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A certain class of antibiotics prompts cells to produce low levels of novel self proteins that could trigger an autoimmune disease, research suggests. 
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Investigadores del Centro de Investigación en Salud Internacional de Barcelona (CRESIB) y del Instituto de Bioingeniería de Cataluña (IBEC) han desarrollado por primera vez un modelo funcional de un bazo integrado en un chip que es capaz de actuar como este órgano filtrando los glóbulos rojos de la sangre.
Alfredo Corell's insight:
En concreto, lo han conseguido recreando a microescala las propiedades físicas y las fuerzas hidrodinámicas de la unidad funcional de la pulpa roja del bazo y, según los autores, este dispositivo podría servir para detectar posibles fármacos contra la malaria y otras enfermedades hematológicas.
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David Vetter, aka "Bubble Boy," was born in 1971 with a rare hereditary disorder called severe combined immunodeficiency (SCID). He could not be exposed to any germs or he would die.
Alfredo Corell's insight:
We should not forget the scientific and medical errors done in the past. David literally lived in a bubble his whole life
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Científicos del Instituto Hospital del Mar de Investigaciones Médicas han descrito un nuevo subtipo de células linfoides innatas esenciales para la producción de anticuerpos, un hallazgo que puede desembocar en el desarrollo de vacunas más eficaces contra las bacterias encapsuladas.
Alfredo Corell's insight:
Estas células linfoides innatas son la primera línea de defensa inmunológica de las superficies del cuerpo más expuestas a bacterias, como el intestino o la piel Referencia bibliográfica: Giuliana Magri, Michio Miyajima, Sabrina Bascones, Arthur Mortha, Irene Puga, Linda Cassis, Carolina M. Barra, Laura Comerma, Aleksey Chudnovskiy, Maurizio Gentile, David Llige, Montserrat Cols, Sergi Serrano, Juan Ignacio Aróstegui, Manel Juan, Jordi Yagüe, Miriam Merad, Sidonia Fagarasan & Andrea Cerutti. "Innate lymphoid cells integrate stromal and immunological signals to enhance antibody production by splenic marginal zone B cells". Nature Immunology. DOI: 10.1038/ni.2830.
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Alfredo Corell's insight:
A lot of drawings, quests, facts, tests, mnemonics... about immunology
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Andras Fazakas Severe combined immunodeficiency - A deadly combination of defects of T & B lymphocytes + Natural killer cells Its a primary immunodeficiency ...
Alfredo Corell's insight:
a really clear, understandable and visual presentation on Severe combined immunodeficiency. Strongly Recommended for university students.
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SINC, Servicio de Información y Noticias Científicas, plataforma multimedia de comunicación científica (Obtienen nanocápsulas con actividad antitumoral en líneas celulares de cáncer de mama http://t.co/AZYAuzAGh4)...
Alfredo Corell's insight:
Enlace al artículo científico:
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This is a crucial step to understand the vast diversity of Immune specific receptors.
Alfredo Corell's insight:
Neil Greenspan Website http://www.case.edu/med/pathology/faculty/greenspan.html ;
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En este video se muestra le entrevista que me han hecho en la Aventura del Saber y que se ha emitido el 5 de febrero de 2014
Alfredo Corell's insight:
Enlace al programa completo en rtve: http://www.rtve.es/alacarta/videos/la-aventura-del-saber/aventura-del-saber-05-02-14/2377592/ Enlace al videoclip de la entrevista en rtve a la carta: http://www.rtve.es/alacarta/videos/la-aventura-del-saber/aventura-del-saber-alfredo-corell/2374403/
Nuria Parra Macías's curator insight,
February 8, 2014 3:24 AM
Inmunomedia 3.0: una pica en Flandes en innovación docente. El ejemplo de flipped classroom de la facultad de Medicina de la universidad de Valladolid. 
Alfredo Corell's comment,
February 12, 2014 3:20 PM
Cualquier tipo de difusión entre personal docente afin es bienvenida, así que gracias de corazón!!1
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Learn about different aspects of primary immunodeficiency, including primary immune deficiency symptoms.
Alfredo Corell's insight:
A simple page for University students
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ExRNA: Decoding messages between cells
Alfredo Corell's insight:
Extracellular RNA could communicate between cells in a manner not suspected until now. A cancer cell could send an ex-RNA to a healthy one and the opossite, by ex-RNA we could probably treat some tumours. Exciting new field!!!!! Explicative YouTube video: http://www.youtube.com/watch?v=bfMg3RhxNm8#t=13
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This page describes secondary (peripheral) lymphatic organs, and is part of Art Anderson's immunology 522 lecture for the Foundation for Advanced Education in the Sciences (FAES) at NIH. Click on
Alfredo Corell's insight:
With artistic drawings of the secondary organs!!!
a must visit! Secondary lymphatic Tissues control the quality of immune responses. Differences among the various lymphatic tissues significantly affect the form of immunity and relate to how antigens are acquired by these organs. Lymph nodes are filters of lymph, the spleen is a filter of blood and mucosal associated lymphatic tissues acquire antigens by transcytosis to lymphoid tissue from the "external" environment across specialized follicle-associated epithelial cells.
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Perspective from The New England Journal of Medicine — The Quest for an HIV-1 Vaccine — Moving Forward Dan H. Barouch, M.D., Ph.D. N Engl J Med 2013; 369:2073-2076 November 28, 2013DOI: 10.1056/NEJMp1312711
Alfredo Corell's insight:
Testing only four HIV-1 vaccine concepts for clinical efficacy over the past three decades is insufficient given the scope of the global HIV-1 epidemic. We clearly need more “shots on goal.” We should therefore accelerate the advancement of a diverse series of novel and promising HIV-1 vaccine candidates into clinical efficacy trials over the next several years.
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Ante la problemática causada por la ausencia de la vacuna de la varicela en las farmacias españolas, así como la aparición de los primeros casos de varicela grave en nuestro país, la Asociación Española de Pediatría (AEP) ha solicitado incluir en...
Alfredo Corell's insight:
El calendario común de vacunación infantil para 2014 del Ministerio de Sanidad contempla la inmunización frente a la varicela a los 12 añosen aquellos niños que no hayan pasado todavía la enfermedad. En este sentido, el coordinador del CAV-AEP, David Moreno, ha avisado de un 15 por ciento de los casos de varicela pueden complicarse, a veces, de forma grave.
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A young child’s immune system appears to have a significant effect on his or her brain development, according to a new study from the University of Virginia School of Medicine (UVA).
Alfredo Corell's insight:
“What is of the most interest and of a great novelty is the fact that [inflammation-fighting cytokines] have positive correlation with cognitive function. My lab published results showing that these IL-4 cytokines are required for proper brain function in mice, and this work from Dr. Petri’s lab completely independently shows similar correlation in humans.” Link to the BMC publication http://www.biomedcentral.com/1471-2431/14/50/abstract
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Nature Reviews Immunology 14, 141 (2014).
Alfredo Corell's insight:
The abundance of innate and adaptive immune cells that reside together with trillions of beneficial commensal microorganisms in the mammalian gastrointestinal tract requires barrier and regulatory mechanisms that conserve host–microbial interactions and tissue homeostasis. This homeostasis depends on the diverse functions of intestinal epithelial cells (IECs), which include the physical segregation of commensal bacteria and the integration of microbial signals. Hence, IECs are crucial mediators of intestinal homeostasis that enable the establishment of an immunological environment permissive to colonization by commensal bacteria. In this Review, we provide a comprehensive overview of how IECs maintain host–commensal microbial relationships and immune cell homeostasis in the intestine. Free download with registration: http://www.nature.com/nri/journal/v14/n3/pdf/nri3608.pdf
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Adults account for 95 percent of individuals who die from vaccine-preventable diseases (The weak link: adult immunisations. Adults account for 95% of individuals who die from vaccine-preventable diseases.
Alfredo Corell's insight:
Adults account for 95 percent of individuals who die from vaccine-preventable diseases. Yet vaccination rates among adults remain “very low”. The latest feature film from Chain of Protection discusses the importance and need for adult immunisation in the fight against preventable infectious diseases.
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The skin is the body's main barrier against physical insults and microbial pathogens. Diverse and functionally specialized subsets of immune cells in the ski...
Alfredo Corell's insight:
a remarkable video about skin immune system and pathogenesis in the particular case of psoriasis.
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Las vacunas son uno de los pilares básicos entre los que se asienta la medicina científica y la sanidad actuales. Y aunque desde nuestra visión occidental marcada por el ideal de progreso y supera...
Alfredo Corell's insight:
Estamos llegando a límites insospechados. El movimiento anti-vacunas que últimamente está creciendo (por poner un ejemplo están llegando ya a Valencia las llamadas "small-pox parties") puede poner en jaque el sistema sanitario de muchos países.
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Probiotic supplementation during pregnancy or infancy for the prevention of asthma and wheeze: system... http://t.co/gP1CfCGOp0
Alfredo Corell's insight:
Conclusions We found no evidence to support a protective association between perinatal use of probiotics and doctor diagnosed asthma or childhood wheeze. Randomised controlled trials to date have not yielded sufficient evidence to recommend probiotics for the primary prevention of these disorders. Extended follow-up of existing trials, along with further clinical and basic research, are needed to accurately define the role of probiotics in the prevention of childhood asthma.
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INNATE IMMUNITY The inside story on complement activation
Alfredo Corell's insight:
The evolutionarily ancient complement system might have started life as an intracellular activation pathway rather than as a liver-derived serum effector cascade.
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This immunology video explains autoimmunity and the effect of autoimmune symptoms in human body. For more information, log on to- http://shomusbiology.weebly...
Alfredo Corell's insight:
a simple and accesible video for Immunology university students
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Alfredo Corell's insight:
Another handwritten mini-lecture by Armando Hasudungan for class II processing: http://www.youtube.com/watch?v=TMnkihN6zVM&feature=youtu.be&a
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This is the concluding lecture about the T cells. Function of T helper 1, and 2, cytotoxic T cells, NK cells and T regulator cells (T17) are discussed.
Alfredo Corell's insight:
Another video-series by Mobeen Syed
Alfredo Corell's curator insight,
April 23, 2013 2:14 PM
By Mobeen Syed part 1: http://www.youtube.com/watch?v=GKf8-Ex6F7Y&list=TLv1_K8sf8xWw part 2: http://www.youtube.com/watch?v=j7vlkt93UEc&list=TLv1_K8sf8xWw Part 3: http://www.youtube.com/watch?v=wap9Ilm7HPE&list=TLv1_K8sf8xWw part 4: http://www.youtube.com/watch?v=u5O2avcbkzY&list=TLv1_K8sf8xWw part 5: http://www.youtube.com/watch?v=PLCPjFsD8Kc&list=TLv1_K8sf8xWw
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Libro publicado en 2012 con el patrocinio de la SEAIC
Alfredo Corell's insight:
dirigido por JOSE MANUEL ZUBELDIA Mª LUISA BAEZA IGNACIO JAÚREGUI CARLOS J. SENENT escrito por más de 50 alergólogos de prestigio.
Descarga el libro en pdf: http://www.alergiafbbva.es/alergia.pdf ;
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Link to the PNAS journal: http://www.pnas.org/content/early/2014/03/26/1402670111
SignificanceMany genetic disorders, including Duchenne muscular dystrophy and cystic fibrosis, are caused by a defective protein resulting from a premature termination codon (PTC) in the mutant gene. Aminoglycosides have been proposed as therapies for these disorders because they increase the frequency of translational read-through of PTCs, permitting expression of full-length protein. We consider the possibility that this approach may prompt an autoimmune response to HLA-presented epitopes encoded downstream of the PTC or other stop codons. We demonstrate that gentamicin induces immunologically relevant levels of an epitope derived from PTC read-through. Furthermore, we identify multiple HLA class I-binding peptides derived from read-through of conventional stop codons in gentamicin-treated cells. These results substantiate the possibility of immune autoreactivity from read-through therapies.