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Scooped by
Ed Rybicki
July 16, 2024 11:23 AM
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The covid pandemic has been linked to quicker progression to clinical disease in young people with presymptomatic type 1 diabetes. This accelerated progression was confined to people who had a confirmed covid infection, German researchers said in a research letter in JAMA.
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Scooped by
Ed Rybicki
July 16, 2024 11:21 AM
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An international research collaboration has uncovered a new mechanism of the crosstalk between microtubules and actin cytoskeleton during cell division and revealed unique characteristics of the previously unexplored protein FAM110A.
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Scooped by
Ed Rybicki
July 16, 2024 11:20 AM
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CRISPR-Cas systems, defense systems in bacteria, have become a plentiful source of technologies for molecular diagnostics. Researchers at the Helmholtz Institute for RNA-based Infection Research (HIRI) in Würzburg have expanded this extensive toolbox.
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Scooped by
Ed Rybicki
July 9, 2024 8:19 AM
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A series of experiments with highly pathogenic H5N1 avian influenza (HPAI H5N1) viruses circulating in infected U.S. dairy cattle found that viruses derived from lactating dairy cattle induced severe disease in mice and ferrets when administered via intranasal inoculation.
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Scooped by
Ed Rybicki
July 9, 2024 8:18 AM
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A team of astronomers has identified a temperate exoplanet as a promising super-Earth ice or water world.
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Scooped by
Ed Rybicki
July 9, 2024 8:16 AM
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In a study published in the journal National Science Review, researchers developed an amplifiable protein identification method called "AmproCode."...
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Scooped by
Ed Rybicki
July 9, 2024 7:22 AM
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Researchers reveal both direct and indirect mechanisms of SARS-CoV-2-induced lymphopenia, highlighting the role of CD147 and alternative viral entry routes into T cells.
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Scooped by
Ed Rybicki
July 9, 2024 7:21 AM
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Researchers investigated whether COVID-19-related sensory deficiencies are associated with transcriptome changes in the foliate papillae area of the tongue.
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Scooped by
Ed Rybicki
July 2, 2024 2:19 PM
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Background More than a year after recovering from COVID-19, a large proportion of individuals, many of whom work in the healthcare sector, still report olfactory dysfunctions. However, olfactory dysfunction was common already before the COVID-19 pandemic, making it necessary to also consider the...
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Scooped by
Ed Rybicki
July 2, 2024 2:18 PM
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During the COVID-19 pandemic, the EMA Emergency Task Force (ETF) issued two guidance documents on regulatory requirements for COVID-19 vaccines. The first, issued in November 2020, covered clinical requirements for COVID-19 vaccine approval, and the second, issued in February 2021, addressed quality, non-clinical, clinical and clinical requirements for SARS-CoV-2 variant vaccines. Since these documents were published there have been several developments in the field of COVID-19 vaccines. In parallel, the predominant circulating variants of SARS-CoV-2 continue to evolve over time and the immunity of the European Union (EU) population to prior and current variants has increased due to natural exposures and vaccination campaigns. Experience with applications for scientific advice and for marketing authorisation since 2021 have pointed to the need for revision of the guidance documents. It is proposed to consolidate the two guidance documents into a single guideline that covers the non-clinical and clinical aspects of the development of vaccines against COVID-19.Keywords: Vaccine platforms, mRNA, immunobridging, effectiveness, SARS-COV-2, regulatory requirements, sarbecovirus, broad coverage Current version Concept paper on the revision of the COVID-19 vaccines guidance documentsConsultation dates: 01/07/2024 to 30/09/2024Reference Number: EMA/CHMP/276798/2024 English (EN) (187.42 KB - PDF)First published: 01/07/2024View Related content Multidisciplinary: vaccinesCOVID-19 guidance: assessment and marketing authorisationCOVID-19 vaccines: key factsClinical evaluation of new vaccinesShare this page
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Scooped by
Ed Rybicki
July 2, 2024 2:17 PM
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A new study challenges the common theory that the devastating potato blight pathogen Phytophthora infestans originated in Mexico. Researchers meticulously reconstructed its global migration history and found it likely originated in the South American Andes before spreading globally.
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Scooped by
Ed Rybicki
July 2, 2024 2:15 PM
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Researchers have programmed a close relative of tobacco plants to produce prebiotic sugars found in human breast milk.
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Scooped by
Ed Rybicki
July 2, 2024 2:15 PM
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Babies born during the COVID-19 pandemic in India were more likely to have a lower birth weight (LBW) than those who were born before the pandemic. Newborns with LBW are at a higher risk of physical and cognitive deficits and behavioral abnormalities later in life.
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Scooped by
Ed Rybicki
July 16, 2024 11:22 AM
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Researchers at the vast facility describe the ‘pre-pandemic’ jabs being made there as a ‘first line of defence’...
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Scooped by
Ed Rybicki
July 16, 2024 11:20 AM
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Budding new plant biology research is paving the potential to produce food crops that not only survive but thrive in salty conditions. With salt estimated to affect up to 30% of arable land worldwide—jeopardizing the survival of crops—the salinity crisis is a costly burden on agricultural...
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Scooped by
Ed Rybicki
July 16, 2024 11:19 AM
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A new study of radar experiment data from the Cassini-Huygens mission to Saturn has yielded fresh insights related to the makeup and activity of the liquid hydrocarbon seas near the north pole of Titan, the largest of Saturn's 146 known moons.
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Scooped by
Ed Rybicki
July 9, 2024 8:19 AM
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The grapes that give us wine likely originated in the New World 60 million years ago, according to new research.
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Scooped by
Ed Rybicki
July 9, 2024 8:17 AM
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Plant pathogens often infect specific tissues, causing significant agricultural losses. Recent studies highlight the crucial role of small RNAs (sRNAs), including miRNAs, in regulating these interactions.
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Scooped by
Ed Rybicki
July 9, 2024 8:00 AM
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A research team developed hybrid bio-nanostructures then used them to fabricate fibrous solar cells (FSCs) and fibrous organic light-emitting diodes (FOLEDs) that demonstrated high performance and stability across a wide temperature range, from minus 80 degrees Celsius to 150 degrees Celsius.
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Scooped by
Ed Rybicki
July 9, 2024 7:22 AM
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Antibiotics are widely used in clinical treatment and animal production as an effective means to combat microbial infections. Antimicrobial peptides, as potential alternatives to antibiotics, have shown promising applications.
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Scooped by
Ed Rybicki
July 2, 2024 2:20 PM
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Despite assurances from the federal government that bird flu will be eradicated from the nation's dairy cows, some experts worry the disease is here to stay.
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Scooped by
Ed Rybicki
July 2, 2024 2:19 PM
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Angiogenin, an enzyme that plays a critical role in cellular stress responses and aids vascular formation, has previously been implicated in the formation of solid cancer tumors, neurodegenerative disorders and epigenetic inheritance, and has been the focus of intense study by scientists for four...
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Scooped by
Ed Rybicki
July 2, 2024 2:17 PM
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In recent years, messenger RNA (mRNA) has emerged as a promising avenue for accurate and potent therapeutic interventions. Unlike DNA drugs, mRNA can express genetic information without the risk of integrating into the host genome.
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Scooped by
Ed Rybicki
July 2, 2024 2:16 PM
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"This could really change the game for the early screening of esophageal cancer and is a project that we are very excited about."...
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Scooped by
Ed Rybicki
July 2, 2024 2:15 PM
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Imagine opening a time capsule, hoping to learn about the ancient past. Except, instead of a box or a chest, it's an asteroid that could provide insights into the very dawn of life on Earth.
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