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Hepatitis A virus discovered to cloak itself in membranes hijacked from infected cells

Hepatitis A virus discovered to cloak itself in membranes hijacked from infected cells | Virology News | Scoop.it
Viruses have historically been classified into one of two types – those with an outer lipid-containing envelope and those without an envelope.

Via Kenzibit
Ed Rybicki's insight:

...and hep A steals membranes from liver cells to circulate as an enveloped particle(s) in blood. This is a fascinating find, and doubtless will be followed by similar for other viruses.

 

The commentary has some speculation as to how vaccines work, if antibodies can't see the virus - but they forget the virus has to get INTO the host in the first place, and environmental forms are non-enveloped, AND that the vaccine may well elicit some degree of cell-mediated immunity, which would target infected cells displaying degraded protein on their surfaces via MHC I-type receptors.

Gaby's curator insight, October 20, 2014 7:20 PM

Una noticia que revolucionará a los virologos!

Virology News
Topical news snippets about viruses that affect people.  And other things. Like Led Zeppelin. And zombies B-)
Curated by Ed Rybicki
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Whole genome, transcriptome, smallRNAome and methylome profiling during tomato-geminivirus interaction

Preguntas frecuentesManual de usoDerechos de autorContacto/Sugerencias Whole genome, transcriptome, smallRNAome and methylome profiling during tomato-geminivirus interaction Autor Romero-Rodríguez, Beatriz; Kriznik, Maja; Morilla, Ian; Petek, Marko; Jiao, Chen; [et al.] Fecha 2022 Palabras clave Virus fitopatógenos; Tomates - Enfermedades y plagas Resumen Geminiviruses constitute the largest family of plant-infecting viruses with small, single- stranded DNA genomes that replicate through double-stranded DNA intermediates. Because of their limited coding capacity, geminiviruses use plant nuclear machinery to amplify their genomes, which are packaged into nucleosomes forming chromatin as multiple circular minichromosomes. Thus, viral minichromosomes must encounter the nuclear pathways that regulate host gene expression and chromatin states. DNA methylation and post-transcriptional gene silencing play critical roles in controlling infection of geminiviruses and this pathogen can counteract these host defense mechanisms and promote its infectivity. Tomato Yellow Leaf Curl Virus (TYLCV) belongs to the Begomovirus genus and is transmitted by the whitefly Bemisia tabaci. With only seven viral proteins, TYLCV must create a proper environment for viral replication, transcription, and propagation. Behind the apparent simplicity of geminiviruses lies a complex network of molecular interactions with their host and their natural vector, which induces a wide variety of transcriptional, post-transcriptional and chromatin changes in the host. To better understand this virus-host interaction at a genetic and epigenetic level we carried out a global approach of the TYLCV-tomato interaction to generate integrated single-base resolution maps by Next-Generation Sequencing of the transcriptome, smallRNAome and methylome of the pathogen and the host. Total RNA and DNA was extracted from tomato–infected plants (three biological replicates) and analysed at 2, 7, 14 and 21-day post-infection (dpi). Analysis of the changes in host transcription during the infection and its correlation with changes in sRNA profiles (microRNA and phasiRNA) and DNA methylation patterns will be presented and discussed. URI https://hdl.handle.net/10630/24432 Compartir Mostrar el registro completo del ítem Ficheros abs_libro_omics.pdf (37.69Kb) Colecciones BCGF - Contribuciones a congresos científicos Estadísticas Ver Estadísticas de uso Buscar en Dimension
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All the -omes!! This should make That Person Who Hates -Omes happy??
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Listeria-based booster improves vaccine's protection against recurring colon cancer

Listeria-based booster improves vaccine's protection against recurring colon cancer | Virology News | Scoop.it
Colorectal, pancreatic, esophageal and stomach cancers—some of the deadliest kinds of cancer—have high recurrence rates where the cancer comes back even after successful surgery or radiation treatment.
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How many lives have been saved by covid-19 vaccines?

How many lives have been saved by covid-19 vaccines? | Virology News | Scoop.it
A new study estimates that the number is greater than the population of Chile | Graphic detail...
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Flu Vaccination Linked to 40% Lower Risk of Alzheimer’s Disease

A new study finds that flu vaccination was associated with a 40% reduced risk for Alzheimer’s disease over a four-year period.Over the course of four...
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Endline: COVID-19 Perception Survey - South Africa

Endline: COVID-19 Perception Survey - South Africa | Virology News | Scoop.it
Web survey powered by SurveyMonkey.com. Create your own online survey now with SurveyMonkey's expert certified FREE templates.
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Phylodynamic analysis of current Porcine circovirus 4 sequences: does the porcine circoviruses evolutionary history repeat itself?

Four porcine circoviruses (PCVs) have been discovered over time and seem to share a common history, particularly for PCV-2 and -3.Despite being reported as apparently new viruses, rapidly emerging as a threat for the worldwide swine industry, they were then proven to have been circulating and coexi...
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COVID-19 vaccine patent waiver falls short for developing world, experts say

COVID-19 vaccine patent waiver falls short for developing world, experts say | Virology News | Scoop.it
A long-running fight to ease intellectual property protections for COVID-19 vaccines at the World Trade Organization has ended, but experts are concerned the final outcome won't go far enough.
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Poultry Competition to Go Virtual at Illinois State Fair Because of Bird Flu, Officials Say –

Poultry Competition to Go Virtual at Illinois State Fair Because of Bird Flu, Officials Say – | Virology News | Scoop.it
Competitors will not get the chance to exhibit poultry at this year’s Illinois State Fair, as the Department of Agriculture announced the postponement of the...
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The Virtual Chicken just became A Thing B-)
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The risky business of chicken and pig farms in Canada

The risky business of chicken and pig farms in Canada | Virology News | Scoop.it
It is of critical concern that our next pandemic is being hastened by our use of animals susceptible to influenza, especially chickens and pigs.
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Inactivated whole-virion vaccine BBV152/Covaxin elicits robust cellular immune memory to SARS-CoV-2 and variants of concern

Inactivated whole-virion vaccine BBV152/Covaxin elicits robust cellular immune memory to SARS-CoV-2 and variants of concern | Virology News | Scoop.it
Analysis of the humoral and cellular immune response to the BBV152/Covaxin inactivated vaccine reveals that it induces a robust SARS-CoV-2-specific immune memory that persists for at least 6 months and shows somewhat reduced efficiency against SARS-CoV-2 variants.
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Scientists identify a protein key to inhibiting replication of the flu virus

Scientists identify a protein key to inhibiting replication of the flu virus | Virology News | Scoop.it
A collaborative study from UT Southwestern scientists has identified a new function for a protein called TAO2 that appears to be key to inhibiting replication of the influenza virus, which sickens millions of individuals worldwide each year and kills hundreds of thousands.
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Influenza A virus undergoes compartmentalized replication in vivo dominated by stochastic bottlenecks | Nature Communications

Influenza A virus undergoes compartmentalized replication in vivo dominated by stochastic bottlenecks | Nature Communications | Virology News | Scoop.it
Transmission of influenza A viruses (IAV) between hosts and replication within host impose genetic bottlenecks, constraining viral diversity and adaptation. Here, Amato et al. perform site-specific inoculation of barcoded IAV of ferrets and track viral diversity as infection spreads to the lower...
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FDA authorizes Pfizer and Moderna Covid vaccines for infants, toddlers, and preschoolers

FDA authorizes Pfizer and Moderna Covid vaccines for infants, toddlers, and preschoolers | Virology News | Scoop.it
The FDA on Friday authorized the Pfizer and Moderna Covid vaccines for use in children as young as 6 months of age, setting the stage for a government push to make the shots available for the youngest children.
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Covid: Omicron subvariants BA.4 and BA.5 escape antibodies from vaccination and prior infection, studies suggest

Covid: Omicron subvariants BA.4 and BA.5 escape antibodies from vaccination and prior infection, studies suggest | Virology News | Scoop.it
Omicron subvariants BA.4 and BA.5 appear to escape antibody responses among both people who had previous Covid-19 infection and those who have been fully vaccinated and boosted, according to new data from researchers at Beth Israel Deaconess Medical Center, of Harvard Medical School.
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Ghana will help make pan-African vaccine manufacturing project a success

Ghana will help make pan-African vaccine manufacturing project a success | Virology News | Scoop.it
As I said in Marburg, the Pan-African Vaccine Manufacturing Project fits perfectly with Ghana’s roadmap for domestic vaccine development and manufacturing. Ghana is ready to play her role, and I reaffirm, once again, her determination to make the project work successfully.
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Polio: Virus found in London prompts misleading vaccine claims

Polio: Virus found in London prompts misleading vaccine claims | Virology News | Scoop.it
What do these cases really tell us about the virus, which hasn't spread in the UK for decades?
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‘You get goosebumps from the data’: hopes rise for new malaria vaccine | Malaria | The Guardian

‘You get goosebumps from the data’: hopes rise for new malaria vaccine | Malaria | The Guardian | Virology News | Scoop.it
The disease is a leading killer of under fives across Africa.But trials for a new vaccine suggest an end to the death toll could be in sight...
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Gene may hold clues to heart attacks in women

Gene may hold clues to heart attacks in women | Virology News | Scoop.it
"For reasons that remain uncertain, women can experience heart disease differently than men." A gene called RAP1GAP2 may clarify why.
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Cross-reactive immunity potentially drives global oscillation and opposed alternation patterns of seasonal influenza A viruses

Cross-reactive immunity potentially drives global oscillation and opposed alternation patterns of seasonal influenza A viruses | Virology News | Scoop.it
Several human pathogens exhibit distinct patterns of seasonality and circulate as pairs. For instance, influenza A virus subtypes oscillate and peak during winter seasons of the world’s temperate climate zones.
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How it Moves

A UK program aims to uncover how bird flu is transmitted across bird populations and species, including from wild to domesticated animals.
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Some people do better on cognitive tasks while walking

Some people do better on cognitive tasks while walking | Virology News | Scoop.it
While past research has found that people perform worse on cognitive tasks while walking, a new study shows that might not be true for everyone.
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Emergence and Evolution of H5N1 Bird Flu | Avian Influenza (Flu)

Emergence and Evolution of H5N1 Bird Flu | Avian Influenza (Flu) | Virology News | Scoop.it
How current H5N1 bird flu viruses emerged and evolved...
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Zoonotic avian influenza viruses evade human BTN3A3 restriction

bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution...
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Bacteria triggers material to release infection-fighting drugs

Bacteria triggers material to release infection-fighting drugs | Virology News | Scoop.it
A new material can deliver medications on demand and only when bacteria are present. The advance could be particularly helpful for wound dressings.
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Highly pathogenic avian influenza (HPAI): An emerging disease threat in North America

Highly pathogenic avian influenza (HPAI): An emerging disease threat in North America | Virology News | Scoop.it
Highly pathogenic avian influenza (HPAI) is an ecologically and economically significant avian disease that is quickly spreading among wild and domestic birds throughout North America. In this blog post, we provide information and resources that can help you to be informed, be prepared, and be...
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