UCLA AIDS Institute / CFAR Grand Rounds This monthly lecture series, which is offered by the UCLA CFAR / AIDS Institute, consists of hour-long lunchtime lectures, delivered by invited guests...
Florian Hladik from the University of Washington and the Fred Hutchinson Cancer Research Center in Seattle, USA, explains why recent research on how to study the rectal and genital mucosa – featured in the new PLOS Collection Advances in HIV...
A vaccine can safely help the vast majority of HIV-positive women produce antibodies against the cancer-causing human papillomavirus, even if their immune system is weak and even if they've had some prior HPV exposure, a three-nation clinical trial...
... transmitted HIV infections.To monitor immune responses induced by candidate HIV vaccines in these tissues, the HVTN has developed procedures to collect and process a variety of mucosal and genital specimens.1…...
Irvine, Calif., Dec. 3, 2013 — Infectious disease researchers have identified a novel mechanism wherein HIV-1 may facilitate its own transmission by usurping the antibody response directed against itself.
Scientists have identified a milk protein called Tenascin C that binds to HIV and prevents it from injecting its DNA into human cells (Congrats to my boss/mentor for discovering an innate immunity protein that helps prevent HIV transmission
Elevated immune activation levels linked to increased HIV seroconversion Healio Prior studies have indicated variable susceptibility to HIV among commercial sex workers exposed to HIV, dependent upon higher levels of mucosal and systemic immune...
Study suggests why circumcised men are less likely to become infected with HIV HealthCanal.com Circumcision reduces the amount of mucosal tissue exposed to vaginal secretions during heterosexual intercourse and thus may reduce the potential...
PLoS Blogs (blog) Advances in HIV Mucosal Immunology: Challenges and Opportunities PLoS Blogs (blog) Among the many challenges to the development of an effective HIV vaccine has been the technical difficulty of assessing a vaccine's impact on the...
Early antiretroviral therapy may limit gut damage and immune activation aidsmap Alexandra Schuetz from the Armed Forces Research Institute of Medical Sciences and colleagues in Thailand looked at whether early ART during acute HIV infection might...
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.... Rectal fluid that contains high IgA, but low IgG levels, displayed low neutralizing activity independent of antibodies. Therefore, external secretions should be evaluated before and after selective depletion of Ig. At the systemic level, HIV-specific IgA may interfere with the effector functions of IgG, as suggested by recent studies of individuals systemically immunized with an experimental HIV vaccine. Although HIV-specific IgG and IgA antibodies may exhibit their protective activities at mucosal surfaces through interference with viral entry and local neutralization at the systemic level, such antibodies may display discordant effector functions.
Infectious Disease Medical Article: Distinct cytokine patterns in semen influence local HIV shedding and HIV target cell activation (Distinct cytokine patterns in semen influence local HIV shedding and HIV target cell activation: The Journ...
Infectious Disease Medical Article: The role of serpin and cystatin antiproteases in mucosal innate immunity and their defense against HIV (The role of serpin and cystatin antiproteases in mucosal innate immunity and their defense against HIV: Am...
Breast Milk Protein May be Key to Protecting Babies from HIV Infection Infection Control Today The study was funded by the Doris Duke Charitable Foundation Clinical Scientist Development Award; Duke University School of Medicine; Center for...
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