In this episode of SMILEFactor, we explore the critical role of adult learning in personal and professional growth. From professional development to lifelong learning strategies, we’ll dive into why investing in adults as learners is key to fostering innovation, adaptability, and success in any...
December 4, 2024//ResearchESM Cambrian: Revealing the mysteries of proteins with unsupervised learningStart with ESM C on Github Provision on SageMaker Today we’re introducing ESM Cambrian, a next generation language model trained on protein sequences at the scale of life on Earth. ESM C models define a new state of the art for protein representation learning.Unsupervised learning for scientific discoveryAI is beginning to unlock an era of digital biology where we can use computation to go beyond the limits of experiments in the physical world. The universe of protein function is so vast and complex that we lack the ability to fully characterize it experimentally, and for many applications, we need to engineer functions that go beyond those in nature.The physical limitations of performing experiments in the real world mean that unsupervised learning—algorithms that can learn from patterns in unlabeled data—is critical to unlocking the promise of digital biology. Discovering scalable techniques that can learn directly from protein sequences can illuminate biology at a level not yet possible with experimental characterization.ESM CambrianESM Cambrian is a parallel model family to our flagship ESM3 generative models. While ESM3 focuses on controllable generation of proteins for therapeutic and many other applications, ESM C focuses on creating representations of the underlying biology of proteins. ESM C scales up data and training compute to deliver dramatic performance improvements over ESM2.ESM2 and its predecessor models have been used in a wide range of applications across basic scientific discovery, development of medicines, and sustainability, including a covid early warning system, state of the art models for protein design, and antibody optimization. ESM C is a drop-in replacement for previous models that provides major improvements in both capability and efficiency.ESM C models are available immediately for academic and commercial use under a new license structure designed to promote openness and enable scientists and builders.ESM C is trained at three scales: 300M, 600M, and 6B parameters. We’re releasing ESM C 300M, and 600M as open weight models. ESM C 6B is available on Forge for academic use, and AWS Sagemaker for commercial use. ESM C will also be available on NVIDIA BioNemo soon. ESM models are always available for academic use for basic research.Our frontier ESM3 models remain available for commercial use through partnerships to advance AI for drug discovery and other specific applications.A preprint describing the new models is coming soon. In the meantime get started building with ESM C. We’re excited to see what you create!Defining a new frontier of performanceSince the introduction of ESM1, the first large transformer language model for proteins, ESM models have consistently defined the state of the art. Now we’re introducing a new generation of ESM models, ESM C, with major performance benefits over ESM2. ESM C achieves linear scaling across orders of magnitude in parameters, with each model matching, or even greatly exceeding, the performance of larger models of the previous generation. For example, the 300M parameter ESM C delivers similar performance to ESM2 650M with reduced memory requirements and faster inference. The 600M parameter ESM C rivals the 3B parameter ESM2 and approaches the performance of the 15B model. The 6B parameter ESM C sets a new benchmark, outperforming the best ESM2 models by a wide margin.Learning biology from protein sequencesLanguage models are trained to predict the words or characters in a sequence. ESM C is trained using a masked language modeling objective, which requires the model to predict characters that have been masked out from their surrounding context.Just as a person can fill in the blanks, such as:To __ or not to __ that is the ___ We can train language models to fill in the blanks. Except in biology, instead of training the model to predict words, we train it to predict the characters in a protein sequence, i.e. its sequence of amino acids:MSK_EEL_TG_VPILVELD_DVNGH_FSVS__GEGDA_YGThe patterns in protein sequences are linked to their underlying biological properties. Like a beam of light that shows an image of an object through its shadow, evolution encodes the biology of proteins into their sequences. This is because evolution is only free to select mutations to the sequence that are consistent with the biological function of the protein.As language models learn to predict the patterns across many diverse protein sequences, information emerges within their internal representations that reflects the underlying biology of proteins. The information emerges through unsupervised learning, without the model ever seeing structure or function directly. Through the task of predicting amino acids, language models develop representations that reflect the hidden biological variables that determine which amino acids evolution chooses. The ability to learn structure and function from unlabeled sequence data means that language models can in principle scale far beyond existing AI approaches that only learn from structural or functional data.Scaling laws link the emergence of information about the biology of proteins with the scale of parameters, compute, and data. This allows the capabilities of models to be predicted as they are scaled up. ESM C demonstrates non diminishing returns to scale up to 6 billion parameters, suggesting that continued scaling will result in further improvements.ConclusionESM C is a step toward a more complete understanding of the deep and fundamental mysteries of life at the molecular level. As a practical technology, proteins have the potential to solve some of the most important problems facing our society from human health, to sustainability. Unlocking the secrets of protein molecules is making it possible to design proteins from first principles. ESM C is a foundational model for protein biology, one that can be used by builders across a wide range of applications, to imbue AI models with a deeper understanding of the biology of life’s most important and mysterious molecules.Responsible DevelopmentEvolutionaryScale is committed to the responsible development of artificial intelligence for biology. ESM C was reviewed by a committee of scientific experts who concluded that the benefits of releasing the models greatly outweigh any potential risks. As we continue to push the frontier of AI for biology, we will continue to engage with the scientific community and stakeholders in government, civil society, and policy to ensure that we can maximize the benefits and minimize the potential risks to deliver the promise of this rapidly advancing new technology.Training and EvaluationsTraining data. ESM C is trained on protein sequences from UniRef, MGnify, and the Joint Genome Institute (JGI). Sequence data is clustered at the 70% sequence identity level, resulting in 83M, 372M, and 2B clusters for UniRef, MGnify, and JGI, respectively.Architecture. ESM C is based on the transformer architecture. It features Pre-LN, rotary embeddings, and SwiGLU activations. No biases are used in linear layers or layer norms. Params # layers width # heads Context length Learning rate Batch size in tokens Num steps Total tokens FLOPs 300M 30 960 15 2048 5e-4 4.2M 1.5M 6.2T 1.26e22 600M 36 1152 18 2048 4.6e-4 4.2M 1.5M 6.2T 2.17e22 6B 80 2560 40 2048 3.1e-4 4.2M 1.5M 6.2T 2.37e23 Training stages. ESM C is trained in two stages:Stage 1: For the first 1 million steps, the model uses a context length of 512, with metagenomic data constituting 64% of the training dataset.Stage 2: In the final 500,000 steps, the context length is increased to 2048, and the proportion of metagenomic data is reduced to 37.5%.Evaluations. We use the methodology of Rao et al. to measure unsupervised learning of tertiary structure in the form of contact maps. A logistic regression is used to identify contacts. For a protein of length L, we evaluate the precision of the top L contacts (P@L) with sequence separation of 6 or more residues. The average P@L is computed on a temporally held out set of protein structures (Cutoff date: May 1, 2023) for the scaling laws, and on CASP15 for the performance benchmark.Citing ESM CESM C will be fully described in an upcoming preprint. This blog post will be updated with citation information as soon as the preprint is available. In the meantime, if necessary, you can cite:ESM Team. "ESM Cambrian: Revealing the mysteries of proteins with unsupervised learning." EvolutionaryScale Website, December 4, 2024. https://evolutionaryscale.ai/blog/esm-cambrian.Table of Contents{links are generated when publishing the site}
Laurie and Matt kick off the new podcast SMILE Factor introducing audience to the backstory of the show and introduce listeners to their journey in education.
This open access book The Living Standards of Nations provides a practical policy framework to encourage economic inclusion, sustainability and resilience.
/PRNewswire/ -- The inaugural International MICE Summit (IMS24) has delivered transformational change for the Meetings, Incentives, Conferences and Exhibitions...
GlobalData assists a leading materials provider’s strategic planning process by delivering an in-depth value chain analysis The Situation A leading materials provider wanted to understand the market dynamics and long-term drivers of aluminium demand for beverage cans. This included a focus on demand, capacity, regulatory conditions, packaging substitution and consumer behavior, with a view to understanding where they could add value across the supply chain. Our Solution Here are some examples of the in-depth value chain analysis that we provided the client: Beverage Packaging Market Overview Detailed analysis of European beverage demand, including breakdowns by country, category and packaging type. Opportunity areas for future industry growth, and macroeconomic and geopolitical threats. Aluminium Industry Trends In-depth interviews with leading industry experts across the supply chain, with key questions answered about capacity, production, imports/exports, costs and recycling. ESG Analysis Rigorous secondary research on future European waste and sustainability legislation – the businesses impacted and affects on the wider industry. Find out more about this solution Outcome The client used our custom report to gain a deeper understanding of the main issues affecting the aluminium packaging industry and the ways in which they could better support their customers. Our insights included: Prospects for Growth Leading countries and product categories which have the best prospects for growth in the years ahead. Market share opportunities Identification of opportunities and partnerships which could help the client gain market share. Understanding EU Rules & Regs A clear understanding of the legislative and regulatory environment for packaging businesses operating within the EU. “In an uncertain economic environment, consumers are taking a close look at the price they pay for FMCG products. At the same time, governments are increasingly scrutinizing the environmental impact of packaging and the companies which generate the most waste. It has never been more important to have the best data and insights to make the right strategic decisions. GlobalData has decades of experience in these areas and continues to advise some of the largest packaging and consumer businesses in the world.” Ed Barham, Director of Consulting – Packaging Consumer Custom Solutions at GlobalData Find out how GlobalData Custom Solutions can help you Our consultants work closely with you to understand requirements and develop a tailored approach and deliverables.
Custom cart packaging, particularly for vape cartridges, is a critical component in the cannabis industry.It serves multiple purposes, from protecting the product to enhancing brand recognition and…...
Transform Your Space with Expert Painters in New York Painting is one of the simplest yet most impactful ways to enhance the aesthetics of any space. Whether you want to rejuvenate your home, office, or commercial property, choosing the right painters in New York is essential.
Listen to Morgan Stanley's award-winning podcasts, featuring daily market analysis to in-depth conversations around diverse entrepreneurship, emerging trends and more.
Amy Delcorvo and Mary Beth Guthrie share all the exciting activated and learning happening at NYSCATE 24.
November 24th - 26th
Each year NYSCATE sponsors an annual statewide conference attended by 1,500 attendees and 150+ exhibitors showcasing exemplary education applications of technology.
/PRNewswire/ -- Report with market evolution powered by AI - The global maintenance repair operations (MRO) for automation solutions market size is estimated...
Budgeting is crucial for the success and sustainability of any small business. Here are some practical tips and tricks to help you manage your finances effectively:
### **1. Set Clear Financial Goals:** - **Short-Term Goals:** Define your financial goals for the next month, quarter, or year. This could include revenue targets, reducing expenses, or saving for future investments. - **Long-Term Goals:** Consider your 3-5 year goals, such as expanding your business, purchasing equipment, or opening new locations.
### **2. Understand Your Income:** - **Track Revenue:** Keep detailed records of all sources of income, including sales, services, and any other revenue streams. - **Forecasting:** Use historical data to predict future income and plan accordingly.
### **3. Categorize Expenses:** - **Fixed Expenses:** These are regular, predictable costs like rent, salaries, insurance, and utilities. - **Variable Expenses:** These costs can fluctuate, such as raw materials, marketing expenses, and travel. - **One-Time Expenses:** Occasionally, you may have significant one-time expenses, like equipment purchases or renovations.
### **4. Monitor Cash Flow:** - **Regular Updates:** Keep a close eye on your cash flow, ensuring that you have enough liquidity to cover day-to-day operations. - **Cash Flow Projections:** Forecast future cash flow to anticipate periods of surplus or deficit.
### **5. Implement a Contingency Plan:** - **Emergency Fund:** Set aside a portion of your budget as an emergency fund to cover unexpected expenses or economic downturns. - **Risk Assessment:** Identify potential risks to your business and plan how to mitigate them financially.
### **6. Use Budgeting Tools:** - **Accounting Software:** Utilize accounting software like QuickBooks, Xero, or FreshBooks to automate and streamline your budgeting process. - **Spreadsheets:** For smaller businesses, detailed spreadsheets can help track income and expenses effectively.
### **7. Regularly Review and Adjust:** - **Monthly Reviews:** Conduct monthly budget reviews to compare actual spending against your budget. Identify any discrepancies and adjust as needed. - **Yearly Analysis:** Analyze your annual financial performance and adjust your budget for the next year based on this analysis.
### **8. Reduce Costs and Increase Efficiency:** - **Cost-Cutting Measures:** Look for ways to reduce costs without compromising quality. This could include negotiating better deals with suppliers, reducing waste, or finding more cost-effective marketing strategies. - **Operational Efficiency:** Improve efficiency by streamlining processes, using technology, and training staff effectively.
### **9. Plan for Taxes:** - **Tax Obligations:** Be aware of your tax obligations and set aside funds to cover them. This includes income tax, sales tax, and any other relevant taxes. - **Professional Help:** Consider hiring an accountant or tax advisor to ensure compliance and optimize your tax strategy.
### **10. Involve Your Team:** - **Transparency:** Share your budget and financial goals with your team to create a sense of ownership and accountability. - **Collaboration:** Encourage team members to contribute ideas for cost savings and revenue generation.
By following these tips and tricks, you can create a solid budgeting foundation for your small business, helping you achieve financial stability and growth. 💰
Is there a specific area of budgeting you'd like to delve deeper into?
In the bustling world of consumer goods, custom Mylar bags have become essential for brands looking to shine. These durable, versatile, and eye-catching bags not only protect products but also tell a brand’s story. But where do brands source these custom Mylar bags? Enter BrandMyDispo, also known as brand my dispo, a trailblazer in the custom packaging industry. Let’s unravel the journey of how brands craft and acquire their custom Mylar bags through BrandMyDispo. The Creative Spark: Concept and Design Every exceptional Mylar bag starts with a burst of creativity. Brands collaborate with BrandMyDispo to transform their vision into tangible designs that captivate and protect. Here’s how the magic happens: 1. Idea Generation and Brainstorming It all kicks off with a brainstorming session. BrandMyDispo’s team dives deep with the brand to understand the product, target audience, and brand ethos. Ideas flow, sketches are made, and the foundation for the custom Mylar bag is set. 2. Digital Mockups and Graphic Design Once the concept is clear, BrandMyDispo's graphic designers turn ideas into digital mockups. Using advanced design tools like Adobe Illustrator and Photoshop, they create detailed visuals that depict the final product. These mockups incorporate all essential elements, from logos and color schemes to product information and unique features. 3. Feedback and Refinement Collaboration doesn’t stop at the first draft. The brand reviews the digital mockups and provides feedback. This iterative process ensures that the final design perfectly aligns with the brand’s vision and goals. Material Magic: Choosing the Right Components The choice of materials is crucial in ensuring that the custom Mylar bags are not only attractive but also functional and durable. BrandMyDispo offers a range of high-quality materials to meet diverse needs: 1. Premium Mylar Film At the heart of every bag is the Mylar film, renowned for its superior strength, flexibility, and barrier properties. BrandMyDispo uses premium Mylar to ensure optimal protection against moisture, oxygen, and light. 2. Eco-Friendly Options For brands looking to minimize their environmental footprint, BrandMyDispo provides eco-friendly materials, including recyclable and biodegradable options. These sustainable choices resonate well with environmentally conscious consumers. 3. Special Features Customization doesn’t end with the design. BrandMyDispo offers additional features such as resealable zippers, tear notches, clear windows, and child-resistant closures. These features enhance functionality and user experience. Bringing the Vision to Life: The Production Process Once the design and materials are finalized, the production phase begins. Here’s a look at the steps involved: 1. Advanced Printing Techniques BrandMyDispo employs state-of-the-art printing techniques to bring designs to life. Options include: Digital Printing: Ideal for short runs and intricate designs, offering vibrant colors and fine details. Flexographic Printing: Perfect for large quantities, providing consistent quality and fast production times. Rotogravure Printing: Known for its superior print quality and detail, suitable for high-end packaging. 2. Precision Cutting and Sealing After printing, the Mylar sheets are cut and sealed to form the bags. Precision is key to ensure that each bag meets exact specifications and maintains its structural integrity. 3. Quality Control BrandMyDispo takes quality seriously. Each batch of printed Mylar bags undergoes rigorous quality control checks to ensure they meet the highest standards. This includes verifying print quality, material durability, and proper sealing. From Factory to Shelf: The Delivery Process With production complete, the custom Mylar bags are ready for delivery. BrandMyDispo ensures a seamless transition from their facilities to the brand’s distribution channels: 1. Secure Packaging The finished bags are securely packaged to prevent damage during transit. Attention to detail ensures that the bags arrive in perfect condition, ready for use. 2. Timely Delivery BrandMyDispo understands the importance of timely delivery. They work with reliable logistics partners to ensure that the printed Mylar bags reach their destination on schedule. 3. Ongoing Support The relationship doesn’t end with delivery. BrandMyDispo offers ongoing support to address any questions or concerns, ensuring a smooth experience for their clients. Why Brands Choose BrandMyDispo for Printed Mylar Bags Brands choose BrandMyDispo for their custom Mylar bags for several compelling reasons: 1. Expertise and Experience With years of experience in the custom cannabis packaging industry, BrandMyDispo brings unparalleled expertise to the table. Their team understands the nuances of design, material selection, and production. 2. Endless Customization Options From design and material to special features, BrandMyDispo offers a wide array of customization options. This flexibility allows brands to create packaging that truly reflects their identity. 3. Quality Assurance Quality is a cornerstone of BrandMyDispo’s operations. Rigorous quality control measures ensure that each bag meets the highest standards. 4. Commitment to Sustainability BrandMyDispo is committed to sustainability. They offer eco-friendly materials and production processes, helping brands reduce their environmental impact. 5. Customer-Centric Approach BrandMyDispo prides itself on its customer-centric approach. They work closely with clients, providing personalized service and support throughout the process. Conclusion Printed Mylar bags are a powerful tool for brands looking to differentiate themselves in a crowded market. With BrandMyDispo, brands can transform their vision into reality, creating packaging that not only protects their products but also enhances their brand identity. From initial concept to final delivery, BrandMyDispo’s expertise, customization options, and commitment to quality make them the go-to choice for custom Mylar bags. Whether you’re a startup or an established brand, partnering with BrandMyDispo ensures your packaging stands out on the shelf and resonates with consumers.
Designing custom cartridge boxes involves a careful blend of aesthetics, functionality, and compliance.These boxes are not only essential for protecting vape cartridges but also play a crucial role…...
To get content containing either thought or leadership enter:
To get content containing both thought and leadership enter:
To get content containing the expression thought leadership enter:
You can enter several keywords and you can refine them whenever you want. Our suggestion engine uses more signals but entering a few keywords here will rapidly give you great content to curate.
Your new post is loading...
Scoop.it!
