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Scooped by
Ed Rybicki
August 19, 2025 8:43 AM
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Imagine never catching a cold again.Scientists have discovered why some people are naturally virus-proof...
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Scooped by
Ed Rybicki
August 19, 2025 8:42 AM
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Within the past few years, models that can predict the structure or function of proteins have been widely used for a variety of biological applications, such as identifying drug targets and designing new therapeutic antibodies.
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Scooped by
Ed Rybicki
August 19, 2025 8:41 AM
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Une étude révèle que le COVID-19 accélère le vieillissement des vaisseaux sanguins, en particulier chez les femmes.
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Scooped by
Ed Rybicki
July 30, 2025 4:59 AM
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Visualisation of multiprotein complexes in cellular contexts remains challenging. Here, the authors present a tripartite chemogenetic fluorescent reporter, which enables the imaging of ternary protein complexes in living cells, advancing the study of dynamic multiprotein interactions across...
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Scooped by
Ed Rybicki
July 30, 2025 4:59 AM
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This Review reflects on the major challenges in bacterial mRNA vaccine design, provides strategies for tailoring mRNA construct design to promote humoral or cellular immunity, and provides an overview of the translational landscape for mRNA vaccines.
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Scooped by
Ed Rybicki
July 30, 2025 4:58 AM
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Imagine you're a molecular biologist wanting to launch a project seeking treatments for a newly emerging disease. You know you need the expertise of a virologist and an immunologist, plus a bioinformatics specialist to help analyze and generate insights from your data. But you lack the resources or connections to build a big multidisciplinary team.
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Scooped by
Ed Rybicki
July 30, 2025 4:56 AM
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In a groundbreaking study recently published in npj Viruses, a team of researchers led by Halfmann and colleagues has unveiled promising new insights into vaccine design against Merbecoviruses, a subgenus of coronaviruses that includes the Middle East Respiratory Syndrome coronavirus (MERS-CoV).
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Scooped by
Ed Rybicki
May 7, 2025 8:08 AM
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The rapid deployment of mRNA vaccines for SARS-CoV-2, such as BNT162b2 (BioNTech-Pfizer) and mRNA-1273 (Moderna), provided a critical tool in combatin…...
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Scooped by
Ed Rybicki
May 7, 2025 8:08 AM
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The burden of herpes simplex virus (HSV) infection is exacerbated due to the emergence of antiviral drug resistance and a lack of effective antibodies. Here the authors construct a bispecific nanobody that blocks receptor binding and prevents gD-gH/gL interaction, and show that it protects against...
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Scooped by
Ed Rybicki
May 7, 2025 8:07 AM
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Researchers used AI models to design antibodies that neutralize over 1,300 SARS-CoV-2 strains, including Delta and Omicron. The models demonstrated faster, cheaper, and more adaptable therapeutic development compared to traditional methods.
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Scooped by
Ed Rybicki
May 7, 2025 8:04 AM
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Ribonucleic acid (RNA) molecules may be best known for their job ferrying the genetic information encoded in DNA to a cell's protein factories, but these molecules aren't just a middleman for protein production. In fact, some RNA molecules don't code for proteins at all and serve various other important functions in cells, such as regulating gene expression and catalyzing chemical reactions. However, the functions of many non-coding RNAs remain mysterious.
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Scooped by
Ed Rybicki
May 7, 2025 8:03 AM
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Exactly 100 years ago, famed Austrian physicist Erwin Schrödinger (yes, the cat guy) postulated his eponymous equation that explains how particles in quantum physics behave. A key component of quantum mechanics, Schrödinger's Equation provides a way to calculate the wave function of a system and how it changes dynamically in time.
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Scooped by
Ed Rybicki
May 7, 2025 8:02 AM
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Patients suffering from long COVID may exhibit persistent inflammation in the heart and lungs for up to a year following SARS-CoV-2 infection-even when standard medical tests return normal results-potentially placing them at elevated risk for future cardiac and pulmonary conditions.
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Scooped by
Ed Rybicki
August 19, 2025 8:43 AM
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Wastewater from aircraft toilets could provide a critical warning system for the global spread of antimicrobial resistant (AMR) superbugs, a silent pandemic that threatens to kill more peopl...
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Scooped by
Ed Rybicki
August 19, 2025 8:41 AM
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“Immunity debt,” a theory to explain the global surge in non-covid infections since pandemic restrictions were lifted, is increasingly being challenged by emerging evidence. Nick Tsergas reportsMycoplasma pneumoniae is a bacterial infection not known to cause widespread hospital admissions. “I can count on my two hands the number of times I’d ever seen mycoplasma pneumoniae before 2023,” says Samira Jeimy, clinical immunologist at the University of Western Ontario. “All of a sudden I feel like everybody has it.”
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Scooped by
Ed Rybicki
July 30, 2025 5:00 AM
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The three-dimensional (3D) atomistic-resolution structure and dynamics of RNA kissing complexes (KCs) and extended duplexes (EDs), homodimers formed through palindromic base pairing, are crucial for understanding viral replication and structure-informed therapeutic design.
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Scooped by
Ed Rybicki
July 30, 2025 4:59 AM
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Drivers of viral evolution in SARS-CoV-2 are insufficiently understood. In this study, the authors show how a key SARS-CoV-2 mutation, NSP4 T492I, is potentially responsible for accelerating genome evolution to develop adaptive variants (e.g.
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Scooped by
Ed Rybicki
July 30, 2025 4:58 AM
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Researchers around the world are testing wastewater for the SARS-CoV-2 virus, in hopes that what goes down the drain can act as an early warning...
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Scooped by
Ed Rybicki
July 30, 2025 4:57 AM
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Amyloids are perhaps best known as a key driver of Alzheimer's disease.
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Scooped by
Ed Rybicki
July 30, 2025 4:56 AM
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Wastewater-based epidemiology (WBE) is the analysis of wastewater to identify the presence of biologicals or chemicals for the purpose of monitoring...
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Scooped by
Ed Rybicki
May 7, 2025 8:08 AM
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Sudan virus (SUDV) outbreaks in Uganda created public health concerns due to a lack of approved vaccines. In this study, the authors develop a repRNA SUDV vaccine and demonstrate full protection of a single dose of this vaccine in a lethal SUDV guinea pig model.
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Scooped by
Ed Rybicki
May 7, 2025 8:07 AM
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In this Review, Chen, Farzan and Choe discuss our current understanding of the structure and function of the SARS-CoV-2 spike protein, the molecular mechanism of viral entry and the emergence of new variants, as well as the implications of these insights for development of spike protein-related...
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Scooped by
Ed Rybicki
May 7, 2025 8:07 AM
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Journal of Virology, Ahead of Print.
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Scooped by
Ed Rybicki
May 7, 2025 8:04 AM
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USask researchers recently published a paper in Scientific Reports that identified a promising alternative for controlling infectious diseases such as swine dysentery. Porcine β-defensin 5, or pBD-5, is a host defense peptide (HDP) that may help to reduce the industry's reliance on antibiotics.
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Scooped by
Ed Rybicki
May 7, 2025 8:02 AM
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President Trump issued an executive order on Monday, banning federal funding for gain-of-function (GoF) research in “countries of concern" like China.
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