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RT @PaulWhiteleyPhD: Anti-NMDA receptor encephalitis, autoimmunity, and psychosis http://t.co/bR6sCipiVu Mmm... http://t.co/0r4rbyrUsl 
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Susceptibility to Multiple Sclerosis (MS) has been linked mainly to the HLA-DRB1 locus, with the HLA-DR15 haplotype (DRB1*1501-DQA1*0102-DQB1*0602- DRB5*0101) dominating MS-risk in Caucasians. Alth...
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Secondary autoimmunity occurs in ~50% of MSers treated with alemtuzumab. #ClinicSpeak #MSBlog #MSResearch http://t.co/QNUpF0gUx0 Via Krishan Maggon
Krishan Maggon 's curator insight,
August 17, 2014 11:08 AM
Tuohy et al. Alemtuzumab treatment of multiple sclerosis: long-term safety and efficacy. J Neurol Neurosurg Psychiatry. 2014 May 21. pii: jnnp-2014-307721. doi: 10.1136/jnnp-2014-307721. CONCLUSIONS: Alemtuzumab is associated with disease stabilisation in the majority of MSers with highly active RRMS over an average seven-year follow-up. No new safety concerns arose over this extended follow-up.
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Cytosolic DNA sensing activates the stimulator of IFN genes (STING) adaptor to induce IFN type I (IFN-αβ) production. Constitutive DNA sensing to induce sustained STING activation incites tolerance breakdown, leading to autoimmunity.
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Effects of UVB light were analyzed in a murine model of CNS autoimmunity (experimental autoimmune encephalomyelitis (EAE)). Additionally, patients with relapsing-remitting MS were treated with narrowband UVB phototherapy. Immunomodulatory effects were examined in skin biopsies, serum samples and in immune cells of the peripheral blood
Gilbert C FAURE's insight:
Local UVB radiation of the skin influences systemic immune reactions and attenuates systemic autoimmunity via the induction of skin-derived tolerogenic DCs and Tregs. Our data could have implications for the understanding or therapeutic modulation of environmental factors which influence immune tolerance. ANN NEUROL 2014
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The docs at Cambridge have been investigating this and have ways to stop the neutralising antibodies and have found a marker they think shows your risk of developing autoimmunity. This type of study has not been reported ...
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PubMed comprises more than 23 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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![Gene Therapy Delivery of Myelin Oligodendrocyte Glycoprotein (MOG) via Hematopoietic Stem Cell Transfer Induces MOG-Specific B Cell Deletion [AUTOIMMUNITY] | NeuroImmunology | Scoop.it](https://img.scoop.it/0kC-b95Z4baJE9o0fGtLWDl72eJkfbmt4t8yenImKBVvK0kTmF0xjctABnaLJIm9)
The various mechanisms that have been described for immune tolerance govern our ability to control self-reactivity and minimize autoimmunity.
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Multiple sclerosis (MS) is the most common autoimmune disease of the central nervous system (CNS) in the Western world. The disease is characterized histologically by the infiltration of encephalitogenic 1/ 17-polarized CD4 ...
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RT @JAMANeuro: Purkinje Cell Cytoplasmic Antibody Type 1 (Anti-Yo) Autoimmunity in a Child With Down Syndrome http://t.co/mLIEaLRxS2
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Cunningham Paper Links Autoimmunity with #Neuropsychiatric Symptoms. http://t.co/pqefELUu2B #autoimmunity #mentalhealth #dopamine
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Mechanisms of autoimmunity in the central nervous system: 2013 Clinical and Experimental Neuroimmunology http://t.co/ssl82WabFE
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Neuropsychiatric disease in murine lupus is dependent on the TWEAK/Fn14 pathway [Journal of Autoimmunity] http://t.co/dTZcLltGNy
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Multiple sclerosis (MS) is an autoimmune disease of the CNS, and autoreactive CD4+ T cells are considered important for its pathogenesis.
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We have previously identified eight novel autoantibody targets in the cerebrospinal fluid of multiple sclerosis (MS) patients, including sperm-associated Ag 16 (SPAG16).
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Multiple sclerosis (MS) is an autoimmune disease in which inflammatory lesions lead to tissue injury in the brain and/or spinal cord.
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Enhanced sphingosine-1-phosphate receptor 2 expression underlies female CNS autoimmunity susceptibility http://t.co/9mk8l014Xz via @feedly
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UVB light attenuates the systemic immune response in CNS autoimmunity http://t.co/pEbEfvOkdy
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Tumor progression locus 2 (TPL-2) expression is required for efficient polarization of naive T cells to Th1 effector cells in vitro, as well as for Th1-mediated immune responses.
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Multiple sclerosis (MS) is an inflammatory disease of the CNS that causes the demyelination of nerve cells and destroys oligodendrocytes, neurons, and axons.
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We performed unbiased, comprehensive immunophenotyping of cerebrospinal fluid (CSF) and blood leukocytes in 221 subjects referred for the diagnostic work-up of neuroimmunological disorders to obtain insight about disease-specific phenotypes of...
Gilbert C FAURE's insight:
The study adds to the increasing number of publications that demonstrate poor correlation between systemic and intrathecal inflammatory biomarkers in patients with neuroimmunological diseases and stresses the importance of studying immune responses directly in the intrathecal compartment.
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PLOS ONE: an inclusive, peer-reviewed, open-access resource from the PUBLIC LIBRARY OF SCIENCE. Reports of well-performed scientific studies from all disciplines freely available to the whole world.
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Autoimmunity, seizures, and status epilepticus. Epilepsia 2013 http://t.co/FcFSrcuJ84
Gilbert C FAURE's curator insight,
December 18, 2013 6:07 AM
already posted in september as pubmed reference see also neurology in this topic http://www.scoop.it/t/autoimmunity?q=neurology
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For centuries after its first description by Galen, the thymus was considered as only a vestigial endocrine organ until the discovery in 1961 by Jacques FAP Miller of its essential role in the development of T (thymo-dependent) lymphocytes.
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Glutamic acid decarboxylase (GAD) is the rate-limiting enzyme in the synthesis of gamma-aminobutyric acid (GABA).
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