Genetic Engineering in the Press by GEG
37.8K views | +3 today
Follow
Genetic Engineering in the Press by GEG
Biology
Your new post is loading...
Your new post is loading...
Scooped by BigField GEG Tech
October 24, 2014 8:12 AM
Scoop.it!

Total Synthesis of a Functional Designer Eukaryotic Chromosome

From www.sciencemag.org - May 30, 2014 4:43 PM

Rapid advances in DNA synthesis techniques have made it possible to engineer viruses, biochemical pathways and assemble bacterial genomes. Here, we report the synthesis of a functional 272,871–base pair designer eukaryotic chromosome, synIII, which is based on the 316,617–base pair native Saccharomyces cerevisiae chromosome III. Changes to synIII include TAG/TAA stop-codon replacements, deletion of subtelomeric regions, introns, transfer RNAs, transposons, and silent mating loci as well as insertion of loxPsym sites to enable genome scrambling. SynIII is functional in S. cerevisiae. Scrambling of the chromosome in a heterozygous diploid reveals a large increase in a-mater derivatives resulting from loss of the MATα allele on synIII. The complete design and synthesis of synIII establishes S. cerevisiae as the basis for designer eukaryotic genome biology.

more...
No comment yet.
Sign up to comment
Scooped by BigField GEG Tech
October 24, 2014 8:11 AM
Scoop.it!

Craig Venter creates synthetic life form

Craig Venter creates synthetic life form | Genetic Engineering in the Press by GEG | Scoop.it
From www.theguardian.com - May 30, 2014 4:40 PM
Craig Venter and his team have built the genome of a bacterium from scratch and put it into a cell to make a synthetic life form
more...
No comment yet.
Sign up to comment
Scooped by BigField GEG Tech
October 24, 2014 8:09 AM
Scoop.it!

Building the Ultimate Yeast Genome

From www.sciencemag.org - May 30, 2014 4:43 PM

Although Jef Boeke first scoffed at the idea of building an artificial chromosome for yeast, he and his colleagues eventually decided to tackle what at the time was a very daunting task. They spent more than a year figuring out what DNA they should remove to make the new chromosome more stable and what DNA to add to be able to mutate it at will. They started with just the 90,000-base arm of one chromosome and when that worked, began remaking chromosome 3. Now, with the help of partners from around the world, the New York University geneticist has set his sights on the whole genome.

more...
No comment yet.
Sign up to comment
Scooped by BigField GEG Tech
October 24, 2014 5:59 AM
Scoop.it!

The Dawn of Virtual Cell Biology: Cell

The Dawn of Virtual Cell Biology: Cell | Genetic Engineering in the Press by GEG | Scoop.it
From www.cell.com - May 30, 2014 4:36 PM

To fulfill systems biology’s promise of providing fundamental new insights will require the development of quantitative and predictive models of whole cells. In this issue, Karr et al. present the first integrated and dynamic computational model of a bacterium that accounts for all of its components and their interactions.

more...
No comment yet.
Sign up to comment
Scooped by BigField GEG Tech
October 24, 2014 5:58 AM
Scoop.it!

Preventative genetics: The ultimate way to halt disease

Preventative genetics: The ultimate way to halt disease | Genetic Engineering in the Press by GEG | Scoop.it
From www.bbc.com - May 30, 2014 10:54 AM
Can the information in our genes reveal serious medical issues years in advance? A leading geneticist thinks it’s possible.
more...
No comment yet.
Sign up to comment
Scooped by BigField GEG Tech
October 24, 2014 5:57 AM
Scoop.it!

Tissue engineering: Grow your own smart organs

Tissue engineering: Grow your own smart organs | Genetic Engineering in the Press by GEG | Scoop.it
From www.bbc.com - May 30, 2014 10:51 AM
Robert Langer thinks one day we could grow tissues and organs from our cells, which contain sensors that can alert you when illness is about to strike.
more...
No comment yet.
Sign up to comment
Scooped by BigField GEG Tech
October 24, 2014 5:56 AM
Scoop.it!

Access : Elevated nitrate enriches microbial functional genes for potential bioremediation of complexly contaminated sediments : The ISME Journal

From www.nature.com - May 30, 2014 10:35 AM
The ISME Journal: Multidisciplinary Journal of Microbial Ecology is the official Journal of the International Society for Microbial Ecology, publishing high-quality, original research papers, short communications, commentary articles and reviews in the rapidly expanding and diverse discipline of microbial ecology.
more...
No comment yet.
Sign up to comment
Scooped by BigField GEG Tech
October 24, 2014 5:55 AM
Scoop.it!

Getting even | The Sunday Times

Getting even | The Sunday Times | Genetic Engineering in the Press by GEG | Scoop.it
From www.thesundaytimes.co.uk - May 30, 2014 9:31 AM

Many women who have been quietly appalled by friends’ forays into plastic surgery are starting to place their faith elsewhere. Not anywhere outlandish, mind you; they’re simply placing their bets on skincare once more. That’s because there’s a new generation of scientifically validated skincare innovations that offers ways of countering the ageing process.

more...
No comment yet.
Sign up to comment
Scooped by BigField GEG Tech
October 24, 2014 5:53 AM
Scoop.it!

Top guns fly on algae in the US battle for fuel | The Sunday Times

Top guns fly on algae in the US battle for fuel | The Sunday Times | Genetic Engineering in the Press by GEG | Scoop.it
From www.thesundaytimes.co.uk - May 30, 2014 9:24 AM

In just a few years, algae have moved from a pond-life nuisance to a significant part of Washington’s strategy to sideline foreign oil.

more...
No comment yet.
Sign up to comment
Scooped by BigField GEG Tech
October 24, 2014 5:51 AM
Scoop.it!

Developing countries leap ahead in biotech crop growth

Developing countries leap ahead in biotech crop growth | Genetic Engineering in the Press by GEG | Scoop.it
From online.wsj.com - May 30, 2014 8:49 AM
Developing countries are leaping ahead of industrial nations in planting genetically modified crops, according to a study
more...
No comment yet.
Sign up to comment
Scooped by BigField GEG Tech
October 24, 2014 5:50 AM
Scoop.it!

Don’t Turn Your Back on GMOs Yet, Adviser Urges China - China Real Time Report - WSJ

Don’t Turn Your Back on GMOs Yet, Adviser Urges China - China Real Time Report - WSJ | Genetic Engineering in the Press by GEG | Scoop.it
From blogs.wsj.com - May 30, 2014 8:49 AM
Ye Xingqing, director of the rural economy department at the State Council Development Research Center, said Beijing still regards GMO as the kind of cutting-edge global technology the country must pursue, at least in research.
more...
No comment yet.
Sign up to comment
Scooped by BigField GEG Tech
October 24, 2014 5:48 AM
Scoop.it!

Can Genetic Engineering Save the Orange, and Vice Versa?

Can Genetic Engineering Save the Orange, and Vice Versa? | Genetic Engineering in the Press by GEG | Scoop.it
From dotearth.blogs.nytimes.com - May 30, 2014 10:57 AM
An orange grower’s wise and promising search for a gene that can save citrus from a spreading scourge.
more...
No comment yet.
Sign up to comment
Scooped by BigField GEG Tech
October 24, 2014 5:47 AM
Scoop.it!

Genetically Modified Babies

Genetically Modified Babies | Genetic Engineering in the Press by GEG | Scoop.it
From www.nytimes.com - May 30, 2014 10:56 AM
Regulators consider radical biological procedures.
more...
No comment yet.
Sign up to comment
Scooped by BigField GEG Tech
October 24, 2014 8:11 AM
Scoop.it!

High-level semi-synthetic production of the potent antimalarial artemisinin : Nature : Nature Publishing Group

High-level semi-synthetic production of the potent antimalarial artemisinin : Nature : Nature Publishing Group | Genetic Engineering in the Press by GEG | Scoop.it
From www.nature.com - May 30, 2014 4:47 PM
In 2010 there were more than 200[thinsp]million cases of malaria, and at least 655,000 deaths. The World Health Organization has recommended artemisinin-based combination therapies (ACTs) for the treatment of uncomplicated malaria caused by the parasite Plasmodium falciparum. Artemisinin is a sesquiterpene endoperoxide with potent antimalarial properties, produced by the plant Artemisia annua. However, the supply of plant-derived artemisinin is unstable, resulting in shortages and price fluctuations, complicating production planning by ACT manufacturers. A stable source of affordable artemisinin is required. Here we use synthetic biology to develop strains of Saccharomyces cerevisiae (baker/'s yeast) for high-yielding biological production of artemisinic acid, a precursor of artemisinin. Previous attempts to produce commercially relevant concentrations of artemisinic acid were unsuccessful, allowing production of only 1.6[thinsp]grams per litre of artemisinic acid. Here we demonstrate the complete biosynthetic pathway, including the discovery of a plant dehydrogenase and a second cytochrome that provide an efficient biosynthetic route to artemisinic acid, with fermentation titres of 25[thinsp]grams per litre of artemisinic acid. Furthermore, we have developed a practical, efficient and scalable chemical process for the conversion of artemisinic acid to artemisinin using a chemical source of singlet oxygen, thus avoiding the need for specialized photochemical equipment. The strains and processes described here form the basis of a viable industrial process for the production of semi-synthetic artemisinin to stabilize the supply of artemisinin for derivatization into active pharmaceutical ingredients (for example, artesunate) for incorporation into ACTs. Because all intellectual property rights have been provided free of charge, this technology has the potential to increase provision of first-line antimalarial treatments to the developing world at a reduced average annual price.
more...
No comment yet.
Sign up to comment
Scooped by BigField GEG Tech
October 24, 2014 8:11 AM
Scoop.it!

Bridging the layers: towards integration of signal transduction, regulation and metabolism into mathematical models - Molecular BioSystems (RSC Publishing)

Bridging the layers: towards integration of signal transduction, regulation and metabolism into mathematical models - Molecular BioSystems (RSC Publishing) | Genetic Engineering in the Press by GEG | Scoop.it
From pubs.rsc.org - May 30, 2014 4:35 PM
Mathematical modelling is increasingly becoming an indispensable tool for the study of cellular processes, allowing their analysis in a systematic and comprehensive manner. In the vast majority of the cases, models focus on specific subsystems, and in particular describe either metabolism, gene expression or
Molecular BioSystems 2013 Review Articles in Systems Biology
Molecular BioSystems Network Biology
more...
No comment yet.
Sign up to comment
Scooped by BigField GEG Tech
October 24, 2014 8:09 AM
Scoop.it!

J Craig Venter sequenced the human genome. Now he wants to convert DNA into a digital signal (Wired UK)

J Craig Venter sequenced the human genome. Now he wants to convert DNA into a digital signal (Wired UK) | Genetic Engineering in the Press by GEG | Scoop.it
From www.wired.co.uk - May 30, 2014 4:41 PM
Wired interviews J Craig Venter: the first person to sequence the human genome
more...
No comment yet.
Sign up to comment
Scooped by BigField GEG Tech
October 24, 2014 5:59 AM
Scoop.it!

Don’t Be Afraid of Genetic Modification

Don’t Be Afraid of Genetic Modification | Genetic Engineering in the Press by GEG | Scoop.it
From www.nytimes.com - May 30, 2014 10:56 AM
We shouldn’t let political calculations or unfounded fears keep safe genetically modified animals off the market.
more...
No comment yet.
Sign up to comment
Scooped by BigField GEG Tech
October 24, 2014 5:58 AM
Scoop.it!

First 'microsubmarines' designed to help clean up oil spills

First 'microsubmarines' designed to help clean up oil spills | Genetic Engineering in the Press by GEG | Scoop.it
From www.sciencedaily.com - May 30, 2014 10:49 AM
Scientists are reporting development and successful testing of the first self-propelled "microsubmarines" designed to pick up droplets of oil from contaminated waters and transport them to collection facilities. The report concludes that these tiny machines could play an important role in cleaning up oil spills, like the 2010 Deepwater Horizon incident in the Gulf of Mexico.
more...
No comment yet.
Sign up to comment
Scooped by BigField GEG Tech
October 24, 2014 5:56 AM
Scoop.it!

Oil-Eating Bacteria Engineered

Oil-Eating Bacteria Engineered | Genetic Engineering in the Press by GEG | Scoop.it
From news.nationalgeographic.com - May 30, 2014 10:42 AM
Scientists are experimenting with "green" microbes in the lab that could someday be used to gobble up oil spills along coastlines without damaging the environment.
more...
No comment yet.
Sign up to comment
Scooped by BigField GEG Tech
October 24, 2014 5:55 AM
Scoop.it!

Discovery of ‘messenger’ link brings hope of new drugs for Parkinson’s | The Times

From www.thetimes.co.uk - May 30, 2014 9:18 AM
A chemical messenger that is critical in protecting the brain against Parkinson’s disease has been identified by scientists
more...
healthcare's curator insight, January 26, 2024 6:03 AM
 
 
 
 
 
 
 
 
 
Sign up to comment
Scooped by BigField GEG Tech
October 24, 2014 5:54 AM
Scoop.it!

Novozymes raises 2014 outlook after strong first-quarter results

Novozymes raises 2014 outlook after strong first-quarter results | Genetic Engineering in the Press by GEG | Scoop.it
From online.wsj.com - May 30, 2014 9:11 AM
Novozymes raised its outlook for 2014 after seeing strong sales of its industrial enzymes used in washing detergents and in ethanol production.
more...
No comment yet.
Sign up to comment
Scooped by BigField GEG Tech
October 24, 2014 5:52 AM
Scoop.it!

Google Ventures Leads $130M Round For Big Data Medical Software Company Flatiron Health - Venture Capital Dispatch - WSJ

Google Ventures Leads $130M Round For Big Data Medical Software Company Flatiron Health - Venture Capital Dispatch - WSJ | Genetic Engineering in the Press by GEG | Scoop.it
From blogs.wsj.com - May 30, 2014 9:08 AM
The search giant's venture arm has provided its largest-ever funding round to a medical software company.
more...
No comment yet.
Sign up to comment
Scooped by BigField GEG Tech
October 24, 2014 5:50 AM
Scoop.it!

The data companies wish they had about customers.

The data companies wish they had about customers. | Genetic Engineering in the Press by GEG | Scoop.it
From online.wsj.com - May 30, 2014 9:07 AM
Big companies know a lot about the people they serve—but they'd like to know even more.
more...
No comment yet.
Sign up to comment
Scooped by BigField GEG Tech
October 24, 2014 5:49 AM
Scoop.it!

A Whole-Cell Computational Model Predicts Phenotype from Genotype: Cell

A Whole-Cell Computational Model Predicts Phenotype from Genotype: Cell | Genetic Engineering in the Press by GEG | Scoop.it
From www.cell.com - May 30, 2014 4:34 PM

Understanding how complex phenotypes arise from individual molecules and their interactions is a primary challenge in biology that computational approaches are poised to tackle. We report a whole-cell computational model of the life cycle of the human pathogen Mycoplasma genitalium that includes all of its molecular components and their interactions. An integrative approach to modeling that combines diverse mathematics enabled the simultaneous inclusion of fundamentally different cellular processes and experimental measurements. Our whole-cell model accounts for all annotated gene functions and was validated against a broad range of data. The model provides insights into many previously unobserved cellular behaviors, including in vivo rates of protein-DNA association and an inverse relationship between the durations of DNA replication initiation and replication. In addition, experimental analysis directed by model predictions identified previously undetected kinetic parameters and biological functions. We conclude that comprehensive whole-cell models can be used to facilitate biological discovery.

more...
No comment yet.
Sign up to comment
Scooped by BigField GEG Tech
October 24, 2014 5:47 AM
Scoop.it!

A Race to Save the Orange by Altering Its DNA

A Race to Save the Orange by Altering Its DNA | Genetic Engineering in the Press by GEG | Scoop.it
From www.nytimes.com - May 30, 2014 10:56 AM
Growers turned to genetics in hopes of building a tougher orange tree. But would the public accept genetically modified food?
more...
No comment yet.
Sign up to comment
About Follow us Resources Terms Mobile Features
Facebook
X
LinkedIn