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Scooped by
Gilbert C FAURE
February 8, 2017 12:47 PM
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Invariant NKT (iNKT) cells in healthy people express iNKT-TCRs with widely varying affinities for CD1d, suggesting different roles for high- and low-affinity iNKT clones in immune regulation. However, the functional implications of this heterogeneity have not yet been determined. Functionally aberrant iNKT responses have been previously demonstrated in different autoimmune diseases, including human type 1 diabetes, but their relationship to changes in the iNKT clonal repertoire have not been addressed. In this study, we directly compared the clonal iNKT repertoire of people with recent onset type 1 diabetes and age- and gender-matched healthy controls with regard to iNKT-TCR affinity and cytokine production. Our results demonstrate a selective loss of clones expressing high-affinity iNKT-TCRs from the iNKT repertoire of people with type 1 diabetes. Furthermore, this bias in the clonal iNKT repertoire in type 1 diabetes was associated with increased GM-CSF, IL-4, and IL-13 cytokine secretion among Ag-stimulated low-affinity iNKT clones. Thus, qualitative changes of the clonal iNKT repertoire with the potential to affect the regulatory function of this highly conserved T cell population are already established at the early stages in type 1 diabetes. These findings may inform future rationales for the development of iNKT-based therapies aiming to restore immune tolerance in type 1 diabetes.
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Scooped by
Gilbert C FAURE
January 25, 2017 12:34 PM
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The European Biotech News Website
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Scooped by
Gilbert C FAURE
January 15, 2017 9:26 AM
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The interactions of the gut microbiota in children with typical diabetes autoantibodies differ from that in healthy children. The fact that these differences already exist before antibodies are detectable in the blood add
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Scooped by
Gilbert C FAURE
January 7, 2017 1:04 PM
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Invariant NKT (iNKT) cells in healthy people express iNKT-TCRs with widely varying affinities for CD1d, suggesting different roles for high- and low-affinity iNKT clones in immune regulation. However, the functional implications of this heterogeneity have not yet been determined. Functionally aberrant iNKT responses have been previously demonstrated in different autoimmune diseases, including human type 1 diabetes, but their relationship to changes in the iNKT clonal repertoire have not been addressed. In this study, we directly compared the clonal iNKT repertoire of people with recent onset type 1 diabetes and age- and gender-matched healthy controls with regard to iNKT-TCR affinity and cytokine production. Our results demonstrate a selective loss of clones expressing high-affinity iNKT-TCRs from the iNKT repertoire of people with type 1 diabetes. Furthermore, this bias in the clonal iNKT repertoire in type 1 diabetes was associated with increased GM-CSF, IL-4, and IL-13 cytokine secretion among Ag-stimulated low-affinity iNKT clones. Thus, qualitative changes of the clonal iNKT repertoire with the potential to affect the regulatory function of this highly conserved T cell population are already established at the early stages in type 1 diabetes. These findings may inform future rationales for the development of iNKT-based therapies aiming to restore immune tolerance in type 1 diabetes.
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Scooped by
Gilbert C FAURE
December 15, 2016 2:00 PM
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Flexible peptide recognition by HLA-DR triggers specific autoimmune T-cell responses in autoimmune thyroiditis and diabetes
Cheuk Wun Li
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Scooped by
Gilbert C FAURE
December 6, 2016 10:36 AM
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By looking in pancreatic islets rather than blood, a UMass team has uncovered a trove of new antigens that drive Type I diabetes.
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Scooped by
Gilbert C FAURE
November 25, 2016 7:09 AM
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Progress and challenges for treating Type 1 diabetes
Justin W. Garyua, Eric Meffrea, Chris Cotsapasc, Kevan C. Herold
Journa
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Scooped by
Gilbert C FAURE
November 21, 2016 12:29 PM
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Credit: EPFL
Type-1 diabetes occurs when immune cells attack the pancreas. EPFL scientists have now discovered what may trigger this attack, opening new directions for treatments.
Type-1 diabetes is..
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Scooped by
Gilbert C FAURE
November 15, 2016 2:42 PM
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A group of researchers from UMass Medical School has isolated immune cells from the islets of nine donors with type 1 diabetes to understand and prevent the immune-mediated destruction of beta cells.
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Scooped by
Gilbert C FAURE
November 8, 2016 10:20 AM
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Immunol Res. 2016 Feb;64(1):36-43. Review
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Scooped by
Gilbert C FAURE
November 8, 2016 4:04 AM
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Certain proteins in the blood of children can predict incipient type 1 diabetes, even before the first symptoms appear. A team of scientists at the Helmholtz Zentrum München, partners in the German Center for Diabetes Research (DZD), reported these findings in the ‘Diabetologia’ journal.
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Scooped by
Gilbert C FAURE
October 19, 2016 6:10 AM
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Diabetes/Metabolism Research and ReviewsCLICK HERE TO READ MORE DETAILS
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Scooped by
Gilbert C FAURE
October 15, 2016 10:43 AM
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The prevalence of celiac disease autoimmunity or tissue transglutaminase autoantibodies (TGA) amongst patients with type 1 diabetes (T1D) and autoimmune thyroid disease (AITD) in the Chinese population remains unknown.
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Scooped by
Gilbert C FAURE
January 31, 2017 8:45 AM
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Psychological health, access to care, expanded and personalized treatment options, and the tracking of hypoglycemia in people with diabetes are key areas emphasized in the American Diabetes Association’s (Association) new 2017 Standards of Medical Care in Diabetes (Standards). Produced annually by the Association, the guidelines focus on screening, diagnosis and treatment to provide better health outcomes for children, adults and older people with type 1, type 2 or gestational diabetes, and to improve the prevention and delay of type 2 diabetes.
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Scooped by
Gilbert C FAURE
January 23, 2017 8:28 AM
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Diabetes Educ. 2016 Feb;42(1):23-33. doi: 10.1177/0145721715620019. Epub 2015 Dec 7. Research Support, N.I.H., Extramural
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Scooped by
Gilbert C FAURE
January 10, 2017 9:52 AM
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New research published in Diabetologia (the journal of the European Association for the Study of Diabetes [EASD]) shows that children with type 1 diabetes (T1D) have a higher incidence of enterovirus infections prior to experiencin
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Scooped by
Gilbert C FAURE
December 19, 2016 4:58 AM
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Tolerance is required to prevent rejection of intrahepatic islet allografts as a potential treatment for type 1 diabetes.
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Scooped by
Gilbert C FAURE
December 11, 2016 12:52 PM
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Official Full-Text Publication: Social media for empowering people with diabetes: Current status and future trends on ResearchGate, the professional network for scientists.
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Scooped by
Gilbert C FAURE
December 1, 2016 12:14 PM
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By converting α cells to functional β-like cells, the neurotransmitter GABA can act
to reverse chemically induced diabetes in vivo.
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Scooped by
Gilbert C FAURE
November 23, 2016 2:07 PM
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"Parallel use of 16S profiling & virome sequencing in stool samples from children with islet autoimmunity...": https://t.co/FjqcJ7Fh3G
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Scooped by
Gilbert C FAURE
November 20, 2016 3:46 AM
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Type 1 Diabetes
In the case of autoimmune diseases, such as type 1 diabetes, so-called “exhausted” T cells may be the answer to stopping disease. Long et al.
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Suggested by
Société Francaise d'Immunologie
November 9, 2016 2:50 AM
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Scooped by
Gilbert C FAURE
November 8, 2016 4:10 AM
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We sought to identify minimal sets of serum peptide signatures as markers for islet autoimmunity and predictors of progression rates to clinical type 1 diabetes in a case–control study.
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Rescooped by
Gilbert C FAURE
from Type 1 diabetes
November 5, 2016 6:27 AM
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Type 1 diabetes occurs when the immune system attacks pancreas cells. Now, scientists suggest blocking some signaling molecules might prevent the attacks.
Via Remi Creusot
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Scooped by
Gilbert C FAURE
October 18, 2016 8:28 PM
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Frank Waldron-Lynch and colleagues investigate immune cell biomarker responses in patients with type 1 diabetes following a single dose of recombinant interleukin-2.
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