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GeoVax and Enesi Pharma to Collaborate on Development of Multiple Vaccines Administered by ImplaVax®

GeoVax and Enesi Pharma to Collaborate on Development of Multiple Vaccines Administered by ImplaVax® | Healthcare: reloaded... | Scoop.it

GeoVax’s vaccine technology is based on its patented Modified Vaccinia Ankara (MVA) Virus-Like Particle (VLP) platform, which generates noninfectious VLPs in the individual being vaccinated. This technology mimics a natural viral infection, triggering the body to produce a robust and durable immune response.
Enesi’s proprietary ImplaVax® solid-dose formulation and needle-free device technology comprises three main components: a single precision-engineered solid-dose Universal Vaccine Implant (UVI) containing the vaccine construct, a separate single-use disposable unit dose cassette pre-loaded with a single solid UVI and a reusable handheld spring-powered actuator.

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Drug-regulated CD33-targeted CAR T cells control AML using clinically optimized rapamycin dosing

Drug-regulated CD33-targeted CAR T cells control AML using clinically optimized rapamycin dosing | Healthcare: reloaded... | Scoop.it

Chimeric antigen receptor (CAR) designs that incorporate pharmacologic control are desirable; however, designs suitable for clinical translation are needed. We designed a fully human, rapamycin-regulated drug product for targeting CD33+ tumors called dimerizaing agent–regulated immunoreceptor complex (DARIC33). T cell products demonstrated target-specific and rapamycin-dependent cytokine release, transcriptional responses, cytotoxicity, and in vivo antileukemic activity in the presence of as little as 1 nM rapamycin. Rapamycin withdrawal paused DARIC33-stimulated T cell effector functions, which were restored following reexposure to rapamycin, demonstrating reversible effector function control.

johnsmithh59999@gmail.com's curator insight, May 17, 12:40 AM
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Strengthening CAR-T therapy to work against solid tumors

Strengthening CAR-T therapy to work against solid tumors | Healthcare: reloaded... | Scoop.it

The promising findings, reported in Science Advances, involve CAR-T cell therapy, which supercharges the immune system to identify and attack cancer cells. The paper is titled "TOP CAR with TMIGD2 as a safe and effective costimulatory domain in CAR cells treating human solid tumors."

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La chronicisation des maladies : un nouveau paradigme social

La chronicisation des maladies : un nouveau paradigme social | Healthcare: reloaded... | Scoop.it

La chronicisation des maladies représente un défi pour la médecine du XXIe siècle. L’augmentation du nombre de patients atteints d’une affection chronique rend incontournable une réflexion sur l’enjeu social et économique que constitue leur prise en charge.

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Avancée majeure : les tumeurs ne seraient pas forcément induites par des mutations génétiques

Avancée majeure : les tumeurs ne seraient pas forcément induites par des mutations génétiques | Healthcare: reloaded... | Scoop.it
Si des études ont déjà souligné l'influence de l'épigénétique dans le développement de tumeurs, c'est la première fois qu'il est démontré que les mutations de l’ADN - qui s'accumulent au niveau du génome - ne sont pas indispensables à l'apparition des cancers. En d'autres termes, cette découverte montre que des processus pas forcément génétiques sont entièrement capables de provoquer l'apparition et le développement de tumeur, ouvrant ainsi la voie à de nouvelles pistes thérapeutiques.
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Résistance aux antibiotiques : un constat alarmant

Résistance aux antibiotiques : un constat alarmant | Healthcare: reloaded... | Scoop.it

Le Groupe de direction mondial sur la résistance aux antimicrobiens – antibiotiques notamment – appelle les Etats membres de l’ONU à réagir urgemment face à cette menace croissante. Sa dernière étude laisse envisager un coût humain et économique vertigineux si des mesures fortes ne sont pas rapidement prises contre la résistance aux antimicrobiens.

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CAR T Cell Therapies Last Longer, Work Better with FOXO1 Protein

CAR T Cell Therapies Last Longer, Work Better with FOXO1 Protein | Healthcare: reloaded... | Scoop.it

Fewer than 50% of patients who are treated with CAR T therapies remain cured after one year. One of the reasons for this is that CAR T cells often don’t survive long enough in patients to completely eradicate their cancer. However, other studies showed that patients who were cured by CAR T therapy had cells that were more durable and able to fight the cancer longer. Results from the Nature study indicate that longer lasting cells benefit from a protein called FOXO1, which improves the survival and function of CAR T cells.

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Poseida examines CAR-T conditioning to crack into solid tumors

Poseida examines CAR-T conditioning to crack into solid tumors | Healthcare: reloaded... | Scoop.it

Why haven’t CAR-T therapies cracked into solid tumors yet? Poseida Therapeutics is trying to fill in at least one piece of the puzzle with a new analysis presented at the American Association for Cancer Research annual meeting showing that patients may need a higher dose of lymphodepletion than those with blood cancers.

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Compounding Pharmacies for Semaglutide Cause Concern

Compounding Pharmacies for Semaglutide Cause Concern | Healthcare: reloaded... | Scoop.it

In June, the FDA released a warning about the new antiobesity medications, stating it had received reports of adverse events after people self-administered semaglutide from a compounding pharmacy. The warning also states that compounding pharmacies may be selling salt forms of the active ingredient, including semaglutide sodium and semaglutide acetate, though the FDA is not aware of any basis for compounding a drug using semaglutide salts that would meet federal requirements.

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A Novel Noninvasive Method for Treating Alzheimer’s Disease

A Novel Noninvasive Method for Treating Alzheimer’s Disease | Healthcare: reloaded... | Scoop.it

A paradigm change in the understanding of Alzheimer’s pathogenesis has been made evident by recent research, highlighting the significance of concentrating on the soluble oligomeric form of the pathogenic amyloid beta (A-beta) protein to target its early-stage aggregation.

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Tendances clés en 2024 dans le secteur de la santé

Tendances clés en 2024 dans le secteur de la santé | Healthcare: reloaded... | Scoop.it

Bien que la COVID ait perdu son statut d’urgence, le secteur de la santé publique continue de traiter avec “des cicatrices profondes sur notre monde“. La crise a souligné d’énormes lacunes dans nos systèmes de santé, en particulier dans la capacité des responsables de la santé publique à coordonner une réponse informée et rapide. Il y a un nouvel élan pour la digitalisation rapide des systèmes de santé. Il y a une reconnaissance de l’importance de placer les personnes au-dessus des processus. Et il y a une urgence croissante à fournir des services de santé durables. Par-dessus tout, les dirigeants reconnaissent maintenant que chacun de ces objectifs dépend d’une stratégie de données, avec un accès sécurisé et simple aux données de santé.

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What is Patient Engagement in Healthcare?

What is Patient Engagement in Healthcare? | Healthcare: reloaded... | Scoop.it

Patient engagement in healthcare is defined as the active participation of patients in their own care, treatment decisions, and health management processes. It involves empowering patients to take an active role in managing their health and well-being by providing them with information, resources, and support to make informed decisions and participate in their care journey effectively. Patient engagement encompasses various activities and initiatives aimed at involving patients in their healthcare, promoting collaboration between patients and healthcare providers, and ultimately improving health outcomes and patient satisfaction.

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Self-Reported Survey Data: Fast & Reliable, or Imprecise & Risky?

Self-Reported Survey Data: Fast & Reliable, or Imprecise & Risky? | Healthcare: reloaded... | Scoop.it

Human beings are creatures of habit. Ours days have a particular rhythm to them, and behaviours we exhibit today are generally indicative of how we behaved yesterday and will behave tomorrow. Yet for how routine our lives can be, behavioural research conducted the last 50 years has found that people tend to struggle when asked to recall specific details about their day-to-day life.

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Optimizing antithrombotic therapy in patients with coexisting cardiovascular and gastrointestinal disease

Optimizing antithrombotic therapy in patients with coexisting cardiovascular and gastrointestinal disease | Healthcare: reloaded... | Scoop.it

Balancing the safety and efficacy of antithrombotic therapy in patients with gastrointestinal disorders is challenging because of the potential for interference with the absorption of antithrombotic drugs or for an increased risk of bleeding. Various clinical states, including malabsorption syndromes, bariatric surgery, short-bowel syndrome or enteral tube feeding, can influence the absorption and bioavailability of oral antithrombotic agents. Bleeding events are an essential prognosticator in patients with cardiovascular diseases — at times as important as thrombotic events — and using antithrombotic agents in patients at high risk of gastrointestinal bleeding (GIB) is very challenging. Most of the existing models to predict the risk of bleeding in patients with coronary artery disease do not estimate the risk of GIB specifically. Identifying patients at high risk of GIB, modifying the bleeding risk by using gastroprotective agents, and determining the appropriate antithrombotic therapy regimen have crucial roles in preventing GIB. After an episode of acute GIB, determining the duration of antithrombotic therapy interruption and the regimen for re-initiation requires consideration of the balance between the bleeding severity and the risk of thrombotic events.

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Preliminary Findings Point to Low Risk of Secondary Cancers from CAR-T Therapies

Preliminary Findings Point to Low Risk of Secondary Cancers from CAR-T Therapies | Healthcare: reloaded... | Scoop.it

At a joint event held by the Friends of Cancer Research and Parker Institute for Cancer Immunotherapy on Monday, cell therapy pioneer Carl June of the University of Pennsylvania Perelman School of Medicine revealed findings from a recent unpublished study from his group that looked at 783 patients who had received CAR-T treatments for HIV-1 or various cancers. Over more than 2,200 patient-years of observation, the group found 18 patients, or 2.3%, who developed secondary malignancies.

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Review Describes Semaglutide-Associated Skin Effects

Review Describes Semaglutide-Associated Skin Effects | Healthcare: reloaded... | Scoop.it
Alopecia, dysesthesia, and other types of skin sensations have been reported in patients treated with semaglutide, but more research is needed to understand skin findings associated with this drug.
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CARMAT

Carmat ambitionne de répondre à un enjeu majeur de santé publique lié aux maladies cardiovasculaires, l’insuffisance cardiaque, qui représente la première cause de décès dans le monde. Plus précisément, Carmat vise à apporter une solution durable au traitement de l’insuffisance cardiaque terminale, maladie pour laquelle il existe aujourd’hui très peu d’options efficaces, la principale étant la transplantation cardiaque.

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How Are Hypodermic Needles Made?

How Are Hypodermic Needles Made? | Healthcare: reloaded... | Scoop.it

Today’s hypodermic needles are hollow devices made from flat sheets of stainless steel heated to achieve pliability. Fabrication then occurs by rolling stainless steel strips into a tubular shape and using a laser to weld the two seams.

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Subcutaneous Immunotherapy: Better Life for Cancer Patients

Subcutaneous Immunotherapy: Better Life for Cancer Patients | Healthcare: reloaded... | Scoop.it

Instead of waiting anywhere from 30 minutes to several hours for infusions into their veins, patients would spend just a few minutes being injected under the loose skin of their abdomens or thighs. Clinicians would save time and money, and patients would leave the clinic much sooner than normal. The ease of subcutaneous injections also opens up an opportunity for home treatment, a potential boon for people who don't want to spend their remaining time on hospital visits.

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Researchers stimulate gene that enhances CAR T-cell treatments for solid tumors

Researchers stimulate gene that enhances CAR T-cell treatments for solid tumors | Healthcare: reloaded... | Scoop.it

CAR T-cell therapy is a type of cancer treatment that genetically modifies your own immune T-cells to recognize and fight cancer. This treatment has been successful in some blood cancers but is less effective in solid cancers for several reasons, including poor cell persistence and functionality in a hostile tumor environment. The latest research, using ovarian, breast and colon cancer models, has identified a gene that can be stimulated to make the cells younger, fitter, more dynamic and effective in fighting solid tumors.

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FDA approves earlier use of Carvykti CAR-T for multiple myeloma

FDA approves earlier use of Carvykti CAR-T for multiple myeloma | Healthcare: reloaded... | Scoop.it

The expanded indication permits treatment with the chimeric antigen receptor T cells after first relapse and applies to adults who are refractory to lenalidomide and have received at least one previous line of therapy, including a proteasome inhibitor and an immunomodulatory agent.

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Concerns Rising Over Risk that Ozempic May Cause Birth Control to Fail

Concerns Rising Over Risk that Ozempic May Cause Birth Control to Fail | Healthcare: reloaded... | Scoop.it

Health experts urge women not to use Ozempic or similar drugs to increase fertility, due to increased risks of birth defects and miscarriage.

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How can medical device OEMs support the circular economy?

How can medical device OEMs support the circular economy? | Healthcare: reloaded... | Scoop.it

“First, do no harm” is as central to the circular economic mindset as it is to the ethos of caregivers. This philosophy is making its way into boardrooms via environmental, social and governance (ESG) policies and it’s prompting medical device manufacturers to rethink their approach to design, production and what happens after the sale.

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Why Physicians Resist Using Algorithm-Based Apps

Why Physicians Resist Using Algorithm-Based Apps | Healthcare: reloaded... | Scoop.it

A limited study of physicians in the United Kingdom’s National Health Service found that they are resistant to using algorithm-based tools, including AI-based applications. The research, which consisted of interviews with 32 physicians, identified four reasons for their reluctance. This article suggests ways their resistance can be overcome.

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Breakthrough skin model accelerates development for testing and beyond

Breakthrough skin model accelerates development for testing and beyond | Healthcare: reloaded... | Scoop.it

A recent collaboration between researchers at the University of Oregon (UO) and L’Oréal has resulted in the development of a multilayered artificial skin model, designed to resemble the complexity of real human skin closely. This achievement has implications for improving the testing of skin care products and potentially enhancing skin healing methods. Led by Associate Professor Paul Dalton from the Phil and Penny Knight Campus for Accelerating Scientific Impact at the UO, the research relies on Dalton’s novel 3D printing technique. Published in the journal Advanced Functional Materials, this technique enables the creation of a two-layered artificial skin, with each layer separated by a membrane, mirroring the structure of natural skin.

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Mechanism of traditional Chinese medicine in elderly diabetes mellitus and a systematic review of its clinical application

Mechanism of traditional Chinese medicine in elderly diabetes mellitus and a systematic review of its clinical application | Healthcare: reloaded... | Scoop.it

Affected by aging, the elderly diabetes patients have many pathological characteristics different from the young people, including more complications, vascular aging, cognitive impairment, osteoporosis, and sarcopenia. This article will explore their pathogenesis and the mechanism of Traditional Chinese medicine (TCM) intervention, and use the method of systematic review to evaluate the clinical application of TCM in elderly diabetes.

Daniel Fonkeng's curator insight, March 30, 4:20 AM
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