Mucosal Immunity
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Mucosal Immunity
The largest immune tissue in the body
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June 11, 2015 4:24 AM
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Innate immunity is sufficient for the clearance of Chlamydia trachomatis from the female mouse genital tract. - PubMed - NCBI

Innate immunity is sufficient for the clearance of Chlamydia trachomatis from the female mouse genital tract. - PubMed - NCBI | Mucosal Immunity | Scoop.it
Pathog Dis. 2014 Oct;72(1):70-3. doi: 10.1111/2049-632X.12164. Epub 2014 Apr 10. Research Support, N.I.H., Intramural
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June 9, 2015 3:42 PM
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Relationship of the quaternary structure of human secretory IgA to neutralization of influenza virus

Relationship of the quaternary structure of human secretory IgA to neutralization of influenza virus. Tadaki Suzuki et al (2015), Proceedings of the National ...
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June 8, 2015 4:35 PM
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Secretory Aspartyl Proteinases Cause Vaginitis and Can Mediate Vaginitis Caused by Candida albicans in Mice. - PubMed - NCBI

Secretory Aspartyl Proteinases Cause Vaginitis and Can Mediate Vaginitis Caused by Candida albicans in Mice. - PubMed - NCBI | Mucosal Immunity | Scoop.it
MBio. 2015 Jun 2;6(3). pii: e00724-15. doi: 10.1128/mBio.00724-15.
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June 7, 2015 6:04 AM
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Immune homeostasis, dysbiosis and therapeutic modulation of the gut microbiota - Peterson - 2015 - Clinical & Experimental Immunology - Wiley Online Library

Immune homeostasis, dysbiosis and therapeutic modulation of the gut microbiota - Peterson - 2015 - Clinical & Experimental Immunology - Wiley Online Library | Mucosal Immunity | Scoop.it
Immune homeostasis, dysbiosis and therapeutic modulation of the gut microbiota - Clinical & Experimental Immunology http://t.co/QBLclKS18U
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June 6, 2015 2:58 AM
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American Society for Reproductive Immunology |

American Society for Reproductive Immunology | | Mucosal Immunity | Scoop.it
http://t.co/6GhYkMVRRT - American Society for Reproductive Immunology. The #morefunz page https://t.co/bLc717IeBM
Gilbert C FAURE's insight:

35TH ANNUAL MEETING

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June 4, 2015 8:06 AM
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Vaginal type-II mucosa is an inductive site for primary CD8+ T-cell mucosal immunity

Nature Communications | doi:10.1038/ncomms7100
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paper itself?

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June 3, 2015 2:57 PM
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Dental researchers find some immune cells change to prolong inflammation

One of the mysteries of how a small group of immune cells work has been unraveled by researchers: some inflammation-fighting immune cells may actually convert into cells that trigger disease.
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June 3, 2015 10:59 AM
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Airway-Resident Memory CD8 T Cells Provide Antigen-Specific Protection against Respiratory Virus Challenge through Rapid IFN-γ Production. - PubMed - NCBI

Airway-Resident Memory CD8 T Cells Provide Antigen-Specific Protection against Respiratory Virus Challenge through Rapid IFN-γ Production. - PubMed - NCBI | Mucosal Immunity | Scoop.it
J Immunol. 2015 May 29. pii: 1402975. [Epub ahead of print]
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June 3, 2015 2:27 AM
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The role of Syk signaling in antifungal innate immunity of human corneal epithelial cells

The role of Syk signaling in antifungal innate immunity of human corneal epithelial cells - up-to-the-minute news and headlines. 7thSpace is a online portal covering topics such as Family, Business, Entertainment, Headlines, Recipes and more.
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June 1, 2015 3:13 PM
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Insight into how we protect ourselves from certain bacteria and fungi — Garvan Institute of Medical Research

Insight into how we protect ourselves from certain bacteria and fungi — Garvan Institute of Medical Research | Mucosal Immunity | Scoop.it
Australian scientists have shown that a specific gene determines the development and function of important cells that shield us against a variety of fungal and bacterial infections.
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May 31, 2015 4:10 AM
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PHYSIOLOGY AND ENDOCRINOLOGY SYMPOSIUM: Uterine infection: Linking infection and innate immunity with infertility in the high-producing dairy cow. - PubMed - NCBI

PHYSIOLOGY AND ENDOCRINOLOGY SYMPOSIUM: Uterine infection: Linking infection and innate immunity with infertility in the high-producing dairy cow. - PubMed - NCBI | Mucosal Immunity | Scoop.it
J Anim Sci. 2015 May;93(5):2021-2033.
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May 29, 2015 8:46 AM
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Bladder cells regurgitate bacteria to prevent urinary tract infections - Medical Xpress

Bladder cells regurgitate bacteria to prevent urinary tract infections - Medical Xpress | Mucosal Immunity | Scoop.it
Duke Medicine researchers have found that bladder cells have a highly effective way to combat E. coli bacteria that cause urinary tract infections (UTIs).
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May 26, 2015 3:06 PM
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Inflammatory Bowel Disease Transmitted by Maternal Bacteria - Scientific American

Inflammatory Bowel Disease Transmitted by Maternal Bacteria - Scientific American | Mucosal Immunity | Scoop.it
A study finds that a mother mouse can pass along susceptibility to intestinal disorders via birthing, breast-feeding and affection
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June 9, 2015 3:49 PM
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Mucosal immunology Message in a bottle - Nature.com

Nature.com
Mucosal immunology Message in a bottle
Nature.com
The intestinal epithelial barrier is covered by a thick layer of stratified mucus that physically separates commensal bacteria from the epithelial cells and underlying immune cells.
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June 8, 2015 4:36 PM
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Host–Pathogen Coevolution: The Selective Advantage of Bacillus thuringiensis Virulence and Its Cry Toxin Genes

Host–Pathogen Coevolution: The Selective Advantage of Bacillus thuringiensis Virulence and Its Cry Toxin Genes | Mucosal Immunity | Scoop.it
by Leila Masri, Antoine Branca, Anna E. Sheppard, Andrei Papkou, David Laehnemann, Patrick S. Guenther, Swantje Prahl, Manja Saebelfeld, Jacqueline Hollensteiner, Heiko Liesegang, Elzbieta Brzuszkiewicz, Rolf Daniel, Nicolaas K.
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June 8, 2015 4:35 PM
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Secretory IgA reactivity to social threat in youth: Relations with HPA, ANS, and behavior. - PubMed - NCBI

Secretory IgA reactivity to social threat in youth: Relations with HPA, ANS, and behavior. - PubMed - NCBI | Mucosal Immunity | Scoop.it
Psychoneuroendocrinology. 2015 May 21;59:81-90. doi: 10.1016/j.psyneuen.2015.04.021. [Epub ahead of print]
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June 7, 2015 6:00 AM
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IL-25 as a novel therapeutic target in nasal polyps of patients with chronic rhinosinusitis - Journal of Allergy and Clinical Immunology

IL-25 as a novel therapeutic target in nasal polyps of patients with chronic rhinosinusitis http://t.co/Otg3t3ni52
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June 4, 2015 8:07 AM
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Mucosal delivery of a vectored RSV vaccine is safe and elicits protective immunity in rodents and nonhuman primates

Mucosal delivery of a vectored RSV vaccine is safe and elicits protective immunity in rodents and nonhuman primates | Mucosal Immunity | Scoop.it
Molecular Therapy — Methods & Clinical Development, Published online: 20 May 2015; | doi:10.1038/mtm.2015.18
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June 4, 2015 8:03 AM
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Interleukin 34 in the gut

Interleukin 34 in the gut | Mucosal Immunity | Scoop.it
Two new studies look at the role of interleukin 34 in inflammatory bowel diseases in the latest issue of Clinical ScienceNeutralization of IL-34 function attenuates mucosal production of inflammatory cytokines, and therefore IL-34 could be a promising...
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June 3, 2015 2:47 PM
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Is our first line of defense sleeping on the job?

The skin microbiome is considered our first line of defense against pathogens. Across our bodies, we are covered with a diverse assemblage of bacteria.
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June 3, 2015 8:00 AM
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Fecal Microbiota in Healthy Subjects Following Omnivore, Vegetarian and Vegan Diets: Culturable Populations and rRNA DGGE Profiling

Fecal Microbiota in Healthy Subjects Following Omnivore, Vegetarian and Vegan Diets: Culturable Populations and rRNA DGGE Profiling | Mucosal Immunity | Scoop.it
by Ilario Ferrocino, Raffaella Di Cagno, Maria De Angelis, Silvia Turroni, Lucia Vannini, Elena Bancalari, Kalliopi Rantsiou, Gianluigi Cardinali, Erasmo Neviani, Luca Cocolin In this study, the fecal microbiota of 153 healthy volunteers, recruited...
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June 2, 2015 7:25 AM
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Metagenome Sequencing of the Hadza Hunter-Gatherer Gut Microbiota: Current Biology

Metagenome Sequencing of the Hadza Hunter-Gatherer Gut Microbiota: Current Biology | Mucosal Immunity | Scoop.it
Metagenome Sequencing of the Hadza Hunter-Gatherer Gut Microbiota: Current Biology http://t.co/NE5MxJroMs
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Rescooped by Gilbert C FAURE from Top Selling Monoclonal Antibodies
June 1, 2015 7:26 AM
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Editorial: CCR7 is required for leukocyte egression in Crohn’s disease experimental model - J. Leukocyte Biology

Editorial: CCR7 is required for leukocyte egression in Crohn’s disease experimental model  - J. Leukocyte Biology | Mucosal Immunity | Scoop.it

The human intestine encompasses the greatest epithelial surface of the body, being exposed to the highest number and diversity of resident microbes. Therefore, the enteric immune system faces more antigens than any other part of the body, and it must be able to discriminate between invasive organisms and harmless antigens, such as the ones derived from food and commensal bacteria.

The fine-tuning of the intestinal immune system is altered during IBD, a chronic relapsing disorder of the gastrointestinal tract that includes 2 major conditions: CD and UC. Similar to other inflammatory processes, IBD is characterized by an initial response that involves the innate immune cells located in the intestinal mucosa. Subsequently, the maintenance and chronicity of the inflammation are aberrantly promoted by abnormal recruitment and stimulation of the adaptive immune cells [1].

The current first-line therapies are designed to inhibit the overactivation of innate immune cells, targeting proinflammatory cytokines, such as the TNF-α. However, anti-TNF-α antibodies often lead to unwanted secondary side effects, and two-thirds of the patients become refractory to such therapy [2].

In contrast, recent drugs, such as vedolizumab, have been designed to target the interaction between T cells and the endothelium to reduce the leukocyte traffic to the intestine [3] and halt the chronicity of the inflammatory response.

These new-generation treatments result from the scientific advances gained in the understanding of the functional heterogeneity of intestinal effector Th cells.


Via Krishan Maggon
Krishan Maggon 's curator insight, June 1, 2015 7:13 AM
doi:10.1189/jlb.5CE0215037RRJune 2015Journal of Leukocyte Biologyvol. 97 no. 6 1000-1002

 

Editorial: CCR7 is required for leukocyte egression in an experimental model of Crohn’s disease-like ileitisMarco Genua*, Alessandro Sgambato† and Silvio Danese*,1

+Author Affiliations

*IBD Center, Humanitas Clinical and Research Center, Rozzano, Milan, Italy; and †Istituto di Patologia Generale, Università Cattolica del Sacro Cuore, Rome, Italy↵1Correspondence: IBD Center, Humanitas Clinical and Research Center, Via Manzoni 113, Rozzano, Milan 20089, Italy. E-mail: sdanese@hotmail.com
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May 29, 2015 2:10 PM
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Maturation of Oral Microbiota in Children with or without Dental Caries

Maturation of Oral Microbiota in Children with or without Dental Caries | Mucosal Immunity | Scoop.it
by Pernilla Lif Holgerson, Carina Öhman, Agneta Rönnlund, Ingegerd Johansson Background The aim of this longitudinal study was to evaluate the oral microbiota in children from age 3 months to 3 years, and to determine the association of the...
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May 26, 2015 3:34 PM
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Intestinal intraepithelial lymphocyte activation promotes innate antiviral resistance : Nature Communications : Nature Publishing Group

Intestinal intraepithelial lymphocyte activation promotes innate antiviral resistance : Nature Communications : Nature Publishing Group | Mucosal Immunity | Scoop.it
Intestinal Intraepithelial Lymphocyte Activation Promotes Innate Antiviral Resistance @thecrick @NatureComms http://t.co/qxd3oXoR65
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