 Your new post is loading...
Your new post is loading...
|
Scooped by
Gilbert C FAURE
May 26, 2023 5:12 AM
|
A population of unconventional white blood cells has recently captured the attention of immunologists and clinicians alike. Unlike conventional T cells, which circulate throughout the body in our blood, mucosal-associated invariant T (MAIT) cells are largely found in tissues where they provide...
|
|
Scooped by
Gilbert C FAURE
May 23, 2023 4:51 AM
|
|
|
Scooped by
Gilbert C FAURE
May 22, 2023 5:06 AM
|
|
|
Rescooped by
Gilbert C FAURE
from veille vaccination
May 15, 2023 3:56 AM
|
The importance of vaccination has been proven particularly significant the last three years, as it is revealed to be the most efficient weapon for the…
Via HAS-veille
|
|
Scooped by
Gilbert C FAURE
May 13, 2023 2:05 AM
|
Clinicians have an expanding therapeutic armamentarium to improve outcomes in immunoglobulin A nephropathy...
|
|
Scooped by
Gilbert C FAURE
April 20, 2023 3:45 AM
|
IBD competitive landscape & disease primer
Exploring the highly competitive space on the heels of Merck's $10.8B acquisition of Prometheus
If you'd like a…
|
|
Scooped by
Gilbert C FAURE
April 13, 2023 11:45 AM
|
On November 7th and 8th, 2022, The National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH), The Coalition for Epidemic Preparedness Innovation (CEPI), The Bill & Melinda Gates Foundation (BMGF), The Biomedical Advanced Research and Development Authority (BARDA), and the Wellcome Trust hosted a virtual workshop entitled “Mucosal Vaccines for SARS-CoV-2: Scientific Gaps and Opportunities.” During the workshop, researchers and vaccine developers from around the world discussed the potential of mucosal vaccines to block SARS-CoV-2 transmission and reviewed the status of SARS-CoV-2 mucosal vaccine research. Here, we summarize key challenges and opportunities in basic, translational, and clinical research that were highlighted during the meeting. We also provide recommendations to advance the field and accelerate the development of mucosal vaccines for SARS-CoV-2.
|
|
Scooped by
Gilbert C FAURE
April 5, 2023 4:38 AM
|
📖 The ERS ESICM ESCMID ALAT international guidelines for managing severe community-acquired pneumonia have just been published in the Intensive Care Medicine…
|
|
Scooped by
Gilbert C FAURE
April 4, 2023 2:33 AM
|
Mucosal infections pose a significant global health burden. Antigen-specific tissue resident T cells are critical to maintaining barrier immunity. Previous studies in the context of systemic infection suggest that memory CD8 T cells may also provide innate-like protection against antigenically...
|
|
Scooped by
Gilbert C FAURE
April 1, 2023 12:07 PM
|
Protective immune responses against respiratory pathogens, such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and influenza virus, are initiated by the mucosal immune system.However, most licensed vaccines are administered parenterally and are largely ineffective at inducing mucos...
|
|
Scooped by
Gilbert C FAURE
March 23, 2023 3:37 PM
|
Researchers have found that IgA autoantibodies that bind to a specific antigen on the mesangial cells are the trigger fo...
|
|
Scooped by
Gilbert C FAURE
March 21, 2023 2:12 PM
|
|
|
Scooped by
Gilbert C FAURE
March 14, 2023 10:45 AM
|
de Visser and Joyce review the complex interplay between the tumor and its microenvironment
throughout cancer evolution and discuss the tumor cell-intrinsic, cell-extrinsic,
and systemic factors that may be exploited for rational design of anti-cancer treatments.
|
|
|
Scooped by
Gilbert C FAURE
May 26, 2023 5:10 AM
|
Vitamin D deficiency, characterized by low circulating levels of calcifediol (25-hydroxyvitamin D, 25D) has been linked to increased risk of infections of bacterial and viral origin. Innate immune cells produce hormonal calcitriol (1,25-dihydroxyvitamin D, 1,25D) locally from circulating...
|
|
Scooped by
Gilbert C FAURE
May 22, 2023 5:11 AM
|
Primary nasal epithelial cells and culture models are used as important diagnostic, research and drug development tools for several airway diseases. Various instruments have been used for the collection of human nasal epithelial (HNE) cells but no global consensus yet exists regarding the optimal...
|
|
Scooped by
Gilbert C FAURE
May 16, 2023 1:45 PM
|
Lockhart et al. demonstrate that exposure to food protein drives an antigen-specific CD4+ T cell response characterized at steady state by accumulation at the i
|
|
Scooped by
Gilbert C FAURE
May 14, 2023 9:44 AM
|
|
|
Scooped by
Gilbert C FAURE
May 13, 2023 2:03 AM
|
Author Summary Unlike induction of Foxp3+ regulatory T cell development, it remains unclear how intestinal environmental factors regulate development of another regulatory T cell subset, Tr1 cells that produce IL-10.
|
|
Scooped by
Gilbert C FAURE
April 17, 2023 8:56 AM
|
|
|
Scooped by
Gilbert C FAURE
April 12, 2023 1:22 PM
|
Current available vaccines for COVID-19 are effective in reducing severe diseases and deaths caused by SARS-CoV-2 infection but less optimal in preventing infection. Next-generation vaccines which are able to induce mucosal immunity in the upper respiratory to prevent or reduce infections caused by highly transmissible variants of SARS-CoV-2 are urgently needed. We have developed an intranasal vaccine candidate based on a live attenuated influenza virus (LAIV) with a deleted NS1 gene that encodes cell surface expression of the receptor-binding-domain (RBD) of the SARS-CoV-2 spike protein, designated DelNS1-RBD4N-DAF. Immune responses and protection against virus challenge following intranasal administration of DelNS1-RBD4N-DAF vaccines were analyzed in mice and compared with intramuscular injection of the BioNTech BNT162b2 mRNA vaccine in hamsters. DelNS1-RBD4N-DAF LAIVs induced high levels of neutralizing antibodies against various SARS-CoV-2 variants in mice and hamsters and stimulated robust T cell responses in mice. Notably, vaccination with DelNS1-RBD4N-DAF LAIVs, but not BNT162b2 mRNA, prevented replication of SARS-CoV-2 variants, including Delta and Omicron BA.2, in the respiratory tissues of animals. The DelNS1-RBD4N-DAF LAIV system warrants further evaluation in humans for the control of SARS-CoV-2 transmission and, more significantly, for creating dual function vaccines against both influenza and COVID-19 for use in annual vaccination strategies. Current vaccines are less efficient in preventing infection. Here, the authors show that an intranasal vaccine (DelNS1-RBD) based on a live attenuated influenza virus induces robust levels of neutralizing antibodies and T cells and prevents replication of SARS-CoV-2 Delta and Omicron variants in respiratory tissues.
|
|
Scooped by
Gilbert C FAURE
April 4, 2023 2:35 AM
|
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
|
|
Scooped by
Gilbert C FAURE
April 1, 2023 12:09 PM
|
*Correspondence author.Email: goplen.nicholas@mayo.edu Once T cell responses peak in response to early antigenic and pro-inflammatory programming, ~95% of the accumulated die, contracting clonally expanded pools.
|
|
Scooped by
Gilbert C FAURE
April 1, 2023 12:02 PM
|
Crohn's disease and ulcerative colitis are idiopathic inflammatory bowel disorders. In this paper, we discuss how environmental factors (eg, geography, cigarette smoking, sanitation and hygiene), infectious microbes, ethnic origin, genetic susceptibility, and a dysregulated immune system can...
|
|
Scooped by
Gilbert C FAURE
March 23, 2023 3:37 PM
|
There is insufficient evidence to confirm the involvement of tonsillar immune disorders in the pathogenesis of IgA nephropathy (IgAN). This cross-sectional study investigated the association between histological changes in the palatine tonsil, its clinical presentation, and renal histopatholog...
|
|
Scooped by
Gilbert C FAURE
March 14, 2023 11:24 AM
|
|
Scoop.it!
