Genetics - GEG Tech top picks
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Scooped by BigField GEG Tech
September 30, 2014 2:30 AM
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Mutations in SPRTN cause early onset hepatocellular carcinoma, genomic instability and progeroid features - Nature Genetics

Mutations in SPRTN cause early onset hepatocellular carcinoma, genomic instability and progeroid features - Nature Genetics | Genetics - GEG Tech top picks | Scoop.it
From www.nature.com - September 29, 2014 10:57 AM
Kristijan Ramadan and colleagues report the identification of three individuals from two families with biallelic inactivating mutations in SPRTN causing early onset hepatocellular carcinoma and defects in the DNA replication stress response. Functional studies confirmed critical roles for SPRTN in G2/M checkpoint response and DNA replication.
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Rescooped by BigField GEG Tech from Genetic Engineering Publications - GEG Tech top picks
December 9, 2013 5:29 AM
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Transposon mutagenesis identifies genes driving hepatocellular carcinoma in a chronic hepatitis B mouse model

Transposon mutagenesis identifies genes driving hepatocellular carcinoma in a chronic hepatitis B mouse model | Genetics - GEG Tech top picks | Scoop.it
December 9, 2013 4:25 AM

http://www.nature.com/ng/journal/vaop/ncurrent/full/ng.2847.html

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An original use of a transposon to better understand the hepatocarcinoma mechanisms.

 

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BigField GEG Tech's curator insight, December 9, 2013 4:25 AM

An original use of a transposon to better understand the hepatocarcinoma mechanisms.

 

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Scooped by BigField GEG Tech
January 20, 2014 10:36 AM
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Transposon mutagenesis identifies genes driving hepatocellular carcinoma in a chronic hepatitis B mouse model : Nature Genetics : Nature Publishing Group

Transposon mutagenesis identifies genes driving hepatocellular carcinoma in a chronic hepatitis B mouse model : Nature Genetics : Nature Publishing Group | Genetics - GEG Tech top picks | Scoop.it
From www.nature.com - January 20, 2014 10:36 AM
Neal Copeland and colleagues use a transposon mutagenesis screen to identify drivers of hepatocellular carcinoma in a mouse model of chronic hepatitis B infection.
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Smart use of transposon to better characterize hepatocellular carcinoma.

 

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