens. Dendritic cells present tumor antigen epitopes to T cells on major histocompatibility complex class I but may not activate a sufficient number of antitumor T cells. Therapeutic dendritic cell vaccines that present tumor antigen to T cells have seen some clinical success. Lentiviral vectors provide a means to achieve long-term expression of transgenes by virtue of their ability to integrate into the host cell chromosome.
Despite huge advances in our understanding of COVID-19 over the past four years, the disease is still very much among us—and there remains a lot to learn.
To get content containing either thought or leadership enter:
To get content containing both thought and leadership enter:
To get content containing the expression thought leadership enter:
You can enter several keywords and you can refine them whenever you want. Our suggestion engine uses more signals but entering a few keywords here will rapidly give you great content to curate.
Your new post is loading...
Scoop.it!
