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Scooped by Gilbert C FAURE
February 3, 2015 1:46 PM
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EKF Molecular Diagnostics collaborates with ANGLE for liquid biopsy ... - News-Medical.net

EKF Molecular Diagnostics collaborates with ANGLE for liquid biopsy ... - News-Medical.net | from Flow Cytometry to Cytomics | Scoop.it
From www.news-medical.net - January 29, 2015 9:29 PM
EKF Molecular Diagnostics has agreed a collaboration with specialist medtech company ANGLE plc, to investigate the combination of ANGLE's Parsortix circulating tumour cell (CTC) harvesting platform with EKF Molecular's PointMan™ DNA enrichment...
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Scooped by Gilbert C FAURE
December 20, 2014 2:36 PM
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Circulating Tumor Cells in Patients With Colorectal Liver Me... : Annals of Surgery

Circulating Tumor Cells in Patients With Colorectal Liver Me... : Annals of Surgery | from Flow Cytometry to Cytomics | Scoop.it
From journals.lww.com - December 18, 2014 12:01 PM
Objective: The aim of the study is to assess the prognostic and predictive value of circulating tumor cells (CTCs) and disseminated tumor cells (DTCs) in bone marrow (BM) in patients with colorectal liver metastasis referred to surgery.
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Background: A total of 194 patients were included. Treatment of the patients was decided in a multidisciplinary team.

Methods: BM aspirates and blood samples were collected at surgery, or in local anesthesia in nonresectable patients. CTCs were disclosed with CellSearch System, DTC with immunocytology.

Results: Liver resection was completed in 153 patients. Forty-one patients were nonresectable, 22 preoperatively and 19 intraoperatively. The median follow-up was 22 (range 1–61) months. Relapse was diagnosed in 103 of the resected patients. Totally, 67 patients died of cancer. CTCs were detected in 19.6% of the patients. CTC positivity was significantly higher in nonresectable (46%) than in resectable patients (11.7%), P < 0.001. 13.8% of the patients had 2 or more CTCs, 31% of the nonresectable and 9.1% of the resectable patients (P = 0.001). Patients with 2 or more CTCs experienced reduced time to relapse/progression, both analyzing all patients (P = 0.002) and analyzing resectable patients (P < 0.001). Two or more CTCs was a strong predictor of progression and mortality in all subgroups of patients, together with more than 3 liver metastases, R1 resection, and extrahepatic disease. DTCs were detected in 9.9% of the patients, but not associated with clinical outcome in resectable patients.

Conclusions: CTCs predict nonresectability and impaired survival. CTC analysis should be considered as a tool for decision-making before liver resection in these patients.

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Scooped by Gilbert C FAURE
November 10, 2014 11:33 AM
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New MEMS is the first to capture and classify CTC's by phenotype.

New MEMS is the first to capture and classify CTC's by phenotype. | from Flow Cytometry to Cytomics | Scoop.it
From health-innovations.org - November 7, 2014 9:48 AM
For most cancer patients, primary tumours are often not the most deadly. Instead, it is the metastatic tumours - tumours that spread from their original location to other parts of the body - that a...
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Scooped by Gilbert C FAURE
September 1, 2014 1:43 PM
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CTC clusters cause metastasis - News-Medical.net

CTC clusters cause metastasis - News-Medical.net | from Flow Cytometry to Cytomics | Scoop.it
From www.news-medical.net - August 29, 2014 5:01 AM
CTC clusters cause metastasis News-Medical.net Circulating tumor cell (CTC) clusters - clumps of from 2 to 50 tumor cells that break off a primary tumor and are carried through the bloodstream - appear to be much more likely to cause metastasis...
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Scooped by Gilbert C FAURE
August 22, 2014 3:41 AM
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Circulating tumor cells measurements in hepato... [Int J Hepatol. 2012] - PubMed - NCBI

From www.ncbi.nlm.nih.gov - August 22, 2014 3:39 AM
PubMed comprises more than 23 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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review and analyze the different new methods existing to detect, enumerate, and characterize the CTC in the peripheral circulation of patients with HCC..

no personal results

no application of cytomics

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Scooped by Gilbert C FAURE
June 19, 2014 5:04 AM
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CAP TODAY: “Unraveling Metastasis With Circulating Tumor Cells”

CAP TODAY: “Unraveling Metastasis With Circulating Tumor Cells” | from Flow Cytometry to Cytomics | Scoop.it
From news.mayomedicallaboratories.com - June 17, 2014 10:35 AM
In the MAY issue of CAP TODAY, Minetta Liu, M.D., of the Department of Medical Oncology and the Department of Laboratory Medicine and Pathology at Mayo Clinic discusses the use of circulating tumor cell (CTC) enumeration in her clinical practice.
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Scooped by Gilbert C FAURE
May 21, 2014 2:44 PM
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Could a Blood Test Predict Breast Cancer's Return? – WebMD

Could a Blood Test Predict Breast Cancer's Return? – WebMD | from Flow Cytometry to Cytomics | Scoop.it
From www.webmd.com - May 15, 2014 6:25 PM
The blood test looks for circulating tumor cells (CTCs) in patients with breast cancer. While conclusive data about their relevance has been established for breast cancer that has spread, the CTC test has not been proven to be ...
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Scooped by Gilbert C FAURE
May 9, 2014 3:19 PM
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Circulating Tumor Cells (CTCs)

Circulating Tumor Cells (CTCs) | from Flow Cytometry to Cytomics | Scoop.it
From www.oncologytube.com - May 4, 2014 11:21 AM
In this demonstration of the CTC-Chip, circulating tumor cells (fluorescent labeled, shown in white) mixed with blood (not labeled) are captured on nano-scale posts as they flow through the chip.
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Scooped by Gilbert C FAURE
April 8, 2014 9:26 AM
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Mesenchymal Phenotype of CTC-Enriched Blood Fraction and Lymph Node Metastasis Formation Potential

Mesenchymal Phenotype of CTC-Enriched Blood Fraction and Lymph Node Metastasis Formation Potential | from Flow Cytometry to Cytomics | Scoop.it
From www.plosone.org - April 7, 2014 5:00 PM
by Aleksandra Markiewicz, Magdalena Książkiewicz, Marzena Wełnicka-Jaśkiewicz, Barbara Seroczyńska, Jarosław Skokowski, Jolanta Szade, Anna J.
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Scooped by Gilbert C FAURE
April 1, 2014 1:55 PM
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Universal Marker and Detection Tool for Human ... - Cancer Research

From cancerres.aacrjournals.org - March 14, 2014 12:06 AM
Abstract. To date, no specific marker exists for the detection of circulating tumor cells (CTC) from different types of sarcomas, though tools are available for detection of CTCs in peripheral blood of patients with cancer for ...
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Scooped by Gilbert C FAURE
March 26, 2014 5:44 PM
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CTCs As A Biomarker to Predict Survival in Men with Metastatic ...

CTCs As A Biomarker to Predict Survival in Men with Metastatic ... | from Flow Cytometry to Cytomics | Scoop.it
From advancedprostatecancer.net - March 25, 2014 9:36 PM
They also found that men who had elevated CTC counts after having chemotherapy had up to a 5-fold increased risk of death, whereas men whose CTC counts dropped by 50% or more were half as likely to die.
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Scooped by Gilbert C FAURE
March 16, 2014 2:40 PM
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WO2014037552A1 METHOD FOR IDENTIFYING SUBGROUPS OF CIRCULATING TUMOR CELLS (CTCS) IN THE CTC POPULATION OF A BIOLOGICAL SAMPLE

WO2014037552A1 METHOD FOR IDENTIFYING SUBGROUPS OF CIRCULATING TUMOR CELLS (CTCS) IN THE CTC POPULATION OF A BIOLOGICAL SAMPLE | from Flow Cytometry to Cytomics | Scoop.it
From w.pat.tc - March 15, 2014 3:05 PM
WIPO patent: The invention generally relates to the field of individualized medicine. (Method For Identifying Subgroups Of Circulating Tumor Cells (ctcs) In The Ctc Population Of A ...
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Scooped by Gilbert C FAURE
February 21, 2014 1:13 PM
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Single-Cell Analysis Is a Multifaceted Marketplace - Genetic Engineering News

Single-Cell Analysis Is a Multifaceted Marketplace - Genetic Engineering News | from Flow Cytometry to Cytomics | Scoop.it
From www.genengnews.com - February 21, 2014 6:55 AM
Single-Cell Analysis Is a Multifaceted Marketplace
Genetic Engineering News
In this report we provide an update on CTCs as a special case of SCA wherein some clinical utility of CTC measurements has been demonstrated.
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Scooped by Gilbert C FAURE
January 9, 2015 2:24 PM
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CTC Testing Offers Current Value and Future Promise in MBC - OncLive

CTC Testing Offers Current Value and Future Promise in MBC - OncLive | from Flow Cytometry to Cytomics | Scoop.it
From www.onclive.com - January 6, 2015 1:29 PM
Circulating tumor cell (CTC) enumeration is a strong prognostic factor in metastatic breast cancer (MBC) and predicts treatment failure.
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Scooped by Gilbert C FAURE
November 23, 2014 1:45 PM
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Epic Sciences to Present CTC-cfDNA Method for Lung Cancer Analysis - Lung Cancer News Today

Epic Sciences to Present CTC-cfDNA Method for Lung Cancer Analysis - Lung Cancer News Today | from Flow Cytometry to Cytomics | Scoop.it
From lungcancernewstoday.com - November 19, 2014 6:52 AM
Learn how Epic Sciences will Present CTC-cfDNA Method for Lung Cancer Analysis at the EORTC-NCI-AACR Symposium on Thursday, November 20.
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Scooped by Gilbert C FAURE
October 18, 2014 10:18 AM
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Many Companies Join Race to Create Novel CTC Technology - OncLive

Many Companies Join Race to Create Novel CTC Technology - OncLive | from Flow Cytometry to Cytomics | Scoop.it
From www.onclive.com - October 16, 2014 4:11 PM
At least 30 companies are seeking to develop the next generation of circulating tumor cell (CTC) technology, part of an emerging focus on analyzing the biofluids of patients with cancer as a “liquid biopsy,” particularly for solid tumors.
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Scooped by Gilbert C FAURE
August 24, 2014 12:14 PM
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Researchers Report ScreenCell® Usage for Colorectal Cancer - CTC Biomarker - PharmiWeb.com (press release)

Researchers Report ScreenCell® Usage for Colorectal Cancer - CTC Biomarker - PharmiWeb.com (press release) | from Flow Cytometry to Cytomics | Scoop.it
From www.pharmiweb.com - August 12, 2014 9:06 AM
Researchers Report ScreenCell® Usage for Colorectal Cancer - CTC Biomarker PharmiWeb.com (press release) ScreenCell headquartered in Paris France is a privately held company dedicated to provide products protocols and training support for cancer...
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Scooped by Gilbert C FAURE
July 15, 2014 2:05 PM
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Ex vivo culture of circulating breast tumor cells for individualized testing of drug susceptibility

From www.sciencemag.org - July 14, 2014 2:44 PM

Science 11 July 2014:
Vol. 345 no. 6193 pp. 216-220

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authors abstract

Circulating tumor cells (CTCs) are present at low concentrations in the peripheral blood of patients with solid tumors. It has been proposed that the isolation, ex vivo culture, and characterization of CTCs may provide an opportunity to noninvasively monitor the changing patterns of drug susceptibility in individual patients as their tumors acquire new mutations. In a proof-of-concept study, we established CTC cultures from six patients with estrogen receptor–positive breast cancer. Three of five CTC lines tested were tumorigenic in mice. Genome sequencing of the CTC lines revealed preexisting mutations in the PIK3CA gene and newly acquired mutations in the estrogen receptor gene (ESR1), PIK3CA gene, and fibroblast growth factor receptor gene (FGFR2), among others. Drug sensitivity testing of CTC lines with multiple mutations revealed potential new therapeutic targets. With optimization of CTC culture conditions, this strategy may help identify the best therapies for individual cancer patients over the course of their disease.

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Scooped by Gilbert C FAURE
June 3, 2014 2:30 PM
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Cancer Biology: Further Hindrance in CTC measurement

From islaslab.blogspot.com - May 30, 2014 12:55 AM
My partner's previous post illustrated several issues which might change the number of detected CTCs in the bloodstream. While the study of CTCs holds many possibilities, my partner made a fair point to discuss that they ...
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Xianglei WU's comment, June 7, 2014 4:46 PM
seems to weaken the comparability of CTC quantification results from different patients ?
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Scooped by Gilbert C FAURE
May 12, 2014 1:19 PM
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3D nuclear telomeric signatures define circulating tumor cells (CTCs ...

3D nuclear telomeric signatures define circulating tumor cells (CTCs ... | from Flow Cytometry to Cytomics | Scoop.it
From www.screencell.com - April 25, 2014 5:40 AM
3D nuclear telomeric signatures define circulating tumor cells (CTCs) and characterize CTC subpopulations in intermediate risk prostate cancer patients. ScreenCell.com Published on April 25th, 2014. Awe, et.al.
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Scooped by Gilbert C FAURE
May 8, 2014 3:10 PM
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Investing in CTC Testing with Biocept - Nanalyze

Investing in CTC Testing with Biocept - Nanalyze | from Flow Cytometry to Cytomics | Scoop.it
From www.nanalyze.com - May 7, 2014 8:35 AM
Nanalyze Investing in CTC Testing with Biocept Nanalyze In previous articles we discussed such companies as Apocell and Raindance Technologies that are developing blood tests that can detect cancer by looking for circulating tumor cells (CTCs) in...
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Scooped by Gilbert C FAURE
April 5, 2014 1:54 PM
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Epic Sciences | AACR14: data from Epic's CTC technology in prostate and lung cancer

Epic Sciences | AACR14: data from Epic's CTC technology in prostate and lung cancer | from Flow Cytometry to Cytomics | Scoop.it
From www.epicsciences.com - April 5, 2014 12:40 AM
Epic CTCs highlighted at 2 talks and 2 posters, concordance to tissue and epithelial plasticity discussed #AACR14
http://t.co/0bkQsA0R80
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Scooped by Gilbert C FAURE
April 1, 2014 1:55 PM
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Can Biomarker Assessment on Circulating Tumor Cells ... - MDPI.com

From www.mdpi.com - March 25, 2014 3:00 AM
Circulating tumor cell (CTC) count has prognostic significance in metastatic breast cancer, but the predictive utility of CTCs is uncertain. Molecular studies on CTCs have often been limited by a low number of CTCs isolated ...
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Scooped by Gilbert C FAURE
March 20, 2014 3:50 PM
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Characterization of Circulating Tumor Cells (CTC) From Patients With Metastatic Breast Cancer Using the CTC-Endocrine Therapy Index - Full Text View - ClinicalTrials.gov

From clinicaltrials.gov - March 19, 2014 6:09 AM
elegant trial for #biomarker correlations in #CTCs by #Janssen Dx http://t.co/nMN8rGNEID
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March 4, 2014 12:40 PM
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Adaptation of Semiautomated Circulating Tumor Cell (CTC ... - JoVE

Adaptation of Semiautomated Circulating Tumor Cell (CTC ... - JoVE | from Flow Cytometry to Cytomics | Scoop.it
From www.jove.com - February 28, 2014 2:00 PM
Detection and Isolation of Circulating Melanoma Cells using Photoacoustic Flowmetry thumbnail. Detection and Isolation of Circulating Melanoma Cells using Photoacoustic Flowmetry… Published 11/25/2011 · Monitoring Tumor ...
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