Vectorology - GEG Tech top picks

In this study, the authors used lentiviral vectors to investigated the protective effect of SIRT3 for Parkinson’s disease (PD) cell model. They observe that SIRT3 knockdown significantly worsen rotenone-induced decline of cell viability and enhanced cell apoptosis, exacerbated the decrease of SOD and GSH, and augmented the accumulation of α-synuclein. While SIRT3 overexpression dramatically increased cell viability, and decreased cell apoptosis, prevented the accumulation of α-synuclein, suppressed the reducing of SOD and GSH, decreased ROS generation. These results show that SIRT3 has neuroprotective effect in PD cell model and suggest that it could be developed into a therapeutic agent for PD patients.