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Scooped by
Ed Rybicki
March 16, 2020 4:49 AM
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Wang Chen, Chinese respiratory expert, vice president of the Chinese Academy of Engineering and president of the Chinese Academy of Medical Sciences, during the interview with CCTV. Special: Battle Against Novel Coronavirus It's possible that the novel coronavirus pneumonia could be a chronic disease, that persists for a long period of time like influenza, said Wang Chen, a Chinese respiratory expert and vice president of the Chinese Academy of Engineering, in an exclusive CCTV interview on Wednesday evening. SARS, though highly transmissible and lethal, is relatively short-lived and unlikely to sustain transmission among humans, as the virus kills its host and thus has nowhere to survive. The novel coronavirus has the possibility of being much more enduring and could coexist with humans like the flu, said Wang. "We should be prepared for that," said Wang. Corresponding arrangements for the disease should be made to its epidemic and biological laws and taking measures in both clinical treatment and in life and work. "The most powerful way to prevent and control the disease must come from scientific research, the understanding of scientific laws and the development of technologies," said Wang. Injured lungs can be recovered "The limited observations suggest that the impaired lung of novel coronavirus patients can recover, even fully recover," said Wang, adding that it needs further and longer-term observation. "Don't get overly worried about that." Discovery and treatment of asymptomatic patients "The major method of detecting asymptomatic cases now is mainly by nucleic acid test, and we will also have antigen test and antibody test later, which are all effective means of screening out such cases," said Wang. Methods in medical prevention, diagnosis and treatment will be developed with deepening understanding of the disease, in case the virus undergoes changes. Increasing measures and drugs There are more measures and drugs to treat the virus, but "all are in the exploratory stage," said Wang. It is a new disease whose regularity is not yet well understood. "Though the treatment has become more pertinent and standardized, our understanding remains superficial, and the exploration of new drugs and therapies are still on an early stage," said the expert, calling for the respect for scientific procedures when promoting the research.
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Scooped by
Ed Rybicki
March 16, 2020 4:47 AM
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"For every dollar invested in vaccination in the world's 94 lowest-income countries, the net return is $44. Hard to argue against," an analyst said.
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Scooped by
Ed Rybicki
March 16, 2020 4:47 AM
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China's ambassador to Russia Zhang Hanhui told Interfax news agency on Monday that his country has developed a vaccine to cure the coronavirus, which also...
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Scooped by
Ed Rybicki
March 16, 2020 4:45 AM
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Author summary African nonhuman primates that are natural hosts to SIVs can provide us with unique insight into the pathogenesis of HIV disease due to their remarkable ability to avoid progression to AIDS, despite high levels of viral replication.
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Scooped by
Ed Rybicki
March 16, 2020 4:44 AM
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As COVID-19 spreads around the world, more and more things such as conferences, schools, and large events such as SXSW are being canceled – an effort to halt the spread of the virus and reduce the strain on our healthcare system.
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Scooped by
Ed Rybicki
March 16, 2020 4:42 AM
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Germany's CureVac, among the vaccine developers funded by the Coalition for...
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Scooped by
Ed Rybicki
March 16, 2020 4:40 AM
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Berlin is trying to stop Washington from persuading a German company seeking a coronavirus vaccine to move its research to the United States.
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Scooped by
Ed Rybicki
March 16, 2020 4:38 AM
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Scooped by
Ed Rybicki
March 13, 2020 5:04 AM
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Kaiser's Seattle research institute was chosen as a trial site because it is one of nine National Institutes of Health (NIH) designated Vaccine and Treatment Evaluation Units (VTEU). The Kaiser...
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Scooped by
Ed Rybicki
March 13, 2020 5:01 AM
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Two infectious disease experts have put together a "COVID-19 primer" that includes information on prevention, symptoms, and work toward a vaccine.
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Scooped by
Ed Rybicki
March 13, 2020 4:18 AM
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Professor Lynn Morris has a lifetime of experience fighting viruses. In her last 27 years at the National Institute for Communicable Diseases, she has encountered HIV, Ebola, TB, Listeria, Klebsiella and a multitude of ‘lesser’ pathogens. She thinks that Covid-19 presents one of the greatest challenges yet to both South Africa and the world.
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Scooped by
Ed Rybicki
March 13, 2020 4:11 AM
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As coronavirus continues to spread around the globe, it's interesting to ponder what would happen if such a virus were to spread in space.
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Scooped by
Ed Rybicki
March 12, 2020 8:29 AM
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The Spanish flu got worse because the government – and the media – lied about it to the American people...
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Scooped by
Ed Rybicki
March 16, 2020 4:48 AM
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Researchers at the University of Queensland (UQ) say they are just days away from testing a new vaccine for coronavirus, or COVID-19, on animals. Paul Researchers at the University of Queensland (UQ) say they are just days away from testing a new vaccine for coronavirus, or COVID-19, on animals.
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Scooped by
Ed Rybicki
March 16, 2020 4:47 AM
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Given the exquisite precariousness of the global financial system and economy, hopes for a brief and mild downturn are wildly unrealistic...
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Scooped by
Ed Rybicki
March 16, 2020 4:46 AM
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Without a vaccine, testing to identify who has the virus is crucial to containing it.
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Scooped by
Ed Rybicki
March 16, 2020 4:45 AM
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The Spanish flu that spread around the world a century ago killing millions puts the coronavirus crisis in perspective.
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Scooped by
Ed Rybicki
March 16, 2020 4:43 AM
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Naser Makarem Shirazi, 93, a Holocaust-denying hardliner and one of the highest religious authorities in Iran, says using vaccine made by 'Zionists' okay if 'there's no substitute'...
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Scooped by
Ed Rybicki
March 16, 2020 4:41 AM
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Senior researcher Dr Paul McKay of Imperial College London says he's injected mice and the vaccine 'works really, really well'...
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Scooped by
Ed Rybicki
March 16, 2020 4:39 AM
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The first dose of a potential coronavirus vaccine will be delivered Monday, according to a governement official. ...
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Scooped by
Ed Rybicki
March 13, 2020 5:22 AM
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Scientific American is the essential guide to the most awe-inspiring advances in science and technology, explaining how they change our understanding of the world and shape our lives.
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Scooped by
Ed Rybicki
March 13, 2020 5:02 AM
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Fresh air, sunlight and improvised face masks seemed to work a century ago; and they might help us now.When new, virulent diseases emerge, such SARS and Covid-19, the race begins to find new…...
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Scooped by
Ed Rybicki
March 13, 2020 4:21 AM
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In the 1980s and early 1990s organisations such as Gay Men’s Health Crisis, ACT-UP and later the Treatment Action Campaign in South Africa pioneered ‘treatment literacy’ as one strategy to empower vulnerable communities in the response to HIV/AIDS. The premise of treatment literacy is that people are better equipped to respond to disease threats if they understand the science of the disease they are confronting. The same will be true of Covid-19.
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Scooped by
Ed Rybicki
March 13, 2020 4:15 AM
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A growing body of evidence supports the importance of T cell responses to protect against severe influenza, promote viral clearance, and ensure long-term immunity. Plant-derived virus-like particle (VLP) vaccines bearing influenza hemagglutinin (HA) have been shown to elicit strong humoral and CD4+ T cell responses in both pre-clinical and clinical studies. To better understand the immunogenicity of these vaccines, we tracked the intracellular fate of a model HA (A/California/07/2009 H1N1) in human monocyte-derived macrophages (MDMs) following delivery either as VLPs (H1-VLP) or in soluble form. Compared to exposure to soluble HA, pulsing with VLPs resulted in ~3-fold greater intracellular accumulation of HA at 15 min that was driven by clathrin-mediated and clathrin-independent endocytosis as well as macropinocytosis/phagocytosis. At 45 min, soluble HA had largely disappeared suggesting its handling primarily by high-degradative endosomal pathways. Although the overall fluorescence intensity/cell had declined 25% at 45 min after H1-VLP exposure, the endosomal distribution pattern and degree of aggregation suggested that HA delivered by VLP had entered both high-degradative late and low-degradative static early and/or recycling endosomal pathways. At 45 min in the cells pulsed with VLPs, HA was strongly co-localized with Rab5, Rab7, Rab11, MHC II, and MHC I. High-resolution tandem mass spectrometry identified 115 HA-derived peptides associated with MHC I in the H1-VLP-treated MDMs. These data suggest that HA delivery to antigen-presenting cells on plant-derived VLPs facilitates antigen uptake, endosomal processing, and cross-presentation. These observations may help to explain the broad and cross-reactive immune responses generated by these vaccines. Producing vaccines in plants can have several important advantages, including scalability and relatively low cost. Brian J. Ward and colleagues at McGill University examine the intracellular processing of a plant-derived virus-like particle (VLP) expressing influenza hemagglutinin H1 (H1-VLP) and compare this systematically with soluble monomeric H1. Human monocyte-derived macrophages rapidly take up soluble H1 via degradative pathways resulting in its poor presentation by MHC class I. In contrast, multiple endocytic and pinocytic mechanisms are used to internalize H1-VLP, including handling by non-degradative pathways which favors efficient cross-presentation by MHC class I. This specialized intracellular handling of plant-derived VLPs might underlie their ability to stimulate robust CD8+ T cell responses.
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Scooped by
Ed Rybicki
March 12, 2020 8:38 AM
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Medicago, a biopharmaceutical company headquartered in Quebec City, announced today that they have successfully produced a Virus-Like Particle (VLP) of the coronavirus just 20 days after obtaining the SARS-CoV-2 (virus causing the COVID-19 disease) gene. Production of the VLP is the first step in developing a vaccine for COVID-19 which will now undergo preclinical testing for safety and efficacy. Once this is completed, Medicago expects to discuss with the appropriate Health Agencies to initiate human trials of the vaccine by summer (July/August) 2020.
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![First dose to be delivered Monday in clinical trial for potential COVID-19 vaccine [in US] | Virology News | Scoop.it](https://img.scoop.it/Fx1NsbLlisgZktKgMFsxhTl72eJkfbmt4t8yenImKBVvK0kTmF0xjctABnaLJIm9)
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