AUTOIMMUNITY
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AUTOIMMUNITY
Pathology, Diagnosis and Therapies
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Scooped by Gilbert C FAURE
October 15, 2015 2:12 PM
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Co-Positivity for Anti-dsDNA, -Nucleosome and -Histone Antibodies in Lupus Nephritis Is Indicative of High Serum Levels and Severe Nephropathy

Co-Positivity for Anti-dsDNA, -Nucleosome and -Histone Antibodies in Lupus Nephritis Is Indicative of High Serum Levels and Severe Nephropathy | AUTOIMMUNITY | Scoop.it
by Jinfeng Yang, Zhaozhen Xu, Manshu Sui, Jihua Han, Lijie Sun, Xiuzhi Jia, Haiyu Zhang, Changsong Han, Xiaoming Jin, Fei Gao, Yanhong Liu, Yang Li, Jianbin Cao, Hong Ling, Fengmin Zhang, Huan Ren Objective To characterize the significance of...
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Scooped by Gilbert C FAURE
September 26, 2015 7:21 AM
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Increased expression of IL-28RA mRNA in peripheral blood mononuclear cells from patients with systemic lupus erythematosus - Springer

Increased expression of IL-28RA mRNA in peripheral blood mononuclear cells from patients with systemic lupus erythematosus - Springer | AUTOIMMUNITY | Scoop.it
Increased expression of IL - 28RA mRNA in peripheral blood mononuclear cells from patients with systemic lupus... http://t.co/DpKzxBNnsV
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Scooped by Gilbert C FAURE
September 19, 2015 2:34 PM
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The Role of a Receptor-Ligand Pathway in Autoimmune Diseases, Lupus - Lupus News Today

The Role of a Receptor-Ligand Pathway in Autoimmune Diseases, Lupus - Lupus News Today | AUTOIMMUNITY | Scoop.it
Read more on The Role of a Receptor-Ligand Pathway in Autoimmune Diseases, Lupus
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Rescooped by Gilbert C FAURE from Immunology
September 2, 2015 4:52 AM
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Autoimmunity: Antigen presentation by B cells contributes to murine lupus : Nature Reviews Rheumatology : Nature Publishing Group


Via Marcelo de Carvalho Bittencourt
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Scooped by Gilbert C FAURE
August 17, 2015 6:22 AM
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10 Strategies to Reverse Autoimmune Disease - Huffington Post

10 Strategies to Reverse Autoimmune Disease - Huffington Post | AUTOIMMUNITY | Scoop.it
Autoimmune diseases, when taken all together, become a HUGE health burden. Among these are rheumatoid arthritis, lupus, multiple sclerosis, psoriasis, celiac disease, and thyroid disease.
Gilbert C FAURE's insight:

what laypeople learn about autoimmunity!

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Suggested by Société Francaise d'Immunologie
July 30, 2015 3:44 PM
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Autoregulatory function of interleukin-10-producing pre-naïve B cells is defective in systemic lupus erythematosus. - PubMed - NCBI

Autoregulatory function of interleukin-10-producing pre-naïve B cells is defective in systemic lupus erythematosus. - PubMed - NCBI | AUTOIMMUNITY | Scoop.it
Arthritis Res Ther. 2015 Jul 25;17(1):190.
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Scooped by Gilbert C FAURE
July 27, 2015 4:41 AM
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Temple University scientists make breakthrough in lupus research | USA TODAY ... - USA TODAY College

Temple University scientists make breakthrough in lupus research | USA TODAY ... - USA TODAY College | AUTOIMMUNITY | Scoop.it
The team found that biofilm -- or bacterial communities in the body -- may provoke the onset of the disease.
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Scooped by Gilbert C FAURE
July 21, 2015 5:11 AM
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Genome-Wide Assessment of Differential DNA Methylation Associated with Autoantibody Production in Systemic Lupus Erythematosus

Genome-Wide Assessment of Differential DNA Methylation Associated with Autoantibody Production in Systemic Lupus Erythematosus | AUTOIMMUNITY | Scoop.it
by Sharon A. Chung, Joanne Nititham, Emon Elboudwarej, Hong L. Quach, Kimberly E. Taylor, Lisa F. Barcellos, Lindsey A.
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Scooped by Gilbert C FAURE
July 11, 2015 1:32 AM
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Microbial Biofilms Connected To Autoimmune Diseases Lupus News Today - Lupus News Today

Microbial Biofilms Connected To Autoimmune Diseases Lupus News Today - Lupus News Today | AUTOIMMUNITY | Scoop.it
Read about how biofilms might affect and trigger autoimmune responses in the host, leading to autoimmune diseases like systemic lupus erythematosus.
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Scooped by Gilbert C FAURE
June 29, 2015 8:49 AM
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Novel Autoantigens Associated with Lupus Nephritis

Novel Autoantigens Associated with Lupus Nephritis | AUTOIMMUNITY | Scoop.it
by Sachiko Onishi, Endy Adnan, Jun Ishizaki, Tatsuhiko Miyazaki, Yuki Tanaka, Takuya Matsumoto, Koichiro Suemori, Masachika Shudou, Takafumi Okura, Hiroyuki Takeda, Tatsuya Sawasaki, Masaki Yasukawa, Hitoshi Hasegawa Systemic lupus erythematosus...
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Scooped by Gilbert C FAURE
June 18, 2015 5:19 AM
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Longitudinal analysis of peripheral blood T cell receptor diversity in patients with systemic lupus erythematosus by next-generation sequencing

IntroductionT cells play an important role in the pathogenesis of systemic lupus erythematosus (SLE). Clonal expansion of T cells correlating with disease activity has been observed in peripheral blood (PB) of SLE subjects.
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Scooped by Gilbert C FAURE
June 15, 2015 4:22 AM
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Suppression of autoimmunity by CD5 + IL-10-producing B cells in lupus-prone ... - Nature.com

Suppression of autoimmunity by CD5 + IL-10-producing B cells in lupus-prone ...
Nature.com
Systemic lupus erythematosus is a complex autoimmune disorder characterized by the production of pathogenic anti-nuclear antibodies.
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Scooped by Gilbert C FAURE
June 10, 2015 4:47 AM
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PRECISESADS | IMI - Innovative Medicines Initiative

PRECISESADS | IMI - Innovative Medicines Initiative | AUTOIMMUNITY | Scoop.it

Inflammatory autoimmune diseases such as rheumatoid arthritis and lupus affect 1-3% of the population, and while treatments exist, these are costly and have a number of serious side effects. There is growing evidence that many of these conditions may be incorrectly classified. The PRECISESADS project will study 2 500 people with various autoimmune diseases, gathering data on the molecular causes of their disease as well as their clinical symptoms. Using this information, they will pave the way for a new classification of these diseases, something that will allow doctors to offer patients more personalised treatments at an earlier stage of their disease.

 
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Scooped by Gilbert C FAURE
October 12, 2015 1:03 PM
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ImmunArray launches SLE-key Rule-Out test for lupus patients - News-Medical.net

ImmunArray launches SLE-key Rule-Out test for lupus patients - News-Medical.net | AUTOIMMUNITY | Scoop.it
Following a limited three-month trial period in which more than one hundred and fifty patients with lupus-like symptoms were tested for the difficult-to-diagnose disease, a new blood test for lupus is being rolled out nationally.
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Scooped by Gilbert C FAURE
September 26, 2015 3:14 AM
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Elevated Concentrations of Serum Immunoglobulin Free Light Chains in Systemic Lupus Erythematosus Patients in Relation to Disease Activity, Inflammatory Status, B Cell Activity and Epstein-Barr Vir...

Elevated Concentrations of Serum Immunoglobulin Free Light Chains in Systemic Lupus Erythematosus Patients in Relation to Disease Activity, Inflammatory Status, B Cell Activity and Epstein-Barr Vir... | AUTOIMMUNITY | Scoop.it
by Anette H. Draborg, Magnus C. Lydolph, Marie Westergaard, Severin Olesen Larsen, Christoffer T.
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Scooped by Gilbert C FAURE
September 13, 2015 1:31 PM
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JHDM1D and HDAC1-3 mRNA expression levels in peripheral blood mononuclear cells of patients with systemic lupus erythematosus. - PubMed - NCBI

JHDM1D and HDAC1-3 mRNA expression levels in peripheral blood mononuclear cells of patients with systemic lupus erythematosus. - PubMed - NCBI | AUTOIMMUNITY | Scoop.it
Z Rheumatol. 2015 Sep 9. [Epub ahead of print]
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Scooped by Gilbert C FAURE
August 23, 2015 3:00 PM
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Autoregulatory function of interleukin-10-producing pre-naïve B cells is defective in systemic lupus erythematosus

IntroductionPre-naïve B cells represent an intermediate stage in human B-cell development with some functions of mature cells, but their involvement in immune responses is unknown.
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Scooped by Gilbert C FAURE
August 16, 2015 4:21 AM
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Pathophysiology of cutaneous lupus erythematosus

The pathophysiology of cutaneous lupus erythematosus (CLE) encompasses the complex interactions between genetics, the environment, and cells and their products.
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Scooped by Gilbert C FAURE
July 27, 2015 8:45 AM
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Genome-Wide Assessment of Differential DNA Methylation Associated with Autoantibody Production in Systemic Lupus Erythematosus. - PubMed - NCBI

Genome-Wide Assessment of Differential DNA Methylation Associated with Autoantibody Production in Systemic Lupus Erythematosus. - PubMed - NCBI | AUTOIMMUNITY | Scoop.it
PLoS One. 2015 Jul 20;10(7):e0129813. doi: 10.1371/journal.pone.0129813.
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Scooped by Gilbert C FAURE
July 21, 2015 5:20 AM
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Functional analyses of polymorphic variants of human terminal deoxynucleotidyl ... - Nature.com

Functional analyses of polymorphic variants of human terminal deoxynucleotidyl ...
Nature.com
Absence of TdT in inbred mice has been shown to correlate with decreased severity of autoimmune diseases, such as lupus and diabetes.
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Scooped by Gilbert C FAURE
July 14, 2015 12:52 AM
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Autoantigen microarrays reveal autoantibodies associated with proliferative nephritis and active disease in pediatric systemic lupus erythematosus

IntroductionPediatric systemic lupus erythematosus (pSLE) patients often initially present with more active and severe disease than adults, including a higher frequency of lupus nephritis.
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Scooped by Gilbert C FAURE
July 8, 2015 5:20 AM
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Impact of the Gut Metagenome on Autoimmunity

Impact of the Gut Metagenome on Autoimmunity | AUTOIMMUNITY | Scoop.it
Dr. Diane Kamen is investigating whether microbes in the gut are capable of contributing to the development of lupus in African Americans with a genetic predisposition for the disease.
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Scooped by Gilbert C FAURE
June 21, 2015 4:30 AM
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Autoantibody to MDM2: A Potential Serological Marker of Systemic Lupus Erythematosus. - PubMed - NCBI

Autoantibody to MDM2: A Potential Serological Marker of Systemic Lupus Erythematosus. - PubMed - NCBI | AUTOIMMUNITY | Scoop.it
J Immunol Res. 2015;2015:963568. doi: 10.1155/2015/963568. Epub 2015 May 18.
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Scooped by Gilbert C FAURE
June 16, 2015 5:31 AM
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C1q rs292001 polymorphism and C1q antibodies in juvenile lupus and their relation to lupus nephritis

C1q rs292001 polymorphism and C1q antibodies in juvenile lupus and their relation to lupus nephritis | AUTOIMMUNITY | Scoop.it
Rheumatology Article: C1q rs292001 polymorphism and C1q antibodies in juvenile lupus and their relation to lupus nephritis
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Suggested by Société Francaise d'Immunologie
June 12, 2015 2:07 PM
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Concordance of Increased B1 Cell Subset and Lupus Phenotypes in Mice and Humans Is Dependent on BLK Expression Levels [AUTOIMMUNITY]

Polymorphisms in the B lymphoid tyrosine kinase (BLK) gene have been associated with autoimmune diseases, including systemic lupus erythematosus, with risk correlating with reduced expression of BLK.
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