Immunology
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Immunology
Teaching and Learning Immunology. Information you never would have searched for!
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Scooped by Gilbert C FAURE
October 2, 2012 2:49 PM
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Advance online publication : Nature Reviews Nephrology

Three new Reviews from our upcoming Focus Issue on targeting complement in renal disease published online today http://t.co/uVxmSchD...
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Scooped by Gilbert C FAURE
September 13, 2012 4:15 PM
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La 7ème journée d'immuno-pathologie Raoul Guyader...

 ... se tiendra à Brest le 20 décembre 2012, Faculté de Médecine de Brest, amphithéâtre 3, avec comme thèmes abordés: les auto-anticorps (les nouveaux Ac, les Ac de la glomérulonéphrite, les ANCA), le complément, la démarche qualité en immunologie, l'approche clinico-biologique (classification des vascularites, dermato/polymyosites, atopie, maladies parodontales) et enfin l'intérêt des consultations multidisciplinaires pour une approche globale des patients.

Une dizaine d'orateurs reconnus pour leurs qualités pédagogiques et universitaires interviendront (L Guillevin, P Youinou, M Hamidou, A Chevailler, etc).

Pour participer à cette journée il est nécessaire de s'inscrire (yves.renaudineau@univ-brest.fr). Les frais d'inscriptions sont pris en charge par les organisateurs et les partenaires de cette journée.
Public concerné: immunologistes, biologistes, internistes, rhumatologues, néphrologues, dermatologues, étudiants en 3ème cycle, techniciens de laboratoire...

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Scooped by Gilbert C FAURE
September 11, 2012 6:38 AM
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Identification of a Catalytic Exosite for Complement Component C4 on the Serine Protease Domain of C1s

Identification of a Catalytic Exosite for Complement Component C4 on the Serine Protease Domain of C1s | Immunology | Scoop.it
New paper from Dr Richard Payne. JOURNAL OF IMMUNOLOGY, 189 (5), 2365-2373, 2012.
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Scooped by Gilbert C FAURE
March 17, 2012 5:16 AM
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rILYd4, a human CD59 inhibitor, enhances complement-dependent ...

rILYd4, a human CD59 inhibitor, enhances complement-dependent ... | Immunology | Scoop.it
You are here: Home / Key Scientific Articles / rILYd4, a human CD59 inhibitor, enhances complement-dependent cytotoxicity of ofatumumab against rituximab-resistant B-cell lymphoma cells and chronic lymphocytic leukemia.
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Scooped by Gilbert C FAURE
February 9, 2012 11:06 AM
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Takeda opens new drug development center in China - FierceCRO

Takeda opens new drug development center in China - FierceCRO | Immunology | Scoop.it
Japan's Takeda is adding a new drug development center in Shanghai intended to complement the international clinical work now under way in Singapore and Cambridge, MA. Both of the existing Read more...
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Scooped by Gilbert C FAURE
January 21, 2012 10:39 AM
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Ophthalmology Article | Relevance of complement factor H-related 1 ...

Ophthalmology Article | Relevance of complement factor H-related 1 ... | Immunology | Scoop.it
Relevance of complement factor H-related 1 (CFHR1) genotypes in age-related macular degeneration (AMD).
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Scooped by Gilbert C FAURE
January 19, 2012 9:41 AM
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Sialic Acid on the Neuronal Glycocalyx Prevents Complement C1 Binding and Complement Receptor-3-Mediated Removal by Microglia

Sialic Acid on the Neuronal Glycocalyx Prevents Complement C1 Binding and Complement Receptor-3-Mediated Removal...
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Scooped by Gilbert C FAURE
December 1, 2011 12:21 PM
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Alexion's Soliris Gets EU Approval To Treat AHUS Patients - RTT News

Alexion's Soliris Gets EU Approval To Treat AHUS Patients - RTT News | Immunology | Scoop.it
Alexion's Soliris Gets EU Approval To Treat AHUS PatientsRTT NewsSoliris, a first-in-class terminal complement inhibitor, specifically targets uncontrolled complement activation.
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Scooped by Gilbert C FAURE
November 16, 2011 6:58 AM
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Identification of C3 complement molecule at the site of injury to ...

Lead Inventor: Dr. John T. Flynn, M.D.Problem or Unmet Need:Retinopathy of prematurity (ROP) is the most common cause of acquired blindness in prematurely born babies. Infants with ROP are consider...
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Scooped by Gilbert C FAURE
November 12, 2011 2:15 AM
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Longer-Term Data on Soliris Showed Significant and Sustained Benefits for ... - BioMedReports (subscription)

Longer-Term Data on Soliris Showed Significant and Sustained Benefits for ... - BioMedReports (subscription) | Immunology | Scoop.it
Longer-Term Data on Soliris Showed Significant and Sustained Benefits for ...BioMedReports (subscription)By Business Wire Health: Biotechnology News Results demonstrated that ongoing treatment with Soliris sustained the suppression of complement-mediated...
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Scooped by Gilbert C FAURE
September 25, 2011 2:14 PM
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Eculizumab Gains FDA Approval - Drug Discovery & Development

Eculizumab Gains FDA ApprovalDrug Discovery & DevelopmentEculizumab is a monoclonal antibody that inhibits the production of the terminal complement components C5a and the membrane attack complex C5b-9 by binding to complement protein C5.
Gilbert C FAURE's insight:

Eculizumab is a monoclonal antibody that inhibits the production of the terminal complement components C5a and the membrane attack complex C5b-9 by binding to complement protein C5. Prevention of C5a formation and the terminal complement complex inhibits complement-mediated thrombotic microangiopathy in patients with aHUS.

Scooped by Gilbert C FAURE
September 2, 2011 7:45 AM
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Complement Summary | VCOMSC

I summarized the complement slides. My notes may be in a little more detail than we have to know but it helped me make sense of all the nonsense letter and numbers. Hope it helps! –Ann Dobry. pdf icon Complement pg ...
Scooped by Gilbert C FAURE
September 26, 2012 1:59 AM
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Protective effects of different combinations of human MCP, DAF, and ...

Protective effects of different combinations of human MCP, DAF, and ... | Immunology | Scoop.it
We constructed 3 double and 3 single-human complement regulatory protein plasmids (pIRES-hMCP-hDAF, pIRES-hMCP-hCD59, pIRES-hDAF-hCD59, pIRES-A-hMCP, pIRES-B-hDAF, and pIRES-B-hCD59). The plasmids ...
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Scooped by Gilbert C FAURE
September 11, 2012 2:50 PM
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Chain Reaction in the Human Immune System Trapped in Crystals - Science Daily (press release)

Chain Reaction in the Human Immune System Trapped in Crystals - Science Daily (press release) | Immunology | Scoop.it
Chain Reaction in the Human Immune System Trapped in CrystalsScience Daily (press release)The complement system is part of the innate immune system and is composed of about 40 different proteins that work together to defend the body against...
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Scooped by Gilbert C FAURE
September 5, 2012 3:05 AM
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Content Curation and Aggregation Complement Each Other

Content Curation and Aggregation Complement Each Other | Immunology | Scoop.it
Content curation and content aggregation are two very different practices—but they aren't mutually exclusive. Aggregation is the means; curation is the end.
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Scooped by Gilbert C FAURE
February 29, 2012 2:21 PM
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Alexion Joins EURORDIS, NORD and Patient Organizations Worldwide in ... - Genetic Engineering News

Alexion Joins EURORDIS, NORD and Patient Organizations Worldwide in ...Genetic Engineering NewsPNH is an ultra-rare blood disorder in which chronic, uncontrolled activation of complement, a component of the normal immune system, results in...
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Scooped by Gilbert C FAURE
January 30, 2012 3:49 AM
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The Disease-promoting Role of Complement Activation in the ...

Inflammatory Bowel Disease (IBD) is a chronic and relapsing non-specific intestinal inflammatory disease. The incidence of IBD is higher in the west, however, at present its incidence has been increasing gradually in China.
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Scooped by Gilbert C FAURE
January 19, 2012 9:45 AM
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InflaRx Announces Successful Conduct of Its Clinical Phase I Trial with IFX-1, a New Monoclonal Antibody Inhibiting Complement Driven Inflammation - Drugs.com MedNews

InflaRx Announces Successful Conduct of Its Clinical Phase I Trial with IFX-1, a New Monoclonal Antibody Inhibiting Complement Driven Inflammation - Drugs.com MedNews | Immunology | Scoop.it
Jan 18, 2012 - InflaRx announced today the successful completion of its recent clinical phase I study investigating its lead drug candidate IFX-1, a new first i (InflaRx Announces Successful Conduct of Its Clinical Phase I Trial with IFX-1, a New ...
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Scooped by Gilbert C FAURE
December 6, 2011 7:51 AM
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Role of complement cascade in abdominal aortic aneurysms.

Role of complement cascade in abdominal aortic aneurysms. | Immunology | Scoop.it
Role of complement cascade in abdominal aortic aneurysms. Hinterseher I, Erdman R, Donoso LA, Vrabec TR, Schworer CM, Lillvis JH, Boddy AM, Derr K, Golden A, Bowen WD, Gatalica Z, Tapinos N, Elmore JR, Franklin DP ...
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Scooped by Gilbert C FAURE
November 26, 2011 1:50 AM
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Desensitization With Antigen-Specific Immunoadsorption Inter... : Transplantation

Background.Complement activation was characterized during and after desensitization treatment in 19 (Ahead of Print: Desensitization With Antigen-Specific Immunoadsorption Interferes With Complement in ABO-Incompa...)...
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Scooped by Gilbert C FAURE
November 14, 2011 8:36 AM
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Longer-Term Data on Soliris Showed Significant and Sustained Benefits for ... - MarketWatch (press release)

Longer-Term Data on Soliris Showed Significant and Sustained Benefits for ... - MarketWatch (press release) | Immunology | Scoop.it
Longer-Term Data on Soliris Showed Significant and Sustained Benefits for ...MarketWatch (press release)Results demonstrated that ongoing treatment with Soliris sustained the suppression of complement-mediated thrombotic microangiopathy (TMA),...
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Scooped by Gilbert C FAURE
November 7, 2011 2:24 AM
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Identification of a central role for complement in osteoarthritis : Nature Medicine : Nature Publishing Group

Identification of a central role for complement in osteoarthritis : Nature Medicine : Nature Publishing Group | Immunology | Scoop.it
Osteoarthritis, the breakdown of cartilage in synovial joints, has long been viewed as the result of 'wear and tear', but this report shows that dysregulation of the complement system has an active role in the pathogenesis of this disease.
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Scooped by Gilbert C FAURE
September 20, 2011 2:22 PM
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Current Topics in Innate Immunity II

Current Topics in Innate Immunity II | Immunology | Scoop.it
Mounting evidence in the past decade indicates that innate immunity mediates functions above and beyond first-line defense against infection. It is now appreciated that innate immune mechanisms are critically involved in the ...
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Summary of latest Aegean Conferences meeting - the 7th Innate Immunity ConferenceBrings together findings of international scientists with different advanced perspectivesDiscusses Evolution of the Innate Immune System, Host-pathogen interactions, and interactions with adaptive immunity.....  in the development of adaptive immunity and, moreover, the regulation of diverse physiological and homeostatic processes. The latter explains why deregulation of innate immunity may lead to pathological disorders that are not necessarily or directly related to host defense. This Volume compiles the latest advances in this rapidly evolving field as presented by eminent scientists at the 7th International Aegean Conference on Innate Immunity in Rhodes, Greece. It includes topics related to the biology and function of Toll-like and other pattern-recognition receptors, complement and its crosstalk with other physiological systems, inflammatory mechanisms and diseases, natural killer cells, and the cooperative interplay between innate and adaptive immune cells. This book is an excellent source of information for researchers and clinicians with interests in immunology, host-microbe interactions, and infectious and inflammatory diseases.
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