AUTOIMMUNITY

Information on a number of conditions that are associated with diabetes including coeliac disease, thyroid disease and dental health complications.

The presence of Intrinsic Factor Antibodies (IFAB) as well as megaloblastic anaemia and low serum vitamin B12 are diagnostic of pernicious anaemia. A positive Intrinsic Factor antibody result can exclude the need for further testing, such as the Schillings test. The following autoimmune disease states are associated with pernicious anaemia and the presence of intrinsic factor antibodies: Hashimoto’s thyroiditis, insulin dependent diabetes mellitus, Grave’s disease, rheumatoid arthritis, myasthenia gravis, hypoparathyroidism and Lambert-Eaton syndrome.

Immunology of Diabetes Society Review Series: Insights into Pathogenesis of Type 1 Diabetes Series Editors: F. Susan Wong and Timothy I. Tree A wave of exciting research in recent years has given us greater insight into the immunological processes involved in the pathogenesis of type-1 diabetes. In this issue of Clinical & Experimental Immunology, Guest Editors F. Susan Wong, of Cardiff University, and Timothy I. Tree, of King’s College London, present a new Review Series exploring key focus areas in this developing field of immunology. The series papers were commissioned in collaboration with the Immunology of Diabetes Society, and encompass new findings presented at their 2018 IDS conference in London. The role of autoantibodies in the early diagnosis of type-1 diabetes. The discovery of a new CD4 T cell autoantigenic target that facilitates this. The mechanisms by which immune cells subsequently infiltrate the pancreas. Finally, the destructive interactions of immune cells with islets in diagnosed patients. These four reviews provide a detailed coverage from the original to latest discoveries into these areas of the immunology behind type-1 diabetes.  We invite you to read the freely accessible series papers below. Part One Editorial: Historical and New Insights into Pathogenesis of Type 1 Diabetes F.S. Wong, T.I. Tree Series papers: Birth and coming of age of islet autoantibodies Bonifacio, P. Achenbach Islet-Immune Interactions in Type 1 Diabetes: The Nexus of Beta Cell Destruction Peters, A. Posgai, T. Brusko Immune cell trafficking to the islets during type 1 diabetes A.M. Sandor, J. Jacobelli, R.S. Friedman HIPs and HIP-reactive T cells T.A. Wiles, T. Delong Part Two Editorial: Historical and New Insights into Pathogenesis of Type 1 Diabetes (2) F.S. Wong, T.I. Tree Series papers: Identifying the ‘Achilles heel’ of type 1 diabetes M. Battaglia, J. H. Buckner, M. K. Levings, S. J. Richardson, F. S. Wong and T. I. Tree Spliced HLA‐bound peptides: a Black Swan event in immunology P. Faridi , M. Dorvash, A. W. Purcell

Abstract Different lymphocyte subsets are involved in autoimmune pathogenesis of Type 1 Diabetes (T1D). Previous studies suggested a role of CD5 expressing T and B cells including rare unconvention...

Abstract Type 1 diabetes (T1D) is a chronic metabolic disease caused by the autoimmune destruction of insulin‐producing β‐cells. Ever since the 1920s, the fate of patients suffering from T1D was dr...

Summary Recent studies in Type 1 Diabetes (T1D) support an emerging model of disease pathogenesis that involves intrinsic β‐cell fragility combined with defects in both innate and adaptive immune c...

Nonalcoholic fatty liver disease (NAFLD) prevalence is high, especially in patients with obesity and type 2 diabetes, and is expected to rise steeply in the coming decades.We estimated NAFLD prevalence in patients with type 1 diabetes and explored associated ...

Your pancreas is studded with cell clusters called islets. In most people, special beta cells live snug in the islets, happily making the insulin that the body uses to regulate blood sugar. But in people with type 1 diabetes, the body's T cells mistakenly move into the islets and kill the beta...

Tocilizumab (TCZ) in New-onset Type 1 Diabetes - Full Text View.

Autoantibody Reversion: Changing Risk Categories in Multiple-Autoantibody–Positive Individuals Michelle So, Colin O’Rourke, Henry T. Bahnson, Carla J.Greenbaum, Cate Speake Diabetes Care Apr 2020,…...

The phenotype of autoreactive T cells in type 1 diabetes is described as Th1, Th17 and/or Th21, but is largely uncharacterized.We combined multi-para…...

Type 1 diabetes (T1D) is an auto-immune disorder characterized by a complex interaction between the host immune system and various environmental factors in genetically susceptible individuals. Genome-wide association studies (GWAS) identified different T1D risk and protection alleles, however,...

Type 1 diabetes (T1D) is a chronic metabolic disease characterized by insulin deficiency, generally resulting from progressive autoimmune-mediated destruction of pancreatic beta cells. While the phenomenon of beta cell autoimmunity continues to be an active area of investigation, recent evidence...

Type 1 diabetes (T1D) is an autoimmune disease, which is characterized by the destruction of islet β cells in the pancreas triggered by genetic and environmental factors. In past decades, extensive familial and genome‐wide association ...