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Suggested by
Société Francaise d'Immunologie
March 27, 2017 2:29 AM
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Objective The nasal mucosa is equipped with abundant lymphatic tissues, serving as the first line of defense against invasion by microorganisms. In this study, we characterized the features of the nasal mucosa of Bama minipigs (Sus scrofa domestica) via histological analysis. Methods Five cross sections (I, II, III, IV, and V) were obtained from the distal end of the nasal cavity toward the pharynx (along the cavity axis) and examined. Specifically, CD3+ T cells, immunoglobulin A (IgA)+ cells, and M cells were detected by immunohistochemistry, while dendritic cells (DCs) were detected by immunofluorescence. The distribution of goblet cells was determined by periodic acid-Schiff (PAS) staining. Results The nasal cavity of Bama minipigs can be divided into three parts: the regio vestibularis (I, II), regio respiratoria (III, IV), and regio olfactoria (V). Lymphoid tissue was present at random locations in the nasal cavity. Abundant lymphoid tissue was located in the roof of the nasopharyngeal meatus and was continuous with the lymphoid tissue of the pharynx. The distribution of CD3+ T cells, IgA+ cells, M cells, and DCs increased distally in the nasal cavity. Conclusions The present work comprises a histological study of the nasal cavity of Bama minipigs, and will be beneficial for understanding the mechanisms of immunity in these animals after nasal vaccination.
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Scooped by
Gilbert C FAURE
January 27, 2017 5:12 AM
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Background: Diesel exhaust particles (DEPs), the major contributors to air pollution, induce inflammatory responses in the nasal epithelium. Overproduction of airway mucins is an importa
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Scooped by
Gilbert C FAURE
January 9, 2017 9:00 AM
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Am J Respir Cell Mol Biol. 2017 Jan 6. doi: 10.1165/rcmb.2016-0024OC. [Epub ahead of print]
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Scooped by
Gilbert C FAURE
December 12, 2016 12:51 PM
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Mucosal Immunol. 2016 Dec 7. doi: 10.1038/mi.2016.103. [Epub ahead of print]
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Scooped by
Gilbert C FAURE
May 29, 2016 2:21 PM
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J Allergy Clin Immunol. 2016 Jan;137(1):214-22.e2. doi: 10.1016/j.jaci.2015.07.042. Epub 2015 Sep 26. Research Support, Non-U.S. Gov't
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Scooped by
Gilbert C FAURE
February 5, 2016 2:30 PM
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NewsResearchers decided to test dupilumab, a human antibody which already demonstrated clinical efficacy for asthma and atopic dermatitis, on nasal polyps.Contributed Author: Ghent UniversityTopics: Drug Development...
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Scooped by
Gilbert C FAURE
September 28, 2015 2:17 PM
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The interaction between infections and the microbiota during infancy in the lungs could help provide clues to disease development later in life, according to the findings of a new study.
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Scooped by
Gilbert C FAURE
August 14, 2015 9:48 AM
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by Evelien M. E. van Bijnen, John Paget, Elly S. M. de Lange-de Klerk, Casper D. J. den Heijer, Ann Versporten, Ellen E. Stobberingh, Herman Goossens, François G.
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Suggested by
Société Francaise d'Immunologie
June 11, 2015 10:36 AM
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RT @Aller_MD: Increase in the Level of Proinflammatory Cytokine HMGB1 in Nasal Fluids of Patients With Rhinitis ... http://t.co/P5PQoMjYx4
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Suggested by
Société Francaise d'Immunologie
April 18, 2015 4:58 AM
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Biochem Biophys Res Commun. 2015 Jan 30;457(1):58-64. doi: 10.1016/j.bbrc.2014.12.058. Epub 2014 Dec 18. Research Support, Non-U.S. Gov't
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Scooped by
Gilbert C FAURE
March 4, 2015 2:03 PM
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Interleukin-25 secretions generated from the sinonasal epithelia and infiltrating mast cells play a crucial role in the pathogenesis of chronic rhinosinusitis among Asian patients with nasal polyps, according to study results.“IL-25 production by ...
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Suggested by
Société Francaise d'Immunologie
January 9, 2015 2:51 PM
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Significance of CYCLOOXYGENASE - 2(COX - 2), PERIOSTIN (POSTN) and INTERLEUKIN - 4(IL - 4) gene expression in ... http://t.co/169NzHzzvX
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Scooped by
Gilbert C FAURE
November 17, 2014 2:31 PM
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by Jung-Sun Cho, Ju-Hyung Kang, Ji-Young Um, In-Hye Han, Il-Ho Park, Heung-Man Lee
Nasal polyposis is characterized by persistent inflammation and remodeling in sinonasal mucosa.
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Scooped by
Gilbert C FAURE
March 7, 2017 1:10 PM
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A hallmark of autoimmunity is the breakdown of tolerance and generation of effector responses against self-antigens. A hallmark of autoimmunity is the breakdown of tolerance and generation of effector responses against self-antigens. Re-establishment of tolerance in autoimmune disorders was always the most desired treatment option; however, despite many efforts, clinical trials have been largely unsuccessful. This also applies to the generation of oral tolerance, which seems to be a default response type of the mucosa-associated lymphoid tissues (MALT) to harmless antigens. In this study we report improved efficacy of oral tolerance induction by coupling antigen with the newly identified mucosal carrier peptide 13C. Antigen coupled to 13C is efficiently taken up in the gastrointestinal tract and could be visualized in cells of the lamina propria. Oral, rectal or nasal treatment effectively induced the proliferation of antigen-specific T cells with some increase in the frequency of regulatory T cells. In a model of delayed type hypersensitivity, especially intrarectal tolerization treatment resulted in reduced footpad swelling, demonstrating a moderate tolerogenic effect of mucosal treatment with 13C coupled antigen. Coupling of antigens to a transmucosal carrier therefore is a promising tool to improve the efficacy of vaccination via mucosal surfaces.
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Scooped by
Gilbert C FAURE
January 23, 2017 5:09 AM
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Infect Immun. 2017 Jan 17. pii: IAI.01044-16. doi: 10.1128/IAI.01044-16. [Epub ahead of print]
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Scooped by
Gilbert C FAURE
December 14, 2016 10:11 AM
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Annu Rev Pathol. 2016 Dec 5. [Epub ahead of print]
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Scooped by
Gilbert C FAURE
August 17, 2016 12:46 AM
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For the study, the research team conducted a three-year trial in a Hutterite colony, where people live communally and are relatively isolated from cities and towns, to determine whether vaccinating children and adolescents with the flu nasal spray provided better direct and community protection than the standard flu shot.
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Scooped by
Gilbert C FAURE
April 3, 2016 4:19 AM
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PLoS One. 2015 May 28;10(5):e0126463. doi: 10.1371/journal.pone.0126463. eCollection 2015. Clinical Trial; Research Support, Non-U.S. Gov't
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Scooped by
Gilbert C FAURE
October 8, 2015 3:44 AM
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Defense systems against pathogens are a critical life-support system of fish that helps protect against infection. A complex network of immune cells and molecules that are located at the interface between the environment ...
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Scooped by
Gilbert C FAURE
August 17, 2015 6:00 AM
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Scooped by
Gilbert C FAURE
June 30, 2015 5:13 AM
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HealthCanal.com Next step toward a vaccine against genital herpes HealthCanal.com “The studies show that both methods provide effective immunity to acute genital infection and that the nasal vaccination also offers partial immunity to establishment...
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Scooped by
Gilbert C FAURE
June 7, 2015 6:00 AM
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IL-25 as a novel therapeutic target in nasal polyps of patients with chronic rhinosinusitis http://t.co/Otg3t3ni52
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Scooped by
Gilbert C FAURE
April 15, 2015 2:45 PM
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by Ahmed Bassiouni, Edward John Cleland, Alkis James Psaltis, Sarah Vreugde, Peter-John Wormald
Background The role of the sino-nasal microbiome in CRS remains unclear.
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Scooped by
Gilbert C FAURE
February 3, 2015 2:03 PM
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by Melissa D. Clouse, Ronald A. Shikiya, Jason C. Bartz, Anthony E.
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Scooped by
Gilbert C FAURE
November 26, 2014 2:28 PM
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(Phys.org) —Researchers at the University of New Mexico recently discovered an olfactory immune system in fish previously thought to be associated with terrestrial vertebrates only.
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