Paradigm Shifts
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The bionic cardiac patch

The bionic cardiac patch | Paradigm Shifts | Scoop.it
It could act like a pacemaker, monitoring and responding to heart problems more quickly | Harvard Professor Charles Lieber and other scientists conducted a study that describes the construction of nanoscale electronic scaffolds that can be seeded...
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Paradigm Shifts
Paradigms and Paradigm Shifts
Curated by James Schreier
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March 30, 2020 6:02 AM
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Paradigms - Paradigm Shifts

Paradigms - Paradigm Shifts | Paradigm Shifts | Scoop.it

Understanding "paradigms" and "paradigm shifts" has exploded into greater importance -- with new problems and the need for new solutions occurring more rapidly than ever before.

nikabrand's curator insight, October 20, 2023 5:21 PM

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Scooped by James Schreier
October 19, 9:00 AM
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Developer Creates KillSwitch Language to Test LLM Coding Limits

Developer Creates KillSwitch Language to Test LLM Coding Limits | Paradigm Shifts | Scoop.it
Dominik Picheta released KillSwitch, an esoteric language with hidden lies in its spec, letter-count rules and guardrail triggers. Benchmarks show Claude Opus 5 leading at 66.8 while no model completes all simple tasks.
James Schreier's insight:

"One can imagine other paradigms..."

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October 5, 9:00 AM
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Mapping futures literacy as a competence space: structure, measuring and empirical patterns 

Mapping futures literacy as a competence space: structure, measuring and empirical patterns  | Paradigm Shifts | Scoop.it

Although futures literacy (FL) has gained increasing attention as a key concept in futures studies and education, its empirical operationalisation and measurement remain underdeveloped. Existing approaches often frame futures literacy either normatively, as a desirable capacity, or functionally, as a set of skills and methods, while its internal structure and the role of consciousness are rarely addressed in an integrated way. This paper responds to this gap by conceptualising futures literacy as a socially and culturally embedded competence space and by examining how its structure can be explored empirically. The study models futures literacy as a three-dimensional competence pattern consisting of knowledge as uses of the future, futures-related skills and capabilities, and consciousness, understood as the degree to which these uses and capabilities are recognised and applied intentionally. 

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September 21, 9:00 AM
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From Control to Foresight: Simulation as a New Paradigm for Human-Agent Collaboration

From Control to Foresight: Simulation as a New Paradigm for Human-Agent Collaboration | Paradigm Shifts | Scoop.it
Large Language Models (LLMs) are increasingly used to power autonomous agents for complex, multi-step tasks. However, human-agent interaction remains pointwise and reactive: users approve or correct individual actions to mitigate immediate risks, without visibility into subsequent consequences. This forces users to mentally simulate long-term effects, a cognitively demanding and often inaccurate process. Users have control over individual steps but lack the foresight to make informed decisions. We argue that effective collaboration requires foresight, not just control. We propose simulation-in-the-loop, an interaction paradigm that enables users and agents to explore simulated future trajectories before committing to decisions. Simulation transforms intervention from reactive guesswork into informed exploration, while helping users discover latent constraints and preferences along the way. This perspective paper characterizes the limitations of current paradigms, introduces a conceptual framework for simulation-based collaboration, and illustrates its potential through concrete human-agent collaboration scenarios.
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September 7, 11:04 AM
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AI ethics clash with social work codes in Hong Kong and Singapore

AI ethics clash with social work codes in Hong Kong and Singapore | Paradigm Shifts | Scoop.it
Whose ethics govern when artificial intelligence enters the counselling room or the social worker’s caseload? A new study argues that in Hong Kong and Singapore, the answer is far from straightforward.
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August 24, 9:00 AM
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BMW's weird Minecraft-like car harvests more energy than it uses

BMW's weird Minecraft-like car harvests more energy than it uses | Paradigm Shifts | Scoop.it
Discover Luminetta, a BMW-sponsored student solar car from Clemson University that generates more energy than it uses.
James Schreier's insight:

For anyone who's watched Joel's "New Business of Paradigms," this rings a bell.  Joel would probably want to go check this one out in person.

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August 3, 8:54 AM
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Potential for a Single-Phase 3-Trial Registration Plan and a Trial...

Potential for a Single-Phase 3-Trial Registration Plan and a Trial... | Paradigm Shifts | Scoop.it
Acurx has received FDA guidance in meeting minutes from a July 13, 2026 Type C Meeting to discuss ibezapolstat's (IBZ) Phase 3 clinical program, including the...
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July 20, 1:54 PM
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Migraine and Hormones: New Ideas Needed

Migraine and Hormones: New Ideas Needed | Paradigm Shifts | Scoop.it
Neurologist Indu Subramanian and migraine expert Andrew Charles discuss the how migraine intersects with hormone levels and why the condition is more common in women.
James Schreier's insight:

Paradigm, paradigm, paradigm -- frequent in this story.  Should have been in the title!

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July 6, 9:00 AM
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When the whole is brighter than the parts: Ben Zhong Tang on aggregation-induced emission

When the whole is brighter than the parts: Ben Zhong Tang on aggregation-induced emission | Paradigm Shifts | Scoop.it
Ben Zhong Tang shares the story behind aggregation-induced emission and reflects on its impact across chemistry and materials science.
James Schreier's insight:

"If something does not fit the existing paradigm..."  What an important message here!

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June 8, 12:10 PM
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The Day the USPS Redefined Airmail: The Launch of Missile Mail

The Day the USPS Redefined Airmail: The Launch of Missile Mail | Paradigm Shifts | Scoop.it
On June 8, 1959, the United States Post Office Department carried out one of the most astonishing delivery experiments in American history by firing a guided missile packed with mail. Off the coast of Florida, the submarine USS Barbero launched a Regulus I cruise missile whose warhead compartment had been replaced with two postal containers
James Schreier's insight:

This could have a rather dramatic paradigm shift.  Wondering today whether Joel knew about this -- I'd bet he did.

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June 8, 9:00 AM
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Instead of Taking Your Job, A.I. Might Transform It

Instead of Taking Your Job, A.I. Might Transform It | Paradigm Shifts | Scoop.it
In its current incarnation, A.I. may not be poised to eliminate swaths of human jobs—but it certainly has the power to transform them.
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May 26, 9:57 AM
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Insilico Medicine and Human Longevity Announce Collaboration to Co-Develop Industry-First AI Foundation Model for Longevity Science

Insilico Medicine and Human Longevity Announce Collaboration to Co-Develop Industry-First AI Foundation Model for Longevity Science | Paradigm Shifts | Scoop.it
/PRNewswire/ -- Insilico Medicine ("Insilico", 3696.HK), a clinical-stage generative artificial intelligence (AI)-driven biotechnology company, and Human Life...
James Schreier's insight:

A shift from "reactive" to "proactive."

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May 11, 9:00 AM
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Lipid Profiles in Amygdala: Sporadic vs GBA Parkinson’s

Lipid Profiles in Amygdala: Sporadic vs GBA Parkinson’s | Paradigm Shifts | Scoop.it
In a groundbreaking study soon to be published in npj Parkinson’s Disease, researchers Muñoz, Marlet, Dreier, and colleagues have unveiled compelling insights into the lipid landscapes of the amygdala in Parkinson’s disease (PD), distinguishing between sporadic cases and those linked to mutations...
James Schreier's insight:

Labeled a paradigm shift -- these are occurring more frequently in medicine/science now.

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November 2, 8:00 AM
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Designing a pluriversal foresight epistemology and schematic, an essay | European Journal of Futures Research

Designing a pluriversal foresight epistemology and schematic, an essay | European Journal of Futures Research | Paradigm Shifts | Scoop.it
This article emerges from a reflection on how current global transitions and paradigm shift (the Anthropocene, Artificial Intelligence revolution and post-colonial era being some of its markers) impact conventional western epistemologies; could it be possible, in the more open field of futures research, to explore an innovative pluralistic epistemological position?
James Schreier's insight:

"Paradigm Shift" in the first sentence, but I picked this one because I love the title (the wonderful world of academic research)

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October 12, 9:00 AM
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5 cognitive shifts to help teams navigate uncertainty

5 cognitive shifts to help teams navigate uncertainty | Paradigm Shifts | Scoop.it
Leader reframing is a disciplined practice that questions and invites others to question constraints to unlock new capacity.
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September 28, 9:00 AM
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Beyond the Bodyguard. The Ecosystem of Modern Executive Protection

Beyond the Bodyguard. The Ecosystem of Modern Executive Protection | Paradigm Shifts | Scoop.it
Discover why true executive protection requires more than just an armed bodyguard. Learn how intelligence-driven security mitigates risks.
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September 14, 9:00 AM
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Behind the Polaroids: How Josh Allen and Hailee Steinfeld Navigate High-Stakes Careers and New Parenthood –

Behind the Polaroids: How Josh Allen and Hailee Steinfeld Navigate High-Stakes Careers and New Parenthood – | Paradigm Shifts | Scoop.it
Buffalo Bills star Josh Allen revealed in GQ that wallet Polaroids of wife Hailee Steinfeld and daughter Harper anchor his high-stakes NFL career.
James Schreier's insight:

Modern celebrity paradigm???

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September 1, 11:43 AM
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Middle Managers Will Make or Break AI Adoption

Middle Managers Will Make or Break AI Adoption | Paradigm Shifts | Scoop.it
Generative AI initiatives often stall not because of the board, vendors, or training, but because middle managers determine how AI is translated into day-to-day work. There are five distinct profiles that affect how managers perceive AI and implement new initiatives with their teams: AI skeptics,...
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August 17, 11:53 AM
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📐The Shape of Thinking

📖 Read: https://helioxpodcast.substack.com/publish/post/211486864How 19th-century geometry, a physicist's holographic universe, and a contested theory of AI "psychosis" collide in the race to build intelligence without brute forceHere is a story we tell ourselves about intelligence: it is a...
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July 27, 9:00 AM
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ONR Unveils 2026 Science and Technology Strategy for Navy and Marine Corps

ONR Unveils 2026 Science and Technology Strategy for Navy and Marine Corps | Paradigm Shifts | Scoop.it
The Office of Naval Research (ONR) has unveiled a new Science and Technology (S&T) Strategy designed as a roadmap for how the organization will prioritize, develop, and transition technologies for the U.S.
James Schreier's insight:

Search for "paradigm shifting strategies."

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July 13, 9:00 AM
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"A massive paradigm shift"

"A massive paradigm shift" | Paradigm Shifts | Scoop.it
Beyond the Prescription: Why Functional Health is Turning to "Food as Medicine"We’ve all heard the old adage, "You are what you eat." But for decades, conventional medicine treated nutrition as a secondary afterthought—a footnote to exercise or something to track solely for weight management. If you got sick, you took a pill. If your joints ached, you took an anti-inflammatory.Today, a massive paradigm shift is underway. Driven by the rise of Functional Health, a growing chorus of practitioners and patients are asking a deeper question: What if the tool to heal our bodies isn't sitting in a pharmacy, but waiting in our grocery carts?Welcome to the world of Food as Medicine. What is Functional Health?To understand why food is taking center stage, we first have to understand Functional Health (often called Functional Medicine).Conventional medicine excels at acute care—fixing a broken bone or treating an emergency. But when it comes to chronic issues like autoimmune diseases, chronic fatigue, type 2 diabetes, and digestive disorders, it often merely manages the symptoms.Functional health takes a different approach. It treats the body as an interconnected ecosystem and hunts for the root cause of imbalances.Think of your body like a tree. Conventional medicine looks at browning leaves and tries to paint them green again. Functional health looks at the soil, the roots, and the water supply to figure out why the tree is struggling from the bottom up.And what forms the absolute foundation of that soil? The fuel you put into it every single day.The Core Philosophy: Food as MedicineThe "Food as Medicine" movement isn't about ignoring modern medical science or refusing life-saving pharmaceuticals. Instead, it’s the practice of utilizing whole, nutrient-dense foods as proactive, therapeutic interventions to prevent, manage, and sometimes even reverse chronic disease.Every time you eat, you aren't just consuming calories; you are consuming information. The compounds in your food talk to your microbes, dictate your hormone signaling, influence systemic inflammation, and can even turn specific genes on or off (a field known as nutrigenomics).Here is how specific dietary choices act as direct medicine in the body: 1. Cooling the Fire: Anti-Inflammatory FoodsChronic, low-grade inflammation is the underlying driver of almost every modern disease, from heart disease to Alzheimer's.The Food Medicine: Omega-3 fatty acids found in wild-caught salmon, walnuts, and flaxseeds actively block inflammatory pathways in the body, acting much like a natural, low-dose aspirin.The Contrast: A diet high in ultra-processed foods, refined sugars, and industrial seed oils acts as lighter fluid, keeping the inflammatory fire burning.2. Cultivating the Soil: Gut Microbiome SupportYour gut is home to trillions of bacteria that dictate your immunity, digestion, and even your mood (producing over 90% of your body's serotonin).The Food Medicine: Diverse dietary fiber from vegetables, berries, and legumes acts as prebiotics (food for your good bacteria). Fermented foods like kimchi, sauerkraut, and kefir deliver live probiotics to reinforce the ranks.3. Cellular Defense: Antioxidants and PhytonutrientsEvery minute, your cells experience oxidative stress—essentially "rusting" from the inside out due to environmental toxins and normal metabolism.The Food Medicine: Plants produce chemical compounds called phytonutrients to protect themselves from harsh environments. When we eat vibrant, deeply colored plants (think blueberries, kale, turmeric, and purple sweet potatoes), those antioxidants act as a shield for our own cells, neutralizing damage.Moving Beyond "One-Size-Fits-All"One of the most vital principles of Functional Health is bio-individuality. There is no single "perfect" diet that works for every human being on earth.A specific food that acts as a healing medicine for one person might trigger an immune response in another. For instance:A high-fiber, raw-vegetable diet might deeply cleanse and energize one individual, while causing severe bloating and distress in someone dealing with SIBO (Small Intestinal Bacterial Overgrowth).Nightshade vegetables (like tomatoes and eggplants) are packed with vitamins, yet someone with a specific autoimmune flare-up might find they aggravate joint pain.Functional health utilizes targeted elimination protocols, food symptom journaling, and advanced lab testing to determine exactly what your unique biological "soil" needs to thrive. a3 Steps to Start Using Food as Medicine TodayTransitioning to a functional approach to food doesn't require a radical, stressful overhaul overnight. You can start with three foundational shifts:Eat the Rainbow: Don't just stick to broccoli and carrots. Aim for a wide variety of colors on your plate each week. Different colors represent different protective phytochemical compounds.Crowd Out the Processed: Instead of focusing strictly on what you need to restrict, focus on what you can add. By crowding your plate with whole foods—avocades, berries, leafy greens, clean proteins—you will naturally have less room for ultra-processed snacks.Listen to Your Body’s Feedback: Start tracking how you feel 1 to 2 hours after eating. Do you feel vibrant and clear-headed, or bloated, foggy, and ready for a nap? Your body is constantly giving you data; you just have to tune in.The Bottom LineA prescription pad will always have its place in crisis care. But for the day-to-day cultivation of vibrant longevity, the most powerful pharmacy on the planet is the one inside your kitchen. By embracing functional health and viewing food as the ultimate medicine, you take the power of healing back into your own hands—one meal at a time.
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June 15, 9:00 AM
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Why AI is key to XPENG's plans for self-driving cars

Why AI is key to XPENG's plans for self-driving cars | Paradigm Shifts | Scoop.it
XPENG's VLA 2.0 uses physical AI for its autonomous driving system. Dr. Xianming Liu explained to Mashable how it works.
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June 8, 9:00 AM
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Why Isn’t AI Taking Our Jobs?

Why Isn’t AI Taking Our Jobs? | Paradigm Shifts | Scoop.it
If automation is the wrong analogy, what could be better? In my most recent article for The New Yorker, which is titled ​“Instead of Taking Your Job, A.I. Might Transform It”​, I investigated possible answers.
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June 1, 9:12 AM
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The Phrase Elon Musk Slipped Into SpaceX's IPO Documents That Sounds Like Science Fiction

The Phrase Elon Musk Slipped Into SpaceX's IPO Documents That Sounds Like Science Fiction | Paradigm Shifts | Scoop.it
Buried inside the IPO paperwork is this line: “We believe the next paradigm shift for humanity is the creation of a resilient, perpetually expanding spacefaring civilization that drives continuous innovation across new frontiers, ultimately propelling us to Kardashev Type II status.”
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May 18, 1:27 PM
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Scientists Unveil a New Strategy for Enhancing Energy Storage with Porous Organic Polymer Anodes

Scientists Unveil a New Strategy for Enhancing Energy Storage with Porous Organic Polymer Anodes | Paradigm Shifts | Scoop.it
Spread the loveThe quest for more efficient energy storage has taken an exciting turn with recent breakthroughs in the field of materials science. A groundbreaking study has revealed that the molecular architecture of porous organic polymer anodes can significantly influence interfacial evolution,...
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May 4, 9:21 AM
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Targeting Positive vs Negative Emotions May Improve MDD

Targeting Positive vs Negative Emotions May Improve MDD | Paradigm Shifts | Scoop.it
Targeting impaired reward processing reduces key risk factors in depression and anxiety and produces superior clinical outcomes than negative affect treatment.
James Schreier's insight:

A paradigm shift in mental health -- might be very important!

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