From vaccines and diagnostics to emerging gene-based therapies, RNA molecules are now central to modern medicine. But as their use continues to grow, so does a fundamental challenge: producing RNA quickly, accurately and with the flexibility needed for next-generation biomedical applications.

Researchers at Oregon State University have developed and tested in a mouse model a new type of nanoparticle that enables the removal of melanoma tumors with a low-power laser. After the systemically administered nanoparticles accumulate in cancerous tissue, exposure to near-infrared light causes them to heat up and destroy the melanoma cells, leaving healthy tissue unharmed.

Chromosomes are masters of organization. These long strings of DNA fold down into an ensemble of compact structures that keep needed parts of the genome accessible while tucking away those that aren't used as often. Understanding the complexity of these structures has been challenging; chromosomes are large systems, and deciphering the structure and dynamics requires a combination of experimental data and theoretical approaches.

In Europe, Maedi-Visna disease has high prevalence rates at the individual and flock levels, respectively, and is regarded as one of the most significant infectious disease in sheep. The lack of treatment or a commercial vaccine underscores the need for accurate and reliable diagnostic tools to...

Newly emerging SARS-CoV-2 variants underscore the need for broad-spectrum antiviral solutions. This study shows a macrocyclic peptide inhibitor that locks the SARS-CoV-2 spike trimer into a “closed” conformation by engaging a conserved region, and demonstrates that intranasal administration of the...

Iron (Fe) is a vital micronutrient for plants, which is required for processes such as photosynthesis and enzyme activity. Plants must carefully manage iron levels to maintain health and productivity. They activate iron uptake genes when deficient and suppress them when iron is excessive to prevent toxicity. This careful balance is known as iron homeostasis.

MicroRNAs, whose discovery was recognized with the 2025 Nobel Prize in Physiology or Medicine, are central regulators of gene expression, yet a fundamental question has remained unanswered: how cells choose between the two strands produced from each microRNA precursor.

The authors demonstrate that targeted protein degradation of the dengue virus capsid suppresses infection through capsid-dependent pathways rather than classical inhibition, revealing a new antiviral strategy effective against resistant viral variants.

In a new study, researchers say that nonbiological sources they considered could not fully account for the abundance of organic compounds in a sample collected on Mars by NASA's Curiosity rover. The paper is published in the journal Astrobiology.

Researchers at the Jacobs School of Medicine and Biomedical Sciences at the University at Buffalo have developed a new inhalable form of tuberculosis (TB) treatment that could significantly reduce the burden of current therapy. Jessica L. Reynolds, Ph.D., associate professor of medicine in the Jacobs School, is senior author on the paper, titled "Repeated Pulmonary Dosing of β-Glucan-Chitosan-PLGA Nanoparticles Controls Mycobacterium Tuberculosis in Mice," published in Antimicrobial Agents and Chemotherapy.

New findings from NASA's Perseverance rover have revealed evidence of wave-formed beaches and rocks altered by subsurface water in a Martian crater that once held a vast lake—considerably expanding the timeline for potential habitability at this ancient site. In an international study led by Imperial College London, researchers uncovered that the so-called "Margin unit" in Mars's Jezero crater preserves evidence of extensive underground interactions between rock and water, as well as the first definitive traces of an ancient shoreline.

A team of researchers from the Ministry of Health in Kuwait has successfully demonstrated the destruction of SARS-CoV-2 virus particles through exposure to high-frequency sound waves, marking a promising advance in non-pharmacological antiviral strategies. The findings were published in the journal Viruses in a study titled "Destruction/Inactivation of SARS-CoV-2 Virus Using Ultrasound Excitation: A Preliminary Study."

In a study published in Telestes, Dr. Joshua Kumbani and Dr. Margarita Díaz-Andreu categorized the various dance scenes depicted in South African rock art, drawing on ethnographic sources, published studies, and the comprehensive SARADA database to identify dance scenes, thus capturing this invaluable archive for the understanding of the San's various cultural practices.

Conventional treatments of Alzheimer's disease, one of the most common forms of dementia, have been largely focused on targeting individual pathological features. However, Alzheimer's disease is a multifactorial disorder driven by multiple, tightly interconnected processes, rendering single-target therapeutic approaches inherently limited. Addressing this challenge, KAIST researchers propose a new strategy that enables the simultaneous regulation of multiple disease-inducing factors simply by rearranging the structural positions of drug candidate molecules without altering their chemical substituents.

A few thousand years ago, sugar was unknown in the western world. Sugarcane, a tall grass first domesticated in New Guinea around 6000BC, was initially chewed for its sweet juice rather than crystallized. By around 500BC, methods to boil sugarcane juice into crystals were first developed in India.

Through new experiments, researchers in Japan and Germany have recreated the chemical conditions found in the subsurface ocean of Saturn's moon, Enceladus. Published in Icarus, the results show that these conditions can readily produce many of the organic compounds observed by the Cassini mission, strengthening evidence that the distant world could harbor the molecular building blocks of life.