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Vectorology - GEG Tech top picks
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BigField GEG Tech's insight:
In order to know the role ofPlatelet-derived growth factor-BB (PDGF-BB), the authors performed it knockdown in cultured cardiomyocytes thanks to a lentiviral vectors which expresses shRNA. They observed that the number of apoptotic cells and the level of LDH were significantly increased and that the beat rhythm was reduced. 
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The author show generation and cardiomyocyte differentiation potential of iPS cells from thymic epithelial cells of a patient with ventricular septal defect (VSD) by overexpressing the four factors: OCT4, SOX2, NANOG, and LIN28 with lentiviral vectors. The self-renewal and pluripotency of the VSD-iPS cells was verified in iPS cells by in vitro expression of pluripotency markers and formation of teratoma in vivo.
www.geg-tech.com/Vectors