The future of e-cigarette

Underlying mechanisms of e-cig-induced vascular endothelial dysfunction are delineated. e-cig exposure activates and increases expression of NADPH oxidase and disrupts activation and coupling of eNOS, leading to a vicious cycle of superoxide generation and peroxynitrite formation, with tetrahydrobiopterin depletion, causing loss of NO that triggers vascular endothelial dysfunction. This process is progressive, increasing with the duration of e-cig exposure, and is more severe in the presence of nicotine, but observed even with nicotine-free vaping.

The present study establishes inhaled models of cigarette and e-cigarette use with normalized nicotine delivery, then characterizes the impact on blood-brain barrier (BBB) function. Sequencing of microvessel RNA following exposure revealed downregulation of several genes with critical roles in BBB function. Reduced protein expression of Occludin and Glut1 is also observed at the tight junction in all groups following exposure. Pro-inflammatory changes in leukocyte-endothelial cell interaction are also noted, and mice exposed to nicotine-free e-cigarettes have impaired novel object recognition performance.

Both waterpipe and ECIGs deliver the dependence-producing drug nicotine. Waterpipe tobacco smoking has been associated with periodontitis, dry socket, premalignant lesions, and oral and esophageal cancer. The health effects of long-term ECIG use are unknown.

Alors qu’à l’heure actuelle la cigarette électronique est consommée par 8% des Français, elle semble bénéficier d’un potentiel de développement puisque 52% des fumeurs ont envisagé d’arrêter la cigarette classique pour se tourner vers cette dernière. Invités à identifier les principaux freins à une transition vers ce type de produit, les fumeurs citent avant tout leur préférence pour le goût de la cigarette classique (1ère raison citée par 30% d’entre eux), puis le sentiment que ce produit n’est pas forcément moins nocif pour la santé (20%) ou encore qu’il coûte trop cher (17%).

At first glance, the study seems to undermine the case for e-cigarette use (“vaping”) as a smoking cessation tool. But first glances, as we all know, rarely tell the whole story. A closer look at the paper indicates that its authors improperly assessed how smokers utilize e-cigarettes, thus generating results that don't reflect reality.

Under the amended Smokefree Environments and Regulated Products Act, all retailers, manufacturers and importers are only allowed to sell notified vaping and smokeless tobacco products that have been registered with the Health Advisory and Regulatory Platform. All products must comply with the relevant product safety requirements before they can be notified, and notifications must be renewed every 12 months, or they will expire.

Nicotine inhaling products containing more than 2% nicotine, or with more than 2ml of liquid, are illegal to sell as they do not comply with UK safety requirements. However, illegal products with up to 5% nicotine have been found on sale locally. There are also serious concerns that underage children are accessing these products.

The company said 4.8 million more consumers than last year used non-combustible products such as Vuse e-cigarettes, glo heated tobacco and Velo oral nicotine. BAT said it expects global tobacco industry volumes to decline by around 2.5% this year. For 2021, the company had estimated those volumes to remain flat.

Due to the harmfulness of cigarettes, a high frequency of smokers is suspected among people suffering from COVID-19. However, some studies report that the number of current smokers hospitalized for SARS-CoV-2 infection is lower than expected, considering the prevalence of smoking in individual countries. Nicotine could restore the impaired function of the nicotine cholinergic system and possibly mitigate the cytokine storm.

When the tobacco industry targeted young people to build a future stable of adult smokers, one of the most effective responses was to raise the price of their product. The Institute of Medicine, the U.S. Surgeon General and the World Health Organization all have determined that increasing the price of tobacco products is the single most effective way to reduce tobacco use. Studies show that a 10 percent cigarette price increase results in a 3 to 5 percent reduction in consumption. It’s even more impactful on young people, who generally have less disposable income to spend on cigarettes.

Philip Morris (NYSE:PM) announced today that it agreed to acquire inhaled drug delivery technology developer Vectura for $1.2 billion. Vectura develops inhaled drug delivery solutions, with 13 key inhaled as well as 11 non-inhaled products marketed by global pharmaceutical partners. Additionally, the company has a diverse portfolio of partnerships for drugs in clinical development, according to a news release.

The e-cigarette company bought an entire issue of a scholarly journal, with all the articles written by authors on its payroll, to ‘prove’ that its product has a public benefit.

Researchers from the University of Oxford examined 78 studies, including 40 randomised controlled trials, which involved 22 052 adults who smoked to assess the effectiveness, tolerability, and safety of e-cigarettes to help quitting. They found that quit rates among adults using nicotine e-cigarettes were higher than those receiving nicotine replacement therapy (risk ratio 1.63, 95% confidence interval 1.30 to 2.04; I2=10%; six studies, 2378 participants). This could translate to an additional 4 quitters per 100 (95% CI 2 to 6), the researchers said.

Electronic cigarettes (e-cigarettes) are handheld devices that work by heating a liquid that usually contains nicotine and flavourings. E-cigarettes allow you to inhale nicotine in a vapour rather than smoke. Because they do not burn tobacco, e-cigarettes do not expose users to the same levels of chemicals that can cause diseases in people who smoke conventional cigarettes.

Innokin says water-based vaping was developed to deliver smoother vapour, faster satisfaction and more accurate flavours, while enhancing the potential for harm reduction. These benefits are achieved using a proprietary e-liquid formulation with 30% water content and new vaping hardware tailored to thinner liquids. Independent testing by TCT Lab has demonstrated that water-based vaping reduces acetaldehyde and formaldehyde emissions by 91% and 81% respectively compared to traditional vapes.

If you’re worried about lung cancer, then smoking is incredibly dangerous. The chance of a non-smoker developing the disease is roughly one in 6,000. For someone who smokes regularly, the chances skyrocket to one in five or ten. And yet, most people who smoke won’t develop lung cancer.

“While RTBA Malaysia understands the Health Ministry’s (MOH) motive, the proposed ban on cigarettes and vape for the next generation is 100% theory and 0% evidence,” claimed RTBA Malaysia managing director Datuk Fazli Nordin. “Banning is not a solution.”

Through research and interviews with experts, we explore the truth about vaping and whether misconceptions are preventing us from reducing the largest preventable cause of cancer in Yorkshire.
This short investigative film tackles the myths and misconceptions surrounding vaping and provides smokers with the information needed to make an informed decision about using vape products.

Our findings are consistent with the idea that substituting tobacco cigarettes with e-cigarettes may substantially reduce exposure to selected tobacco-specific toxicants. E-cigarettes as a harm reduction strategy among smokers unwilling to quit, warrants further study. (To view this abstract in Polish and German, please see the supplementary files online.).

These days, there are many alternatives to cigarettes on the market. Cigalikes, vape pens, vape mods, pod mods, tanks, and more—each of these devices suits a specific purpose and lifestyle.
One of the main distinctions between types of vapes is whether they are rechargeable or disposable. Vapes of all kinds require some voltage to operate. The tiny machinery inside needs power to combust the e-liquid and produce vapor.

Les fabricants de tabac assurent vouloir désormais aller vers des produits moins nocifs, comme le tabac chauffé ou la cigarette électronique, pour aider les fumeurs à décrocher. Philip Morris, lui, se voit carrément un avenir dans le bien-être. Virage stratégique ou fariboles ?

Although it is well established that cigarette smoking is associated with morbidity and mortality in several respiratory infections, data from recent studies suggest that active smokers are underrepresented among patients with COVID-19. This has led to claims that a ‘smoker’s paradox’ may exist in COVID-19, wherein smokers are protected from infection and severe complications of COVID-19. We aimed to review and summarise existing literature in this context.

The digital health startup received FDA clearance for its carbon monoxide sensor to be used for smoking cessation without oversight from a healthcare provider.  The expanded indication came after Carrot submitted the results of a single-arm study claiming its device increased people’s motivation to quit smoking. 

Juul Labs, the once high-flying e-cigarette company that became a public health villain to many people over its role in the teenage vaping surge, has been operating as a shadow of its former self, spending the pandemic largely out of the public eye in what it calls "reset" mode. Now its very survival is at stake as it mounts an all-out campaign to persuade the Food and Drug Administration to allow it to continue to sell its products in the United States.