In a 2023 paper on hypoxia and glucose metabolism, our lab showed how organisms rewire their metabolism to adapt to low oxygen levels—such as those found at high altitudes. One of the most striking observations from that work was a dramatic drop in circulating blood sugar.

Astronomers have long debated why so many icy objects in the outer solar system look like snowmen. Michigan State University researchers now have evidence of the surprisingly simple process that could be responsible for their creation.

The climate crisis is warming Antarctica fast, with potentially disastrous consequences. Now scientists have modeled the best- and worst-case scenarios for climate change in Antarctica, demonstrating just how high the stakes are—but also how much harm can still be prevented.

Many insects rely on heritable bacterial endosymbionts for essential nutrients that they cannot get through their diet. A new study, published in Nature Communications, indicates that the genomes of these symbiotic bacteria often shrink over time. Some of these bacteria, which live inside certain insect cells, have lost so many genes that they have broken the record for the tiniest genome ever found—almost blurring the lines between organelle and bacteria.

The authors demonstrate that targeted protein degradation of the dengue virus capsid suppresses infection through capsid-dependent pathways rather than classical inhibition, revealing a new antiviral strategy effective against resistant viral variants.

In a new study, researchers say that nonbiological sources they considered could not fully account for the abundance of organic compounds in a sample collected on Mars by NASA's Curiosity rover. The paper is published in the journal Astrobiology.

Researchers at the Jacobs School of Medicine and Biomedical Sciences at the University at Buffalo have developed a new inhalable form of tuberculosis (TB) treatment that could significantly reduce the burden of current therapy. Jessica L. Reynolds, Ph.D., associate professor of medicine in the Jacobs School, is senior author on the paper, titled "Repeated Pulmonary Dosing of β-Glucan-Chitosan-PLGA Nanoparticles Controls Mycobacterium Tuberculosis in Mice," published in Antimicrobial Agents and Chemotherapy.

New findings from NASA's Perseverance rover have revealed evidence of wave-formed beaches and rocks altered by subsurface water in a Martian crater that once held a vast lake—considerably expanding the timeline for potential habitability at this ancient site. In an international study led by Imperial College London, researchers uncovered that the so-called "Margin unit" in Mars's Jezero crater preserves evidence of extensive underground interactions between rock and water, as well as the first definitive traces of an ancient shoreline.

A team of researchers from the Ministry of Health in Kuwait has successfully demonstrated the destruction of SARS-CoV-2 virus particles through exposure to high-frequency sound waves, marking a promising advance in non-pharmacological antiviral strategies. The findings were published in the journal Viruses in a study titled "Destruction/Inactivation of SARS-CoV-2 Virus Using Ultrasound Excitation: A Preliminary Study."

The tiny shell protecting the HIV virus resembles a slightly rounded ice cream cone, but there is nothing sweet about it. More than 40 million people worldwide live with AIDS because of this virus, and treatments must continually evolve as HIV mutates. During the acute stage of infection, a single human cell can produce as many as 10,000 new HIV particles.

DNA is the blueprint of life. Genes encode proteins and serve as the body's basic components. However, building a functioning organism also requires precise instructions about when, where, and how much those components should be produced.

To capture higher-definition and sharper images of cosmological objects, astronomers sometimes combine the data collected by several telescopes. This approach, known as long-baseline interferometry, entails comparing the light signals originating from distant objects and picked up by different telescopes that are at different locations, then reconstructing images using computational techniques.

Ribosomes, the cell's protein-making factories, consume large amounts of energy as they build the proteins that keep cells alive and functioning. When cells experience stress—such as lack of nutrients or sudden drops in temperature—they quickly switch into survival mode. New research from the Schuman Lab at the Max Planck Institute for Brain Research in Frankfurt now reveals an unexpected way cells manage this transition: by pairing up inactive ribosomes using a ribosomal RNA link. This RNA-based mechanism reveals a previously unknown role for ribosomal RNA in the cellular stress response. The new study is published in Science.

Inspired by the simple mechanism of a seesaw—when one side goes up, the other side goes down—researchers asked an intriguing question: Could a single molecule switch between two different roles like a seesaw? This idea led to the creation of a new type of artificial protein called the "seesaw protein."

From vaccines and diagnostics to emerging gene-based therapies, RNA molecules are now central to modern medicine. But as their use continues to grow, so does a fundamental challenge: producing RNA quickly, accurately and with the flexibility needed for next-generation biomedical applications.

Researchers at Oregon State University have developed and tested in a mouse model a new type of nanoparticle that enables the removal of melanoma tumors with a low-power laser. After the systemically administered nanoparticles accumulate in cancerous tissue, exposure to near-infrared light causes them to heat up and destroy the melanoma cells, leaving healthy tissue unharmed.

Chromosomes are masters of organization. These long strings of DNA fold down into an ensemble of compact structures that keep needed parts of the genome accessible while tucking away those that aren't used as often. Understanding the complexity of these structures has been challenging; chromosomes are large systems, and deciphering the structure and dynamics requires a combination of experimental data and theoretical approaches.