Vectorology - GEG Tech top picks

The authors showed that pharmacological stimulation of A2A receptors or injection of lentiviral vectors expressing the A2A receptor into white fat induces brown-like cells. Importantly, mice fed a high-fat diet and treated with an A2A agonist are leaner with improved glucose tolerance. These results demonstrate that adenosine–A2A signalling plays an unexpected physiological role in sympathetic BAT activation and protects mice from diet-induced obesity. Those findings reveal new possibilities for developing novel obesity therapies.

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