Similar to G-quadruplexes, these folded DNA structures could be selective drug targets
|
Scooped by
BigField GEG Tech
onto Genetics - GEG Tech top picks April 30, 2018 7:44 AM
|
In 2013, a research group confirmed that G-quadruplexes were present in human cells (Nat. Chem.2013, DOI: 10.1038/nchem.1548 and C&EN, Jan. 21, 2013, page 8). Now a separate group, led by Marcel E. Dinger and Daniel Christ of the Garvan Institute of Medical Research, has confirmed that i-motifs are also there (Nat. Chem. 2018, DOI: 10.1038/s41557-018-0046-3). The work helps pave the way for the search for i-motif-targeted drugs.