Genetic Engineering in the Press by GEG
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Part goat, part spider? - CNN.com Video

From edition.cnn.com - May 30, 2014 5:08 PM
A look at a the recent controversy in Canada of a mammal genetically engineered with arachnid DNA.
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AM - Scientists to create world's first synthetic complex life form 27/05/2014

AM - Scientists to create world's first synthetic complex life form 27/05/2014 | Genetic Engineering in the Press by GEG | Scoop.it
From www.abc.net.au - May 30, 2014 4:57 PM

It's the stuff of science fiction, not just altering life but creating it from the chromosomes up.
Today an international alliance, including Australian scientists, will unveil plans to build the world's first synthetic complex organism - a new strain of yeast.
The team says if they're successful it will be just the beginning, but they're well aware of the project's potential to cause controversy.

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Emerging biomedical applications of synthetic biology : Abstract : Nature Reviews Genetics

From www.nature.com - May 30, 2014 4:52 PM

Synthetic biology aims to create functional devices, systems and organisms with novel and useful functions on the basis of catalogued and standardized biological building blocks. Although they were initially constructed to elucidate the dynamics of simple processes, designed devices now contribute to the understanding of disease mechanisms, provide novel diagnostic tools, enable economic production of therapeutics and allow the design of novel strategies for the treatment of cancer, immune diseases and metabolic disorders, such as diabetes and gout, as well as a range of infectious diseases. In this Review, we cover the impact and potential of synthetic biology for biomedical applications.

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Total Synthesis of a Functional Designer Eukaryotic Chromosome

From www.sciencemag.org - May 30, 2014 4:43 PM

Rapid advances in DNA synthesis techniques have made it possible to engineer viruses, biochemical pathways and assemble bacterial genomes. Here, we report the synthesis of a functional 272,871–base pair designer eukaryotic chromosome, synIII, which is based on the 316,617–base pair native Saccharomyces cerevisiae chromosome III. Changes to synIII include TAG/TAA stop-codon replacements, deletion of subtelomeric regions, introns, transfer RNAs, transposons, and silent mating loci as well as insertion of loxPsym sites to enable genome scrambling. SynIII is functional in S. cerevisiae. Scrambling of the chromosome in a heterozygous diploid reveals a large increase in a-mater derivatives resulting from loss of the MATα allele on synIII. The complete design and synthesis of synIII establishes S. cerevisiae as the basis for designer eukaryotic genome biology.

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Craig Venter creates synthetic life form

Craig Venter creates synthetic life form | Genetic Engineering in the Press by GEG | Scoop.it
From www.theguardian.com - May 30, 2014 4:40 PM
Craig Venter and his team have built the genome of a bacterium from scratch and put it into a cell to make a synthetic life form
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Building the Ultimate Yeast Genome

From www.sciencemag.org - May 30, 2014 4:43 PM

Although Jef Boeke first scoffed at the idea of building an artificial chromosome for yeast, he and his colleagues eventually decided to tackle what at the time was a very daunting task. They spent more than a year figuring out what DNA they should remove to make the new chromosome more stable and what DNA to add to be able to mutate it at will. They started with just the 90,000-base arm of one chromosome and when that worked, began remaking chromosome 3. Now, with the help of partners from around the world, the New York University geneticist has set his sights on the whole genome.

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The Dawn of Virtual Cell Biology: Cell

The Dawn of Virtual Cell Biology: Cell | Genetic Engineering in the Press by GEG | Scoop.it
From www.cell.com - May 30, 2014 4:36 PM

To fulfill systems biology’s promise of providing fundamental new insights will require the development of quantitative and predictive models of whole cells. In this issue, Karr et al. present the first integrated and dynamic computational model of a bacterium that accounts for all of its components and their interactions.

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Preventative genetics: The ultimate way to halt disease

Preventative genetics: The ultimate way to halt disease | Genetic Engineering in the Press by GEG | Scoop.it
From www.bbc.com - May 30, 2014 10:54 AM
Can the information in our genes reveal serious medical issues years in advance? A leading geneticist thinks it’s possible.
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Tissue engineering: Grow your own smart organs

Tissue engineering: Grow your own smart organs | Genetic Engineering in the Press by GEG | Scoop.it
From www.bbc.com - May 30, 2014 10:51 AM
Robert Langer thinks one day we could grow tissues and organs from our cells, which contain sensors that can alert you when illness is about to strike.
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October 24, 2014 5:56 AM
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Access : Elevated nitrate enriches microbial functional genes for potential bioremediation of complexly contaminated sediments : The ISME Journal

From www.nature.com - May 30, 2014 10:35 AM
The ISME Journal: Multidisciplinary Journal of Microbial Ecology is the official Journal of the International Society for Microbial Ecology, publishing high-quality, original research papers, short communications, commentary articles and reviews in the rapidly expanding and diverse discipline of microbial ecology.
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Getting even | The Sunday Times

Getting even | The Sunday Times | Genetic Engineering in the Press by GEG | Scoop.it
From www.thesundaytimes.co.uk - May 30, 2014 9:31 AM

Many women who have been quietly appalled by friends’ forays into plastic surgery are starting to place their faith elsewhere. Not anywhere outlandish, mind you; they’re simply placing their bets on skincare once more. That’s because there’s a new generation of scientifically validated skincare innovations that offers ways of countering the ageing process.

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Top guns fly on algae in the US battle for fuel | The Sunday Times

Top guns fly on algae in the US battle for fuel | The Sunday Times | Genetic Engineering in the Press by GEG | Scoop.it
From www.thesundaytimes.co.uk - May 30, 2014 9:24 AM

In just a few years, algae have moved from a pond-life nuisance to a significant part of Washington’s strategy to sideline foreign oil.

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Developing countries leap ahead in biotech crop growth

Developing countries leap ahead in biotech crop growth | Genetic Engineering in the Press by GEG | Scoop.it
From online.wsj.com - May 30, 2014 8:49 AM
Developing countries are leaping ahead of industrial nations in planting genetically modified crops, according to a study
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Reducing greenhouse gases in China - CNN.com Video

From edition.cnn.com - May 30, 2014 5:09 PM
As CNN's Stan Grant reports, genetically engineered rice seeds will be used to reduce greenhouse gases in China.
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Sanofi ramps up artemisinin plant

Sanofi ramps up artemisinin plant | Genetic Engineering in the Press by GEG | Scoop.it
From www.european-biotechnology-news.com - May 30, 2014 4:50 PM
From its Italian manufacturing site at Garessio, Sanofi has launched large-scale production of semi-synthetic artemisinin, a potent anti-malarial drug.
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Genome‐scale engineering for systems and synthetic biology

Genome‐scale engineering for systems and synthetic biology | Genetic Engineering in the Press by GEG | Scoop.it
From msb.embopress.org - May 30, 2014 4:46 PM

Genome‐modification technologies enable the rational engineering and perturbation of biological systems. Historically, these methods have been limited to gene insertions or mutations at random or at a few pre‐defined locations across the genome. The handful of methods capable of targeted gene editing suffered from low efficiencies, significant labor costs, or both. Recent advances have dramatically expanded our ability to engineer cells in a directed and combinatorial manner. Here, we review current technologies and methodologies for genome‐scale engineering, discuss the prospects for extending efficient genome modification to new hosts, and explore the implications of continued advances toward the development of flexibly programmable chasses, novel biochemistries, and safer organismal and ecological engineering.

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High-level semi-synthetic production of the potent antimalarial artemisinin : Nature : Nature Publishing Group

High-level semi-synthetic production of the potent antimalarial artemisinin : Nature : Nature Publishing Group | Genetic Engineering in the Press by GEG | Scoop.it
From www.nature.com - May 30, 2014 4:47 PM
In 2010 there were more than 200[thinsp]million cases of malaria, and at least 655,000 deaths. The World Health Organization has recommended artemisinin-based combination therapies (ACTs) for the treatment of uncomplicated malaria caused by the parasite Plasmodium falciparum. Artemisinin is a sesquiterpene endoperoxide with potent antimalarial properties, produced by the plant Artemisia annua. However, the supply of plant-derived artemisinin is unstable, resulting in shortages and price fluctuations, complicating production planning by ACT manufacturers. A stable source of affordable artemisinin is required. Here we use synthetic biology to develop strains of Saccharomyces cerevisiae (baker/'s yeast) for high-yielding biological production of artemisinic acid, a precursor of artemisinin. Previous attempts to produce commercially relevant concentrations of artemisinic acid were unsuccessful, allowing production of only 1.6[thinsp]grams per litre of artemisinic acid. Here we demonstrate the complete biosynthetic pathway, including the discovery of a plant dehydrogenase and a second cytochrome that provide an efficient biosynthetic route to artemisinic acid, with fermentation titres of 25[thinsp]grams per litre of artemisinic acid. Furthermore, we have developed a practical, efficient and scalable chemical process for the conversion of artemisinic acid to artemisinin using a chemical source of singlet oxygen, thus avoiding the need for specialized photochemical equipment. The strains and processes described here form the basis of a viable industrial process for the production of semi-synthetic artemisinin to stabilize the supply of artemisinin for derivatization into active pharmaceutical ingredients (for example, artesunate) for incorporation into ACTs. Because all intellectual property rights have been provided free of charge, this technology has the potential to increase provision of first-line antimalarial treatments to the developing world at a reduced average annual price.
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Bridging the layers: towards integration of signal transduction, regulation and metabolism into mathematical models - Molecular BioSystems (RSC Publishing)

Bridging the layers: towards integration of signal transduction, regulation and metabolism into mathematical models - Molecular BioSystems (RSC Publishing) | Genetic Engineering in the Press by GEG | Scoop.it
From pubs.rsc.org - May 30, 2014 4:35 PM
Mathematical modelling is increasingly becoming an indispensable tool for the study of cellular processes, allowing their analysis in a systematic and comprehensive manner. In the vast majority of the cases, models focus on specific subsystems, and in particular describe either metabolism, gene expression or
Molecular BioSystems 2013 Review Articles in Systems Biology
Molecular BioSystems Network Biology
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J Craig Venter sequenced the human genome. Now he wants to convert DNA into a digital signal (Wired UK)

J Craig Venter sequenced the human genome. Now he wants to convert DNA into a digital signal (Wired UK) | Genetic Engineering in the Press by GEG | Scoop.it
From www.wired.co.uk - May 30, 2014 4:41 PM
Wired interviews J Craig Venter: the first person to sequence the human genome
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Don’t Be Afraid of Genetic Modification

Don’t Be Afraid of Genetic Modification | Genetic Engineering in the Press by GEG | Scoop.it
From www.nytimes.com - May 30, 2014 10:56 AM
We shouldn’t let political calculations or unfounded fears keep safe genetically modified animals off the market.
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First 'microsubmarines' designed to help clean up oil spills

First 'microsubmarines' designed to help clean up oil spills | Genetic Engineering in the Press by GEG | Scoop.it
From www.sciencedaily.com - May 30, 2014 10:49 AM
Scientists are reporting development and successful testing of the first self-propelled "microsubmarines" designed to pick up droplets of oil from contaminated waters and transport them to collection facilities. The report concludes that these tiny machines could play an important role in cleaning up oil spills, like the 2010 Deepwater Horizon incident in the Gulf of Mexico.
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Oil-Eating Bacteria Engineered

Oil-Eating Bacteria Engineered | Genetic Engineering in the Press by GEG | Scoop.it
From news.nationalgeographic.com - May 30, 2014 10:42 AM
Scientists are experimenting with "green" microbes in the lab that could someday be used to gobble up oil spills along coastlines without damaging the environment.
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Discovery of ‘messenger’ link brings hope of new drugs for Parkinson’s | The Times

From www.thetimes.co.uk - May 30, 2014 9:18 AM
A chemical messenger that is critical in protecting the brain against Parkinson’s disease has been identified by scientists
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Novozymes raises 2014 outlook after strong first-quarter results

Novozymes raises 2014 outlook after strong first-quarter results | Genetic Engineering in the Press by GEG | Scoop.it
From online.wsj.com - May 30, 2014 9:11 AM
Novozymes raised its outlook for 2014 after seeing strong sales of its industrial enzymes used in washing detergents and in ethanol production.
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Google Ventures Leads $130M Round For Big Data Medical Software Company Flatiron Health - Venture Capital Dispatch - WSJ

Google Ventures Leads $130M Round For Big Data Medical Software Company Flatiron Health - Venture Capital Dispatch - WSJ | Genetic Engineering in the Press by GEG | Scoop.it
From blogs.wsj.com - May 30, 2014 9:08 AM
The search giant's venture arm has provided its largest-ever funding round to a medical software company.
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