Scientists at Harvard Medical School and Boston University Chobanian & Avedisian School of Medicine have mapped a critical component of the Nipah virus, a highly lethal bat-borne pathogen that has caused outbreaks in humans almost every year since it was identified in 1999.
Researchers have revealed new details about the CRISPR-Cas5-HNH/Cascade complex, a variant of the type I-E CRISPR-Cas system, providing insights into its DNA recognition and cleavage mechanisms.
Asthma has long been associated with increased susceptibility to viral respiratory infections, leading to significant exacerbations and poorer clinical outcomes. Contrarily and interestingly, emerging data and research surrounding the COVID-19 pandemic have shown that patients with asthma infected...
The emergence of COVID-19 has transformed global health priorities, igniting the search for effective treatments to combat SARS-CoV-2.A recent study conducted…...
Long COVID represents a significant challenge in understanding the prolonged impact of the disease. Despite its increasing recognition, detailed insights into the long-term cardiopulmonary consequences remain sparse.
Researchers review the ever-growing list of human viruses, examining their diversity, transmission pathways, and the urgent need for prevention and global surveillance.
The Leibniz Institute DSMZ-German Collection of Microorganisms and Cell Cultures has added the syphilis pathogen to its collection and makes it available to researchers around the world for scientific studies.
The incidence of male reproductive cancers, including prostate, testicular, and penile cancers, has risen in recent years, raising important health concerns. Prostate cancer is the second leading cause of cancer-related mortality in men, while penile cancer, though rare, typically affects men over...
Becoming Led Zeppelin explores the origins of this iconic group and their meteoric rise in just one year against all the odds.
Powered by awe-inspiring, psychedelic, never-before-seen footage, performances, and music, Bernard MacMahon’s experiential cinematic odyssey explores Led Zeppelin’s creative, musical, and personal origin story. The film is told in Led Zeppelin’s own words and is the first officially sanctioned film on the group.
Background: The Influenza A virus (IAV), a pathogen affecting the respiratory system, represents a major risk to public health worldwide. Immunization remains the foremost strategy to control the transmission of IAV.
Scientists at Harvard Medical School and Boston University Chobanian & Avedisian School of Medicine have mapped a critical component of the Nipah virus, a highly lethal bat-borne pathogen that has caused outbreaks in humans almost every year since it was identified in 1999.
Science has revealed some of the secrets of the X chromosome, but many remain. In humans, female cells contain two X chromosomes (XX) and male cells contain one (XY). In each female cell, one X chromosome must be inactivated—crumpled up in such a way that the genetic code it contains cannot be read out.
Antibodies are key proteins in the immune system that can reversibly and non-covalently bind specifically to their corresponding antigens, forming antigen-antibody complexes. They play a crucial role in recognizing foreign or self-antigens during the adaptive immune response.
The continuously evolving Omicron subvariants has diminished the effectiveness of almost all RBD-targeted antibodies in neutralizing these subvariants. The development of broad-spectrum neutralizing antibodies is desired for addressing both current and future variants.
This study tested the efficacy of xenomonitoring using contaminated flies and cockroaches at ports in Shenzhen by analysing sample data from imported flies and cockroaches from October 2023 to April 2024 to identify the pathogens they carried.
COVID-19-related non-pharmaceutical interventions impacted the circulation of other pathogens. Here, the authors compile a global viral activity dataset and compare the timing of resurgence of seven common respiratory viruses following the relaxation of interventions across different geographical...
When speaking of motors, most people think of those powering vehicles and human machinery. However, biological motors have existed for millions of years in microorganisms. Among these, many bacterial species have tail-like structures—called flagella—that spin around to propel themselves in fluids. These movements employ protein complexes known as the "flagellar motor."
University of Queensland researchers have for the first time introduced genetic material into plants via their roots, opening a potential pathway for rapid crop improvement. The research is published in Nature Plants.
The COVID-19 pandemic has underscored the urgent need for effective antiviral treatments, particularly as SARS-CoV-2 continues to evolve.Researchers are now focusing…...
Gene II Protein (Gp2/P2) is a nicking enzyme of the M13 bacteriophage that plays a role in the DNA replication of the viral genome. P2 recognizes a specific sequence at the f1 replication origin and nicks one of the strands and starts replication.
Ed Rybicki's insight:
Turns out that either M13 Rep recognises geminivirus Ori sequences, or the geminivirus Rep recognises M13 - because a geminivirus genomes cloned into M13 can be liberated as a replicon in E coli!
As experts continue monitoring and surveying the environment and the nation's food supply for H5N1 bird flu, a rash of dead cats has many officials on edge.
Over half of our genomes consist of thousands of remnants of ancient viral DNA, known as transposable elements, which are widespread across the tree of life. Once dismissed as the "dark side" of the genome, researchers at Helmholtz Munich and Ludwig-Maximilians-Universität (LMU) have now revealed their crucial role in early embryo development. The study is published in the journal Cell.
Kawasaki disease is an acute paediatric vasculitis of unknown origin. Environmental exposures have been suggested to contribute to disease development, but these remain to be defined.WHAT THIS STUDY ADDSThe findings suggest that infections are closely linked with Kawasaki disease, with a wider temporal association than previously described.Further, the data imply that many different agents may induce Kawasaki disease.
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