Mucosal Immunity
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Mucosal Immunity
The largest immune tissue in the body
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Scooped by Gilbert C FAURE
September 30, 2015 1:36 PM
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New book chronicles 50 years of clinical research in Singapore - Malay Mail Online

New book chronicles 50 years of clinical research in Singapore - Malay Mail Online | Mucosal Immunity | Scoop.it
SINGAPORE, Sept 28 — In the past, clinical research was sometimes done on researchers’ personal time — and even on their own dime — because of a shortage of resources, and getting published in | Read | Malay Mail Online...
Gilbert C FAURE's insight:

IgA nephropathy inside

published online

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Scooped by Gilbert C FAURE
September 16, 2015 3:12 PM
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Association of Relapse with Renal Outcomes under the Current Therapy Regimen for IgA Nephropathy: A Multi-Center Study

Association of Relapse with Renal Outcomes under the Current Therapy Regimen for IgA Nephropathy: A Multi-Center Study | Mucosal Immunity | Scoop.it
by Yanhong Yuan, Xiajing Che, Zhaohui Ni, Yifei Zhong, Yinghui Qi, Xinghua Shao, Qin Wang, Liou Cao, Minfang Zhang, Yuanyuan Xie, Chaojun Qi, Lei Tian, Shan Mou Background and Objectives Renal relapse is a very common manifestation of IgA...
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Scooped by Gilbert C FAURE
July 24, 2015 9:45 AM
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Journal of Human Genetics - Genome-wide association study of IgA nephropathy ... - Nature.com

Journal of Human Genetics - Genome-wide association study of IgA nephropathy ...
Nature.com
Various mechanisms have been proposed for the characteristic IgA deposits in glomerular mesangial areas.
Gilbert C FAURE's insight:

un bit disappointing?

TSPAN8?

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Scooped by Gilbert C FAURE
June 14, 2015 1:45 PM
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Expressions of mRNA for innate immunity-associated functional molecules in urinary sediment in IgA nephropathy. - PubMed - NCBI

Expressions of mRNA for innate immunity-associated functional molecules in urinary sediment in IgA nephropathy. - PubMed - NCBI | Mucosal Immunity | Scoop.it
Nephrology (Carlton). 2015 Jun 7. doi: 10.1111/nep.12533. [Epub ahead of print]
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Scooped by Gilbert C FAURE
April 11, 2015 3:28 PM
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Glomerular disease: Efficacy of corticosteroids in high-risk IgA nephropathy - Nature.com

Glomerular disease: Efficacy of corticosteroids in high-risk IgA nephropathy Nature.com Corticosteroids are frequently used to treat patients with IgA nephropathy (IgAN) despite a paucity of data to support their use in individuals with...
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Scooped by Gilbert C FAURE
February 15, 2015 2:53 PM
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DEFA gene variants associated with IgA nephropathy in a Chinese population - Nature.com

DEFA gene variants associated with IgA nephropathy in a Chinese population
Nature.com
IgA nephropathy (IgAN) is a complex syndrome with high genetic heterogeneity.
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Scooped by Gilbert C FAURE
February 1, 2015 1:23 PM
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Nephrokeli, a Chinese Herbal Formula, May Improve IgA Nephropathy through Regulation of the Sphingosine-1-Phosphate Pathway

Nephrokeli, a Chinese Herbal Formula, May Improve IgA Nephropathy through Regulation of the Sphingosine-1-Phosphate Pathway | Mucosal Immunity | Scoop.it
by Yifei Zhong, Ke Wang, Xianwen Zhang, Xiaofan Cai, Yiping Chen, Yueyi Deng
Nephrokeli (NPKL) is a Chinese herbal formula that has been used to treat patients with IgA nephropathy (IgAN) for improvement of proteinuria and kidney injury.
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Scooped by Gilbert C FAURE
December 13, 2014 2:51 PM
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Is Lettuce Good for IgA Nephropathy Patients_IGA Cure

Is Lettuce Good for IgA Nephropathy Patients_IGA Cure | Mucosal Immunity | Scoop.it
Lettuce is a kind of popular and healthy green vegetable packed with essential nutrients. Is lettuce good for IgA Nephropathy patients? As we all know, IgA Neph
Gilbert C FAURE's insight:

IGACure from China through the social network...

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Scooped by Gilbert C FAURE
October 19, 2014 2:56 PM
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Leicester IgA research group receives funding - Kidney Research UK - Kidney Research UK

Leicester IgA research group receives funding - Kidney Research UK - Kidney Research UK | Mucosal Immunity | Scoop.it
Have you read about our latest research into IgA Nephropathy? Read more: http://t.co/WROygMO12b #kidneydisease #kidney
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Scooped by Gilbert C FAURE
June 12, 2014 6:03 AM
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Enzymatic Sialylation of IgA1 O-Glycans: Implications for Studies of IgA Nephropathy

Enzymatic Sialylation of IgA1 O-Glycans: Implications for Studies of IgA Nephropathy | Mucosal Immunity | Scoop.it
by Kazuo Takahashi, Milan Raska, Milada Stuchlova Horynova, Stacy D. Hall, Knud Poulsen, Mogens Kilian, Yoshiyuki Hiki, Yukio Yuzawa, Zina Moldoveanu, Bruce A. Julian, Matthew B.
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Scooped by Gilbert C FAURE
April 25, 2014 1:43 PM
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Transplant Outcomes Better in IgA Nephropathy Patients - Renal and Urology News

Transplant Outcomes Better in IgA Nephropathy Patients - Renal and Urology News | Mucosal Immunity | Scoop.it
Transplant Outcomes Better in IgA Nephropathy Patients Renal and Urology News Aditya Kadiyala, MD, of Hofstra-North Shore Long Island Jewish Health System in Great Neck, NY, and colleagues analyzed data from 98,450 adult first-time kidney...
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Scooped by Gilbert C FAURE
November 24, 2013 11:59 AM
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WO2013172347A1 METHOD FOR DETECTING IGA AGGREGATE, AND METHOD FOR TESTING IGA NEPHROPATHY

WIPO patent: Provided is a novel method for detecting IgA nephropathy using a lectin having binding specificity to a structure characteristic of an IgA aggregate that is observed in an IgA nephropathy patient.
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Scooped by Gilbert C FAURE
June 24, 2013 1:03 PM
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Anthera Announces Initiation of BRIGHT-SC Phase 2 Clinical Study in IgA ... - PR Newswire (press release)

Anthera Announces Initiation of BRIGHT-SC Phase 2 Clinical Study in IgA ... - PR Newswire (press release) | Mucosal Immunity | Scoop.it
Anthera Announces Initiation of BRIGHT-SC Phase 2 Clinical Study in IgA ...
PR Newswire (press release)
In May, the company met with the US FDA to discuss the future of the IgA nephropathy development plan.
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Scooped by Gilbert C FAURE
September 26, 2015 5:22 AM
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Soluble Urokinase Receptor Levels Are Correlated with Focal Segmental Glomerulosclerosis Lesions in IgA Nephropathy: A Cohort Study from China

Soluble Urokinase Receptor Levels Are Correlated with Focal Segmental Glomerulosclerosis Lesions in IgA Nephropathy: A Cohort Study from China | Mucosal Immunity | Scoop.it
by Shui-Ming Guo, Min Han, Mei-Xue Chen, Yong Ning, Guang-Chang Pei, Yue-Qiang Li, Wei Dai, Shu-Wang Ge, Yuan-Jun Deng, Yan-Yan Guo, Xiao-Qing Li, Hermann Haller, Gang Xu, Song Rong Background Soluble urokinase receptor (suPAR) may be involved in...
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Scooped by Gilbert C FAURE
July 28, 2015 8:23 AM
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A new monoclonal antibody for detecting degalactosylated IgA1 as serum biomarker of IgA nephropathy

A new monoclonal antibody for detecting degalactosylated IgA1 as serum biomarker of IgA nephropathy | Mucosal Immunity | Scoop.it
"A new monoclonal antibody for detecting degalactosylated IgA1 as serum biomarker of IgA nephropathy" #nephrology http://t.co/FRVdvzuGgj
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Suggested by Société Francaise d'Immunologie
July 23, 2015 8:53 AM
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Proliferation and Cytokine Production of Human Mesangial Cells Stimulated by Secretory IgA Isolated from Patients with IgA Nephropathy. - PubMed - NCBI

Proliferation and Cytokine Production of Human Mesangial Cells Stimulated by Secretory IgA Isolated from Patients with IgA Nephropathy. - PubMed - NCBI | Mucosal Immunity | Scoop.it
Cell Physiol Biochem. 2015 Jul 13;36(5):1793-1808. [Epub ahead of print]
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Scooped by Gilbert C FAURE
April 20, 2015 1:55 PM
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NEFIGAN Trial of Nefecon for treatment of primary IgA nephropathy meets ... - News-Medical.net

NEFIGAN Trial of Nefecon for treatment of primary IgA nephropathy meets ... - News-Medical.net | Mucosal Immunity | Scoop.it
Pharmalink AB, a specialty pharma company, today announces that the NEFIGAN Trial of Nefecon for the treatment of primary IgA nephropathy has fully met its primary efficacy endpoint at a planned interim analysis and been stopped early with respect...
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Scooped by Gilbert C FAURE
March 13, 2015 3:26 PM
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Corticosteroids Okay for IgA Nephropathy Regardless of Renal Function - Renal and Urology News

Corticosteroids Okay for IgA Nephropathy Regardless of Renal Function - Renal and Urology News | Mucosal Immunity | Scoop.it
Corticosteroid treatment decreased proteinuria and the rate of renal function decline and increased renal survival, study finds.
Gilbert C FAURE's insight:

In a retrospective study, Rosanna Coppo, MD, of Turin Hospital in Turin, Italy, and colleagues analyzed data from 1,147 patients with IgAN from the European Validation Study of the Oxford Classification of IgAN (VALIGA) cohort. Physicians prescribed immunosuppression for 46% of the patients. Of these, 98% received CS.

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Scooped by Gilbert C FAURE
February 4, 2015 1:33 PM
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DNA Methylation in Cosmc Promoter Region and Aberrantly Glycosylated IgA1 Associated with Pediatric IgA Nephropathy

DNA Methylation in Cosmc Promoter Region and Aberrantly Glycosylated IgA1 Associated with Pediatric IgA Nephropathy | Mucosal Immunity | Scoop.it
by Qiang Sun, Jianqian Zhang, Nan Zhou, Xiaorong Liu, Ying Shen
IgA nephropathy (IgAN) is one of the most common glomerular diseases leading to end-stage renal failure. Elevation of aberrantly glycosylated IgA1 is a key feature of it.
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Scooped by Gilbert C FAURE
January 30, 2015 2:22 PM
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Pharmalink's IND application for IgA Nephropathy now open with FDA - Pharmaceutical Business Review

Pharmalink's IND application for IgA Nephropathy now open with FDA - Pharmaceutical Business Review | Mucosal Immunity | Scoop.it
Sweden-based specialty pharma company Pharmalink has announced that its investigational new drug (IND) application for Nefecon is now open with the US
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Scooped by Gilbert C FAURE
October 20, 2014 5:03 AM
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Discovery of new risk loci for IgA nephropathy imp... [Nat Genet. 2014] - PubMed - NCBI

PubMed comprises more than 23 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Gilbert C FAURE's insight:
Abstract

We performed a genome-wide association study (GWAS) of IgA nephropathy (IgAN), the most common form of glomerulonephritis, with discovery and follow-up in 20,612 individuals of European and East Asian ancestry. We identified six new genome-wide significant associations, four in ITGAM-ITGAX, VAV3 and CARD9 and two new independent signals at HLA-DQB1 and DEFA. We replicated the nine previously reported signals, including known SNPs in the HLA-DQB1 and DEFA loci. The cumulative burden of risk alleles is strongly associated with age at disease onset. Most loci are either directly associated with risk of inflammatory bowel disease (IBD) or maintenance of the intestinal epithelial barrier and response to mucosal pathogens. The geospatial distribution of risk alleles is highly suggestive of multi-locus adaptation, and genetic risk correlates strongly with variation in local pathogens, particularly helminth diversity, suggesting a possible role for host-intestinal pathogen interactions in shaping the genetic landscape of IgAN.

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Scooped by Gilbert C FAURE
August 19, 2014 4:51 AM
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The Molecular Phenotype of Endocapillary Proliferation: Novel Therapeutic Targets for IgA Nephropathy

The Molecular Phenotype of Endocapillary Proliferation: Novel Therapeutic Targets for IgA Nephropathy | Mucosal Immunity | Scoop.it
by Jeffrey B. Hodgin, Celine C. Berthier, Rohan John, Elisabeth Grone, Stefan Porubsky, Hermann-Josef Gröne, Andrew M. Herzenberg, James W. Scholey, Michelle Hladunewich, Daniel C. Cattran, Matthias Kretzler, Heather N.
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Scooped by Gilbert C FAURE
June 4, 2014 1:45 PM
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JCI - The genetics and immunobiology of IgA nephropathy

IgA nephropathy (IgAN) represents the leading cause of kidney failure among East Asian populations and the most frequent form of primary glomerulonephritis among Europeans. Patients with IgAN develop characteristic ...
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Scooped by Gilbert C FAURE
April 11, 2014 5:22 AM
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The Common Causes of IgA Nephropathy - Kidney Disease Symptoms and Treatment

The Common Causes of IgA Nephropathy - Kidney Disease Symptoms and Treatment | Mucosal Immunity | Scoop.it
IgA Nephropathy is an autoimmune disorder that occurs when IgA settles in kidneys. If we want to know causes of IgA Nephropathy, we need to know what IgA is and how it affects kidney.
Gilbert C FAURE's insight:

IgA nephropathy for laypeople, but including mucosal origin of IgA and tonsillectomy as an option

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Scooped by Gilbert C FAURE
June 25, 2013 1:31 PM
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Anthera commences Phase 2 study of IgA nephropathy therapy - Pharmaceutical Business Review

Anthera commences Phase 2 study of IgA nephropathy therapy
Pharmaceutical Business Review
Anthera Pharmaceuticals has begun the BRIGHT-SC Phase 2 IgA nephropathy study of an inhibitor of B-Cell Activating Factor (BAFF), blisibimod.
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