AUTOIMMUNITY

Rheumatology Medical Article: Clinical features and prognostic factors of thrombotic thrombocytopenic purpura associated with systemic lupus erythematosus: a literature review of 105 cases from 1999 to 2011 (RT @MDLinx: Clinical features and...

The pathogenesis of systemic lupus erythematosus—an update

Jinyoung Choi1, *,Sang Taek Kim1, *,Joe Craft1, 2,

1 Department of Internal Medicine (Rheumatology), Yale School of Medicine, New Haven, CT 06520, United States2 Department of Immunobiology, Yale School of Medicine, New Haven, CT 06520, United States

http://dx.doi.org/10.1016/j.coi.2012.10.004,

Systemic lupus erythematosus (SLE, lupus) is characterized by a global loss of self-tolerance with activation of autoreactive T and B cells leading to production of pathogenic autoantibodies and tissue injury. Innate immune mechanisms are necessary for the aberrant adaptive immune responses in SLE. Recent advances in basic and clinical biology have shed new light on disease mechanisms in lupus, with this review discussing the recent studies that offer valuable insights into disease-specific therapeutic targets.

The pathogenesis of systemic lupus erythematosus—an update [Current Opinion in Immunology—an update] http://t.co/gKMERgRK...

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Dr. Mark J. Shlomchik Selected as the First Recipient of the Lupus Insight Prize
PR Newswire (press release)
WASHINGTON, May 30, 2013 /PRNewswire-USNewswire/ -- Mark J.

ACR Publishes List of Top 5 Questionable Procedures
Arthritis Today
An ANA test is used to help screen for autoimmune disorders, such as lupus, Sjögren's syndrome and juvenile arthritis.

Canadian Pediatric Lupus Severity Varies With Ethnicity Doctors Lounge The researchers found that disease manifestations (malar rash, arthritis, serositis, renal disease), autoantibody profiles, and severity of disease expression differed by...

Researchers reveal how defective degradation of neutrophil extracellular traps in SLE patients impacts disease phenotype | Research published by BioMed Central (Defective degradation of neutrophil extracellular traps in Lupus patients - latest research...

Dr. Mark J. Shlomchik Receives Lupus Insight Prize Recognizing Outstanding ...
The Herald | HeraldOnline.com
Dr.

Lupus Foundation of America Grants Lupus Research Fellowships and Career ...
MarketWatch (press release)
... Ph.D.Project Title: Role of microRNAs in Trophoblast Responses to Antiphospholipid Antibodies.

The Magic Molecule of Immunity?
Wall Street Journal
Finally, there is a chance that TRIM21 will help to explain autoimmune diseases, in which the body attacks itself. TRIM21 itself is a target of autoantibodies in autoimmune conditions such as lupus.

Systemic lupus erythematosus (SLE), commonly known as “lupus”, is an autoimmune disease that can affect any of the body’s organs or tissues.

Neuropsychiatric disease in murine lupus is dependent on the TWEAK/Fn14 pathway [Journal of Autoimmunity] http://t.co/dTZcLltGNy

Cutting Edge: Leptin-Induced ROR{gamma}t Expression in CD4+ T Cells Promotes Th17 Responses in Systemic... http://t.co/qtXCkOVGHm #jimmTCB

These compounds target the degradation and elimination of autoantibody-containing immune complexes, which are thought to be the most proximal pathophysiological trigger of lupus. Resolve will conduct all development ...

Scientists Find a Key Element of Lupus, Suggesting Better Drug Targets Science Daily (press release) In recent years, they and other researchers have found evidence that a powerful class of immune-stimulating chemicals, known as type I interferons,...