Mucosal Immunity

T cell tolerance and immunity to commensal bacteria

Katherine M Nutsch,Chyi-Song Hsieh

Department of Medicine, Division of Rheumatology, Washington University School of Medicine, St. Louis, MO 63110, United States

http://dx.doi.org/10.1016/j.coi.2012.04.009,

Highlights

► Tolerance is required to commensal bacteria and depends on regulatory T cells. ► Regulatory T cells specific to commensal bacteria are generated from naïve T cells in the periphery. ► Bacterial products can facilitate Treg cell function via the induction of IL-10, an immunosuppressive cytokine. ► Specific commensal bacterial species induce inflammatory or tolerogenic T cell responses in the gut.

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