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Ultra scale-down (USD) methods operating at the millilitre scale were used to characterise full-scale processing of E. coli fermentation broths autolysed to different extents for release of a domain antibody. The focus was on the primary clarification stages involving continuous centrifugation followed by depth filtration.

In the last five years, the detailed understanding of how to overcome T790M drug resistance in non-small cell lung cancer (NSCLC) has culminated in the development of a third-generation of covalent EGFR inhibitors with excellent clinical outcomes. However, the emergence of a newly discovered acquired drug resistance challenges the concept of small molecule targeted cancer therapy in NSCLC.

The molecular building block approach was employed effectively to construct a series of novel isoreticular, highly porous and stable, aluminumbased metal−organic frameworks with soc topology. From this platform, three compounds were experimentally isolated and fully characterized: namely, the parent Al-soc-MOF-1 and its naphthalene and anthracene analogues.

Mucin-related carbohydrates are overexpressed on the surface of cancer cells, providing a disease-specific target for cancer immunotherapy. Here, we describe the design and construction of peptide-free multivalent glycosylated nanoscale constructs as potential synthetic cancer vaccines that generate significant titers of antibodies selective for aberrant mucin glycans.

A soft porous material [Zn(L)2(OH)2]n·Guest (where L is 4-(1H-naphtho[2,3-d]imidazol-1-yl)benzoate, and Guest is water or methanol) exhibits the strongest ever observed negative area compressibility (NAC), an extremely rare property, as at hydrostatic pressure most materials shrink in all directions and few expand in one direction. This is the first NAC reported in metal−organic frameworks (MOFs), and its magnitude, clearly visible and by far the highest of all known materials, can be reversibly tuned by exchanging guests adsorbed from hydrostatic fluids.

Low adherence to secondary prevention guidelines in stroke survivors may increase the risk for recurrent stroke and adversely impact quality of life. We aimed to determine the feasibility of a self-developed standardized post-stroke pathway and its impact on secondary stroke prevention and longterm outcome in patients with acute stroke.

Currently, evolving ways of communication, interpretation and creation of meaning are challenging the ways people view themselves and the world, altering their learning demands and needs. Closely related to this process of change is the need to re-conceptualize schooling.

This study examined the “Unified Theory of Acceptance and Use of Technology” (UTAUT) in thecontext of tablet devices across multiple generations.

In this research-in-progress work, we adopt an action design research approach and drawing upon theories from the psychology and technology adoption literature, we develop a set of design principles that informs the design of user experiences for wearable computing devices.

The article studies a way of enhancing student cognition by using interdisciplinary project-based learning (IPBL) in a higher education institution. IPBL is a creative pedagogic approach allowing students of one area of specialisation to develop projects for students with different academic profiles.

The hallmarks of cancer comprise six biological capabilities acquired during the multistep development of human tumors.

One of the most influential factors in the quality of the solutions found by an evolutionary algorithm are a correct coding of the search space and an appropriate evaluation function of the potential solutions. Evolutionary algorithms are often used to learn decision rules from datasets, which are encoded as individuals in the genetic population. In this paper, the coding of the search space for the obtaining of those decision rules is approached, i.e., the representation of the individuals of the genetic population and also the design of specific genetic operators.

The objective of the present study was to evaluate the effect of three common cooking practices (i.e., boiling, steaming, and frying) on phytochemical contents (i.e., polyphenols, carotenoids, glucosinolates, and ascorbic acid), total antioxidant capacities (TAC), as measured by three different analytical assays [Trolox equivalent antioxidant capacity (TEAC), total radical-trapping antioxidant parameter (TRAP), ferric reducing antioxidant power (FRAP)] and physicochemical parameters of three vegetables (carrots, courgettes, and broccoli).

The invention in this patent application relates to heterocyclic compounds represented generally by formula (I). These compounds are inhibitors of cysteine proteases, including but not limited to, cathepsins K, L, S, and B, which may be useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis.

Carbon quantum dots (CQDs) are established as excellent photosensitizers in combination with a molecular catalyst for solar light driven hydrogen production in aqueous solution. The inexpensive CQDs can be prepared by straightforward thermolysis of citric acid in a simple one-pot, multigram synthesis and are therefore scalable.

The levels and sources of toxic heavy metals in Amanita loosii (AL) and Cantharellus floridulus (CF) mushrooms and their substrates were studied in some parts of Zimbabwe, Rail Block forest (mining town), Macheke forest (commercial farming), and Muganyi communal lands.

We describe here the construction of a three-dimensional, porous, crystalline framework formed by spherical protein nodes that assemble into a prescribed lattice arrangement through metal−organic linker-directed interactions.

Recent studies have demonstrated that continuous countercurrent tangential chromatography (CCTC) can effectively purify monoclonal antibodies from clarified cell culture fluid. CCTC has the potential to overcome many of the limitations of conventional packed bed protein A chromatography.

This paper presents a first look at some of the challenges associated with enabling a seamless web experience on Optical Head Mounted Display wearables such as Google Glass from the perspective of web content providers, client device, and the network.

Teachers increasingly use virtual manipulatives and other apps on touch-screen devices (e.g., iPads) in an effort to help students understand mathemat-ics concepts. However, students experience these apps and their affordances in different ways. The purpose of this article is to inform teachers’ deci-sions about app implementation in the classroom through discussion of four case studies illustrating ways children interacted with the app Motion Math: Zoom, and how these interactions revealed, concealed, and developed children’s mathematical understanding.

The main purpose of this study is to design a framework for digital storytelling (DS) as a guideline to follow and adapt during the development process.

In this paper, we describe the design and evaluation of Flip, a programming language that aims to help 11–15 year olds develop computational skills through creating their own 3D role-playing games.

Recently it has become clear that many technologies follow a generalized version of Moore's law, i.e. costs tend to drop exponentially, at different rates that depend on the technology. Here we formulate Moore's law as a correlated geometric random walk with drift, and apply it to historical data on 53 technologies.