In this chapter, the scientists describe a protocol of ex vivo delivery of growth factors via lentiviral vector-mediated genetic modification of human mesenchymal stem cells (hMSCs) transplantation into the skeletal muscle of a familial l amyotrophic lateral sclerosis (ALS)rat model. They show that intramuscular growth factor delivery via hMSCs can enhance neuromuscular innervation and motor neuron survival in a rat model of ALS
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In this chapter, the scientists describe a protocol of ex vivo delivery of growth factors via lentiviral vector-mediated genetic modification of human mesenchymal stem cells (hMSCs) transplantation into the skeletal muscle of a familial l amyotrophic lateral sclerosis (ALS)rat model. They show that intramuscular growth factor delivery via hMSCs can enhance neuromuscular innervation and motor neuron survival in a rat model of ALS
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