Enveloped viruses are glycosylated, meaning that their envelope proteins are post-translationally modified by the addition of glycans. Some glycosyltransferases that contribute to terminate glycan chains synthesis are differentially expressed between cell types within or between species, which bears important immunological consequences [1]. A prime example concerns the GGTA1 gene encoding a galactosyltransferase that catalyzes the transfer of a galactose in α1,3 linkage onto subterminal N-acetyllactosamines. This glycosyltransferase is expressed by all mammals except Old World monkeys, apes and humans, due to inactivating mutations that occurred in a common primate ancestor some 20 to 40 million years ago. .. In conclusion, we propose to enhance the innate anti-viral protection conferred by natural anti-glycan antibodies in order to lower both the risk of emergence of coronaviruses, or other enveloped viruses, from a nonprimate mammalian species and the risk of transmission within the human population. This could add-up to other protection and containment measures, mitigating the impact of the epidemic.