Virology News
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Virology News
Topical news snippets about viruses that affect people.  And other things. Like Led Zeppelin. And zombies B-)
Curated by Ed Rybicki
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January 19, 2023 6:04 AM
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Cann's Principles of Molecular Virology - 7th Edition

Cann's Principles of Molecular Virology - 7th Edition | Virology News | Scoop.it

Cann's Principles of Molecular Virology, - 7th Edition, revised by EP Rybicki. Print Book. ISBN 9780128227848. Now published!!


"Cann's Principles of Molecular Virology, Seventh Edition provides an easily accessible introduction to modern virology, presenting principles in a clear and concise manner. The new edition provides the history of virology and the fundamentals of the molecular basis of how viruses work.


Instructor review copies: click on this link.

https://protect-za.mimecast.com/s/qU2qCNxKq0i0ZNRQxcmeDdo

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Today, 4:59 AM
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Design and evaluation of a tripartite chemogenetic fluorescent reporter for visualizing ternary protein complexes 

Design and evaluation of a tripartite chemogenetic fluorescent reporter for visualizing ternary protein complexes  | Virology News | Scoop.it
Visualisation of multiprotein complexes in cellular contexts remains challenging. Here, the authors present a tripartite chemogenetic fluorescent reporter, which enables the imaging of ternary protein complexes in living cells, advancing the study of dynamic multiprotein interactions across...
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Today, 4:59 AM
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Challenges and opportunities in mRNA vaccine development against bacteria 

Challenges and opportunities in mRNA vaccine development against bacteria  | Virology News | Scoop.it
This Review reflects on the major challenges in bacterial mRNA vaccine design, provides strategies for tailoring mRNA construct design to promote humoral or cellular immunity, and provides an overview of the translational landscape for mRNA vaccines.
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Today, 4:58 AM
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With no need for sleep or food, AI-built 'scientists' quickly design nanobodies against SARS-CoV-2 variants

Imagine you're a molecular biologist wanting to launch a project seeking treatments for a newly emerging disease. You know you need the expertise of a virologist and an immunologist, plus a bioinformatics specialist to help analyze and generate insights from your data. But you lack the resources or connections to build a big multidisciplinary team.
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Today, 4:56 AM
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Merbecovirus S2 Vaccines Trigger Cross-Reactive MERS Protection

Merbecovirus S2 Vaccines Trigger Cross-Reactive MERS Protection | Virology News | Scoop.it
In a groundbreaking study recently published in npj Viruses, a team of researchers led by Halfmann and colleagues has unveiled promising new insights into vaccine design against Merbecoviruses, a subgenus of coronaviruses that includes the Middle East Respiratory Syndrome coronavirus (MERS-CoV).
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May 7, 8:08 AM
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Expression of SARS-CoV-2 spike protein in cerebral Arteries: Implications for hemorrhagic stroke Post-mRNA vaccination - ScienceDirect

The rapid deployment of mRNA vaccines for SARS-CoV-2, such as BNT162b2 (BioNTech-Pfizer) and mRNA-1273 (Moderna), provided a critical tool in combatin…...
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May 7, 8:08 AM
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A potent protective bispecific nanobody targeting Herpes simplex virus gD reveals vulnerable epitope for neutralizing | Nature Communications

A potent protective bispecific nanobody targeting Herpes simplex virus gD reveals vulnerable epitope for neutralizing | Nature Communications | Virology News | Scoop.it
The burden of herpes simplex virus (HSV) infection is exacerbated due to the emergence of antiviral drug resistance and a lack of effective antibodies. Here the authors construct a bispecific nanobody that blocks receptor binding and prevents gD-gH/gL interaction, and show that it protects against...
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May 7, 8:07 AM
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Scientists use AI to build mutation-proof antibodies for SARS-CoV-2

Scientists use AI to build mutation-proof antibodies for SARS-CoV-2 | Virology News | Scoop.it
Researchers used AI models to design antibodies that neutralize over 1,300 SARS-CoV-2 strains, including Delta and Omicron. The models demonstrated faster, cheaper, and more adaptable therapeutic development compared to traditional methods.
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May 7, 8:04 AM
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Researchers discover large protein-free RNA structures

Ribonucleic acid (RNA) molecules may be best known for their job ferrying the genetic information encoded in DNA to a cell's protein factories, but these molecules aren't just a middleman for protein production. In fact, some RNA molecules don't code for proteins at all and serve various other important functions in cells, such as regulating gene expression and catalyzing chemical reactions. However, the functions of many non-coding RNAs remain mysterious.
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May 7, 8:03 AM
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Bridging worlds: Physicists develop novel test of the holographic principle

Exactly 100 years ago, famed Austrian physicist Erwin Schrödinger (yes, the cat guy) postulated his eponymous equation that explains how particles in quantum physics behave. A key component of quantum mechanics, Schrödinger's Equation provides a way to calculate the wave function of a system and how it changes dynamically in time.
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May 7, 8:02 AM
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Hidden heart and lung damage detected in patients with long COVID

Hidden heart and lung damage detected in patients with long COVID | Virology News | Scoop.it
Patients suffering from long COVID may exhibit persistent inflammation in the heart and lungs for up to a year following SARS-CoV-2 infection-even when standard medical tests return normal results-potentially placing them at elevated risk for future cardiac and pulmonary conditions.
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May 7, 8:01 AM
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The Story Behind "Aptamer Nanotechnology Bolsters COVID-19 Therapeutic Strategies"

This research provides a comprehensive review of aptamer-based strategies that target SARS-CoV-2, offering a promising avenue for blocking the virus. Behind this groundbreaking paper lies a tale of collaboration across borders, and a quest for the most comprehensive aptamer summary ever compiled.
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April 30, 7:08 AM
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Engineering of extracellular vesicles for efficient intracellular delivery of multimodal therapeutics including genome editors | Nature Communications

Engineering of extracellular vesicles for efficient intracellular delivery of multimodal therapeutics including genome editors | Nature Communications | Virology News | Scoop.it
Delivering functional proteins or protein complexes into cells continues to be a significant challenge. Here, the authors develop efficient systems by using engineered extracellular vesicles to deliver functional cargoes, including CRISPR/Cas9-ribonucleoproteins, both in vitro and in vivo.
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Today, 5:00 AM
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Structural Prediction of Coronavirus s2m Kissing Complexes and Extended Duplexes

Structural Prediction of Coronavirus s2m Kissing Complexes and Extended Duplexes | Virology News | Scoop.it
The three-dimensional (3D) atomistic-resolution structure and dynamics of RNA kissing complexes (KCs) and extended duplexes (EDs), homodimers formed through palindromic base pairing, are crucial for understanding viral replication and structure-informed therapeutic design.
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Today, 4:59 AM
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A single mutation may contribute to accelerated evolution of SARS-CoV-2 toward Omicron

A single mutation may contribute to accelerated evolution of SARS-CoV-2 toward Omicron | Virology News | Scoop.it
Drivers of viral evolution in SARS-CoV-2 are insufficiently understood. In this study, the authors show how a key SARS-CoV-2 mutation, NSP4 T492I, is potentially responsible for accelerating genome evolution to develop adaptive variants (e.g.
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COVID-19 Clues In A Communitys Sewage 4 Questions Answered About Watching Wastewater For Coronavirus

COVID-19 Clues In A Communitys Sewage 4 Questions Answered About Watching Wastewater For Coronavirus | Virology News | Scoop.it
Researchers around the world are testing wastewater for the SARS-CoV-2 virus, in hopes that what goes down the drain can act as an early warning...
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Today, 4:57 AM
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How bacteria use a protein associated with Alzheimer's to fight off threats

Amyloids are perhaps best known as a key driver of Alzheimer's disease.
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Today, 4:56 AM
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Detecting COVID-19 Early Via Wastewater Surveillance

Detecting COVID-19 Early Via Wastewater Surveillance | Virology News | Scoop.it
Wastewater-based epidemiology (WBE) is the analysis of wastewater to identify the presence of biologicals or chemicals for the purpose of monitoring...
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May 7, 8:08 AM
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Single-dose replicon RNA Sudan virus vaccine uniformly protects female guinea pigs from disease | Nature Communications

Single-dose replicon RNA Sudan virus vaccine uniformly protects female guinea pigs from disease | Nature Communications | Virology News | Scoop.it
Sudan virus (SUDV) outbreaks in Uganda created public health concerns due to a lack of approved vaccines. In this study, the authors develop a repRNA SUDV vaccine and demonstrate full protection of a single dose of this vaccine in a lethal SUDV guinea pig model.
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May 7, 8:07 AM
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SARS-CoV-2 spike protein: structure, viral entry and variants | Nature Reviews Microbiology

SARS-CoV-2 spike protein: structure, viral entry and variants | Nature Reviews Microbiology | Virology News | Scoop.it
In this Review, Chen, Farzan and Choe discuss our current understanding of the structure and function of the SARS-CoV-2 spike protein, the molecular mechanism of viral entry and the emergence of new variants, as well as the implications of these insights for development of spike protein-related...
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May 7, 8:07 AM
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Characterization of SARS-CoV-2 intrahost genetic evolution in vaccinated and non-vaccinated patients from the Kenyan population

Journal of Virology, Ahead of Print.
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May 7, 8:04 AM
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Antimicrobial peptide discovery could transform swine disease management

USask researchers recently published a paper in Scientific Reports that identified a promising alternative for controlling infectious diseases such as swine dysentery. Porcine β-defensin 5, or pBD-5, is a host defense peptide (HDP) that may help to reduce the industry's reliance on antibiotics.
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May 7, 8:02 AM
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Trump's 'gain-of-function' order makes it harder for Americans to handle another pandemic

Trump's 'gain-of-function' order makes it harder for Americans to handle another pandemic | Virology News | Scoop.it
President Trump issued an executive order on Monday, banning federal funding for gain-of-function (GoF) research in “countries of concern" like China.
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May 7, 8:01 AM
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Silaproline-bearing nirmatrelvir derivatives are potent inhibitors of the SARS-CoV-2 main protease highlighting the value of silicon-derivatives in structure-activity-relationship studies.

European Journal of Medicinal Chemistry; 07/05/2025(AN 184827373); ISSN: 02235234Academic Search Premier
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April 30, 7:09 AM
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SARS-CoV-2, the human placenta, and adverse perinatal outcomes

The relationship among timing and severity of COVID-19 during pregnancy, placental pathology, and adverse pregnancy outcomes is not well understood. A prospective cohort study of 497 pregnant patients with COVID-19 whose placentas underwent systematic pathologic examination was conducted. The main exposure was timing of COVID-19 during pregnancy (first/second versus third trimester). The primary outcome was composite placental pathology that included high grade maternal vascular malperfusion or greater than 25 percent perivillous fibrin deposition.
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April 30, 7:08 AM
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Global Virus Network urges action to prevent H5N1 pandemic

Global Virus Network urges action to prevent H5N1 pandemic | Virology News | Scoop.it
Today, the Global Virus Network (GVN), representing eminent human and animal virologists from 80+ Centers of Excellence and Affiliates in 40+ countries, published a comprehensive analysis and call-to-action in The Lancet Regional Health-Americas on the North American avian influenza virus, or...
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