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Preparation of targeted lipid nanoparticles for precision nucleic acid delivery | Nature Protocols

Preparation of targeted lipid nanoparticles for precision nucleic acid delivery | Nature Protocols | Virology News | Scoop.it
This protocol outlines the steps to prepare functionalized lipid nanoparticles covalently conjugated with whole antibodies or antibody fragments for targeted nucleic acid delivery to different tissues or cell types.
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Virology News
Topical news snippets about viruses that affect people.  And other things. Like Led Zeppelin. And zombies B-)
Curated by Ed Rybicki
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January 19, 2023 6:04 AM
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Cann's Principles of Molecular Virology - 7th Edition

Cann's Principles of Molecular Virology - 7th Edition | Virology News | Scoop.it

Cann's Principles of Molecular Virology, - 7th Edition, revised by EP Rybicki. Print Book. ISBN 9780128227848. Now published!!


"Cann's Principles of Molecular Virology, Seventh Edition provides an easily accessible introduction to modern virology, presenting principles in a clear and concise manner. The new edition provides the history of virology and the fundamentals of the molecular basis of how viruses work.


Instructor review copies: click on this link.

https://protect-za.mimecast.com/s/qU2qCNxKq0i0ZNRQxcmeDdo

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March 10, 5:58 AM
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DART images reveal asteroids can toss slow 'cosmic snowballs' between moons

About 15% of asteroids near Earth have small moons orbiting them, making binary asteroid systems common in our cosmic neighborhood.
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March 10, 5:57 AM
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Infection-acquired protection against SARS-CoV-2 infection and clinical severity by number of prior infections | Nature Communications

Prior infection is protective against SARS-CoV-2 infection, but the degree of protection provided by multiple subsequent infections is not clear. Here, the authors use data from a household transmission study in Nicaragua and show that 1, 2 or 3+ infections are associated with increasing...
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March 10, 5:57 AM
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Preparation of targeted lipid nanoparticles for precision nucleic acid delivery | Nature Protocols

Preparation of targeted lipid nanoparticles for precision nucleic acid delivery | Nature Protocols | Virology News | Scoop.it
This protocol outlines the steps to prepare functionalized lipid nanoparticles covalently conjugated with whole antibodies or antibody fragments for targeted nucleic acid delivery to different tissues or cell types.
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March 10, 5:56 AM
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Pathogenic virus infects and structurally reorganizes human cells, finds new study

Orthohantaviruses, such as the Puumala virus, are widespread in Europe, causing flu-like illnesses and severe kidney damage in those infected. It is increasingly considered a zoonotic threat. Researchers from the Medical Faculty of the University of Duisburg-Essen and the University Hospital Essen, Germany, have gained new insights into how these viruses alter the internal structure of their host cells. Their findings are published in the Journal of General Virology.
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March 10, 5:55 AM
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Microbes hitchhiking on marine snow could limit how deep carbon sinks

In some parts of the deep ocean, it can look like it's snowing. This "marine snow" is the dust and detritus that organisms slough off as they die and decompose. Marine snow can fall several kilometers to the deepest parts of the ocean, where the particles are buried in the seafloor for millennia.
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March 10, 5:55 AM
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Infection-Acquired Immunity: Impact of Prior COVID-19 Cases

Infection-Acquired Immunity: Impact of Prior COVID-19 Cases | Virology News | Scoop.it
In a groundbreaking advancement that could reshape our understanding of immunity within the COVID-19 pandemic, a recent study published in Nature Communications reveals compelling insights into how protection against SARS-CoV-2 infection—and the severity of ensuing illness—varies significantly depending...
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March 10, 5:54 AM
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CRISPR-based technique unlocks healing power of mitochondria for heart failure therapy

After a heart attack, the heart struggles to recoup and maintain energy. One-third of patients develop heart failure as a result—a condition that impacts 6.8 million Americans and carries a high lifetime risk, with 1 in 4 adults in the U.S. expected to develop the condition during their lifetime. This makes finding lasting treatment a medical priority.
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Contraceptive vaccine reduces fertility in animals to address wildlife overpopulation

A Purdue University contraceptive vaccine seeks to address animal overpopulation by markedly reducing fertility in feral horses, deer, swine and other animals. Dr. Harm HogenEsch, distinguished professor of immunopathology in Purdue University's College of Veterinary Medicine, and Dr. Raluca Ostafe, director of Purdue University's Molecular Evolution Protein Engineering and Production Facility, both members of the Purdue Institute for Inflammation, Immunology and Infectious Disease, have designed the vaccine based on the IZUMO1 mammalian sperm protein. It induces a robust and long-lasting immune response and infertility in female mammals.
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March 6, 5:49 AM
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Covid-19 pandemic in children born very premature with dysexecutive disorders: impact of isolation measures and/or neurobehavioral phenotype? A cross sectional study | Pediatric Research

Covid-19 pandemic in children born very premature with dysexecutive disorders: impact of isolation measures and/or neurobehavioral phenotype? A cross sectional study | Pediatric Research | Virology News | Scoop.it
In France, following the first confinement related to the Covid-19 pandemic, strict government health guidelines aimed at limiting the spread of the disease disrupted the daily lives of children, particularly those with neurobehavioral disorders related to prematurity, which could affect their...
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March 6, 5:46 AM
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Life forms can catch rides to other planets on asteroid debris

Life forms can catch rides to other planets on asteroid debris | Virology News | Scoop.it
"This is a really big deal that changes the way you think about the question of how life begins and how life began on Earth."...
Ed Rybicki's insight:
It is known 
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March 6, 5:45 AM
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Microbial ancestor of complex life was more sophisticated than previously thought, studies suggest

Our single-celled ancestor lived in a world without plants, animals or oxygen-rich oceans. Yet, this seemingly simple microorganism took the first steps toward complex life. From this ancestor emerged all multicellular (complex) life as we know it today: from yeast to blue whales, collectively known as eukaryotes. These organisms are built from cells containing specialized structures, such as a nucleus and other specialized structures, each performing distinct functions.
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March 5, 4:53 AM
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Did the first human ancestor originate in the Balkans? New fossil shows evidence of bipedalism

Walking on two legs has long been considered a milestone in human evolution and one of our most defining characteristics. Until now, researchers assumed that the first humans originated in Africa and that bipedalism developed there around 6 million years ago. However, an international team of researchers say a newly discovered fossil thighbone from Bulgaria could rewrite the history of human origins.
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March 10, 5:59 AM
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The coldest 'stars' in the galaxy might actually be alien megastructures

Ever since physicist Freeman Dyson first proposed the concept in 1960, the "Dyson sphere" has been the holy grail of techno-signature hunters. A highly advanced civilization could build a "sphere" (or, in our more modern understanding, a "swarm" of smaller components) around their host star to harvest its entire energy output. We know, in theory at least, that such a swarm could exist—but what would it actually look like if we were able to observe one? A new paper, available on the arXiv pre-print server and soon to be published in Universe from Amirnezam Amiri of the University of Arkansas, digs into that question—and in the process discloses the types of stars that are the most likely to find them around.
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March 10, 5:58 AM
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How a protein pair ensures that faulty mRNA is destroyed

Nonsense-mediated mRNA decay (NMD) is one of the most important processes in our cells to ensure that no faulty or incomplete proteins are produced. Scientists have now identified a central mechanism behind this control system.
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March 10, 5:57 AM
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Amphotericin B promotes respiratory viral entry by enhancing late endosomal maturation and fusion via glucocerebrosidase-mediated ceramide remodeling | Nature Communications

This study reveals that Amphotericin B activates glucocerebrosidase to remodel late endosomal lipid and protein composition, promoting respiratory viral entry. This highlights a risk of secondary viral infections during antifungal therapy.
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March 10, 5:56 AM
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An interstellar comet packed with alcohol? What ALMA found in 3I/ATLAS

Comet 3I/ATLAS continues to make astonishing headlines, thanks to new findings from astronomers using the Atacama Large Millimeter/submillimeter Array (ALMA). This new research reveals that 3I/ATLAS is packed with an unusually large amount of the organic molecule methanol—more than almost all known comets in our own solar system.
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March 10, 5:55 AM
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Nearby red dwarf star hosts at least four planets—with one in the habitable zone

In 2020, a study confirmed that two planets orbited the nearby red dwarf, GJ 887. Now, astronomers have confirmed the existence of two additional planets orbiting GJ 887 in a new study published in Astronomy and Astrophysics. The new study suggests that one of these newly confirmed planets is in the habitable zone.
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Scientists trace crop viruses back to the last Ice Age

Long before humans cultivated crops or sailed between continents, a group of plant viruses was already evolving among wild plants in Eurasia. According to a new international study published in Plant Disease, the ancestors of modern tymoviruses likely emerged before the last Ice Age, reshaping scientists' understanding of the vast evolutionary history of plant disease.
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March 10, 5:54 AM
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Deep ocean microbes may already be prepared to tackle climate change

Deep-sea waters are warming due to heat waves and climate change, and it could spell trouble for the oceans' delicate chemical and biological balance. However, a study published in Proceedings of the National Academy of Sciences demonstrates that the microbe Nitrosopumilus maritimus may already be adapting well to warmer, nutrient-poor waters. Researchers predict that these surprisingly adaptable iron-dependent ammonia-oxidizing archaea will play an important role in reshaping ocean-nutrient distribution in a changing climate.
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Most pandemic viruses show little adaptation before infecting humans

Most pandemic viruses show little adaptation before infecting humans | Virology News | Scoop.it
A new University of California San Diego study published in Cell challenges a long-standing assumption about how animal viruses become capable of sparking human epidemics and pandemics.
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March 6, 5:50 AM
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Development of a scalable production bioprocess for HIV-1 virus-like particles coupling continuous VLP harvesting with end-to-end downstream processing | Scientific Reports

HIV-1 Gag virus-like particles (VLPs) have been drawing attention as vaccine platform for their non-infectivity, ability to induce robust immune responses and versatility. However, challenges in their production, purification, and preservation still hinder their application.
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March 6, 5:48 AM
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Comment les virus malmènent notre cerveau - Médias - UNIGE

Comment les virus malmènent notre cerveau - Médias - UNIGE | Virology News | Scoop.it
Comment les virus malmènent notre cerveau Publié le 5 mars 2026 Une équipe de l’UNIGE et des HUG a passé en revue 900 articles scientifiques pour mieux comprendre l’impact des virus sur la mémoire, l’attention et la concentration. Quel est l’impact d’une infection virale sur notre mémoire, notre attention ou notre concentration? 
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March 6, 5:46 AM
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Chronic Inflammation Rewires the Brain’s Cognitive Center

Chronic Inflammation Rewires the Brain’s Cognitive Center | Virology News | Scoop.it
Researchers identify specific immune markers, like activated monocytes and cytokines, that drive cognitive decline after viral infections across various diseases.
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March 5, 4:54 AM
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Nanoparticle vaccine approach takes on a new target: Hepatitis C virus

Hepatitis C virus (HCV) infects an estimated 50 million people worldwide, according to the World Health Organization, and remains a leading cause of cirrhosis and liver cancer. While antiviral drugs can cure most infections, global access remains limited and these drugs do not stop reinfection.
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Neither Metformin Nor Ursodeoxycholic Acid Effective for Treating Long COVID

WEDNESDAY, March 4, 2026 -- For patients with postacute sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (PASC), neither metformin nor ursodeoxycholic acid (UDCA) improves symptoms compared with placebo, according...
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