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Translational Psychiatry explores the more translational area between the research in neuroscience and conceptually novel treatments
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February 9, 2016 2:54 AM
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In this study, the authors investigated the contribution of epigenetic factors HDAC1 and DAXX to the developmental perturbation hypothesized to underlie schizophrenia (SZ). For this purpose, they designed lentiviral vectors carrying short hairpin RNA interference (shRNAi) for HDAC1 and DAXX. Their results point to a key role of both HDAC1 and DAXX in the regulation of GAD67 in GABAergic HiB5 cells, strongly suggesting that these epigenetic/transcription factors contribute to mechanisms underlying GABA cell dysfunction in SZ.
www.geg-tech.com/Vectors