Experimental studies in guinea pigs demonstrated that influenza virus transmission is strongly modulated by temperature and humidity. A number of epidemiological studies have followed up on these findings and revealed robust associations between influenza ...

A new study examined electronic health records for approximately half the population of Denmark, looking for people with a diagnosis of COVID-19 or hospitalized with community-acquired pneumonia.

The FDA will rely on data from clinical trials of COVID-19 vaccine boosters against the BA.1 version of the omicron variant to evaluate boosters against the BA.4 and BA.5 variants.

The test will inoculate 100 volunteers with a vaccine that protected mice from lethal doses of six different flu strains...

This paper reports the first cases of pigeon circovirus infection in Belgium. Five pigeons were necropsied and specific lesions with inclusions bod...

An inhalable virus-like-particle consisting of exosomes decorated with a recombinant SARS-CoV-2 receptor-binding domain is stable at room temperature and elicits systemic and mucosal immune responses in small animals.

New research clarifies how some people develop T-cell acute lymphoblastic leukemia.

Omicron subvariants BA.4 and BA.5 appear to escape antibody responses among both people who had previous Covid-19 infection and those who have been fully vaccinated and boosted, according to new data from researchers at Beth Israel Deaconess Medical Center, of Harvard Medical School.

As I said in Marburg, the Pan-African Vaccine Manufacturing Project fits perfectly with Ghana’s roadmap for domestic vaccine development and manufacturing. Ghana is ready to play her role, and I reaffirm, once again, her determination to make the project work successfully.

What do these cases really tell us about the virus, which hasn't spread in the UK for decades?

The disease is a leading killer of under fives across Africa.But trials for a new vaccine suggest an end to the death toll could be in sight...

"For reasons that remain uncertain, women can experience heart disease differently than men." A gene called RAP1GAP2 may clarify why.

Several human pathogens exhibit distinct patterns of seasonality and circulate as pairs. For instance, influenza A virus subtypes oscillate and peak during winter seasons of the world’s temperate climate zones.

medRxiv - The Preprint Server for Health Sciences...

A Q&A with top Japanese virologist Hitoshi Oshitani about reopening tourism, future strains of Covid and the post-pandemic world.

Observations of song learning among humpback whales indicate "a level of 'cultural transmission' beyond any observed non-human species."...

Herpes zoster which is the reactivation of varicella-zoster virus, a pathogenic human alpha-herpes virus, following primary infection or chicken pox, is known to occur especially in advanced age an...

GSK Plc is planning to launch a COVID shot that comes almost two years after Pfizer Inc. took the world by storm. For Phil Dormitzer, it’s a reminder of why he was hired at the UK drugmaker: to help return its immunization business to the top after it stumbled during the pandemic.

The virus-like particles (VLPs) of porcine circovirus type 2 (PCV2) is an attractive vaccine candidate that retains the natural conformation of the virion but lacks the viral genome to replicate, thus balancing safety and immunogenicity.

Preguntas frecuentesManual de usoDerechos de autorContacto/Sugerencias Whole genome, transcriptome, smallRNAome and methylome profiling during tomato-geminivirus interaction Autor Romero-Rodríguez, Beatriz; Kriznik, Maja; Morilla, Ian; Petek, Marko; Jiao, Chen; [et al.] Fecha 2022 Palabras clave Virus fitopatógenos; Tomates - Enfermedades y plagas Resumen Geminiviruses constitute the largest family of plant-infecting viruses with small, single- stranded DNA genomes that replicate through double-stranded DNA intermediates. Because of their limited coding capacity, geminiviruses use plant nuclear machinery to amplify their genomes, which are packaged into nucleosomes forming chromatin as multiple circular minichromosomes. Thus, viral minichromosomes must encounter the nuclear pathways that regulate host gene expression and chromatin states. DNA methylation and post-transcriptional gene silencing play critical roles in controlling infection of geminiviruses and this pathogen can counteract these host defense mechanisms and promote its infectivity. Tomato Yellow Leaf Curl Virus (TYLCV) belongs to the Begomovirus genus and is transmitted by the whitefly Bemisia tabaci. With only seven viral proteins, TYLCV must create a proper environment for viral replication, transcription, and propagation. Behind the apparent simplicity of geminiviruses lies a complex network of molecular interactions with their host and their natural vector, which induces a wide variety of transcriptional, post-transcriptional and chromatin changes in the host. To better understand this virus-host interaction at a genetic and epigenetic level we carried out a global approach of the TYLCV-tomato interaction to generate integrated single-base resolution maps by Next-Generation Sequencing of the transcriptome, smallRNAome and methylome of the pathogen and the host. Total RNA and DNA was extracted from tomato–infected plants (three biological replicates) and analysed at 2, 7, 14 and 21-day post-infection (dpi). Analysis of the changes in host transcription during the infection and its correlation with changes in sRNA profiles (microRNA and phasiRNA) and DNA methylation patterns will be presented and discussed. URI https://hdl.handle.net/10630/24432 Compartir Mostrar el registro completo del ítem Ficheros abs_libro_omics.pdf (37.69Kb) Colecciones BCGF - Contribuciones a congresos científicos Estadísticas Ver Estadísticas de uso Buscar en Dimension

Colorectal, pancreatic, esophageal and stomach cancers—some of the deadliest kinds of cancer—have high recurrence rates where the cancer comes back even after successful surgery or radiation treatment.

A new study estimates that the number is greater than the population of Chile | Graphic detail...

A new study finds that flu vaccination was associated with a 40% reduced risk for Alzheimer’s disease over a four-year period.Over the course of four...

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Four porcine circoviruses (PCVs) have been discovered over time and seem to share a common history, particularly for PCV-2 and -3.Despite being reported as apparently new viruses, rapidly emerging as a threat for the worldwide swine industry, they were then proven to have been circulating and coexi...