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Scooped by
Ed Rybicki
January 19, 2023 6:04 AM
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Cann's Principles of Molecular Virology, - 7th Edition, revised by EP Rybicki. Print Book. ISBN 9780128227848. Now published!!
"Cann's Principles of Molecular Virology, Seventh Edition provides an easily accessible introduction to modern virology, presenting principles in a clear and concise manner. The new edition provides the history of virology and the fundamentals of the molecular basis of how viruses work.
Instructor review copies: click on this link. https://protect-za.mimecast.com/s/qU2qCNxKq0i0ZNRQxcmeDdo
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Scooped by
Ed Rybicki
Today, 4:59 AM
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Visualisation of multiprotein complexes in cellular contexts remains challenging. Here, the authors present a tripartite chemogenetic fluorescent reporter, which enables the imaging of ternary protein complexes in living cells, advancing the study of dynamic multiprotein interactions across...
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Scooped by
Ed Rybicki
Today, 4:59 AM
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This Review reflects on the major challenges in bacterial mRNA vaccine design, provides strategies for tailoring mRNA construct design to promote humoral or cellular immunity, and provides an overview of the translational landscape for mRNA vaccines.
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Scooped by
Ed Rybicki
Today, 4:58 AM
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Imagine you're a molecular biologist wanting to launch a project seeking treatments for a newly emerging disease. You know you need the expertise of a virologist and an immunologist, plus a bioinformatics specialist to help analyze and generate insights from your data. But you lack the resources or connections to build a big multidisciplinary team.
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Scooped by
Ed Rybicki
Today, 4:56 AM
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In a groundbreaking study recently published in npj Viruses, a team of researchers led by Halfmann and colleagues has unveiled promising new insights into vaccine design against Merbecoviruses, a subgenus of coronaviruses that includes the Middle East Respiratory Syndrome coronavirus (MERS-CoV).
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Scooped by
Ed Rybicki
May 7, 8:08 AM
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The rapid deployment of mRNA vaccines for SARS-CoV-2, such as BNT162b2 (BioNTech-Pfizer) and mRNA-1273 (Moderna), provided a critical tool in combatin…...
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Scooped by
Ed Rybicki
May 7, 8:08 AM
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The burden of herpes simplex virus (HSV) infection is exacerbated due to the emergence of antiviral drug resistance and a lack of effective antibodies. Here the authors construct a bispecific nanobody that blocks receptor binding and prevents gD-gH/gL interaction, and show that it protects against...
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Scooped by
Ed Rybicki
May 7, 8:07 AM
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Researchers used AI models to design antibodies that neutralize over 1,300 SARS-CoV-2 strains, including Delta and Omicron. The models demonstrated faster, cheaper, and more adaptable therapeutic development compared to traditional methods.
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Scooped by
Ed Rybicki
May 7, 8:04 AM
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Ribonucleic acid (RNA) molecules may be best known for their job ferrying the genetic information encoded in DNA to a cell's protein factories, but these molecules aren't just a middleman for protein production. In fact, some RNA molecules don't code for proteins at all and serve various other important functions in cells, such as regulating gene expression and catalyzing chemical reactions. However, the functions of many non-coding RNAs remain mysterious.
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Scooped by
Ed Rybicki
May 7, 8:03 AM
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Exactly 100 years ago, famed Austrian physicist Erwin Schrödinger (yes, the cat guy) postulated his eponymous equation that explains how particles in quantum physics behave. A key component of quantum mechanics, Schrödinger's Equation provides a way to calculate the wave function of a system and how it changes dynamically in time.
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Scooped by
Ed Rybicki
May 7, 8:02 AM
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Patients suffering from long COVID may exhibit persistent inflammation in the heart and lungs for up to a year following SARS-CoV-2 infection-even when standard medical tests return normal results-potentially placing them at elevated risk for future cardiac and pulmonary conditions.
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Scooped by
Ed Rybicki
May 7, 8:01 AM
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This research provides a comprehensive review of aptamer-based strategies that target SARS-CoV-2, offering a promising avenue for blocking the virus. Behind this groundbreaking paper lies a tale of collaboration across borders, and a quest for the most comprehensive aptamer summary ever compiled.
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Scooped by
Ed Rybicki
April 30, 7:08 AM
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Delivering functional proteins or protein complexes into cells continues to be a significant challenge. Here, the authors develop efficient systems by using engineered extracellular vesicles to deliver functional cargoes, including CRISPR/Cas9-ribonucleoproteins, both in vitro and in vivo.
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Scooped by
Ed Rybicki
Today, 5:00 AM
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The three-dimensional (3D) atomistic-resolution structure and dynamics of RNA kissing complexes (KCs) and extended duplexes (EDs), homodimers formed through palindromic base pairing, are crucial for understanding viral replication and structure-informed therapeutic design.
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Scooped by
Ed Rybicki
Today, 4:59 AM
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Drivers of viral evolution in SARS-CoV-2 are insufficiently understood. In this study, the authors show how a key SARS-CoV-2 mutation, NSP4 T492I, is potentially responsible for accelerating genome evolution to develop adaptive variants (e.g.
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Scooped by
Ed Rybicki
Today, 4:58 AM
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Researchers around the world are testing wastewater for the SARS-CoV-2 virus, in hopes that what goes down the drain can act as an early warning...
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Scooped by
Ed Rybicki
Today, 4:57 AM
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Amyloids are perhaps best known as a key driver of Alzheimer's disease.
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Scooped by
Ed Rybicki
Today, 4:56 AM
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Wastewater-based epidemiology (WBE) is the analysis of wastewater to identify the presence of biologicals or chemicals for the purpose of monitoring...
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Scooped by
Ed Rybicki
May 7, 8:08 AM
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Sudan virus (SUDV) outbreaks in Uganda created public health concerns due to a lack of approved vaccines. In this study, the authors develop a repRNA SUDV vaccine and demonstrate full protection of a single dose of this vaccine in a lethal SUDV guinea pig model.
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Scooped by
Ed Rybicki
May 7, 8:07 AM
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In this Review, Chen, Farzan and Choe discuss our current understanding of the structure and function of the SARS-CoV-2 spike protein, the molecular mechanism of viral entry and the emergence of new variants, as well as the implications of these insights for development of spike protein-related...
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Scooped by
Ed Rybicki
May 7, 8:07 AM
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Journal of Virology, Ahead of Print.
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Scooped by
Ed Rybicki
May 7, 8:04 AM
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USask researchers recently published a paper in Scientific Reports that identified a promising alternative for controlling infectious diseases such as swine dysentery. Porcine β-defensin 5, or pBD-5, is a host defense peptide (HDP) that may help to reduce the industry's reliance on antibiotics.
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Scooped by
Ed Rybicki
May 7, 8:02 AM
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President Trump issued an executive order on Monday, banning federal funding for gain-of-function (GoF) research in “countries of concern" like China.
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Scooped by
Ed Rybicki
May 7, 8:01 AM
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European Journal of Medicinal Chemistry; 07/05/2025(AN 184827373); ISSN: 02235234Academic Search Premier
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Scooped by
Ed Rybicki
April 30, 7:09 AM
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The relationship among timing and severity of COVID-19 during pregnancy, placental pathology, and adverse pregnancy outcomes is not well understood. A prospective cohort study of 497 pregnant patients with COVID-19 whose placentas underwent systematic pathologic examination was conducted. The main exposure was timing of COVID-19 during pregnancy (first/second versus third trimester). The primary outcome was composite placental pathology that included high grade maternal vascular malperfusion or greater than 25 percent perivillous fibrin deposition.
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Scooped by
Ed Rybicki
April 30, 7:08 AM
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Today, the Global Virus Network (GVN), representing eminent human and animal virologists from 80+ Centers of Excellence and Affiliates in 40+ countries, published a comprehensive analysis and call-to-action in The Lancet Regional Health-Americas on the North American avian influenza virus, or...
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