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Read more about viral infections and type 1 diabetes development in the fetus. 
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by Lilia Maneva-Radicheva, Christina Amatya, Camille Parker, Jacob Ellefson, Ilian Radichev, Arvind Raghavan, Matthew L. Charles, Mark S. Williams, Mark S. Robbins, Alexei Y.
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β-Glucans are naturally occurring polysaccharides in cereal grains, mushrooms, algae, or microbes, including bacteria, fungi, and yeast. Immune cells recognize these β-glucans through a cell surface pathogen recognition receptor called Dectin-1.
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Researchers have for the first time observed immune cells in the pancreas of a type 1 diabetes patient, allowing them to watch as the cells attack and destroy the body’s insulin-producing molecules.
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Genetic associations and functional characterization of M1 aminopeptidases and ...
Gilbert C FAURE's insight:
A series of genome-wide association studies have demonstrated associations of these aminopeptidases with a range of immune-mediated diseases such as ankylosing spondylitis, psoriasis, Behçet’s disease, inflammatory bowel disease and type I diabetes, and significantly, genetic interaction between some aminopeptidases and HLA Class I loci with which these diseases are strongly associated.
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The mechanisms behind destruction of the adrenal glands in autoimmune Addison’s disease remain unclear.
Gilbert C FAURE's insight:
specific T cells, as in diabetes?
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Increasing evidence suggests that type 1 IFN (IFN-αβ) is associated with pathogenesis of Th1-mediated type 1 diabetes (T1D). A major source of IFN-αβ is plasmacytoid dendritic cells (pDCs).
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Plasmonic chip diagnoses diabetes nanotechweb.org T1D is different from T2D in that patients with the disorder have a much higher concentration of autoantibodies against one or more so-called pancreatic islet antigens (such as insulin, glutamic...
Gilbert C FAURE's insight:
with more technical details than the press release
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Genetic Engineering News
Gilbert C FAURE's insight:
bis, out of a large series of posts
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Nice explanation of research developments in autoantibody testing, in ppl at risk of developing type 1 #diabetes http://t.co/jhqv1JyuzJ
Gilbert C FAURE's insight:
nice review on type I diabetes immunology
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Stanford researchers believe microchip holds key to diabetes diagnoses
Société Francaise d'Immunologie's comment,
July 16, 2014 8:36 AM
What we have done is use state-of-the-art technology to come up with a cheap test that uses just a drop of blood and tells people in hours if they have autoantibodies or not.
We really think this technology can be pushed to the bedside very quickly to diagnose between type 1 and type 2. These autoantibodies are the final say in type 1 diabetes? There are basically three autoantibodies that we can measure, simultaneously, and their risk is cumulative. If you have one present, your risk is increased 10 to 20 percent; if all three are present, you have greater than 90 percent risk of developing diabetes in the future.
Société Francaise d'Immunologie's comment,
July 16, 2014 8:37 AM
it is not so difficult with IF technology, and cheaper in europe?
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OBJECTIVE Previous studies demonstrated that the anti-CD3 monoclonal antibody otelixizumab, administered at a total dose of 48–64 mg, can slow the loss of C-peptide in recent-onset type 1 diabetes patients, with frequent ...
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Endocrinology Medical Article: Human mesenchymal stem cell-derived microvesicles modulate T cell response to islet antigen glutamic acid decarboxylase in patients with type 1 diabetes (Human mesenchymal stem cell-derived microvesicles modulate T...
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by Tom L. Van Belle, An-Sofie Vanherwegen, Dorien Feyaerts, Pierre De Clercq, Annemieke Verstuyf, Hannelie Korf, Conny Gysemans, Chantal Mathieu The emergence of regulatory T cells (Tregs) as central mediators of peripheral tolerance in the immune...
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(Medical Xpress)—What do rheumatoid arthritis, type I diabetes, myasthenia gravis, multiple sclerosis, rheumatic heart disease, and narcolepsy have in common?
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Endocrinology Medical Article: Enterovirus RNA in longitudinal blood samples and risk of islet autoimmunity in children with a high genetic risk of type 1 diabetes: the MIDIA study (Enterovirus RNA in longitudinal blood samples and risk of islet...
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The cytokine production of PBMCs reflects the autoantibody profile of patients suffering from type 1 diabetes http://t.co/ZsTheTkLcm
Gilbert C FAURE's insight:
... demonstrated a significant interaction between the patient’s autoantibody profile and mode of stimulation. This suggests that autoantigen stimulation has a different effect on different groups of patients depending on their autoantibody profile. An increased production of IL17 was found in patients with high IA2 autoantibodies compared to patients with low levels of autoantibodies and healthy controls regardless of the mode of stimulation. The titre of IA2 autoantibodies positively correlates with the proportion of Tc lymphocytes and negatively correlates with the proportion of Th lymphocytes.
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FDA allows marketing of first ZnT8Ab autoantibody test to help diagnose type 1 ...
Gilbert C FAURE's insight:
diabetes
Société Francaise d'Immunologie's comment,
August 22, 2014 5:38 AM
a novel anti-CAF-1 autoantibody is frequently found in patients with SLE and is a useful biomarker for diagnosis, especially in cases with CNS involvement.
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A highly sensitive microsphere-based assay for early detection of Type I diabetes Science Codex This is a concept showing microsphere based detection of an Islet Cell Autoantibody (ICA) - Glutamic Acid Decarboxylase (GAD65) using Rolling Circle...
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by Ingrid Kikkas, Roberto Mallone, Etienne Larger, Hervé Volland, Nathalie Morel
Gilbert C FAURE's insight:
In the current study, they describe the development of a novel LFIA for detection of IA-2As.... this could be the first LFIA format described, detecting T1D-associated autoantibodies in human serum samples.
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JDRF Partner ViaCyte Announces Key Project Milestone to Advance Innovative ...
Gilbert C FAURE's insight:
for type 1 diabetes
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Gilbert C FAURE's insight:
The new PEPperCHIP® Autoimmune Epitope Microarray 2.0 now covers 3,359 linear autoimmune epitopes including 192 citrullinated peptides as well as the corresponding arginine variants. The IEDB-derived epitopes correlate with a variety of autoimmune diseases including Crohn’s disease, diabetes mellitus, multiple sclerosis, rheumatoid arthritis, Sjögren’s syndrome, systemic lupus erythematosus, vitiligo and many more.
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IMI2 1st call for proposals 2014
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A plasmonic chip for biomarker discovery and diagnosis of type 1 diabetes
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An inexpensive, portable, microchip-based test for diagnosing type-1 diabetes could improve patient care worldwide and help researchers better understand the disease, according to the device's inventors at the Stanford University School of Medicine.
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