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May 9, 2013 5:49 AM
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Is this the reason why RV144 HIV ‘Thai trial’ didn’t protect more participants?

Is this the reason why RV144 HIV ‘Thai trial’ didn’t protect more participants? | Virology News | Scoop.it

The RV144 ‘Thai trial’ of an HIV vaccine candidate resulted in an unprecedented 31% protection rate among participants – a

result that sparked something of a revival in the HIV vaccine field. Despite this encouraging result, the protection rate was still considered to be too low for the vaccine to be useful. Since then, many HIV vaccines have come and gone – with the NIAID’s HVTN 505 trial being the latest casualty in the drive to stem the HIV pandemic. However, researchers at the Duke Human Vaccine Institute have published researched inProceedings of the National Academy of Sciences (May 6th 2013) which pinpoints a previously unknown interaction between IgA and IgG antibodies as the cause of a lack of response to the RV144 vaccine.

 

Killer T-cell graphic by Russell Kightely Media

Ed Rybicki's insight:

VERY interesting, if true: IgA - supposedly the Ab of choice for mucosal surface protection - interfering with IgG, and stopping killer T / NK cells from binding and killing infected cells?

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Virology News
Topical news snippets about viruses that affect people.  And other things. Like Led Zeppelin. And zombies B-)
Curated by Ed Rybicki
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January 19, 2023 6:04 AM
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Cann's Principles of Molecular Virology - 7th Edition

Cann's Principles of Molecular Virology - 7th Edition | Virology News | Scoop.it

Cann's Principles of Molecular Virology, - 7th Edition, revised by EP Rybicki. Print Book. ISBN 9780128227848. Now published!!


Instructor review copies: click on this link.

https://protect-za.mimecast.com/s/qU2qCNxKq0i0ZNRQxcmeDdo

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February 14, 4:57 AM
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Characterising the asynchronous resurgence of common respiratory viruses following the COVID-19 pandemic | Nature Communications

Characterising the asynchronous resurgence of common respiratory viruses following the COVID-19 pandemic | Nature Communications | Virology News | Scoop.it
COVID-19-related non-pharmaceutical interventions impacted the circulation of other pathogens. Here, the authors compile a global viral activity dataset and compare the timing of resurgence of seven common respiratory viruses following the relaxation of interventions across different geographical...
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February 14, 4:56 AM
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Bacterial flagellar motors: Study sheds light on their ion-driven mechanisms

When speaking of motors, most people think of those powering vehicles and human machinery. However, biological motors have existed for millions of years in microorganisms. Among these, many bacterial species have tail-like structures—called flagella—that spin around to propel themselves in fluids. These movements employ protein complexes known as the "flagellar motor."
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February 14, 4:53 AM
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Nanoparticles successfully deliver genetic material to plants via roots

University of Queensland researchers have for the first time introduced genetic material into plants via their roots, opening a potential pathway for rapid crop improvement. The research is published in Nature Plants.
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February 14, 4:52 AM
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New Oral Antiviral Candidates Target SARS-CoV-2 Protease

New Oral Antiviral Candidates Target SARS-CoV-2 Protease | Virology News | Scoop.it
The COVID-19 pandemic has underscored the urgent need for effective antiviral treatments, particularly as SARS-CoV-2 continues to evolve.Researchers are now focusing…...
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January 21, 8:50 AM
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Nicking Activity of M13 Bacteriophage Protein 2

Nicking Activity of M13 Bacteriophage Protein 2 | Virology News | Scoop.it
Gene II Protein (Gp2/P2) is a nicking enzyme of the M13 bacteriophage that plays a role in the DNA replication of the viral genome. P2 recognizes a specific sequence at the f1 replication origin and nicks one of the strands and starts replication.
Ed Rybicki's insight:
Turns out that either M13 Rep recognises geminivirus Ori sequences, or the geminivirus Rep recognises M13 - because a geminivirus genomes cloned into M13 can be liberated as a replicon in E coli!
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January 21, 8:43 AM
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A wave of cat deaths from bird flu prompts new rules on pet food production

As experts continue monitoring and surveying the environment and the nation's food supply for H5N1 bird flu, a rash of dead cats has many officials on edge.
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January 21, 8:42 AM
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Ancient viral DNA shapes early embryo development, study finds

Over half of our genomes consist of thousands of remnants of ancient viral DNA, known as transposable elements, which are widespread across the tree of life. Once dismissed as the "dark side" of the genome, researchers at Helmholtz Munich and Ludwig-Maximilians-Universität (LMU) have now revealed their crucial role in early embryo development. The study is published in the journal Cell.
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January 21, 8:40 AM
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Associations of infection burden with Kawasaki disease in a population-based setting during 30 years | RMD Open

WHAT IS ALREADY KNOWN ON THIS TOPIC
Kawasaki disease is an acute paediatric vasculitis of unknown origin. Environmental exposures have been suggested to contribute to disease development, but these remain to be defined.WHAT THIS STUDY ADDSThe findings suggest that infections are closely linked with Kawasaki disease, with a wider temporal association than previously described.Further, the data imply that many different agents may induce Kawasaki disease.
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January 15, 6:23 AM
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The mystery of why Covid-19 seems to be becoming milder

The mystery of why Covid-19 seems to be becoming milder | Virology News | Scoop.it
Covid-19 is now ubiquitous – but hospitalisations seem to be on a downward trajectory. No one knows why.
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January 15, 6:22 AM
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Does Hand Sanitizer Kill Norovirus? 3 Ways to Neutralize the Virus

Does Hand Sanitizer Kill Norovirus? 3 Ways to Neutralize the Virus | Virology News | Scoop.it
Infectious disease doctors explain if hand sanitizer kills norovirus, and effective ways to neutralize the stomach bug’s germs, including on surfaces.
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January 15, 6:21 AM
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Genetic mutation linked to higher SARS-CoV-2 risk

Researchers have identified a novel genetic risk factor for SARS-CoV-2 infection, providing new insights into the virus's ability to invade human cells. SARS-CoV-2 is the virus that spreads COVID-19.
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January 15, 6:09 AM
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Plant-Based Antigen Production Strategy for SARS-CoV-2 Nucleoprotein and RBD and Its Application for Detection of Antibody Responses in COVID-19 Patients

Plant-Based Antigen Production Strategy for SARS-CoV-2 Nucleoprotein and RBD and Its Application for Detection of Antibody Responses in COVID-19 Patients | Virology News | Scoop.it
During the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, the development of efficient serological tests for monitoring the dynamics of the disease as well as the immune response after illness or vaccination was critical.
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February 14, 4:57 AM
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Functional Capacity Impairment in Long COVID After 17 Months of Severe Acute Disease

Functional Capacity Impairment in Long COVID After 17 Months of Severe Acute Disease | Virology News | Scoop.it
Long COVID represents a significant challenge in understanding the prolonged impact of the disease. Despite its increasing recognition, detailed insights into the long-term cardiopulmonary consequences remain sparse.
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February 14, 4:56 AM
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The growing list of human viruses: Are we prepared for the next outbreak?

The growing list of human viruses: Are we prepared for the next outbreak? | Virology News | Scoop.it
Researchers review the ever-growing list of human viruses, examining their diversity, transmission pathways, and the urgent need for prevention and global surveillance.
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February 14, 4:55 AM
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Syphilis pathogen grown in lab without animals, aiding global research

The Leibniz Institute DSMZ-German Collection of Microorganisms and Cell Cultures has added the syphilis pathogen to its collection and makes it available to researchers around the world for scientific studies.
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February 14, 4:53 AM
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Evidence-Based Recommendations on the Use of Immunotherapies and Monoclonal Antibodies in the Treatment of Male Reproductive Cancers

Evidence-Based Recommendations on the Use of Immunotherapies and Monoclonal Antibodies in the Treatment of Male Reproductive Cancers | Virology News | Scoop.it
The incidence of male reproductive cancers, including prostate, testicular, and penile cancers, has risen in recent years, raising important health concerns. Prostate cancer is the second leading cause of cancer-related mortality in men, while penile cancer, though rare, typically affects men over...
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February 10, 1:07 AM
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BECOMING LED ZEPPELIN | Full Length Trailer (2025)

Directed by: Bernard MacMahon
Written by: Bernard MacMahon and Allison McGourty
Cast: Robert Plant, Jimmy Page, John Paul Jones, John Bonham

Tickets on Sale Now: https://becomingledzeppelinfilm.com/

Becoming Led Zeppelin explores the origins of this iconic group and their meteoric rise in just one year against all the odds.

Powered by awe-inspiring, psychedelic, never-before-seen footage, performances, and music, Bernard MacMahon’s experiential cinematic odyssey explores Led Zeppelin’s creative, musical, and personal origin story. The film is told in Led Zeppelin’s own words and is the first officially sanctioned film on the group.

#BecomingLedZeppelin #RobertPlant #BernardMacMahon #OfficialTrailer #SonyClassics
Ed Rybicki's insight:
I told you there may be some Led Zeppelin :-)
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January 21, 8:49 AM
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A Study on the Induction of Multi-Type Immune Responses in Mice via an mRNA Vaccine Based on Hemagglutinin and Neuraminidase Antigen

A Study on the Induction of Multi-Type Immune Responses in Mice via an mRNA Vaccine Based on Hemagglutinin and Neuraminidase Antigen | Virology News | Scoop.it
Background: The Influenza A virus (IAV), a pathogen affecting the respiratory system, represents a major risk to public health worldwide. Immunization remains the foremost strategy to control the transmission of IAV.
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January 21, 8:42 AM
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Scientists uncover structure of critical component in deadly Nipah virus

Scientists at Harvard Medical School and Boston University Chobanian & Avedisian School of Medicine have mapped a critical component of the Nipah virus, a highly lethal bat-borne pathogen that has caused outbreaks in humans almost every year since it was identified in 1999.
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January 21, 8:41 AM
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RNA's biophysical behavior offers new insights into X chromosome inactivation

Science has revealed some of the secrets of the X chromosome, but many remain. In humans, female cells contain two X chromosomes (XX) and male cells contain one (XY). In each female cell, one X chromosome must be inactivated—crumpled up in such a way that the genetic code it contains cannot be read out.
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January 15, 6:23 AM
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COVID-19 vaccine developed by Brazilian researchers shows promise in mice

COVID-19 vaccine developed by Brazilian researchers shows promise in mice | Virology News | Scoop.it
Studies conducted in mice have shown that the COVID-19 vaccine being developed by researchers at the University of São Paulo's Medical School (FM-USP) in Brazil is safe and efficacious.
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January 15, 6:22 AM
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New mechanism for maintaining genome stability discovered

Genetically speaking, it's a bacterium's worst-case scenario: During transcription, newly minted RNA sticks to its DNA template, forming a 3-stranded structure known as an R-loop. While these structures have some important roles to play in a cell, R-loops in the wrong place at the wrong time can be disastrous, leading to DNA breaks, mutations, and cell death.
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January 15, 6:21 AM
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Bird flu kills 20 million chickens in US, driving egg prices sky-high

A deadly bird flu outbreak has wreaked havoc on U.S. chicken farms, claiming the lives of over 20 million egg-laying chickens last quarter, marking the worst impact on America's egg supply since the outbreak began in 2022.
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January 15, 6:20 AM
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The bacterium that transformed DNA sequencing

DNA sequencing was revolutionized after scientists discovered a new bacterium in the hot springs of Yellowstone National Park, and today it's a common research technique.
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January 14, 4:14 AM
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Wrong place, wrong time: Why Zika virus hijacks a protein needed for brain growth

The mosquito-borne Zika virus is known for causing microcephaly, a birth defect in which abnormal brain development results in a smaller-than-expected head.
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