The goal of SMI's Oral History Project is to preserve a piece of the knowledge of leaders in the field of mucosal immunology for young investigators emerging in the field today.
The Nobel Prize in Physiology or Medicine 2008 was divided, one half awarded to Harald zur Hausen "for his discovery of human papilloma viruses causing cervical cancer", the other half jointly to Françoise Barré-Sinoussi and Luc Montagnier "for their discovery of human immunodeficiency virus"
Le virus SARS-CoV-2 possède des caractéristiques génétiques très particulières, qui le distinguent des autres coronaviridae et même des deux autres membre du sous-genre des sarbécovirus, SARS-CoV (2002) et MERS (2012).
The 20th century was a dangerous time to be young: a multitude of diseases too often kept children from reaching even their teenage years. Millions suffered…
How was the hundredth anniversary of the smallpox vaccine celebrated? A ton of folks got vaccinated - too help control a smallpox epidemic in the least…
Effective antibody responses are essential to generate protective humoral immunity. Different inflammatory signals polarize T cells towards appropriate effector phenotypes during an infection or immunization.
Interest in the history of medicine has notched up, and scholars say it’s a must-study for the medical community. Chris Crenner, M.D., Ph.D., chair of the…
Step into the dimly lit Victorian lab of 1885, where a young scientist stands alongside Louis Pasteur, unraveling the secrets of diseases that once haunted humanity. 🧪 From extracting spinal tissue from rabbits to administering groundbreaking rabies vaccines, witness the rise of a new era in medicine. This is the story of perseverance, innovation, and the birth of modern immunology. Join us on this historical journey and discover how bravery and science can change the world forever!
Professor Stuart Tangye, Head of Garvan's Immunology Division, give an introduction to immunology. It includes a history of immunology, what the immune system is, diseases related to the immune system and some detailed information about his research. To find out more: https://www.garvan.org.au/research/diseases/immunodeficiency/our-research
Substantial progress in understanding T cell signalling, particularly with respect to T cell co-receptors such as the co-stimulatory receptor CD28, has been made in recent years. This knowledge has been instrumental in the development of innovative immunotherapies for patients with cancer, including immune checkpoint blockade antibodies, adoptive cell therapies, tumour-targeted immunostimulatory antibodies, and immunostimulatory small-molecule drugs that regulate T cell activation. Following the failed clinical trial of a CD28 superagonist antibody in 2006, targeted CD28 agonism has re-emerged as a technologically viable and clinically promising strategy for cancer immunotherapy. In this Review, we explore recent insights into the molecular functions and regulation of CD28. We describe how CD28 is central to the success of current cancer immunotherapies and examine how new questions arising from studies of CD28 as a clinical target have enhanced our understanding of its biological role and may guide the development of future therapeutic strategies in oncology. This Review covers recent advances in our understanding of CD28 co-stimulation of T cells and discusses an emerging paradigm that positions CD28 as central to the success of current and future immunotherapeutic approaches to treating cancer.
NK cells were first described five decades ago and named in 1975. This brief Perspective highlights a timeline of a few selected advancements in NK cell bi
Nous sommes nombreux luttant contre la désinformation scientifique, à constater la proximité des principales figures complotistes et antivax avec les milieux…
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