Mucosal Immunity
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Mucosal Immunity
The largest immune tissue in the body
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Scooped by Gilbert C FAURE
October 21, 2014 2:36 PM
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A novel mucosal vaccine targeting Peyer’s patch M cells induces protective antigen-specific IgA responses

A novel mucosal vaccine targeting Peyer’s patch M cells induces protective antigen-specific IgA responses | Mucosal Immunity | Scoop.it
A novel mucosal vaccine targeting Peyer’s patch M cells induces protective antigen-specific IgA responses #inmuva http://t.co/8zMPzlJNvJ
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Scooped by Gilbert C FAURE
October 21, 2014 1:55 PM
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IL22 and CD160 play additive roles in the host mucosal response to Clostridium difficile infection in mice - Sadighi Akha - Immunology - Wiley Online Library

IL22 and CD160 play additive roles in the host mucosal response to Clostridium difficile infection in mice - Sadighi Akha - Immunology - Wiley Online Library | Mucosal Immunity | Scoop.it
RT @britsocimm: C. Difficile treatment.Promising new research on the 'superbug' published in #Immunology http://t.co/QpAcvzRVeZ http://t.co…
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Scooped by Gilbert C FAURE
October 21, 2014 6:56 AM
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Phase II Data in Crohn's Disease for Celgene's Oral Antisense Therapy GED ... - Stockhouse

Phase II Data in Crohn's Disease for Celgene's Oral Antisense Therapy GED ... - Stockhouse | Mucosal Immunity | Scoop.it
Phase II Data in Crohn's Disease for Celgene's Oral Antisense Therapy GED ...
Gilbert C FAURE's insight:
The investigational oral drug GED-0301 is an antisense oligonucleotide that targets the messenger RNA (mRNA) for Smad7, thereby reducing Smad7 protein levels. In patients with Crohn’s disease, abnormally high levels of Smad7 interfere with TGF-β1 anti-inflammatory pathways in the gut, leading to increased inflammation. The distinct formulation of the tablet is designed to release GED-0301 into the far end of the small intestine (the terminal ileum) and near the end of the colon (right colon), where it is thought to act locally to reduce Smad7 levels.
Read more at http://www.stockhouse.com/news/press-releases/2014/10/20/phase-ii-data-in-crohn-s-disease-for-celgene-s-oral-antisense-therapy-ged-0301#vKMwPWAmiGpzlSRw.99
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Scooped by Gilbert C FAURE
October 19, 2014 2:56 PM
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Leicester IgA research group receives funding - Kidney Research UK - Kidney Research UK

Leicester IgA research group receives funding - Kidney Research UK - Kidney Research UK | Mucosal Immunity | Scoop.it
Have you read about our latest research into IgA Nephropathy? Read more: http://t.co/WROygMO12b #kidneydisease #kidney
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Scooped by Gilbert C FAURE
October 19, 2014 2:13 PM
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Commensal bacteria and cutaneous immunity. [Semin Immunopathol. 2014] - PubMed - NCBI

PubMed comprises more than 23 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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Scooped by Gilbert C FAURE
October 18, 2014 10:12 AM
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Acting locally: innate mucosal immunity in r... [Mucosal Immunol. 2014] - PubMed - NCBI

PubMed comprises more than 23 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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Scooped by Gilbert C FAURE
October 17, 2014 3:41 PM
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Contribution of microbiota to the intestinal ... [Benef Microbes. 2014] - PubMed - NCBI

PubMed comprises more than 23 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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October 17, 2014 3:38 PM
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Mucosal Immunity in the Female Genital Tract,... [Biomed Res Int. 2014] - PubMed - NCBI

PubMed comprises more than 23 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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Suggested by Société Francaise d'Immunologie
October 17, 2014 3:36 PM
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Immune Response to Major GI Surgery, Blood Transfusions Mapped - Anesthesiology News

Immune Response to Major GI Surgery, Blood Transfusions Mapped Anesthesiology News Stockholm—Major gastrointestinal (GI) surgery promotes a specific gene expression pattern that upregulates the anti-inflammatory cytokine interleukin (IL)-10 while...
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Scooped by Gilbert C FAURE
October 17, 2014 3:24 PM
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Nasal delivery of PLG microparticle encapsulated... [Immunol Res. 2014] - PubMed - NCBI

PubMed comprises more than 23 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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Scooped by Gilbert C FAURE
October 16, 2014 3:05 PM
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Defective Innate Immunity and Hype... [Am J Respir Cell Mol Biol. 2014] - PubMed - NCBI

PubMed comprises more than 23 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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Scooped by Gilbert C FAURE
October 15, 2014 2:08 PM
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Feces-filled capsules treat bacterial infection - Science AAAS

Feces-filled capsules treat bacterial infection - Science  AAAS | Mucosal Immunity | Scoop.it
Study finds that unusual therapy is effective against Clostridium difficile
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Scooped by Gilbert C FAURE
October 13, 2014 2:25 PM
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Frontiers | Interaction of Streptococcus agalactiae and cellular innate immunity in colonization and disease | Immunotherapies and Vaccines

Streptococcus agalactiae (Group B streptococcus, GBS) is highly adapted to humans, where it is a normal constituent of the intestinal and vaginal flora. Yet, GBS has highly invasive potential and c...
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October 21, 2014 1:55 PM
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Frontiers | The Role of Toll-Like Receptors in Colorectal Cancer Progression: Evidence for Epithelial to Leucocytic Transition | Tumor Immunity

Toll-like receptors (TLRs) are expressed by immune cells, intestinal epithelium, and tumor cells. In the homeostatic setting they help to regulate control over invading pathogens and maintain the e...
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Scooped by Gilbert C FAURE
October 21, 2014 10:26 AM
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Science/AAAS | Special Collection: Ebola

Science/AAAS | Special Collection: Ebola | Mucosal Immunity | Scoop.it
Gilbert C FAURE's insight:

*The Ebola Files: Given the current Ebola outbreak, unprecedented in terms of number of people killed and rapid geographic spread, Science and Science Translational Medicine have made a collection of research and news articles on the viral disease freely available to researchers and the general public.

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Scooped by Gilbert C FAURE
October 20, 2014 5:03 AM
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Discovery of new risk loci for IgA nephropathy imp... [Nat Genet. 2014] - PubMed - NCBI

PubMed comprises more than 23 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Gilbert C FAURE's insight:
Abstract

We performed a genome-wide association study (GWAS) of IgA nephropathy (IgAN), the most common form of glomerulonephritis, with discovery and follow-up in 20,612 individuals of European and East Asian ancestry. We identified six new genome-wide significant associations, four in ITGAM-ITGAX, VAV3 and CARD9 and two new independent signals at HLA-DQB1 and DEFA. We replicated the nine previously reported signals, including known SNPs in the HLA-DQB1 and DEFA loci. The cumulative burden of risk alleles is strongly associated with age at disease onset. Most loci are either directly associated with risk of inflammatory bowel disease (IBD) or maintenance of the intestinal epithelial barrier and response to mucosal pathogens. The geospatial distribution of risk alleles is highly suggestive of multi-locus adaptation, and genetic risk correlates strongly with variation in local pathogens, particularly helminth diversity, suggesting a possible role for host-intestinal pathogen interactions in shaping the genetic landscape of IgAN.

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Scooped by Gilbert C FAURE
October 19, 2014 2:56 PM
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4181941/

RT @HIV_Insight: Characteristics of Mucosal Immunity of the Female Genital Tract, Its Alterations Due to HIV/AID http://t.co/fu97L8312M
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Scooped by Gilbert C FAURE
October 18, 2014 10:20 AM
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Are your bacteria jet-lagged?

Are your bacteria jet-lagged? | Mucosal Immunity | Scoop.it
Gut microbes' circadian rhythms synced to ours
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Scooped by Gilbert C FAURE
October 18, 2014 10:12 AM
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Taste receptors in innate immunity. [Cell Mol Life Sci. 2014] - PubMed - NCBI

PubMed comprises more than 23 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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Scooped by Gilbert C FAURE
October 17, 2014 3:39 PM
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An Intensive Winter Fixture Schedule Induces a Transient Fall in Salivary IgA in English Premier League Soccer Players

An Intensive Winter Fixture Schedule Induces a Transient Fall in Salivary IgA in English Premier League Soccer Players | Mucosal Immunity | Scoop.it
(2014). An Intensive Winter Fixture Schedule Induces a Transient Fall in Salivary IgA in English Premier League Soccer Players. Research in Sports Medicine: Vol. 22, Football and Sports Medicine, pp. 346-354.
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Scooped by Gilbert C FAURE
October 17, 2014 3:38 PM
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Decade in review—IBD: IBD—genes, bacteria and new therapeutic strategies - Nature.com

Decade in review—IBD: IBD—genes, bacteria and new therapeutic strategies Nature.com Patients homozygous for the ATG16L1 allele have marked structural alterations in their secretory apparatus along with transcriptional abnormalities in Paneth...
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Suggested by Société Francaise d'Immunologie
October 17, 2014 3:36 PM
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Development of ileal cytokine and immunoglobulin e... [Poult Sci. 2014] - PubMed - NCBI

PubMed comprises more than 23 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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Scooped by Gilbert C FAURE
October 17, 2014 2:03 PM
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Humans Carry More Bacterial Cells than Human Ones

Humans Carry More Bacterial Cells than Human Ones | Mucosal Immunity | Scoop.it
You are more bacteria than you are you, according to the latest body census
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Scooped by Gilbert C FAURE
October 16, 2014 2:56 PM
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A Beneficiary Role for Neuraminidase in Influenza Virus Penetration through the Respiratory Mucus

A Beneficiary Role for Neuraminidase in Influenza Virus Penetration through the Respiratory Mucus | Mucosal Immunity | Scoop.it
by Xiaoyun Yang, Lennert Steukers, Katrien Forier, Ranhua Xiong, Kevin Braeckmans, Kristien Van Reeth, Hans Nauwynck Swine influenza virus (SIV) has a strong tropism for pig respiratory mucosa, which consists of a mucus layer, epithelium, basement...
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Scooped by Gilbert C FAURE
October 14, 2014 1:57 PM
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Popular myths in reproductive immunology. [J Reprod Immunol. 2014] - PubMed - NCBI

PubMed comprises more than 23 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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