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While Virginia is moving to repeal the requirement that girls get vaccinated against the human papillomavirus, the federal government and a major medical association are urging just the opposite: that boys as well as girls receive the vaccine...
There ought to be an IQ test to participate in civil society... 
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Lassa fever is a neglected tropical disease with significant impact on the health care system, society, and economy of Western and Central African nations where it is endemic.
An older article, but... "LASV VLP can be generated displaying high levels of immunogenic viral proteins, and that small laboratory scale mammalian expression systems are capable of producing multi-milligram quantities of pseudoparticles. These VLP are structurally and morphologically similar to native LASV virions, but lack replicative functions, and thus can be safely generated in low biosafety level settings. LASV VLP were immunogenic in mice in the absence of adjuvants, with mature IgG responses developing within a few weeks after the first immunization. These studies highlight the relevance of a VLP platform for designing an optimal vaccine candidate against Lassa hemorrhagic fever, and warrant further investigation in lethal challenge animal models to establish their protective potential.
People need to start paying attention to this virus...and another candidate for Green Technology.
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Efforts have been made to eliminate wild poliovirus transmission since 1988 when the World Health Organization began its global eradication campaign. Since then, the incidence of polio has decreased significantly. However, serotype 1 and serotype 3 still circulate endemically in Pakistan and Afghanistan. Both countries constitute a single epidemiologic block representing one of the three remaining major global reservoirs of poliovirus transmission. In this study we used genetic sequence data to investigate transmission links among viruses from diverse locations during 2005-2007.
The last places on the planet where wild-type polio is circulating: the focus will definitely become more obsessive
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The Malian HIV Warrior Presidents Can't Say No ToAllAfrica.com He pressed China to admit that HIV was spreading rapidly among gay men and drug users and that the 500000 Chinese working in Africa and 40 million migrant labourers, many of whom visit...
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Amazon.com: Phage Display In Biotechnology and Drug Discovery eBook: Sachdev S. "The first and only guide to showcase the impact of phage display technology on drug discovery, this reference details the theories, principles, and methods impacting the field and demonstrates applications for peptide phage display, protein phage display, and the development of novel antibodies. Highlighting the current and future role of phage display in the development of protein therapeutics, this book provides a comprehensive overview that will prove invaluable to anyone researching recombinant antibodies."
Phages and biotechnology: what's not to like? The price, possibly??
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There are four sexually transmitted diseases (STDs) that are caused by viruses. They are Human Immunodeficiency Virus (HIV), Human Papillomavirus (HPV), Herpes Simplex Virus (HSV), and Hepatitis C.
Useful refresher, in case you thought it was time to get back on the circuit.
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The editor of a leading scientific journal says he will publish full details of controversial research into the bird flu virus, unless the World Health Organization gives scientists crucial information.
Go Bruce...!!
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HIV has eluded vaccine-makers for thirty years, in part due to the virus' extreme ability to mutate.
With a mathematical tool called random matrix theory, the team searched for high-order evolutionary constraints in the so-called Gag region of HIV. The researchers were looking for collectively co-evolving groups of amino acids with a high number of negative correlations (meaning multiple mutations would destroy the virus) and a low number of positive correlations (meaning the virus could survive multiple mutations). They found this combination in a region, which they call Gag sector 3, that is involved in stabilizing the protein shell of the virus: too many mutations here, and the virus' structure would collapse.
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Vaccinating pregnant women against the flu protects their babies from being born too small, new research suggests.
And, in the case of H1N1(2009) flu, may stop the mothers dying. Yet more reasons to vaccinate everyone!
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Rabies is an avertable viral disease caused by the rabid animal to the warm blooded animals (zoonotic) especially human. Rabies occurs in more than 150 countries and territories.
A very useful review on something that is an underestimated problem in developing countries. Image courtesy of Russell Kightley Media (http://www.rkm.com.au)
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Sacbrood virus (SBV) primarily infects honeybee broods, and in order to deal with the problem cost effective detection methods are required.
...and LAMP (http://en.wikipedia.org/wiki/Loop-mediated_isothermal_amplification) turns out to be a good way to do it! Like this... http://nar.oxfordjournals.org/content/28/12/e63/F1.large.jpg
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Hepatitis C-related deaths outpace HIV deaths, study says | From … http://t.co/iP0ktxnz...
...but not in Africa or Asia, I'd be willing to bet.
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ARCHIVES OF VIROLOGY
Hemp (Cannabis sativa) was found to be a useful propagation host for hop latent virus, a carlavirus. However, when virus preparations were analysed by electron microscopy, along with the expected filamentous particles, spherical particles with a diameter of around 34 nm were found. RNA from virus preparations was purified, and cDNA was prepared and cloned. Sequence information was used to search databases, and the greatest similarity was found with Primula malacoides virus 1, a putative new member of the genus Partitivirus. The full sequences of RNA 1 and RNA 2 of this new hemp cryptic virus were obtained.
Hey, man...this weed's like, cryptic, man...B-) Can we now expect Cannabis mosaic, Cannabis leaf curl, Cannabis mild mottle and Cannabis reality distortion viruses?
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Thousands of lambs have been killed by a new virus that is threatening the
Schmallenberg bites deep. Be interesting to see where it came from originally!
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VLPs were subjected to post-purification disassembly and reassembly (D/R) treatment during bioprocessing to improve VLP immunoreactivity and stability. The post-D/R HPV16 VLPs and their complex with H16.V5 neutralizing antibody Fab fragments were visualized by cryo electron microscopy, showing VLPs densely decorated with antibody. Along with structural improvements, post-D/R VLPs showed markedly higher antigenicity to conformational and neutralizing monoclonal antibodies (mAbs) H16.V5, H16.E70 and H263.A2, whereas binding to mAbs recognizing linear epitopes (H16.J4, H16.O7, and H16.H5) was greatly reduced. Strikingly, post-D/R VLPs showed no detectable binding to H16.H5, indicating that the H16.H5 epitope is not accessible in fully assembled VLPs. An atomic homology model of the entire HPV16 VLP was generated based on previously determined high-resolution structures of bovine papillomavirus and HPV16 L1 pentameric capsomeres.
Image courtesy of Russell Kightley Media
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Bacteriophage T4 and Its Relatives.A Series of Critical Reviews: Amazon.co.uk: Jim D Karam, Eric S Miller: Books...
Gotta love T4: it's EVERYWHERE...and the coolest piece of nanotechnology on the planet
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Via VietNam News: Human trials for birdflu vaccine successful. Viet Nam has successfully produced experimental version of bird flu vaccine to combat the virus which has killed 62 people in 9 years, researchers at Vaccine and Biological Production Company No.1, said.
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There were a number of changes to the 2012 clinical guidelines that doctors follow for adult immunizations, released by a federal panel.
Yet another recommendation that young men get HPV vaccinations: time to start listening, boys!
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"...these results suggest that inactivated SIV vaccines may potentiate clinical signs, inflammation and pneumonia following challenge with divergent homosubtypic viruses that do not share cross-reacting HI or SN antibodies."
Or: getting vaccinated with the wrong strain may hurt you during an epi/pandemic.
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The World Health Organization says the H5N1 bird flu kills nearly 60% of people who become infected, but a study released Thursday suggests the true fatality rate may actually be much lower.
...meaning a lot more people have been infected. Possibly meaning the next pandemic is closer than we thought.
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The CDC says the strain has infected at least 18 Americans since 2010.
SO while you were all fussing about H5N1....
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A pharmaceutical giant is picking up the federal government's slack in funding a program aimed at curbing flu infections.
...and will inevitably own it....
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While an estimated 30 HIV vaccines are being tested around the world, one trial in Canada promises to be unique. After decades of research, development, and high hopes, scientists at the University of Western Ontario are ready to test a new type of vaccine known as SAV001 that they hope will prevent HIV infections. What makes this trial different, said lead researcher Chil-Yong Kang, Ph.D., is that this is the first preventive vaccine to use a “killed whole” HIV-1 virus to activate a person’s immune system. This version of the virus, however, would be genetically altered so it would not be able to cause HIV infection. For insurance, the virus is also inactivated by using chemicals and radiation.
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In a poetic turn of virology, the scientist who discovered hepatitis C in 1989 has now also discovered a vaccine that will hopefully treat and prevent the disease.
Just shows you: stick with a thing for 20+ years....
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These findings are the first to utilize the Sendai virus to achieve cytosolic, targeted intracellular binding of Qdots within Human brain tumor cells. The results are significant to the continued applicability of nanoparticles used for the molecular labeling of cancer cells to determine tumor heterogeneity, grade, and chemotherapeutic resistivity.
It is to like: using liposomes fused to inactivated Sendai to deliver Qdots. Vironanotech rules!
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