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Scooped by
Ed Rybicki
January 19, 2023 6:04 AM
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Cann's Principles of Molecular Virology, - 7th Edition, revised by EP Rybicki. Print Book. ISBN 9780128227848. Now published!!
"Cann's Principles of Molecular Virology, Seventh Edition provides an easily accessible introduction to modern virology, presenting principles in a clear and concise manner. The new edition provides the history of virology and the fundamentals of the molecular basis of how viruses work.
Instructor review copies: click on this link. https://protect-za.mimecast.com/s/qU2qCNxKq0i0ZNRQxcmeDdo
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Scooped by
Ed Rybicki
January 21, 6:05 AM
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Through new experiments, researchers in Japan and Germany have recreated the chemical conditions found in the subsurface ocean of Saturn's moon, Enceladus. Published in Icarus, the results show that these conditions can readily produce many of the organic compounds observed by the Cassini mission, strengthening evidence that the distant world could harbor the molecular building blocks of life.
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Scooped by
Ed Rybicki
January 21, 6:02 AM
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Bacteriophages have been used therapeutically to treat infectious bacterial diseases for over a century. As antibiotic-resistant infections increasingly threaten public health, interest in bacteriophages as therapeutics has seen a resurgence. However, the field remains largely limited to naturally occurring strains, as laborious strain engineering techniques have limited the pace of discovery and the creation of tailored therapeutic strains.
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Scooped by
Ed Rybicki
January 21, 6:01 AM
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Eukaryotic cells regulate gene expression through multiple checkpoints, including post-transcriptional mechanisms mediated by microRNAs (miRNAs). These small non-coding RNAs inhibit translation by binding to target mRNAs, often within a complex regulatory network involving other RNA species such...
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Scooped by
Ed Rybicki
January 21, 6:00 AM
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The mpox virus appears to be circulating silently in parts of Nigeria, in many cases without the symptoms typically associated with the disease, according to new research led by scientists from the University of Cambridge and partners in Nigeria.
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Scooped by
Ed Rybicki
January 21, 6:00 AM
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A recent study by geophysicists at Washington State University offers insight into how nutrients may reach the subsurface ocean of Europa, one of Jupiter's moons and a leading candidate for extraterrestrial life in the solar system.
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Scooped by
Ed Rybicki
January 21, 5:57 AM
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"A plague is upon us'' may have been a common phrase in ancient Jordan, where countless people perished from a mysterious malady that would shape both a society and an era of civilization.
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Scooped by
Ed Rybicki
January 21, 5:55 AM
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This study examined mitochondrial and nuclear-encoded mitochondrial DNA methylation in Indian patients with severe COVID-19 and found region-specific differential methylation linked to disease severity.
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Scooped by
Ed Rybicki
January 21, 5:54 AM
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In a multi-institutional study published today in Nature Nanotechnology, researchers from The University of Texas MD Anderson Cancer Center reported that engineered bispecific nanobodies successfully strengthened mucosal defenses in the respiratory tract, improving protection against influenza...
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Scooped by
Ed Rybicki
November 29, 2025 6:17 AM
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The only wild specimens of a rare blue parrot, which were recently returned to their natural habitat, have been diagnosed with an incurable, likely lethal virus, Brazil's government told AFP Thursday.
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Scooped by
Ed Rybicki
November 29, 2025 6:16 AM
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The importance of peripheral immunity in Alzheimer disease has gained much traction in recent years, mainly due to multiple genome-wide association studies identifying risk loci associated with genes expressed predominantly in the periphery.
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Scooped by
Ed Rybicki
November 29, 2025 6:14 AM
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Inside cells, RNAs and proteins form tiny, liquid-like droplets called biomolecular condensates. These droplets are essential for organizing cellular life, yet why some RNAs cluster more readily than others has remained unclear. Disruptions in condensate formation are linked to developmental defects, cancer, and neurodegenerative diseases.
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Scooped by
Ed Rybicki
November 29, 2025 6:12 AM
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"The risk following vaccination is substantially lower than the risk following infection".
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Scooped by
Ed Rybicki
January 21, 6:06 AM
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MicroRNAs, whose discovery was recognized with the 2025 Nobel Prize in Physiology or Medicine, are central regulators of gene expression, yet a fundamental question has remained unanswered: how cells choose between the two strands produced from each microRNA precursor.
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Scooped by
Ed Rybicki
January 21, 6:03 AM
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In a significant advance for COVID-19 treatment, recent findings emerged from the double-blind randomized placebo-controlled COMCOVID trial, which evaluated the efficacy of Tiprelestat in hospitalized patients.
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Scooped by
Ed Rybicki
January 21, 6:01 AM
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There are limited data on mpox immunity in West Africa. In this study, authors present serological and genomic evidence of residual smallpox vaccination immunity and possibly unrecognized mpox exposure among ostensibly healthy Nigerian adults.
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Scooped by
Ed Rybicki
January 21, 6:01 AM
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In the intricate battlefield of viral infections, microRNAs (miRNAs) have emerged as pivotal regulators orchestrating immune responses.A recent comprehensive review sheds light on the profound roles of miRNAs in modulating immunity across four major viral pathogens: SARS-CoV-2, Hepatitis B virus ...
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Scooped by
Ed Rybicki
January 21, 6:00 AM
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Ayaka Monoi and colleagues model the benefits and risks of maternal RSV vaccination by gestational age and show that benefits outweigh risks with vaccination from the third trimester.
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Scooped by
Ed Rybicki
January 21, 5:57 AM
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Challenging long-held assumptions, Aarhus University researchers have demonstrated that the protein building blocks essential for life as we know it can form readily in space. This discovery, appearing in Nature Astronomy, significantly raises the statistical probability of finding extraterrestrial life.
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Scooped by
Ed Rybicki
January 21, 5:56 AM
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Light is a universal stimulus that influences all living things. Cycles of light and dark help set the biological clocks for organisms ranging from single-celled bacteria to human beings. Some bacteria use photosynthesis to convert sunlight into energy just like plants, but other bacteria sense light for less well-known functions.
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Scooped by
Ed Rybicki
January 21, 5:54 AM
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Monophosphorylation is a key rate-limiting step for the efficacy of broad-spectrum nucleoside antiviral drugs, and designing phosphate prodrugs is an …...
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Scooped by
Ed Rybicki
November 29, 2025 6:21 AM
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Background/Objectives: Beak and feather disease virus (BFDV) is the causative agent of psittacine beak and feather disease (PBFD), affecting psittacine birds. There is currently no commercial vaccine or treatment for this disease. This study developed a novel BFDV coat protein mRNA vaccine encapsidated by TMV coat protein to form pseudovirions (PsVs) and tested its immunogenicity alongside BFDV coat protein (CP) subunit and DNA vaccine candidates. Methods: mRNA and BFDV CP subunit vaccine candidates were produced in Nicotiana benthamiana and subsequently purified using PEG precipitation and gradient ultracentrifugation, respectively. The DNA vaccine candidate was produced in E. coli cells harbouring a plasmid with a BFDV1.1mer pseudogenome. Immunogenicity of the vaccine candidates was evaluated in African grey parrot chicks. Results: Successful purification of TMV PsVs harbouring the mRNA vaccine, and of the BFDV-CP subunit vaccine, was confirmed by SDS-PAGE and western blot analysis. TEM analyses confirmed formation of TMV PsVs, while RT-PCR and RT-qPCR cDNA amplification confirmed encapsidation of the mRNA vaccine candidate within TMV particles. Restriction digests verified presence of the BFDV1.1mer genome in the plasmid. Four groups of 5 ten-week-old African grey parrot (Psittacus erithacus) chicks were vaccinated and received two boost vaccinations 2 weeks apart. Blood samples were collected from all four groups on day 14, 28 and 42, and sera were analysed using indirect ELISA, which showed that all vaccine candidates successfully elicited specific anti-BFDV-CP immune responses. The subunit vaccine candidate showed the strongest immune response, indicated by higher binding titres (>6400), followed by the mRNA and DNA vaccine candidates. Conclusions: The candidate vaccines present an important milestone in the search for a protective vaccine against PBFD, and their inexpensive manufacture could considerably aid commercial vaccine development.
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Scooped by
Ed Rybicki
November 29, 2025 6:16 AM
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This Analysis benchmarks 50 state-of-the-art TCR–epitope binding prediction methods and evaluates key factors that influence predictive performance.
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Scooped by
Ed Rybicki
November 29, 2025 6:16 AM
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Experts warn the H5 bird flu strain could spark a pandemic more severe than Covid-19 as global surveillance intensifies amid rising concerns. Find out what happened.
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Scooped by
Ed Rybicki
November 29, 2025 6:13 AM
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Despite the ubiquity of cats in modern homes, we still don't know many details about the timing and routes of early cat domestication and dispersal into Europe and beyond, aside from the common association of cats with ancient Egyptian culture.
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Scooped by
Ed Rybicki
November 29, 2025 6:12 AM
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You may not realize you’ve benefited from HIV research. But if you’ve received a treatment that was approved through a recent clinical trial, received a CAR T cell for your cancer, or even just taken Paxlovid, you have.
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