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Having some belly fat may be beneficial for brain health in younger individuals due to its role in maintaining healthy BDNF. Aging disrupts this benefit because of decreased production of a key protein, CX3CL1. This leads to lower BDNF levels and potentially contributes to cognitive decline. Excessive fat accumulation, particularly in obesity, is associated with overexpression of 11β-HSD1, which is linked to negative metabolic effects.

Each polymer reacts differently to ionizing radiation. Thus, it is important to verify that the maximum administered dose will not have a detrimental effect on the product’s function or the patient’s safety over the product’s intended shelf life.

Considering that dose rate had no impact on sterilization efficacy,
the data suggests that an easier transition can be obtained within
different ionizing radiation technologies without extensive work related to the sterilization effects as a function of the dose rate. That is, the results reported herein suggest that transfer of minimum doses required for inactivation is possible between irradiators of the same and/or different irradiation source without impacting the sterility assurance level (SAL), in accordance with ISO11137-2:2013.

Over about 3.5 years, Al-Aly and his colleagues tracked more than 200,000 people with diabetes on GLP-1 drugs and about 1.7 million people with diabetes using other blood-sugar-lowering medications. They tracked the effects of GLP-1 drugs on 175 health conditions. Compared with other diabetes medications, GLP-1 drugs were linked to a lower risk of dozens of conditions, including heart disease, stroke and kidney disease. They also lowered the risk of psychotic disorders by 18%, Alzheimer’s disease by 12%, and addiction disorders by an average of 13%.

Measuring less than 5 mm in size, microplastics are formed over time as plastic materials break down but don’t biodegrade. Exposure to these substances can come through food, air, and skin absorption. While scientists are learning more about how these substances are absorbed by the body, questions remain about how much exposure is safe, what effect — if any — microplastics could have on brain function, and what clinicians should tell their patients.

The evolutionary potential of the human immune system in space deals with many (yet unknown) obstacles. Such challenges include different pathogenic potential in microorganisms, altered immune response, low genetic variability, and large immune variability due to small population sizes to name a few. Reflecting on the evolutionary journey of immunity to a future in outer space reveals a crucial insight: the intricate and multifaceted actions and interactions within innate and adaptive immunity stem from a rigorous and enduring process of selection and deselection as described.

Ce dimanche 28 juillet, une nouvelle étude publiée dans la revue scientifique JAMA dévoile les très bons résultats d'un test sanguin pour diagnostiquer la maladie d'Alzheimer, 20 ans avant l'apparition des symptômes. Autrement dit, une simple prise de sang permettrait de prendre en charge plus tôt un patient atteint d'Alzheimer[1] et d'améliorer son quotidien. Ce test simple, non invasif et peu coûteux serait beaucoup plus efficace à un stade précoce qu'une consultation par un médecin ou même un neurologue. Explications.

AST modulates inflammatory signaling pathways such as NF-kB and downregulates the expression of inflammatory cytokines. Although there are only a few clinical reports related to the protective effect of AST against inflammatory diseases, AST should be further characterized for its properties as a potential therapeutic strategy in combating inflammatory diseases.

Nowadays, the mHealth market is flooded with smartphone applications (apps) lacking validation for blood pressure (BP)-lowering effects and BP measurement accuracy. This systematic review for Guidelines for BP control using digital technologies of the Japanese Society of Hypertension aimed to assess the validation studies of apps.

Santé publique France, la Drees et l’Inserm ont publié une étude sur les causes principales de mortalité en France en 2022. Selon cette dernière, un quart des décès sont liés à des tumeurs, 20 % surviennent à la suite d’une maladie cardio-vasculaire

DCBs dilatation may be a safe, effective and feasible treatment for benign esophageal strictures, and can be utilized as an alternative option after standard dilatation has failed. Prospective studies with large samples are needed to further validate its clinical efficacy.

We found that FM-pain-like behavior induced in the ICS mice model elevated the plasma IL-17A and the brain IL-17RA. The results indicated that IL-17A plays a critical role in peripheral and central sensitization as well as neuroinflammation in the ICS FM mice model. Additionally, both EA and Trpv1−/− attenuated the plasma IL-17A and the brain IL-17RA. We also found that Trpv1−/− abolished the IL-17A, IL-17RA, and their downstream pathways, such as PI3K/Akt, MAPKs, and NF-κB. Therefore, IL-17A–IL-17RA might not induce neuroinflammation without TRPV1. Finally, our results indicated that EA relieved the ICS-induced FM mechanical and thermal pain-like behaviors maybe through the TRPV1–IL-17-related pathways in mice. It suggests that EA could lower the use of drugs and other additional pain treatment and is a potential therapeutic strategy in FM.

In the study, the DN gel rapidly reprogrammed differentiated cancer cells into cancer stem cells in just 24 hours in six different human cancer cell lines — brain cancer, uterine cancer, lung cancer, colon cancer, bladder cancer, and sarcoma. After cancer cells were placed on the DN gel, they started to form spherical structures and produce specific molecules known to be markers of cancer stem cells such as SOX2 and Oct3/4, aka Yamanaka factors, named after the Nobel Prize laureate, suggesting they had been reprogrammed.

The U.S. Food and Drug Administration requires testing be performed on new medical devices requiring sterility and on legacy medical devices that a manufacturer desires to switch to another sterilization method to ensure safety (functionality, biocompatibility, and ability to sterilize). ISO 11137-1 guidance provides expectation of being able to transfer maximum acceptable dose from a low dose rate gamma sterilization process to a higher dose rate e-beam or x-ray process.

Looking for alternatives to gamma irradiation? Many gamma sterilized products are compatible with electron beam. With the recent publication of AAMI TIR 104, the process for transferring products from gamma to electron beam is now simple and well defined.

Ces dispositifs miniaturisés peuvent accomplir des missions spécifiques telles que des biopsies, la délivrance de molécules ou encore l’implantation d’électrodes. « Ce financement représente une étape cruciale pour doter les neurochirurgiens des outils nécessaires pour transformer les traitements et les résultats pour les patients », ajoute-t-il.

Researchers are developing the world’s first topical cream to prevent and treat skin cancer, especially for organ transplant recipients.

The researchers created a digital twin of the gene network involved in the differentiation trajectory of normal cells. This computational model allowed them to simulate and analyze the intricate gene interactions that regulate cell differentiation. Through their simulations, the team pinpointed master molecular switches capable of steering cells from colon cancer back into a normal-like state. These findings were then validated through molecular experiments, cellular studies, and animal trials, demonstrating the effectiveness of this approach.

Prostatic stents remain an efficient choice for addressing obstructive symptoms from BPH, offering the advantage of being performed under local anaesthesia, relieving symptoms with good functional outcomes and a low incidence of major complications. Prospective studies are needed to corroborate these results.

Luc's appointment further strengthens the Company's leadership team, as Xeltis expands its clinical presence following the approval of an Investigational Device Exemption (IDE) from the US Food and Drug Administration (FDA) to initiate a US pivotal study for aXess, its restorative vascular access conduit. Luc is familiar to Xeltis having previously served as Senior Vice President of Global Clinical Affairs from 2018 to 2020, and this previous experience of working with Xeltis' transformative Endogenous Tissue Restoration (ETR) technology in a clinical capacity will be invaluable as the Company continues its development.

Les accidents vasculaires cérébraux (AVC), principalement de nature ischémique, trouvent leurs racines dans divers facteurs, parmi lesquels l’athérosclérose occupe une place prépondérante. Cette pathologie se manifeste par la formation de plaques au sein des parois artérielles. Bien que les individus âgés soient généralement plus vulnérables aux AVC, une tendance inquiétante émerge : l’augmentation des cas d’AVC précoce. Une étude récente menée par des chercheurs américains révèle un lien insoupçonné entre ce phénomène et le groupe sanguin. Les conclusions de cette étude indiquent notamment que les individus du groupe sanguin A présentent un risque supérieur de subir un AVC précoce, en comparaison avec ceux des groupes sanguins B et O.

Corneal endothelial dysfunction is a leading cause of vision loss globally, frequently requiring corneal transplantation. However, the limited availability of donor tissues, particularly in developing countries, has spurred on the exploration of tissue engineering strategies, with a focus on polymer biomaterials as scaffolds for corneal endotlhelium regeneration. This review provides a comprehensive overview of the advancements in polymer biomaterials, focusing on their role in supporting the growth, differentiation, and functional maintenance of human corneal endothelial cells (CECs).

For CNLBP patients, warm needle acupuncture, electrical warm needling and meridian-sinew theory-based treatment are mainly recommended. If patients have significant pain, electroacupuncture is strongly suggested. On the contrary, for patients with decreased joint mobility, meridian-sinew theory-based treatment is advocated.

Pour cela, ce petit génie en herbe a élaboré une formule chimique composée d’acide salicylique, d’acide glycolique et de trétinoïne, qui favorise l’activation de cellules indispensables au bon fonctionnement du système immunitaire et à la détection d’agents pathogènes potentiels. Il a ensuite ajouté ce mélange à une nanoparticule à base de lipides afin qu’elle ne se dissolve pas avec la mousse du savon et puisse pénétrer la peau.