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... which resemble those of ESCs. We investigated to reprogram fibroblast-like synoviocytes (FLSs) from patients with rheumatoid arthritis (RA) and osteoarthritis (OA) to generate iPSCs using a 4-in-1 lentiviral vector system. 
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Clinical trials of new treatments for rheumatoid arthritis (RA) typically require subjects to have an elevated acute phase reactant (APR), in addition to tender and swollen joints. However, despite the elevation of individual ...
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The association between ANKH promoter polymorphism and chondrocalcinosis is independent of age and osteoarthritis: results of a case-control study. Abhishek Abhishek, Sally Doherty, Rose Maciewicz, Kenneth Muir, ...
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Juvenile idiopathic arthritis (JIA) is the most common rheumatological disease of childhood with a prevalence of around 1 in 1000. Without appropriate treatment it can have devastating consequences including permanent ...
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Rheumatology Medical Article: Rituximab for the treatment of rheumatoid arthritis: An update (Rituximab for the treatment of rheumatoid arthritis: An update: Drug Design, Development and Therapy http://t.co/MiBMjlrEQj...
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Upon approval, RoACTEMRA would be the first IL-6 biologic available in subcutaneous and intravenous administration for both monotherapy and combination therapyNew subcutaneous formulation would offer greater flexibility for rheumatoid arthritis patients Roche announced today that the subcutaneous formulation of RoACTEMRA (tocilizumab) has received a positive opinion from the Committee for Medicinal Products for Human Use (CHMP) for the treatment of moderate to severe active rheumatoid arthritis (RA) in patients who have either responded inadequately to, or who are intolerant to, previous therapy with one or more disease modifying anti-rheumatic drugs (DMARDs) or tumour necrosis factor (TNF) inhibitors. As with the intravenous (IV) formulation indication, the CHMP has recommended approval of the subcutaneous formulation for use both as monotherapy and in combination with methotrexate (MTX). Via Krishan Maggon
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Rheumatology Medical Article: Maintenance therapy of lupus nephritis with micophenolate or azathioprine: systematic review and meta-analysis (Maintenance therapy of lupus nephritis with micophenolate or azathioprine: systematic review and...
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Self assessment of arthritis is important for recognition of disease activity and early initiation of therapy. Proper interpretation of physical symptoms is necessary for this. The purpose was to investigate the assessment by ...
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Adipo(cyto)kines are mostly produced by adipose tissue and orchestrate the adverse impact of excess adiposity on cardiovascular risk. Adipokines also contribute importantly to the pathophysiology of rheumatoid arthritis.
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Psoriatic arthritis (PsA) is the second most common inflammatory arthropathy, after rheumatoid arthritis diagnosis, in early arthritis clinics. Most patients have established psoriasis, often for years, prior to the onset of joint pain ...
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The FMS-related tyrosine kinase 3 ligand (Flt3L)/CD135 axis plays a fundamental role in proliferation and differentiation of dendritic cells (DCs). As DCs play an important role in rheumatoid arthritis (RA) immunopathology we ...
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Objectives:Osteoarthritis of the knee is a common chronic disease among older adults. Therapeutic approaches mainly consist of physiotherapy or pharmacological therapy, but these approaches are limited over time by their cost and/or side effects.
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We aimed to investigate the expression and therapeutic modulation of the receptor activator of the NF-kappaB ligand (RANKL) system in early-untreated rheumatoid arthritis (RA).
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Moving on from T cells, tolerogenic dendritic cells therapies for rheumatoid arthritis Catharien Hilkens #AICTS http://t.co/boIO3u5ba9
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Etanercept/MTX therapy more effective than DMARD/MTX in RA patients
Gilbert C FAURE's insight:
real life?
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A recent genome-wide association study (GWAS) comprising a French cohort of systemic sclerosis (SSc) reported several non-HLA single-nucleotide polymorphisms (SNPs) showing a nominal association in the discovery ...
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Methotrexate reversed synovial expression in early RA patients Healio Methotrexate therapy reversed a high receptor activator of the Nf-kB ligand and osteoprotegerin ratio, a characteristic in the synovial membrane of early untreated rheumatoid...
Gilbert C FAURE's insight:
check other posts about methotrexate http://www.scoop.it/t/rheumatology-rhumatologie?q=methotrexate
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Christopher H. Evans,Virginia B. Kraus& Lori A. SettonAffiliationsContributionsCorresponding authorNature Reviews Rheumatology 10, 11–22 (2014) doi:10.1038/nrrheum.2013.159Published online 05 November 2013Corrected online 29 November 2012 Via Krishan Maggon
Gilbert C FAURE's insight:
rheumatologists loved corticosteroids "infiltrations", but diagnostic joint punctures seem less fashionable...
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Our objectives were to assess the frequency and sustainability of American College of Rheumatology (ACR)/European League against Rheumatism (EULAR) and Disease Activity Score (DAS)28(4v)-C-reactive protein (CRP) ...
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The aim of this study was to determine the prevalence of gastrointestinal and behavioural symptoms occurring before (anticipatory/associative) and after methotrexate (MTX) administration, termed MTX intolerance, ...
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In vitro apoptosis of peripheral monocytes in rheumatoid arthritis (RA) is disturbed and influenced by cytokine production and transmembrane TNF (tmTNF) reverse signaling. The goal of the study was the analysis of the ...
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Gilbert C FAURE
December 14, 2013 3:17 AM
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RT @doctorakerkar: Baseline levels of soluble IL-6 receptor predict response to tocilizumab in rheumatoid arthritis http://t.co/kEPGemTAJy …
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Gilbert C FAURE
December 5, 2013 3:08 PM
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Patients with rheumatoid arthritis (RA) are at an increased risk for cardiovascular disease (CVD). An early manifestation of CVD is endothelial dysfunction which can lead to functional and morphological vascular abnormalities ...
