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The presentation covered: Phase I/II randomized, double blind, multi-center, placebo-controlled safety and efficacy study designed to evaluate the norovirus monovalent GI.1 VLP vaccine versus placebo Results from the Norovirus vaccine proof-of-concept, multi-center challenge study Ongoing clinical study of an intramuscular bivalent formulation of norovirus vaccine candidate
Of course, they don't mention you can make it in plants too.... 
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Catch up with the latest bird flu news from across the globe with our daily bird flu updates...
Great site to follow avian flu
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A quantitative understanding of the spread of contaminated farm dust between locations is a prerequisite for obtaining much-needed insight into one of the possible mechanisms of disease spread between farms. Here, we develop a model to calculate the quantity of contaminated farm-dust particles deposited at various locations downwind of a source farm and apply the model to assess the possible contribution of the wind-borne route to the transmission of Highly Pathogenic Avian Influenza virus (HPAI) during the 2003 epidemic in the Netherlands.
Atmospherics and physics meets viruses....
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NAT has launched a report, ‘HIV and Hepatitis C Co-infection’, which looks at hepatitis C co-infection among HIV positive men gay men and the UK’s response to this growing health challenge...
Treat one, and another pops up. Roll on the HCV vaccine!
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Pediatricians fed up with parents who refuse to vaccinate their children out of concern it can cause autism or other problems increasingly are firing such families from their practices, raising questions about a doctor's responsibility to these...
Unethical, possibly, but stupid people are their own worst enemies. Trouble is, they extend it to their children.
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Scientists have created a form of the H5N1 avian flu virus that is transmissible between mammals, raising fears that it could trigger a human pandemic if it escapes from the lab - either through accidental release or as part of a bioterror attack. As debate rages over how much of the research should be published, and whether there is sufficient oversight of such work, you can follow all Nature's coverage of the issue here.
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Using the self-controlled case series design we examined 271,495 12 month vaccinations and 184,312 18 month vaccinations to examine the relative incidence of the composite endpoint of emergency room visits or hospital admissions in consecutive one day intervals following vaccination....
There are significantly elevated risks of primarily emergency room visits approximately one to two weeks following 12 and 18 month vaccination.
HOWEVER [Ed]: Given the effectiveness of the MMR vaccine in eliminating both measles and rubella, and the highly infectious nature of these diseases, high vaccination coverage is essential. The diseases that the vaccines are preventing are not benign and vaccination can eliminate many of the serious sequelae of these infections [20]. Complications from measles include otitis media (7–9% of cases), pneumonia (1–6% of cases), encephalitis (1 per 1,000–2,000 cases), subacute sclerosing panecephalitis (1 per 100,000 cases), and death (1 per 3000 cases) [3], [21]. Further studies attempting to predict which children develop post-vaccination reactions, as well as determining the effectiveness of prophylactic treatment with antipyrectics prior to the high risk period for symptom development are warranted.
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by Merry Youle
Imagine that: they'll be spraying live bacteria next...oh, wait! They do!!
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Even if a 59% mortality rate for H5N1 is too high, the virus could still cause a flu pandemic more serious than that of 1918.
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"HIV-1 Gag virus like particles (VLPs) used as candidate vaccines are regarded as inert particles as they contain no replicative nucleic acid, although they do encapsidate cellular RNAs."
In light of HPV VLPs being flagged as containing HPV DNA, this is interesting as it gives an idea of how to get rid of the NA in the HIV Pr55Gag particles. Plus, my lab wrote it.
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Washington, Feb 13 (IANS) A protein knocks out the most virulent form of HIV by starving it of the raw materials it needs to reproduce, in order to protect our immune cells, a study reveals.
...and this may be relevant for other viruses, like herpesviruses...
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![70% of oral cancers now traced to HPV [virus] | Virology News | Scoop.it](https://img.scoop.it/DtzAY_YT4ZRATqf_bGESSTl72eJkfbmt4t8yenImKBVvK0kTmF0xjctABnaLJIm9)
An estimated 7% of American teens and adults carry the human papilloma virus in their mouths, an infection that puts them at heightened risk of developing cancer of the mouth and throat, researchers say.
Of course, a goodly number of NON-Americans do, too...B-)
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"The FDA has recently received inquiries regarding the presence of human papillomavirus (HPV) DNA fragments in Gardasil and is aware that information related to this issue is on the internet."
The thing they don't mention is that there is probably OTHER yeast-derived DNA present as well, seeing as the VLPs are made in yeast - and that the HPV DNA is probably present in very low amounts detectable only by PCR
Picture courtesy of Russell Kightley Media
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Well, not really an RNA virus, given that it has a DNA stage to the lifecycle - but possibly the smallest virus genome known to make miRNAs?
Thanks AJC!
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Scientists from the Antwerp Institute of Tropical Medicine, Antwerp University Hospital and Antwerp University have tested a new 'therapeutic vaccine' against HIV on volunteers.
The next wave of HIV vaccines: we have so many HIV-infected people alive because of ARVs, that other interventions are starting to be seriously trialled.
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A pretty reasonable overview of the pros and cons of vaccinating children - which manages to be mostly pro.
As it should be.
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Carl Zimmer reviews Frank Ryan's Virolution: The Most Important Evolutionary Book Since Dawkins' Selfish Gene.
"We are part virus. This bizarre yet inescapable fact has been revealed over the past 30 years, as scientists have spelunked their way through the human genome and encountered stretches of DNA with the telltale chemical signatures of viruses."
I thoroughly enjoyed this one.
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A Planet of Viruses | If not for a virus, none of us would ever be born.In 2000, a team of Boston scientists discovered a peculiar gene in the human genome.
Thanks Kerry!
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In its effort to eradicate the deadly Foot & Mouth Disease (FMD) in animals by 2030, India has joined hands with the US to jointly develop a new-age single-shot vaccine.
...the new recombinant clone adenovirus virus base vaccine will be sturdier, require less cold storage and be more effective than the present vaccine.
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LONDON/GENEVA (Reuters) - When 22 bird flu experts meet at the World Health Organisation (WHO) this week, they will be tasked with deciding just how far scientists should go in creating lethal mutant viruses (Decision time for researchers of deadly...
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THE SWINE flu vaccine has topped the list of drugs responsible for the largest number of suspected adverse reactions, new figures show.
...followed by (in third place) the HPV vaccine, then other childhood vaccines. But "Most of these were relatively mild, such as localised swelling, gastrointestinal problems and flu-like symptoms."
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HIV-resistant sex workers in Africa have a weak inflammatory response in their vaginas – a surprise for researchers, who were expecting the contrary considering the women’s high exposure to the virus.
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"These results suggest that cholesterol in the plasma membrane, dynamin- and clathrin-dependent endocytosis, and macropinocytosis play crucial roles in the entry of viruses bearing baculovirus GP64 into mammalian cells."
And VLPs: see next one....
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THE deadly virus sweeping through Melbourne's pigeons has been confirmed for the first time in other species, renewing urgent calls for a vaccine.
"the paramyxovirus" - WHICH paramyxovirus??!! We should be told....
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Health authorities have admitted to overreacting to a health scare at Auckland Airport but say it's better to be safe than sorry.
It's going to happen more often, people...I remember flying around Canada during the SARS breakout, and cringing and trying not to breathe every time the guy behind me coughed.
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