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AUTOIMMUNITY
Pathology, Diagnosis and Therapies
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Scooped by Gilbert C FAURE
May 31, 2014 4:58 AM
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RheumShorts: Turmeric, Kids' Vasculitis, Autoantibodies - MedPage Today

RheumShorts: Turmeric, Kids' Vasculitis, Autoantibodies - MedPage Today | AUTOIMMUNITY | Scoop.it
MedPage Today RheumShorts: Turmeric, Kids' Vasculitis, Autoantibodies MedPage Today This week in rheumatology, researchers from around the world reported on the use of curcuminoids for osteoarthritis, autoantibody monitoring for drug-induced lupus,...
Gilbert C FAURE's insight:

Routine monitoring for antinuclear antibodies (ANA) did not help predict the development of drug-induced lupus among patients with rheumatoid arthritis receiving TNF inhibitors, British researchers reported.

Among 454 patients enrolled in a U.K. biologic database who underwent serial testing for the development of ANA, 83 seroconverted by a median time of 2 years, and six developed antibodies to double-stranded DNA (dsDNA). Three patients were diagnosed with lupus, according to Maya H. Buch, MBChB, PhD, of Leeds University, and colleagues.

 

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Scooped by Gilbert C FAURE
May 23, 2014 2:29 PM
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CD4+CD25-Foxp3+ T cells: a marker for lupus nephritis?

IntroductionSystemic lupus erythematosus (SLE) is a heterogenous autoimmune disease, which can affect different organs. Increased proportions of CD4+CD25-Foxp3+ T cells have been described in SLE patients.
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Scooped by Gilbert C FAURE
May 16, 2014 3:51 AM
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AstraZeneca reports successful monoclonal antibody studies in RA, SLE - Healio

AstraZeneca reports successful monoclonal antibody studies in RA, SLE - Healio | AUTOIMMUNITY | Scoop.it
AstraZeneca reports successful monoclonal antibody studies in RA, SLE Healio “Patients with lupus have severely limited options for control of their symptoms, as only one new treatment has been approved in more than 50 years,” Bing Yao, PhD, head...
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Suggested by Société Francaise d'Immunologie
May 8, 2014 2:55 PM
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Opposing Impact of B Cell-Intrinsic TLR7 and TLR9 Signals on Autoantibody Repertoire and Systemic Inflammation [AUTOIMMUNITY]

Systemic lupus erythematosus is a multisystem autoimmune disease characterized by autoantibodies targeting nucleic acid–associated Ags.
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Suggested by Société Francaise d'Immunologie
April 21, 2014 7:36 AM
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Mechanistic Target of Rapamycin Complex 1 Expands Th17 and IL-4+ CD4-CD8- Double-Negative T Cells and Contracts Regulatory T Cells in Systemic Lupus Erythematosus [CLINICAL AND HUMAN IMMUNOLOGY]

The mechanistic target of rapamycin (mTOR) is activated in CD4–CD8– double-negative (DN) T cells and its blockade is therapeutic in systemic lupus erythematosus (SLE) patients.
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Scooped by Gilbert C FAURE
April 16, 2014 1:14 PM
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Immune System Genes Activated by Estrogen May Hold Clues to Lupus Origin - Newswise (press release)

Immune System Genes Activated by Estrogen May Hold Clues to Lupus Origin
Newswise (press release)
The study on TLR8 was published in the March issue of Clinical Immunology.
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Scooped by Gilbert C FAURE
April 1, 2014 4:51 AM
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XTL Biopharmaceuticals Retains Expert Consultants in Rheumatology for Phase II Lupus Trial - Applied Clinical Trials

XTL Biopharmaceuticals Retains Expert Consultants in Rheumatology for Phase II Lupus Trial - Applied Clinical Trials | AUTOIMMUNITY | Scoop.it
XTL Biopharmaceuticals Retains Expert Consultants in Rheumatology for Phase II Lupus Trial http://t.co/gt3ML0FZE1
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Scooped by Gilbert C FAURE
March 25, 2014 4:10 PM
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Shingles Vaccine OK in Mild Lupus - MedPage Today

Shingles Vaccine OK in Mild Lupus - MedPage Today | AUTOIMMUNITY | Scoop.it
Shingles Vaccine OK in Mild Lupus
MedPage Today
The zoster vaccine Zostavax has been available since 2006, but there are no data on either immunogenicity or safety for patients with autoimmune diseases.
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Scooped by Gilbert C FAURE
March 17, 2014 9:32 AM
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IL-37 inhibits the production of inflammatory cytokines in peripheral blood mononuclear cells of patients with systemic lupus erythematosus: its correlation with disease activity

IL-37 inhibits the production of inflammatory cytokines in peripheral blood mononuclear cells of patients with systemic lupus erythematosus: its correlation with disease activity - up-to-the-minute news and headlines.
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Scooped by Gilbert C FAURE
March 12, 2014 6:19 AM
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Rare Double Infection: Lupus Patient Makes Antibodies to Fight HIV - LiveScience.com

Rare Double Infection: Lupus Patient Makes Antibodies to Fight HIV - LiveScience.com | AUTOIMMUNITY | Scoop.it
LiveScience.com Rare Double Infection: Lupus Patient Makes Antibodies to Fight HIV LiveScience.com The researchers found that in response to her HIV, the woman's immune system produced what are called "broadly neutralizing antibodies," which are...
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Scooped by Gilbert C FAURE
March 4, 2014 4:39 AM
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Emerging biological therapies for systemic lupus erythematosus, Expert Opinion on Emerging Drugs, Informa Healthcare

Emerging biological therapies for systemic lupus erythematosus, Expert Opinion on Emerging Drugs, Informa Healthcare | AUTOIMMUNITY | Scoop.it
Emerging biological therapies for systemic lupus erythematosus http://t.co/3tY521KnXz
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Scooped by Gilbert C FAURE
February 25, 2014 2:01 PM
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ANNRHEUMDIS : Annals of the Rheumatic Diseases

B cell depletion therapy for patients with systemic lupus results in significant drop in anticardiolipin antibody tit
http://t.co/tdbKwnlz1d
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Scooped by Gilbert C FAURE
May 28, 2014 8:35 AM
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Lupus Therapies Continue to Evolve

Lupus Therapies Continue to Evolve | AUTOIMMUNITY | Scoop.it
May is National Lupus Awareness Month, a time to think about lupus and the challenges it presents to patients. Learn about this chronic, autoimmune disease and the promise of future therapies. (May is National #Lupus Awareness Month.
Gilbert C FAURE's insight:

for laypeople from FDA

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Scooped by Gilbert C FAURE
May 19, 2014 12:23 PM
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Systemic lupus erythematosus: molecular cloning and analysis of recombinant DNase monoclonal kappa light chain NGK-1

Systemic lupus erythematosus: molecular cloning and analysis of recombinant DNase monoclonal kappa light chain NGK-1 | AUTOIMMUNITY | Scoop.it
Systemic lupus erythematosus: molecular cloning and analysis of recombinant DNase monoclonal kappa light chain NGK-1 http://t.co/Vp5ABUyvL3
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Scooped by Gilbert C FAURE
May 10, 2014 9:42 AM
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Rheuminations: Drug-Induced Lupus, a Case Report - MedPage Today

Rheuminations: Drug-Induced Lupus, a Case Report - MedPage Today | AUTOIMMUNITY | Scoop.it
Rheuminations: Drug-Induced Lupus, a Case Report MedPage Today LIVERPOOL -- Much experience with safety and efficacy has been gained with biologic treatment for rheumatoid arthritis and other autoimmune diseases in the 16 years since infliximab...
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Scooped by Gilbert C FAURE
April 27, 2014 12:49 PM
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Diet, microbiota and autoimmune diseases. [Lupus. 2014] - PubMed - NCBI

PubMed comprises more than 23 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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Scooped by Gilbert C FAURE
April 19, 2014 5:56 AM
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Regulatory CD4+ T Cells Promote B Cell Anergy in Murine Lupus

Regulatory CD4+ T Cells Promote B Cell Anergy in Murine Lupus [AUTOIMMUNITY] http://t.co/ieTe4DzCkP #jimmTCB
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Scooped by Gilbert C FAURE
April 11, 2014 5:16 AM
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New lupus journal - Rheumatology Update

New lupus journal - Rheumatology Update | AUTOIMMUNITY | Scoop.it
New lupus journal Rheumatology Update Professor Jill Buyon, Director of Rheumatology at the New York School of Medicine, and Professor Ronald van Vollenhoven, Head of Clinical Therapy Research, Inflammatory Diseases at the Karolinska Institutet,...
Gilbert C FAURE's insight:

The first online open-access journal for lupus research is now seeking submissions.

Published by BMJ Group, Lupus Science & Medicine “provides a central point for publication of basic, clinical, translational, and epidemiological studies of all aspects of lupus and related diseases”, according to its website.

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Scooped by Gilbert C FAURE
April 1, 2014 2:11 PM
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Antibiotics A Potential Mechanism For Autoimmunity - Science 2.0

Antibiotics A Potential Mechanism For Autoimmunity
Science 2.0
Autoimmune diseases such as Crohn's disease, eczema, or lupus are caused by an immune system that attacks normal components of various tissues of the body.
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Scooped by Gilbert C FAURE
March 31, 2014 1:32 PM
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Lupus nephritis: update on mecha... [Curr Opin Nephrol Hypertens. 2014] - PubMed - NCBI

PubMed comprises more than 23 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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Suggested by Société Francaise d'Immunologie
March 22, 2014 3:39 PM
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Siglec-G Deficiency Leads to More Severe Collagen-Induced Arthritis and Earlier Onset of Lupus-like Symptoms in MRL/lpr Mice [AUTOIMMUNITY]

Siglec-G Deficiency Leads to More Severe Collagen-Induced Arthritis and Earlier Onset of Lupus-like Symptoms in MRL/lpr Mice [AUTOIMMUNITY] | AUTOIMMUNITY | Scoop.it
Siglec-G is a member of the sialic acid–binding Ig-like lectin (Siglec) family expressed on all B cells.
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Scooped by Gilbert C FAURE
March 14, 2014 9:50 AM
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New Antibody Shows Promise in Lupus

New Antibody Shows Promise in Lupus | AUTOIMMUNITY | Scoop.it
Initial clinical studies of epratuzumab in patients with active, moderate-to-severe systemic lupus erythematosus are suggesting promise for this monoclonal antibody.
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Scooped by Gilbert C FAURE
March 7, 2014 3:13 AM
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In the Beginning Was Sm

In the Beginning Was Sm | AUTOIMMUNITY | Scoop.it
RT @hausmannMD: Everything you wanted to know about the anti-Smith antibody, but were afraid to ask. http://t.co/TKzC8o1upf #lupus #rheum
Gilbert C FAURE's insight:

The serum came from Stephanie Smith, who was diagnosed with SLE at the age of 15 in 1959 at the Rockefeller University Hospital, where she presented with arthritis, rash, pleuritis positive lupus erythematosus preparation, complement-fixing Abs with cell nuclei and cytoplasm, elevated sedimentation rate, γ-globulin, and anemia without renal disease. Stephanie succumbed to complications of her disease and treatment 7 years later at the age of 22.

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Scooped by Gilbert C FAURE
February 28, 2014 1:51 PM
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Studies from Scripps Research Institute in the Area of Mononuclear Phagocyte System Reported

Studies from Scripps Research Institute in the Area of Mononuclear Phagocyte System Reported | AUTOIMMUNITY | Scoop.it
Immunology News Article - Studies from Scripps Research Institute in the Area of Mononuclear Phagocyte System Reported (Immunology: Studies from Scripps Research Institute in the Area of Mononuclear Phagocyte System Reported
Gilbert C FAURE's insight:

lupus oriented, but mice model

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